Abstract：
:Although the co-occurrence of myelitis and optic neuritis that characterizes neuromyelitis optica (NMO) was recognized over a century ago, distinguishing NMO from multiple sclerosis relied solely on clinical criteria until recently. The identification of a biomarker that has high specificity for NMO is clinically useful for distinguishing NMO from multiple sclerosis and identifying patients at high risk for recurrent myelitis and optic neuritis. That fact that the biomarker is an autoantibody that recognizes aquaporin 4 (AQP4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that NMO is a humorally mediated autoimmune disease. This review discusses the discovery of the NMO-IgG biomarker, the identification of AQP4 as its target, the clinical applications of these advances, the pathologic implications for the anti-AQP4 antibody, and advances in NMO treatment.
journal_name
Curr Neurol Neurosci Repjournal_title
Current neurology and neuroscience reportsauthors
Cree Bdoi
10.1007/s11910-008-0066-2subject
Has Abstractpub_date
2008-09-01 00:00:00pages
427-33issue
5eissn
1528-4042issn
1534-6293journal_volume
8pub_type
杂志文章,评审abstract：:This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase inhibitors for cognitive impa...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-017-0778-2
更新日期：2017-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Neurogenic stunned myocardium (NSM) is a poorly recognized cardiac manifestation of neurological illness. This review addresses the contemporary understanding of NSM pathophysiology, epidemiology, diagnosis, and clinical management. RECENT FINDINGS:While the precise pathophysiology and diagnosis rema...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-019-0999-7
更新日期：2019-11-13 00:00:00
abstract：PURPOSE OF REVIEW:To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2). RECENT FINDINGS:Sleep-disordered breathing...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-018-0903-x
更新日期：2018-10-31 00:00:00
abstract：PURPOSE OF REVIEW:Our purpose is to review evidence relating to the concept that interictal epileptiform discharges (IEDs) impair brain performance. RECENT FINDINGS:Sophisticated measures of motor and cognitive performance have clarified older observations, confirming that in both animals and humans, IEDs affect aspec...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-018-0892-9
更新日期：2018-10-08 00:00:00
abstract：PURPOSE OF REVIEW:We describe the pervasiveness of headache diseases across the globe and the need for healthcare advocacy, define healthcare advocacy, and identify how providers can incorporate healthcare advocacy into clinical practice and beyond. RECENT FINDINGS:Nearly 3 billion people across the globe experience m...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-020-01073-z
更新日期：2020-09-17 00:00:00
abstract：:The neuropeptides hypocretin-1 and -2 (orexin A and B) are critical in the regulation of arousal and maintenance of wakefulness. Understanding the role of the hypocretin system in sleep/wake regulation has come from narcolepsy-cataplexy research. Deficiency of hypocretin results in loss of sleep/wake control with cons...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-010-0172-9
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Diagnostic classification of patients with disorders of consciousness (DoC) is based on clinician's observation of volitional behaviours. However, patients' caregivers often report higher levels of responsiveness with respect to those observed during the clinical assessment. Thus, increasing efforts h...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章
doi：10.1007/s11910-019-1018-8
更新日期：2019-11-26 00:00:00
abstract：:We review the current state of knowledge regarding headache and brain tumors. The epidemiology of this clinically relevant area is highlighted along with general clinical features of headache disorders seen in brain tumor patients. Some rarer clinical presentations are noted, particularly in relationship to the newly ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-007-0005-7
更新日期：2007-03-01 00:00:00
abstract：:Although migraine symptomatology is well-defined, our understanding of migraine pathophysiology is incomplete. Structural and functional brain imaging can contribute to a greater understanding of migraine pathophysiology. Recent neuroimaging studies demonstrate that migraine is associated with structural and functiona...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-016-0662-5
更新日期：2016-07-01 00:00:00
abstract：:Accumulating evidence indicates a role for metabolic dysfunction in the pathogenesis of Alzheimer's disease (AD). It is widely reported that Type 2 diabetes (T2D) increases the risk of developing AD, and several postmortem analyses have found evidence of insulin resistance in the AD brain. Thus, insulin-based therapie...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-012-0297-0
更新日期：2012-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The surgical management of trauma-related intracranial hemorrhage is characterized by marked heterogeneity. Large prospective randomized trials have generally been prohibited by the ubiquity of concordant pathology, diversity of trauma systems, and paucity of clinical equipoise among providers. RECEN...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-020-01080-0
更新日期：2020-11-02 00:00:00
abstract：:The neurocutaneous disorders (NCDs) embrace an extensive group of developmental disorders associated with involvement of the skin, central nervous system (CNS), and/or the peripheral nervous system (PNS). The neurocutaneous manifestations relate to the common ectodermal origin of these organs. This review intended for...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-015-0612-7
更新日期：2016-02-01 00:00:00
abstract：:A perilymph fistula is an abnormal connection between the inner and middle ear that allows escape of perilymph fluid into the middle ear compartment. The clinical symptomatology that follows leakage of fluid is by and large indistinguishable from a number of other pathologies that affect inner ear function. Definite d...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-001-0111-x
更新日期：2001-09-01 00:00:00
abstract：PURPOSE OF REVIEW:Patients with Parkinson's disease (PD) often display gastrointestinal and genitourinary autonomic symptoms years or even decades prior to diagnosis. These symptoms are thought to be caused in part by pathological α-synuclein inclusions in the peripheral autonomic and enteric nervous systems. It has be...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-018-0889-4
