GBA-Associated Parkinson's Disease and Other Synucleinopathies.

abstract：:Restless legs syndrome is a very common and still under-diagnosed neurologic condition that can cause severe morbidity. The pathology centers around central nervous system iron homeostatic dysregulation with subsequent alterations in dopaminergic functioning. Genetic studies will hopefully soon identify specific abnor...

journal_title：Current neurology and neuroscience reports

authors： Ondo WG

更新日期：2005-07-01 00:00:00

abstract：:Degeneration of neuron and axons following injury to cells with which they synapse is termed trans-synaptic degeneration. This phenomenon may be seen in postsynaptic neurons (anterograde) or in presynaptic neurons (retrograde). Retrograde trans-synaptic degeneration (RTSD) of the retinal ganglion cells and retinal ner...

journal_title：Current neurology and neuroscience reports

authors： Dinkin M

更新日期：2017-02-01 00:00:00

abstract：:This review highlights recent epidemiologic, clinical-genetic, and neurochemical advances in our understanding of sporadic amyotrophic lateral sclerosis (ALS) and their relationships to familial ALS caused by superoxide dismutase (SOD1) gene mutations. It is of fundamental importance to recognize that ALS is a biologi...

journal_title：Current neurology and neuroscience reports

authors： Andersen PM

更新日期：2006-01-01 00:00:00

abstract：:It is well established that several infectious diseases can directly lead to ischemic or hemorrhagic stroke during their course. It appears possible that common viral and bacterial infections can increase the susceptibility to stroke by promoting atherosclerosis, inflammation, and local thrombosis. Stroke commonly lea...

journal_title：Current neurology and neuroscience reports

authors： Manousakis G,Jensen MB,Chacon MR,Sattin JA,Levine RL

更新日期：2009-01-01 00:00:00

abstract：:Neoplastic meningitis (NM) occurs in approximately 5% of all patients with cancer. NM is a disease affecting the entire neuraxis, so staging and treatment need to encompass all cerebrospinal fluid (CSF) compartments. Central nervous system staging of NM includes contrast-enhanced brain and spine imaging and radionucli...

journal_title：Current neurology and neuroscience reports

authors： Chamberlain MC

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Parkinson's disease was studied for a long time from the prism of a motor impairment. Recent advances have outlined the importance of cognitive and neuropsychiatric symptoms (NPS) in the PD equation. This review concentrates on the present possibilities of using neuroimaging techniques in order to qua...

journal_title：Current neurology and neuroscience reports

authors： Hanganu A,Monchi O

更新日期：2018-10-15 00:00:00

abstract：:Despite the growing awareness of mild traumatic brain injury in military and civilian populations, understanding of the acute and chronic effects of concussion on central nervous system structure and function is limited. Even less is understood about the underpinnings of the cardinal postconcussive symptom, post-traum...

journal_title：Current neurology and neuroscience reports

authors： Monteith TS,Borsook D

更新日期：2014-02-01 00:00:00

abstract：:The brain tumor community is a unique, underserved population that has not seen significant improvements in survival over the last four decades. In the search for effective treatments for brain tumors, nonprofit patient advocacy organizations identify and fill the gaps that the for-profit sector and the government hav...

journal_title：Current neurology and neuroscience reports

authors： Rhee M,Mui P,Cadogan C,Imerman J,Lindsell S,Samant LT

更新日期：2014-04-01 00:00:00

abstract：:This discussion reviews the common causes of Horner's syndrome, with emphasis on case reports from the past several years. Much of the recent literature concerns the use of apraclonidine as a diagnostic test for Horner's syndrome, possibly as an alternative for the current gold standard of cocaine eye drops. This new ...

journal_title：Current neurology and neuroscience reports

authors： Martin TJ

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Hiccups are a common problem that crosses multiple disciplines including neurology, gastroenterology and pulmonology, and primary care. There are no formal guidelines to the treatment of intractable hiccups and treatment is based on experience and anecdotal evidence often relying on older medications....

