Mild cognitive impairment in Parkinson's disease.

abstract：:A perilymph fistula is an abnormal connection between the inner and middle ear that allows escape of perilymph fluid into the middle ear compartment. The clinical symptomatology that follows leakage of fluid is by and large indistinguishable from a number of other pathologies that affect inner ear function. Definite d...

journal_title：Current neurology and neuroscience reports

authors： Maitland CG

更新日期：2001-09-01 00:00:00

abstract：:Although the co-occurrence of myelitis and optic neuritis that characterizes neuromyelitis optica (NMO) was recognized over a century ago, distinguishing NMO from multiple sclerosis relied solely on clinical criteria until recently. The identification of a biomarker that has high specificity for NMO is clinically usef...

journal_title：Current neurology and neuroscience reports

authors： Cree B

更新日期：2008-09-01 00:00:00

abstract：:Microglia are the resident macrophages of the nervous system. They serve to protect and preserve neuronal cells from pathogens and facilitate recovery from metabolic insults. In addition, they appear to play a role in the neuropathology of noninfectious inflammatory disorders of the central nervous system, especially ...

journal_title：Current neurology and neuroscience reports

authors： Deng X,Sriram S

更新日期：2005-05-01 00:00:00

abstract：:Migraine and tension-type headaches are two of the most common types of primary headache disorders in children. Migraine is a primary central nervous system disorder characterized by triggered or spontaneous episodes of activation of trigemino-vascular complex, neurogenic inflammation around vessels and meninges, and ...

journal_title：Current neurology and neuroscience reports

authors： Gupta A,Rothner AD

更新日期：2001-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of upper and lower motor neurons that causes progressive weakness and death. The breadth of research in ALS continues to grow with exciting new discoveries in disease pathogenesis and potential future therapeutics. There is a growing list of identified...

journal_title：Current neurology and neuroscience reports

authors： Traub R,Mitsumoto H,Rowland LP

更新日期：2011-02-01 00:00:00

abstract：:Stroke is one of leading causes of mortality and morbidity in the United States. Stroke prevention includes treatment of the stroke risk factors and long-term use of antithrombotic agents. Various agents have been studied for stroke prevention and other trials are ongoing. The aim of this article is to provide an over...

journal_title：Current neurology and neuroscience reports

authors： Kaplan ED,Sacco RL

更新日期：2002-01-01 00:00:00

abstract：:Neurologic paraneoplastic syndromes (NPSs) result from damage to the nervous system due to the remote effects of cancer not related to metastasis, infection, or metabolic derangements. NPSs are rare, affecting 1 in 10,000 patients with cancer. Pathogenesis is likely related to the immune mechanisms: normal neural tiss...

journal_title：Current neurology and neuroscience reports

authors： Mehta SH,Morgan JC,Sethi KD

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Idiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) bioma...

journal_title：Current neurology and neuroscience reports

authors： Liguori C,Paoletti FP,Placidi F,Ruffini R,Sancesario GM,Eusebi P,Mercuri NB,Parnetti L

更新日期：2019-01-14 00:00:00

abstract：:Sleep disorders are common in neurodegenerative diseases such as Parkinson's disease (PD), multiple system atrophy (MSA), amyotrophic lateral sclerosis (ALS), hereditary ataxias, and Alzheimer's disease (AD). Type, frequency, and severity of sleep disturbances vary depending on each of these diseases. Cell loss of the...

journal_title：Current neurology and neuroscience reports

authors： Gaig C,Iranzo A

更新日期：2012-04-01 00:00:00

abstract：:The subjects of this review are the various types of optic nerve disease that involve autoimmune mechanisms, broadly defined. These include optic neuropathy caused by direct inflammatory involvement of the nerve parenchyma and optic nerve damage as an ischemic sequel to primary vasculitis, although there is naturally ...

