Defining Cognitive Reserve and Implications for Cognitive Aging.

abstract：:Multiple sclerosis is a common neurological disease that results in disability in early adulthood that may progress through a relatively normal lifespan. Other comorbid health conditions can increase the likelihood of progression of MS and independently contribute to limitations in activities and social participation....

journal_title：Current neurology and neuroscience reports

authors： Overs S,Hughes CM,Haselkorn JK,Turner AP

更新日期：2012-10-01 00:00:00

abstract：:Prospective studies conducted during the last decade have shown that the majority of patients with Parkinson's disease (PD) develop dementia. In addition, using a variety of definitions and methods, more recent research suggests that approximately a quarter of PD patients without dementia have mild cognitive impairmen...

journal_title：Current neurology and neuroscience reports

authors： Aarsland D,Brønnick K,Fladby T

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:GBA mutations are the most common known genetic cause of Parkinson's disease (PD). Its biological pathway may be important in idiopathic PD, since activity of the enzyme encoded by GBA, glucocerebrosidase, is reduced even among PD patients without GBA mutations. This article describes the structure an...

journal_title：Current neurology and neuroscience reports

authors： Gan-Or Z,Liong C,Alcalay RN

更新日期：2018-06-08 00:00:00

abstract：PURPOSE OF REVIEW:Hematologic diseases are blood disorders which can affect different organs, including the central and peripheral nervous systems. Some of them are associated with increased risk of permanent disability and death. This review highlights a selected group of primary and acquired hematologic disorders tha...

journal_title：Current neurology and neuroscience reports

authors： Cruz ML,Farooq S,Testai FD

更新日期：2017-03-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (ie, statins) are oral cholesterol-lowering drugs. Statins are well tolerated and have an excellent safety record. These agents competitively inhibit HMG CoA reductase, which is the enzyme that catalyzes the conversion of HMG CoA to L-mevalonate. Alt...

journal_title：Current neurology and neuroscience reports

authors： Stüve O,Prod'homme T,Youssef S,Dunn S,Neuhaus O,Weber M,Hartung HP,Steinman L,Zamvil SS

更新日期：2004-05-01 00:00:00

abstract：:The optimal treatment for patients with oligodendrogliomas is unknown, and current management strategies remain controversial. This past year, further exploration of the molecular genetics of the tumors and its prognostic implications for outcome, evaluation of the utility of positron emission tomography imaging, and ...

journal_title：Current neurology and neuroscience reports

authors： Agulnik M,Mason WP

更新日期：2006-05-01 00:00:00

abstract：:Multiple sclerosis is generally regarded as a putative autoimmune disease of the central nervous system in which a chronic T-cell-mediated inflammation leads to focal plaques of demyelination in the white matter of the central nervous system. This plaque-centered view of the disease, however, fails to explain clinical...

journal_title：Current neurology and neuroscience reports

authors： Lassmann H

更新日期：2007-05-01 00:00:00

abstract：:Sleep is a function of the brain and sleep affects brain function, contributing to cerebral pathology through a diversity of direct and indirect mechanisms. Sleep-disordered breathing (SDB) is a very common disorder and is the major sleep-related risk factor for cerebrovascular disease. Epidemiologic studies have show...

journal_title：Current neurology and neuroscience reports

authors： Culebras A

更新日期：2004-03-01 00:00:00

abstract：:Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. Using positron emission tomography, it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation correspond...

journal_title：Current neurology and neuroscience reports

authors： Gerhard A

更新日期：2013-12-01 00:00:00

abstract：:Diffuse infiltrative low grade gliomas (LGG) account for approximately 15 % of all gliomas. The prognosis of LGG differs between high-risk and low-risk patients notwithstanding varying definitions of what constitutes a high-risk patient. Maximal safe resection optimally is the initial treatment. Surgery that achieves ...

journal_title：Current neurology and neuroscience reports

authors： Le Rhun E,Taillibert S,Chamberlain MC

更新日期：2016-02-01 00:00:00

abstract：:Over the past 10 years, the Food and Drug Administration has approved eight prophylactic antiepileptic drugs (AEDs). Although the goal of universal seizure control without side effects has not been reached, the tolerability of medications has improved. This paper reviews the AEDs introduced since 1993 and tries to obj...

journal_title：Current neurology and neuroscience reports

authors： Weinstein SL,Conry J

更新日期：2002-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe the pervasiveness of headache diseases across the globe and the need for healthcare advocacy, define healthcare advocacy, and identify how providers can incorporate healthcare advocacy into clinical practice and beyond. RECENT FINDINGS:Nearly 3 billion people across the globe experience m...

journal_title：Current neurology and neuroscience reports

authors： Arca KN,Starling AJ

更新日期：2020-09-17 00:00:00

abstract：PURPOSE OF REVIEW:Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of m...

journal_title：Current neurology and neuroscience reports

authors： Meisenhelter S,Jobst BC

更新日期：2018-04-19 00:00:00

abstract：:Migraine is a highly prevalent headache disorder that has a substantial impact on the individual and society. In this article, we review the burden of migraine, emphasizing the population-based studies that used standardized diagnostic criteria. We highlight descriptive epidemiology, burden of disease, patterns of dia...

journal_title：Current neurology and neuroscience reports

authors： Bigal ME,Lipton RB,Stewart WF

更新日期：2004-03-01 00:00:00

abstract：:Mitochondria are key organelles in eukaryotic cells that not only generate adenosine triphosphate but also perform such critical functions as hosting essential biosynthetic pathways, calcium buffering, and apoptotic signaling. In vivo, mitochondria form dynamic networks that undergo frequent morphologic changes throug...

