Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy.

abstract：:Tyrosine hydroxylase (TH), catalyzing the conversion of tyrosine into l-DOPA, is the rate-limiting enzyme in dopamine synthesis. Defects in insulin action contribute to alterations of TH expression and/or activity in the brain and insulin increases TH levels in 1-methyl-4-phenylpyridinium (MPP+)-treated neuronal cells...

journal_title：Journal of cellular physiology

authors： Fiory F,Mirra P,Nigro C,Pignalosa FC,Zatterale F,Ulianich L,Prevete N,Formisano P,Beguinot F,Miele C

更新日期：2019-07-01 00:00:00

abstract：:This study was undertaken to gain more insight into the mechanism whereby TGF-beta influences the cell cycle progression of cultured rabbit articular chondrocytes. Using proliferating chondrocytes in fetal calf serum-containing medium, we have previously shown that TGF-beta induced a recruitment of cells at the end of...

journal_title：Journal of cellular physiology

authors： Vivien D,Galéra P,Lebrun E,Daireaux M,Loyau G,Pujol JP

更新日期：1992-02-01 00:00:00

abstract：:During wound healing, myofibroblasts play a central role in matrix formation and wound contraction. At the end of healing, there is evidence that myofibroblasts disappear via apoptotic pathways. Hypertrophic scars are a fibroproliferative disorder that leads to considerable morbidity. It has been postulated that a def...

journal_title：Journal of cellular physiology

authors： Moulin V,Larochelle S,Langlois C,Thibault I,Lopez-Vallé CA,Roy M

更新日期：2004-03-01 00:00:00

abstract：:Mitofusin 2 (MFN2) is a regulatory protein participating in mitochondria dynamics, cell proliferation, death, differentiation, and so on. This study aims at revealing the functional role of MFN2 in the pluripotency maintenance and primitive differetiation of embryonic stem cell (ESCs). A dox inducible silencing and ro...

journal_title：Journal of cellular physiology

authors： Yi S,Cui C,Huang X,Yin X,Li Y,Wen J,Luan Q

更新日期：2020-02-01 00:00:00

abstract：:Hydrocortisone and dexamethasone produced a time-dependent increase [125I]epidermal growth factor [( 125I]EGF) binding in primary cultures of isolated rat hepatocytes. Maximally effective doses of glucocorticoids resulted in a 70-100% increase in binding. The effect was similar when hepatocytes were maintained on coll...

journal_title：Journal of cellular physiology

authors： Lin Q,Blaisdell J,O'Keefe E,Earp HS

更新日期：1984-06-01 00:00:00

abstract：:Protein kinase C and mitogen-activated protein (MAP) kinase are expressed in all smooth muscle cells and believed to be important in several physiologically relevant properties of this muscle. Our goal was to determine if protein kinase C and MAP kinase are activated by a simple increase in cellular Ca(2+) and to dete...

journal_title：Journal of cellular physiology

authors： Katoch SS,Su X,Moreland RS

更新日期：1999-05-01 00:00:00

abstract：:Biosynthesis of selenium-containing proteins requires insertion of the unusual amino acid selenocysteine by alternative translation of a UGA codon, which ordinarily serves as a stop codon. In eukaryotes, selenoprotein translation depends upon one or more selenocysteine insertion sequence (SECIS) elements located in th...

journal_title：Journal of cellular physiology

authors： Shen Q,Fan L,Newburger PE

更新日期：2006-06-01 00:00:00

abstract：:Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the intestinal epithelial cell line, IEC-18, which was derived from rat small intestine crypt cells. In initial radioisotope ef...

journal_title：Journal of cellular physiology

authors： Basavappa S,Vulapalli SR,Zhang H,Yule D,Coon S,Sundaram U

更新日期：2005-01-01 00:00:00

abstract：:COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine...

journal_title：Journal of cellular physiology

authors： Rezaei M,Ziai SA,Fakhri S,Pouriran R

更新日期：2020-09-09 00:00:00

abstract：:Sepsis is a severe clinical disease, which is resulted from the excessive host inflammation response to the infection. Growing evidence indicates that Staphylococcus aureus pneumonia is a significant cause of sepsis, which can lead to intestinal injury, inflammation, and apoptosis. Studies have shown that miR-182-5p c...

