Abstract：
PURPOSE OF REVIEW:Measurements obtained during real-world activity by wearable motion sensors may contribute more naturalistic accounts of clinically meaningful changes in impairment, activity, and participation during neurologic rehabilitation, but obstacles persist. Here we review the basics of wearable sensors, the use of existing systems for neurological and rehabilitation applications and their limitations, and strategies for future use. RECENT FINDINGS:Commercial activity-recognition software and wearable motion sensors for community monitoring primarily calculate steps and sedentary time. Accuracy declines as walking speed slows below 0.8 m/s, less so if worn on the foot or ankle. Upper-extremity sensing is mostly limited to simple inertial activity counts. Research software and activity-recognition algorithms are beginning to provide ground truth about gait cycle variables and reveal purposeful arm actions. Increasingly, clinicians can incorporate inertial and other motion signals to monitor exercise, activities of daily living, and the practice of specific skills, as well as provide tailored feedback to encourage self-management of rehabilitation. Efforts are growing to create a compatible collection of clinically relevant sensor applications that capture the type, quantity, and quality of everyday activity and practice in known contexts. Such data would offer more ecologically sound measurement tools, while enabling clinicians to monitor and support remote physical therapies and behavioral modification when combined with telemedicine outreach.
journal_name
Curr Neurol Neurosci Repjournal_title
Current neurology and neuroscience reportsauthors
Dobkin BH,Martinez Cdoi
10.1007/s11910-018-0896-5subject
Has Abstractpub_date
2018-10-06 00:00:00pages
87issue
12eissn
1528-4042issn
1534-6293pii
10.1007/s11910-018-0896-5journal_volume
18pub_type
杂志文章,评审abstract：:Parkinson's disease, a common neurodegenerative disorder, results in significant morbidity 10 to 15 years after disease onset and increased mortality. Levodopa is the mainstay of therapy and provides benefit for the duration of the illness. However, within 5 years, up to 50% of individuals develop fluctuations, includ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-002-0006-5
更新日期：2002-07-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-012-0313-4
更新日期：2012-12-01 00:00:00
abstract：:Although the co-occurrence of myelitis and optic neuritis that characterizes neuromyelitis optica (NMO) was recognized over a century ago, distinguishing NMO from multiple sclerosis relied solely on clinical criteria until recently. The identification of a biomarker that has high specificity for NMO is clinically usef...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-008-0066-2
更新日期：2008-09-01 00:00:00
abstract：:Respiratory failure complicates a number of acute neurologic conditions, most notably neuromuscular diseases (eg, Guillain-Barré syndrome and myasthenia gravis) and stroke. In addition, pulmonary complications, particularly pneumonia and atelectasis, are fairly common in patients with these diagnoses; their prevention...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-005-0037-9
更新日期：2005-11-01 00:00:00
abstract：:A decade after the US Food and Drug Administration (FDA) approved intravenous tissue plasminogen activator for treatment of acute ischemic stroke, the public health impact of this treatment on stroke outcome remains limited. The extremely small time window for treatment and very low recanalization rates in large arter...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-006-0057-0
更新日期：2006-11-01 00:00:00
abstract：:Tumefactive demyelinating lesions are rare consequences of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions pose a diagnostic challenge because they can mimic tumors and abscesses and because they can be caused by a heterogeneous range of disorders. This ar...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-016-0626-9
更新日期：2016-03-01 00:00:00
abstract：:Mild cognitive impairment (MCI) refers to persons whose memory or other cognitive abilities are not normal, but who do not have clinically diagnosed dementia. MCI has received considerable attention in the medical literature over the past few years. There were 63 original reports in the English language literature wit...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-003-0020-2
更新日期：2003-09-01 00:00:00
abstract：:Neoplastic meningitis (NM) occurs in approximately 5% of all patients with cancer. NM is a disease affecting the entire neuraxis, so staging and treatment need to encompass all cerebrospinal fluid (CSF) compartments. Central nervous system staging of NM includes contrast-enhanced brain and spine imaging and radionucli...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-008-0038-6
更新日期：2008-05-01 00:00:00
abstract：:In the experimental autoimmune encephalitis model of multiple sclerosis, the effects of stress on disease severity depend on multiple factors, including the animal's genetics and the type of stressor. The studies in humans relating stress to the risk of developing multiple sclerosis have found discordant results. The ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-013-0398-4
更新日期：2013-11-01 00:00:00
abstract：:Epidemiologic studies have raised expectations that existing anti-inflammatory drugs may be useful in slowing the progression of Alzheimer's disease (AD). However, the first large-scale studies of anti-inflammatory drug treatment regimens have been negative. These disappointing results, along with new evidence from ce...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-002-0066-6
更新日期：2002-09-01 00:00:00
abstract：:Mitochondria are key organelles in eukaryotic cells that not only generate adenosine triphosphate but also perform such critical functions as hosting essential biosynthetic pathways, calcium buffering, and apoptotic signaling. In vivo, mitochondria form dynamic networks that undergo frequent morphologic changes throug...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-009-0032-7
更新日期：2009-05-01 00:00:00
abstract：:Despite increases in our understanding of rabies pathogenesis, it remains an inevitably fatal disease. Lack of awareness, low level of political commitment to rabies control, and failure to recognize and correlate clinical, laboratory, and neuroimaging features contribute to continuing deaths. Clinical symptomatology,...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-006-0047-2
更新日期：2006-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Abnormal accumulation of tau protein is the main hallmark of tauopathies and is closely associated with neurodegeneration and cognitive impairment, whereas the advance in PET imaging provides a non-invasive detection of tau inclusions in the brain. In this review, we discuss the potential of PET imagi...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-019-0962-7