journal_title：Current neurology and neuroscience reports

authors： Rouse S,Wodziak M

更新日期：2018-06-22 00:00:00

abstract：:Prospective studies conducted during the last decade have shown that the majority of patients with Parkinson's disease (PD) develop dementia. In addition, using a variety of definitions and methods, more recent research suggests that approximately a quarter of PD patients without dementia have mild cognitive impairmen...

journal_title：Current neurology and neuroscience reports

authors： Aarsland D,Brønnick K,Fladby T

更新日期：2011-08-01 00:00:00

abstract：:The presence of autonomic symptoms can make the diagnosis of headache challenging. While commonly seen with the trigeminal autonomic cephalalgias, autonomic dysfunction can also be present in patients with migraine, or with a variety of secondary headaches. The pathophysiology of cranial autonomic symptoms in headache...

journal_title：Current neurology and neuroscience reports

authors： Ailani J

更新日期：2016-05-01 00:00:00

abstract：:Evaluation for psychiatric and cognitive dysfunction is a crucial part of preoperative assessment for deep brain stimulation (DBS) surgery. All candidates for DBS should be treated for active psychiatric disorders, and the treatment team should also screen for past psychiatric history, which may predispose to postoper...

journal_title：Current neurology and neuroscience reports

authors： Anderson KE,Mullins J

更新日期：2003-07-01 00:00:00

abstract：:Mitochondria are key organelles in eukaryotic cells that not only generate adenosine triphosphate but also perform such critical functions as hosting essential biosynthetic pathways, calcium buffering, and apoptotic signaling. In vivo, mitochondria form dynamic networks that undergo frequent morphologic changes throug...

journal_title：Current neurology and neuroscience reports

authors： Lu B

更新日期：2009-05-01 00:00:00

abstract：:Distal myopathy with rimmed vacuoles (DMRV) and hereditary inclusion body myopathy (hIBM) share similar clinical features, including onset in young adulthood with preferential involvement of the anterior compartment of the lower legs and sparing of the quadriceps femoris muscles. The most significant muscle pathology ...

journal_title：Current neurology and neuroscience reports

authors： Nonaka I,Noguchi S,Nishino I

更新日期：2005-02-01 00:00:00

abstract：:Respiratory failure complicates a number of acute neurologic conditions, most notably neuromuscular diseases (eg, Guillain-Barré syndrome and myasthenia gravis) and stroke. In addition, pulmonary complications, particularly pneumonia and atelectasis, are fairly common in patients with these diagnoses; their prevention...

journal_title：Current neurology and neuroscience reports

authors： Rabinstein AA

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Brain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients. RECENT FINDINGS:The advent of targeted therapy has ushered in an ...

journal_title：Current neurology and neuroscience reports

authors： Shonka N,Venur VA,Ahluwalia MS

更新日期：2017-04-01 00:00:00

abstract：:Over the last decade, there has been an emerging interest in the link between obstructive sleep apnea (OSA) and ocular health. Though the evidence for OSA playing a role in cerebrovascular disease risk seems clear, the same cannot be said for optic neuropathies. The association between OSA and glaucoma or non-arteriti...

journal_title：Current neurology and neuroscience reports

authors： Fraser CL

更新日期：2014-08-01 00:00:00

abstract：:Headache attributable to disorders of homeostasis represents a diverse diagnostic category in which external (i.e., high-altitude) or internal (i.e., fasting) demands exceed homeostatic capacity, resulting in symptomatic headaches. Metabolic headaches, especially fasting headache, have been observed to be common in th...

journal_title：Current neurology and neuroscience reports

authors： Grewal P,Smith JH

更新日期：2017-01-01 00:00:00

abstract：:The importance of recognizing and documenting the subjective impact of disease and the side effects of long-term medical therapy in illnesses such as Parkinson's disease is beginning to be fully appreciated. This appreciation follows the recognition that it is necessary to describe the overall results of diagnostic an...