journal_title：Journal of cellular physiology

authors： Du X,Wei J,Tian D,Wu M,Yan C,Hu P,Wu X,Yang W,Yin T

更新日期：2020-01-01 00:00:00

abstract：:Melatonin, the major pineal secretory product, has a significant impact on the female reproductive system. Recently, the beneficial effects of melatonin on mammalian oocyte maturation and embryonic development have drawn increased attention. However, the exact underlying mechanisms remain to be fully elucidated. This ...

journal_title：Journal of cellular physiology

authors： He B,Yin C,Gong Y,Liu J,Guo H,Zhao R

更新日期：2018-01-01 00:00:00

abstract：:Reduced sperm motility (asthenospermia) and resulting infertility arise from deletion of the Plasma Membrane Ca2+ -ATPase 4 (Pmca4) gene which encodes the highly conserved Ca2+ efflux pump, PMCA4. This is the major Ca2+ clearance protein in murine sperm. Since the mechanism underlying asthenospermia in PMCA4's absence...

journal_title：Journal of cellular physiology

authors： Olli KE,Li K,Galileo DS,Martin-DeLeon PA

更新日期：2018-01-01 00:00:00

abstract：:Reactivation of dormant chick erythrocyte (CE) nuclei was studied by fusing chick red cells with rat myoblasts, HeLa cells, and chick fibroblasts. Heterokaryons representing different stages of nuclear reactivation were fixed and examined for nuclear antigens using polyclonal patient autoantisera reacting with mammali...

journal_title：Journal of cellular physiology

authors： Nyman U,Lanfranchi G,Bergman M,Ringertz NR

更新日期：1984-08-01 00:00:00

abstract：:The mechanism(s) by which heparin influences the biological activities of acidic and basic fibroblast growth factors (aFGF and bFGF) is not completely understood. One mechanism by which heparin could alter the biological activities of aFGF and bFGF is by altering their biological half-lives. We investigated the possib...

journal_title：Journal of cellular physiology

authors： Damon DH,Lobb RR,D'Amore PA,Wagner JA

更新日期：1989-02-01 00:00:00

abstract：:Chronic exposure of pancreatic beta-cells to supraphysiologic glucose causes adverse beta-cell dysfunction. Thus, the present study was aimed to investigate the hypothesis that oral administration of resveratrol attenuates hyperglycemia, proinflammatory cytokines and antioxidant competence and protects beta-cell ultra...

journal_title：Journal of cellular physiology

authors： Palsamy P,Subramanian S

更新日期：2010-08-01 00:00:00

abstract：:A factor, termed neutrophil alkaline phosphatase-inducing factor (NAP-IF), that has the capacity to increase the NAP activity of granulocytes was characterized by using two samples: cystic fluid (CF) and conditioned medium of a tumor cell line (T3M5). The molecular weight of NAP-IF was shown to be between 13,000 and 4...

journal_title：Journal of cellular physiology

authors： Sato N,Asano S,Mori M,Ueyama Y,Sugano K,Ohsawa N,Takaku F

更新日期：1985-08-01 00:00:00

abstract：:The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Her...

journal_title：Journal of cellular physiology

authors： Zhou B,Yun EY,Ray L,You J,Ip YT,Lin X

更新日期：2014-04-01 00:00:00

abstract：:The skeleton has recently emerged as a critical insulin target tissue that regulates whole body glucose metabolism and male reproductive function. While our understanding of these new regulatory axes remains in its infancy, the bone-specific protein, osteocalcin, has been shown to be centrally involved. Undercarboxyla...

journal_title：Journal of cellular physiology

authors： Tangseefa P,Martin SK,Fitter S,Baldock PA,Proud CG,Zannettino ACW

更新日期：2018-05-01 00:00:00

abstract：:The oxygen dependence of hepatic cellular respiration was studied by employing simultaneous organ spectrophotometry of cytochromes and hemoglobin, the latter used as an intrasinusoidal optical oxygen probe. The Km of cytochrome aa3 for oxygen was found to be 6.8 microM in the isolated perfused liver and 0.3 microM in ...