journal_title：Current neurology and neuroscience reports

authors： Goodwin J

更新日期：2006-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Although the immune system seems to play an important role in the pathogenesis of disease, target antigens are still uncertain and pathways leading to tissue destruction have not been fully elucidated. Recent stu...

journal_title：Current neurology and neuroscience reports

authors： Hemmer B,Kieseier B,Cepok S,Hartung HP

更新日期：2003-05-01 00:00:00

abstract：:Our understanding of the underlying molecular mechanism of Parkinson's disease (PD) is hampered by a lack of access to affected human dopaminergic (DA) neurons on which to base experimental research. Fortunately, the recent development of a PD disease model using induced pluripotent stem cells (iPSCs) provides access ...

journal_title：Current neurology and neuroscience reports

authors： Byers B,Lee HL,Reijo Pera R

更新日期：2012-06-01 00:00:00

abstract：:Lyme disease is due to infection with a tick-borne spirochete, Borrelia burgdorferi. Risk for infection is confined to regions that contain the Ixodid tick vector. Characteristic skin, musculoskeletal, cardiac, ocular, and neurologic disorders are associated with the local, early dissemination and late stages of infec...

journal_title：Current neurology and neuroscience reports

authors： Coyle PK

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Near-death experiences (NDEs) are conscious perceptual experiences, including self-related emotional, spiritual, and mystical experiences, occurring in close encounters with death or in non-life-threatening situations. The origin of NDEs remains unknown. Here, we review recent advances in the understa...

journal_title：Current neurology and neuroscience reports

authors： Peinkhofer C,Dreier JP,Kondziella D

更新日期：2019-07-27 00:00:00

abstract：:Lipid storage myopathy (LSM) is pathologically characterized by prominent lipid accumulation in muscle fibers due to lipid dysmetabolism. Although extensive molecular studies have been performed, there are only four types of genetically diagnosable LSMs: primary carnitine deficiency (PCD), multiple acyl-coenzyme A deh...

journal_title：Current neurology and neuroscience reports

authors： Liang WC,Nishino I

更新日期：2011-02-01 00:00:00

abstract：:Migraine is a common disabling neurological disorder resulting from excessive cortical excitation and trigeminovascular afferent sensitization. In addition to aberrant neuronal processing, migraineurs are also at significant risk of vascular disease. Consequently, the impact of migraine extends well beyond the ictal h...

journal_title：Current neurology and neuroscience reports

authors： Harriott AM,Barrett KM

更新日期：2015-03-01 00:00:00

abstract：:In utero exposure to some antiepileptic drugs (AEDs) is associated with an increased risk of impaired cognitive development. Specifically, valproate and polytherapy exposure are each associated with an increased risk of cognitive impairment in children compared with other antiepileptic medications. The data regarding ...

journal_title：Current neurology and neuroscience reports

authors： Palac S,Meador KJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews was to review genes where putative or confirmed pathogenic mutations causing Parkinson's disease or Parkinsonism have been identified since 2012, and summarizes the clinical and pathological picture of the associated disease subtypes. RECENT FINDINGS:Newly reported genes for domi...

journal_title：Current neurology and neuroscience reports

authors： Puschmann A

更新日期：2017-09-01 00:00:00

abstract：:Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been associated with chronic encephalopathy, encephalitis, demyelinating disea...

journal_title：Current neurology and neuroscience reports

authors： Crawford JR

更新日期：2010-03-01 00:00:00

abstract：:Migraine is a highly prevalent headache disorder that has a substantial impact on the individual and society. In this article, we review the burden of migraine, emphasizing the population-based studies that used standardized diagnostic criteria. We highlight descriptive epidemiology, burden of disease, patterns of dia...

journal_title：Current neurology and neuroscience reports

authors： Bigal ME,Lipton RB,Stewart WF

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Traumatic brain injuries are common, especially within the elderly population, which is typically defined as age 65 and older. This narrative review aims at summarizing and critically evaluating important aspects of their health care management in covering the entire pathway from prehospital care to r...