journal_title：Current neurology and neuroscience reports

authors： Welsh MD

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Our purpose is to review evidence relating to the concept that interictal epileptiform discharges (IEDs) impair brain performance. RECENT FINDINGS:Sophisticated measures of motor and cognitive performance have clarified older observations, confirming that in both animals and humans, IEDs affect aspec...

journal_title：Current neurology and neuroscience reports

authors： Faught E,Karakis I,Drane DL

更新日期：2018-10-08 00:00:00

abstract：:Cysts and cystic-appearing intracranial lesions are common findings with routine cerebral imaging examination. These lesions often represent a challenge in diagnosis. Intracranial cystic lesions have wide pathologic and imaging spectra, of which some require an aggressive and tailored treatment, whereas many others re...

journal_title：Current neurology and neuroscience reports

authors： Taillibert S,Le Rhun E,Chamberlain MC

更新日期：2014-09-01 00:00:00

abstract：:The surgical treatment of epilepsy is expanding in an exciting and unprecedented way. This review highlights some of the recent advances in neuroimaging that have improved epilepsy surgery. In addition, novel therapies currently being evaluated in clinical trials, including gamma knife radiosurgery, deep brain stimula...

journal_title：Current neurology and neuroscience reports

authors： McKhann GM 2nd

更新日期：2004-07-01 00:00:00

abstract：:Stroke is one of leading causes of mortality and morbidity in the United States. Stroke prevention includes treatment of the stroke risk factors and long-term use of antithrombotic agents. Various agents have been studied for stroke prevention and other trials are ongoing. The aim of this article is to provide an over...

journal_title：Current neurology and neuroscience reports

authors： Kaplan ED,Sacco RL

更新日期：2002-01-01 00:00:00

abstract：:Tumefactive demyelinating lesions are rare consequences of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions pose a diagnostic challenge because they can mimic tumors and abscesses and because they can be caused by a heterogeneous range of disorders. This ar...

journal_title：Current neurology and neuroscience reports

authors： Frederick MC,Cameron MH

更新日期：2016-03-01 00:00:00

abstract：:Sleep disorders are common in patients with multiple sclerosis (MS) and play a crucial role in health and quality of life; however, they are often overlooked. The most important sleep disorders in this context are as follows: insomnia, restless legs syndrome, periodic limb movement disorders, and sleep-related breathi...

journal_title：Current neurology and neuroscience reports

authors： Veauthier C

更新日期：2015-05-01 00:00:00

abstract：:The Neuro-ICU is a multidisciplinary location that presents peculiar challenges and opportunities for patients with life-threatening neurological disease. Communication skills are essential in supporting caregivers and other embedded providers (e.g., neurosurgeons, advanced practice providers, nurses, pharmacists), th...

journal_title：Current neurology and neuroscience reports

authors： Trevick S,Kim M,Naidech A

更新日期：2016-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a leading cause of disability among young adults and has a significant economic impact on society. Although MS is not currently a curable disease, costly treatments known as disease-modifying therapies (DMTs) are available to reduce the disease impact in certain types of MS. In the current e...

journal_title：Current neurology and neuroscience reports

authors： Manouchehrinia A,Constantinescu CS

更新日期：2012-10-01 00:00:00

abstract：:Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific pat...

journal_title：Current neurology and neuroscience reports

authors： Rodriguez-Oroz MC,Gago B,Clavero P,Delgado-Alvarado M,Garcia-Garcia D,Jimenez-Urbieta H

更新日期：2015-07-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric disturbance. In this article, we used polysomnography, actigraphy and a variety of validated questionnaires to ascertain the extent to which sleep changes are identifiable and measurable in mild stage HD, ...

journal_title：Current neurology and neuroscience reports

authors： Goodman AO,Rogers L,Pilsworth S,McAllister CJ,Shneerson JM,Morton AJ,Barker RA

更新日期：2011-04-01 00:00:00