更新日期：2019-06-06 00:00:00
abstract：:Biomarkers are objectively measured characteristics that are indicators of normal biological processes, pathogenic processes, or responses to therapeutic interventions. To date, clinical assessment remains the gold standard in the diagnosis of Parkinson's disease (PD) and clinical rating scales are well established as...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-010-0144-0
更新日期：2010-11-01 00:00:00
abstract：:Chronic migraine occurs in about 3% of pediatric headaches. Many would be intractable to more than two preventive medications. OnabotulinumtoxinA has been approved by the US Food and Drug Administration for the use of chronic migraine in adults in 2010. Data on effectiveness and tolerability in the pediatric populatio...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章
doi：10.1007/s11910-012-0251-1
更新日期：2012-04-01 00:00:00
abstract：:Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. Using positron emission tomography, it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation correspond...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-013-0405-9
更新日期：2013-12-01 00:00:00
abstract：:Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific pat...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-015-0562-0
更新日期：2015-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Parkinson's disease (PD) is a complex neurodegenerative disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates that mitochondrial dysfunction is a central factor in PD pathophysiology. Here we review recent developments around mitochondrial dysfunction in familial a...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-018-0829-3
更新日期：2018-04-03 00:00:00
abstract：:Multiple sclerosis (MS) is a leading cause of disability among young adults and has a significant economic impact on society. Although MS is not currently a curable disease, costly treatments known as disease-modifying therapies (DMTs) are available to reduce the disease impact in certain types of MS. In the current e...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-012-0291-6
更新日期：2012-10-01 00:00:00
abstract：:'Primary progressive aphasia' (PPA) refers to core linguistic disorders caused by neurodegenerative disease. Three main PPA variants are recognized: nonfluent/agrammatic, semantic and logopenic. Correctly classifying patients during life according to the underlying histopathology will become increasingly important as ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-014-0466-4
更新日期：2014-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study was to review recent literature on the early secondary prevention in transient ischemic attack (TIA) and minor stroke. RECENT FINDINGS:The result of Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events and the secondary analysis of Platelet-Orient...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-019-0950-y
更新日期：2019-05-14 00:00:00
abstract：:Contemporary treatment of malignant brain tumors has been hampered by problems with drug delivery to the tumor bed. Inherent boundaries of the central nervous system, such as the blood-brain barrier or the blood-cerebrospinal fluid barrier, and a general lack of response to many chemotherapeutic agents have led to alt...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-001-0020-z
更新日期：2001-05-01 00:00:00
abstract：:Hypersomnia includes a group of disorders in which the primary complaint is excessive daytime sleepiness. Chronic hypersomnia is characterized by at least 3 months of excessive sleepiness prior to diagnosis and may affect 4% to 6% of the population. The severity of daytime sleepiness needs to be quantified by subjecti...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-996-0039-2
更新日期：2006-03-01 00:00:00
abstract：:The treatment of relapsing-remitting multiple sclerosis (RRMS), the most common form of multiple sclerosis, has been revolutionized in recent years. In addition to effective treatment of acute relapses, therapies are now available to prevent relapses, reduce the burden of disease as seen on magnetic resonance imaging,...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-001-0031-9
更新日期：2001-05-01 00:00:00
abstract：:Central nervous system (CNS) HIV-related disorders frequently have devastating consequences. Significant progress has been made in the early diagnosis and treatment of the HIV-infected patient. As a result, the prevalence and natural history of neurologic illnesses have changed. This paper reviews the epidemiology, cl...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-003-0063-4
更新日期：2003-03-01 00:00:00
abstract：:Accumulating evidence indicates a role for metabolic dysfunction in the pathogenesis of Alzheimer's disease (AD). It is widely reported that Type 2 diabetes (T2D) increases the risk of developing AD, and several postmortem analyses have found evidence of insulin resistance in the AD brain. Thus, insulin-based therapie...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-012-0297-0
更新日期：2012-10-01 00:00:00
abstract：:Since the advent of in vivo imaging, first with CT, and then MRI, structural neuroimaging in patients has been widely used as a tool to explore the neural correlates of a wide variety of cognitive functions. Findings from studies using this methodology have formed a core component of current accounts of cognition, but...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-015-0570-0
更新日期：2015-08-01 00:00:00
abstract：:The neurocutaneous disorders (NCDs) embrace an extensive group of developmental disorders associated with involvement of the skin, central nervous system (CNS), and/or the peripheral nervous system (PNS). The neurocutaneous manifestations relate to the common ectodermal origin of these organs. This review intended for...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-015-0612-7
更新日期：2016-02-01 00:00:00
abstract：:Ependymomas are rare primary central nervous system tumors in adults. They occur most commonly in the spinal cord, where histopathologic evaluation is critical to differentiate the grade I myxopapillary ependymoma from the grade II ependymoma or grade III anaplastic ependymoma. Brain ependymomas are either grade II or...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-010-0109-3
更新日期：2010-05-01 00:00:00
abstract：:We review the current state of knowledge regarding headache and brain tumors. The epidemiology of this clinically relevant area is highlighted along with general clinical features of headache disorders seen in brain tumor patients. Some rarer clinical presentations are noted, particularly in relationship to the newly ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-007-0005-7
更新日期：2007-03-01 00:00:00