journal_title：Current neurology and neuroscience reports

authors： Schumacher R,Müri RM,Walder B

更新日期：2017-10-07 00:00:00

abstract：PURPOSE OF REVIEW:Measurements obtained during real-world activity by wearable motion sensors may contribute more naturalistic accounts of clinically meaningful changes in impairment, activity, and participation during neurologic rehabilitation, but obstacles persist. Here we review the basics of wearable sensors, the ...

journal_title：Current neurology and neuroscience reports

authors： Dobkin BH,Martinez C

更新日期：2018-10-06 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (ie, statins) are oral cholesterol-lowering drugs. Statins are well tolerated and have an excellent safety record. These agents competitively inhibit HMG CoA reductase, which is the enzyme that catalyzes the conversion of HMG CoA to L-mevalonate. Alt...

journal_title：Current neurology and neuroscience reports

authors： Stüve O,Prod'homme T,Youssef S,Dunn S,Neuhaus O,Weber M,Hartung HP,Steinman L,Zamvil SS

更新日期：2004-05-01 00:00:00

abstract：:Iatrogenic fungal infections of the central nervous system had been considered a medical curiosity. Generally, they are a rare isolated complication of neurosurgical procedures, but periodically these infections are observed in larger populations as a result of exposure to contaminated materials during diagnostic or t...

journal_title：Current neurology and neuroscience reports

authors： Lahoti S,Berger JR

更新日期：2013-11-01 00:00:00

abstract：:Whipple disease is a rare disease caused by infection with the bacterium Tropheryma whippelii. Humans are the only known host for the infection. The signs of systemic infection include gastrointestinal problems, weight loss, and arthritis. Signs of central nervous system infection include cognitive changes, supranucle...

journal_title：Current neurology and neuroscience reports

authors： Louis ED

更新日期：2003-11-01 00:00:00

abstract：:Evaluation for psychiatric and cognitive dysfunction is a crucial part of preoperative assessment for deep brain stimulation (DBS) surgery. All candidates for DBS should be treated for active psychiatric disorders, and the treatment team should also screen for past psychiatric history, which may predispose to postoper...

journal_title：Current neurology and neuroscience reports

authors： Anderson KE,Mullins J

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF THE REVIEW:The aims of fluid management in acute brain injury are to preserve or restore physiology and guarantee appropriate tissue perfusion, avoiding potential iatrogenic effects. We reviewed the literature, focusing on the clinical implications of the selected papers. Our purposes were to summarize the p...

journal_title：Current neurology and neuroscience reports

authors： Rossi S,Picetti E,Zoerle T,Carbonara M,Zanier ER,Stocchetti N

更新日期：2018-09-11 00:00:00

abstract：PURPOSE OF REVIEW:Our purpose is to review evidence relating to the concept that interictal epileptiform discharges (IEDs) impair brain performance. RECENT FINDINGS:Sophisticated measures of motor and cognitive performance have clarified older observations, confirming that in both animals and humans, IEDs affect aspec...

journal_title：Current neurology and neuroscience reports

authors： Faught E,Karakis I,Drane DL

更新日期：2018-10-08 00:00:00

abstract：:Stroke and especially its complications are a leading cause of death. Despite reduced morbidity in some developed countries, mortality in stroke patients is still high worldwide. In the past decades, treatment of acute stroke has focused on early intervention, such as revascularization and cerebral edema prevention. H...

journal_title：Current neurology and neuroscience reports

authors： Zhang S,He WB,Chen NH

更新日期：2014-08-01 00:00:00

abstract：:Despite a large amount of research on malignant brain tumors over the past 70 years, the prognosis for most tumor types is poor. One current focus of research is increasing dose intensity of chemotherapeutic agents. Various ways to increase dose intensity include high-dose chemotherapy followed by stem cell rescue (eg...

journal_title：Current neurology and neuroscience reports

authors： Kraemer DF,Fortin D,Neuwelt EA

更新日期：2002-05-01 00:00:00