journal_title：Journal of cellular physiology

authors： Kekonen EM,Jauhonen VP,Hassinen IE

更新日期：1987-10-01 00:00:00

abstract：:CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase Ⅲ clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholestero...

journal_title：Journal of cellular physiology

authors： Lei J,Wang H,Zhu D,Wan Y,Yin L

更新日期：2020-05-01 00:00:00

abstract：:It has been reported that p21, p53, and p16 affect the cell cycle and cell senescence. However, their roles in keratinocyte senescence are not clear. We established primary keratinocyte strains from 15 donors and maintained them until replicative senescence; their population doublings ranged from 5.7-45.2. These strai...

journal_title：Journal of cellular physiology

authors： Sayama K,Shirakata Y,Midorikawa K,Hanakawa Y,Hashimoto K

更新日期：1999-04-01 00:00:00

abstract：:The untransformed stable cell line Met murine hepatocytes (MMH), generated from liver explants of transgenic mice expressing a constitutively active truncated form of the human hepatocyte growth factor receptor (cyto-Met), represents an innovative tool for in vitro studies of liver function. In the present report, we ...

journal_title：Journal of cellular physiology

authors： Bellovino D,Lanyau Y,Garaguso I,Amicone L,Cavallari C,Tripodi M,Gaetani S

更新日期：1999-10-01 00:00:00

abstract：:The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two- and four-cell stage embryos (two- and four-cell SBs) can provide a valuable supply both for couples who use fert...

journal_title：Journal of cellular physiology

authors： Yekani F,Fazel-Tabar M,Kowsari-Esfahan R,Renaud P,Kavand H,Esfandiari F,Azarnia M,Montazeri L,Baharvand H

更新日期：2018-12-01 00:00:00

abstract：:Neuroblastoma (NBL) exists in a complex tumor-immune microenvironment. Immune cell infiltration and tumor-immune molecules play a critical role in tumor development and significantly impact the prognosis of patients. However, the molecular characteristics describing the NBL-immune interaction and their prognostic pote...

journal_title：Journal of cellular physiology

authors： Jin W,Zhang Y,Liu Z,Che Z,Gao M,Peng H

更新日期：2021-01-01 00:00:00

abstract：:The methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The enzyme involved in this process is DNA methyltransferase, which catalyzes the transfer of a methyl group from S-adenosyl-methionine to cytosine residues to form 5-methylcytosin...

journal_title：Journal of cellular physiology

authors： Momparler RL,Bovenzi V

更新日期：2000-05-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase complex has been shown to be involved in the process of glucose-stimulated insulin secretion (GSIS). In this study, we examined the effect of palmitic acid on superoxide production and insulin secretion by rat pancreatic islets and the mechanism involved. R...

journal_title：Journal of cellular physiology

authors： Graciano MF,Santos LR,Curi R,Carpinelli AR

更新日期：2011-04-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:The differentiation of human keratinocytes in most culture systems is incomplete; e.g., lamellar bodies, the characteristic lipid-delivery organelles of epidermis, are not present. Moreover, their lipid profile does not reflect the distinctive composition found in cornifying epidermis. In contrast, keratinocytes that ...

journal_title：Journal of cellular physiology

authors： Williams ML,Brown BE,Monger DJ,Grayson S,Elias PM

更新日期：1988-07-01 00:00:00

abstract：:The statins (including mevastatin and lovastatin) are a widely prescribed class of serum-cholesterol lowering drugs that function by inhibiting 3-hydroxymethylglutaryl coenzyme A (HMG CoA) reductase activity and cellular sterol synthesis. Statins are also widely being appreciated for their inhibitory effects upon infl...

journal_title：Journal of cellular physiology

authors： Arikan MC,Shapiro SD,Mariani TJ

更新日期：2005-07-01 00:00:00

abstract：:Our study examines the effect of apoptosis on prothymosin alpha, an abundant, nuclear protein intimately involved with proliferation of all mammalian cells. When HeLa cells were treated with actinomycin D, with etoposide, or with staurosporine following synchronization with hydroxyurea, they underwent apoptosis based ...

journal_title：Journal of cellular physiology

authors： Enkemann SA,Wang RH,Trumbore MW,Berger SL

更新日期：2000-02-01 00:00:00