Size-dependent cytotoxicity study of ZnO nanoparticles in HepG2 cells.

Abstract:

:Zinc oxide (ZnO) nanoparticles (NPs) are widely used in daily life. However, common utilization of ZnO NPs results in increases in environmental release, and their health hazards have attracted extensive attention. To investigate the cytotoxicity of ZnO NPs and their mechanism in HepG2 cells, a comprehensive analytical system was developed. The internalization, cytotoxic mechanism, death mechanism and elimination behavior of three sizes of ZnO NPs were studied by electrothermal vaporization (ETV)-inductively coupled plasma mass spectrometry (ICP-MS), MTT assays, GSH measurements, ROS measurements and analyses of apoptosis and gene expression. The size-, dose- and time-dependent characteristics of ZnO NPs were determined, and the metabolism of ZnO NPs in cells was discussed. The cytotoxicity of ZnO NPs was confirmed to depend on both the size and concentration and was attributed to the release of Zn2+, induction of oxidative stress and inflammatory response; the death mode of HepG2 cells incubated with ZnO NPs was necrotic rather than programmed cell death.

journal_name

Ecotoxicol Environ Saf

authors

Chen P,Wang H,He M,Chen B,Yang B,Hu B

doi

10.1016/j.ecoenv.2018.12.096

subject

Has Abstract

pub_date

2019-04-30 00:00:00

pages

337-346

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(18)31389-7

journal_volume

171

pub_type

杂志文章
  • Comparative toxicity of carbaryl, carbofuran, cypermethrin and fenvalerate in Metaphire posthuma and Eisenia fetida -a possible mechanism.

    abstract::To establish the use of Metaphire posthuma as a sensitive test model for ecotoxicological studies, acute toxicity testing of carbaryl, carbofuran, cypermethrin and fenvalerate on Eisenia fetida and Metaphire posthuma were carried out. Two different types of bioassays, contact filter paper toxicity and soil toxicity bi...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2013.11.006

    authors: Saxena PN,Gupta SK,Murthy RC

    更新日期:2014-02-01 00:00:00

  • Accumulation of polychlorobiphenyl congeners and p,p'-DDE at environmental concentrations by corn and beans.

    abstract::The uptake of polychlorinated biphenyl (PCB) congeners present at low concentrations in the environment was investigated in leaf composites of four crop species and final fruits at two sites. All four species preferentially accumulated the same eight congeners, although not in the same degree or rank. No bean species ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(89)90007-9

    authors: Shane LA,Bush B

    更新日期:1989-02-01 00:00:00

  • Capacity of tissue water regulation is impaired in an osmoconformer living in impacted estuaries?

    abstract::Estuarine osmoconformes rely on their ability to perform tissue and cell water regulation to cope with daily osmotic challenges that occur in the estuary. In addition, these animals currently must deal with pollutants present in the estuarine environment, which can disturb their capacity of water regulation. We collec...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.09.111

    authors: David DD,Lima OG,Nóbrega AMCS,Amado EM

    更新日期:2018-12-30 00:00:00

  • Associations of plasma metal concentrations with the decline in kidney function: A longitudinal study of Chinese adults.

    abstract::Metals are widespread pollutants in the environment which have been reported to be associated with kidney dysfunction in many existing epidemiological studies. However, most of the studies are cross-sectional design and mainly focus on several toxic metals including arsenic, lead and cadmium. Therefore, we conducted t...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.110006

    authors: Liu Y,Yuan Y,Xiao Y,Li Y,Yu Y,Mo T,Jiang H,Li X,Yang H,Xu C,He M,Guo H,Pan A,Wu T

    更新日期:2020-02-01 00:00:00

  • Biosorption of Cd(II) from aqueous solution using xanthated nano banana cellulose: equilibrium and kinetic studies.

    abstract::Present study explored the biosorption capacity of xanthated nano banana cellulose (XNBC) for Cd(II) from aqueous solution. The biosorbent containing sulfur-bearing groups have a high affinity for heavy metals. Sulfur can be considered as a soft ligand group having strong affinity for cadmium. In the present study, th...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2013.09.003

    authors: Pillai SS,Deepa B,Abraham E,Girija N,Geetha P,Jacob L,Koshy M

    更新日期:2013-12-01 00:00:00

  • Phytotoxicity assessment of a methanolic coal dust extract in Lemna minor.

    abstract::Coal mining generates negative effects on environment, human health, hydrodynamics of mining areas and biodiversity. However, the impacts of this activity are less known in plants. Lemna minor is one of the most commonly used plants in aquatic toxicity tests due to its ubiquitous distribution in ponds and lakes, cultu...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2013.05.001

    authors: Coronado-Posada N,Cabarcas-Montalvo M,Olivero-Verbel J

    更新日期:2013-09-01 00:00:00

  • Combined effect of biopesticides on the digestive enzymatic profiles of Cnaphalocrocis medinalis (Guenée) (the rice leaffolder) (Insecta: Lepidoptera: Pyralidae).