journal_title：Current neurology and neuroscience reports

authors： Lu B

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Traumatic brain injuries are common, especially within the elderly population, which is typically defined as age 65 and older. This narrative review aims at summarizing and critically evaluating important aspects of their health care management in covering the entire pathway from prehospital care to r...

journal_title：Current neurology and neuroscience reports

authors： Schumacher R,Müri RM,Walder B

更新日期：2017-10-07 00:00:00

abstract：:A perilymph fistula is an abnormal connection between the inner and middle ear that allows escape of perilymph fluid into the middle ear compartment. The clinical symptomatology that follows leakage of fluid is by and large indistinguishable from a number of other pathologies that affect inner ear function. Definite d...

journal_title：Current neurology and neuroscience reports

authors： Maitland CG

更新日期：2001-09-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no...

journal_title：Current neurology and neuroscience reports

authors： Steiner I,Berger JR

更新日期：2012-12-01 00:00:00

abstract：:Diabetes mellitus is a common cause of peripheral nervous system disorders that manifest in a variety of clinical forms, many of which are often misdiagnosed. Over the past two decades, our understanding of the pathophysiology of diabetic nerve injury has improved remarkably through the elucidation of the important ro...

journal_title：Current neurology and neuroscience reports

authors： Podwall D,Gooch C

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews was to review genes where putative or confirmed pathogenic mutations causing Parkinson's disease or Parkinsonism have been identified since 2012, and summarizes the clinical and pathological picture of the associated disease subtypes. RECENT FINDINGS:Newly reported genes for domi...

journal_title：Current neurology and neuroscience reports

authors： Puschmann A

更新日期：2017-09-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (AD/HD) can cause significant impairment in psychosocial and scholastic achievement. AD/HD should be appropriately managed even if patients have comorbid epilepsy. The diagnosis and treatment of AD/HD in patients with epilepsy presents several challenges. Differentiating indepe...

journal_title：Current neurology and neuroscience reports

authors： Brown MG,Becker DA,Pollard JR,Anderson CT

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Elevated cholesterol is an established risk factor for ischemic stroke. The value of statins for stroke prevention has been clear for more than a decade. RECENT FINDINGS:However, the use of new medication combinations such as ezetimibe or proprotein convertase subtilisin-kexin type 9 inhibitors plus ...

journal_title：Current neurology and neuroscience reports

authors： Aradine E,Hou Y,Cronin CA,Chaturvedi S

更新日期：2020-06-22 00:00:00

abstract：:Seizures represent an important clinical manifestation of inborn errors of metabolism. The presence of myoclonic seizures and very early onset are clues to a metabolic disorder. Specific correlations between age of seizure onset and electroencephalogram patterns with inborn errors of metabolism are discussed. The expl...

journal_title：Current neurology and neuroscience reports

authors： Pearl PL,Bennett HD,Khademian Z

更新日期：2005-03-01 00:00:00

abstract：:In the experimental autoimmune encephalitis model of multiple sclerosis, the effects of stress on disease severity depend on multiple factors, including the animal's genetics and the type of stressor. The studies in humans relating stress to the risk of developing multiple sclerosis have found discordant results. The ...

journal_title：Current neurology and neuroscience reports

authors： Lovera J,Reza T

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnostic classification of patients with disorders of consciousness (DoC) is based on clinician's observation of volitional behaviours. However, patients' caregivers often report higher levels of responsiveness with respect to those observed during the clinical assessment. Thus, increasing efforts h...

journal_title：Current neurology and neuroscience reports

authors： Magliacano A,De Bellis F,Galvao-Carmona A,Estraneo A,Trojano L

更新日期：2019-11-26 00:00:00

abstract：:Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific pat...

journal_title：Current neurology and neuroscience reports

authors： Rodriguez-Oroz MC,Gago B,Clavero P,Delgado-Alvarado M,Garcia-Garcia D,Jimenez-Urbieta H

更新日期：2015-07-01 00:00:00

abstract：:Evaluation for psychiatric and cognitive dysfunction is a crucial part of preoperative assessment for deep brain stimulation (DBS) surgery. All candidates for DBS should be treated for active psychiatric disorders, and the treatment team should also screen for past psychiatric history, which may predispose to postoper...

journal_title：Current neurology and neuroscience reports

authors： Anderson KE,Mullins J

更新日期：2003-07-01 00:00:00

abstract：:Nocturnal frontal lobe epilepsy (NFLE) is a syndrome of heterogeneous etiology, characterized by the occurrence of sleep-related seizures with different complexity and duration. Genetic, lesional, and cryptogenetic NFLE forms have been described. NFLE is generally considered a benign clinical entity, although severe, ...

journal_title：Current neurology and neuroscience reports

authors： Nobili L,Proserpio P,Combi R,Provini F,Plazzi G,Bisulli F,Tassi L,Tinuper P

更新日期：2014-02-01 00:00:00

abstract：:The presence of autonomic symptoms can make the diagnosis of headache challenging. While commonly seen with the trigeminal autonomic cephalalgias, autonomic dysfunction can also be present in patients with migraine, or with a variety of secondary headaches. The pathophysiology of cranial autonomic symptoms in headache...

journal_title：Current neurology and neuroscience reports

authors： Ailani J

更新日期：2016-05-01 00:00:00

abstract：:Hepatic and gastrointestinal disorders can produce a wide spectrum of neurologic complications both affecting the central nervous system (CNS) and the peripheral nervous system. These manifestations range in severity from coma in acute liver failure and acute pancreatitis, to minor cognitive changes in chronic portosy...

journal_title：Current neurology and neuroscience reports

authors： Ferro JM,Oliveira S

更新日期：2014-10-01 00:00:00