更新日期：2018-09-19 00:00:00
abstract：:The importance of recognizing and documenting the subjective impact of disease and the side effects of long-term medical therapy in illnesses such as Parkinson's disease is beginning to be fully appreciated. This appreciation follows the recognition that it is necessary to describe the overall results of diagnostic an...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-001-0088-5
更新日期：2001-07-01 00:00:00
abstract：:The original version of this article contains an error in the second sentence of the second paragraph of the Paleolithic Diet section. ...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11910-017-0804-4
更新日期：2017-10-17 00:00:00
abstract：:Lipid storage myopathy (LSM) is pathologically characterized by prominent lipid accumulation in muscle fibers due to lipid dysmetabolism. Although extensive molecular studies have been performed, there are only four types of genetically diagnosable LSMs: primary carnitine deficiency (PCD), multiple acyl-coenzyme A deh...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-010-0154-y
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:This review overviews perioperative stroke as it pertains to specific surgical procedures. RECENT FINDINGS:As awareness of perioperative stroke increases, so does the opportunity to potentially improve outcomes for these patients by early stroke recognition and intervention. Perioperative stroke is d...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-020-01033-7
更新日期：2020-04-27 00:00:00
abstract：:Stroke is one of leading causes of mortality and morbidity in the United States. Stroke prevention includes treatment of the stroke risk factors and long-term use of antithrombotic agents. Various agents have been studied for stroke prevention and other trials are ongoing. The aim of this article is to provide an over...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-002-0050-1
更新日期：2002-01-01 00:00:00
abstract：:Sleep is a function of the brain and sleep affects brain function, contributing to cerebral pathology through a diversity of direct and indirect mechanisms. Sleep-disordered breathing (SDB) is a very common disorder and is the major sleep-related risk factor for cerebrovascular disease. Epidemiologic studies have show...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-004-0032-6
更新日期：2004-03-01 00:00:00
abstract：:There is an increasing awareness that impulse control disorders (ICDs), including pathologic gambling and compulsive sexual behavior, can occur as a complication of Parkinson's disease (PD). Anecdotal experience and case reporting have suggested an association between ICDs in PD and the use of dopamine agonists. Lacki...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-006-0022-y
更新日期：2006-07-01 00:00:00
abstract：:Neuronal failure leading to dementia in neurodegenerative diseases is evidenced in vivo by functional and structural changes in the brain such as reductions of glucose consumption and volume of grey matter. The earliest phase of cognitive decline and presymptomatic stages of these diseases are heralded by specific pat...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-015-0562-0
更新日期：2015-07-01 00:00:00
abstract：:The surgical treatment of epilepsy is expanding in an exciting and unprecedented way. This review highlights some of the recent advances in neuroimaging that have improved epilepsy surgery. In addition, novel therapies currently being evaluated in clinical trials, including gamma knife radiosurgery, deep brain stimula...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-004-0061-1
更新日期：2004-07-01 00:00:00
abstract：:Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, opportunistic viral infection of the central nervous system that is mainly seen in the context of AIDS and certain monoclonal immune-suppressive therapies. The causative agent, a polyoma virus, named JC virus infects only humans and there is no...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-012-0313-4
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Hematologic diseases are blood disorders which can affect different organs, including the central and peripheral nervous systems. Some of them are associated with increased risk of permanent disability and death. This review highlights a selected group of primary and acquired hematologic disorders tha...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-017-0728-z
更新日期：2017-03-01 00:00:00
abstract：:Depressive disturbances are common in patients with Parkinson's disease (PD) and influence many other clinical aspects of the disease. In addition to causing inherent emotional distress, depressive disorders negatively impact quality of life, motor and cognitive deficits, functional disability, and other psychiatric c...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-013-0409-5
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This chapter focuses on limb apraxia, a cognitive-motor disorder of learned skilled movement, and the nature of the spatiotemporal errors that disrupt movement sequences. RECENT FINDINGS:A cognitive model that attempts to reconcile conceptual and preparatory aspects of the motor program with perceptu...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-019-0989-9
更新日期：2019-11-12 00:00:00
abstract：:Hypersomnia includes a group of disorders in which the primary complaint is excessive daytime sleepiness. Chronic hypersomnia is characterized by at least 3 months of excessive sleepiness prior to diagnosis and may affect 4% to 6% of the population. The severity of daytime sleepiness needs to be quantified by subjecti...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-996-0039-2
更新日期：2006-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Seizures can arise in neocortical, thalamocortical, limbic or brainstem networks. Here, we review recent genetic mechanisms implicated in focal and genetic generalized epilepsies (GGEs). RECENT FINDINGS:Pathogenic variation in GAP activity toward RAGs 1 (GATOR1) complex genes (i.e., DEPDC5, NPRL2 and...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-020-01059-x
更新日期：2020-08-13 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study was to review recent literature on the early secondary prevention in transient ischemic attack (TIA) and minor stroke. RECENT FINDINGS:The result of Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events and the secondary analysis of Platelet-Orient...
journal_title：Current neurology and neuroscience reports
pub_type： 杂志文章,评审
doi：10.1007/s11910-019-0950-y
更新日期：2019-05-14 00:00:00