    abstract::Plant extracts, especially botanical insecticides, are currently studied more and more because of the possibility of their use in plant protection. Many of the natural plant compounds and organic compounds used in the control of insect pests are known to affect digestive enzymes. When fed a diet of rice leaves treated...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2005.04.008

    authors: Nathan SS,Chung PG,Murugan K

    更新日期:2006-07-01 00:00:00

  • Periodic density as an endpoint of customized plankton community responses to petroleum hydrocarbons: A level of toxic effect should be matched with a suitable time scale.

    abstract::As an endpoint of community response to contaminants, average periodic density of populations (APDP) has been introduced to model species interactions in a community with 4 planktonic species. An ecological model for the community was developed by means of interspecific relationship including competition and predation...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.110723

    authors: Wang C,Wang S,Jiao X,Yang B,Liang S,Luo Z,Mao L

    更新日期:2020-09-15 00:00:00

  • Selection and validation of reference genes for target gene analysis with quantitative real-time PCR in the leaves and roots of Carex rigescens under abiotic stress.

    abstract::Carex rigescens is an ornamental turfgrass in northern China which has a relatively low maintenance cost and robust tolerance to many adverse environmental conditions, so it could be considered a new material for researching into plant stress resistance. However, suitable reference genes are vacant for obtaining relia...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.10.049

    authors: Zhang K,Li M,Cao S,Sun Y,Long R,Kang J,Yan L,Cui H

    更新日期:2019-01-30 00:00:00

  • Comprehensive transcriptome profiling of soybean leaves in response to simulated acid rain.

    abstract::As a source of edible oil and protein, soybean is a major globally important economic crop; Improving its production has been an important objective of soybean breeding. Acid rain has been shown to influence soybean growth and productivity, with consequent adverse impacts on its production for use by human populations...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.04.015

    authors: Yang L,Xu Y,Zhang R,Wang X,Yang C

    更新日期:2018-08-30 00:00:00

  • Differential growth and metabolic responses induced by nano-scale zero valent iron in germinating seeds and seedlings of Oryza sativa L. cv. Swarna.

    abstract::Since development of antioxidant defence system is high energy demanding event, innate defence system and stress tolerance of plant is strictly governed by plant age. This study is aimed towards evaluating variation of tolerance in germinating seeds and seedlings of Oryza sativa L. cv. Swarna against nano-scale zero v...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111104

    authors: Guha T,Gopal G,Chatterjee R,Mukherjee A,Kundu R

    更新日期:2020-11-01 00:00:00

  • Toxicity of diesel water accommodated fraction toward microalgae, Pseudokirchneriella subcapitata and Chlorella sp. MM3.

    abstract::Diesel is a commonly used fuel and a key pollutant on water surface through leaks and accidental spills, thus creating risk directly to planktons as well as other aquatic organisms. We assessed the toxicty of diesel and its water accommodated fraction (WAF) towards two microalgal species, Pseudokirchneriella subcapita...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2017.04.052

    authors: Ramadass K,Megharaj M,Venkateswarlu K,Naidu R

    更新日期:2017-08-01 00:00:00

  • The bioavailability of sediment-sorbed chlorobenzenes to larvae of the midge, Chironomus decorus.

    abstract::Larval stages of the midge, Chironomus decorus, were used to define the bioaccumulation of sediment-sorbed mono-, di-, tri-, and hexachlorobenzene. Larvae were exposed to high- and low-organic-content sediments that had been equilibrated with individual radiolabeled chlorobenzenes prior to testing. Equilibrium or none...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(88)90076-0

    authors: Knezovich JP,Harrison FL

    更新日期:1988-04-01 00:00:00

  • Toxic effects of pentachlorophenol and other pollutants on the mineralization of acetate in several soils.

    abstract::The mineralization of [14C]acetate was studied in bottles with fresh soil and groundwater. Addition of toxicants inhibited the formation of 14CO2 and dose-effect curves were obtained. The acetate mineralization was not inhibited by zinc, cadmium, K2Cr2O7, chloropyrifos, and paraquat in an acid sandy soil at 1000 mg/kg...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1993.1036

    authors: van Beelen P,Fleuren-Kemilä AK

    更新日期:1993-08-01 00:00:00

  • Influence of auxochrome group in disperse dyes bearing azo groups as chromophore center in the biotransformation and molecular docking prediction by reductase enzyme: Implications and assessment for environmental toxicity of xenobiotics.

    abstract::Synthetic azo dyes have increasingly become a matter of great concern as a result of the genotoxic and mutagenic potential of the products derived from azo dye biotransformation. This work evaluates the manner in which reducing enzymes produced by Escherichia coli (E. coli) act on three disperse dyes bearing azo group...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.04.066

    authors: Franco JH,da Silva BF,Dias EFG,de Castro AA,Ramalho TC,Zanoni MVB

    更新日期:2018-09-30 00:00:00

  • Possible side effects of airborne pesticides on fungi and vascular plants in The Netherlands.

    abstract::A survey of the potential side effects of volatilized pesticides on fungi and vascular plants in The Netherlands has been made for two herbicides (atrazine and MCPA), a fungicide (captan) and a soil fumigant (metham sodium). By applying existing models, a prediction is presented of post-treatment dispersal and deposit...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1995.1009

    authors: de Jong FM,van der Voet E,Canters KJ

    更新日期:1995-02-01 00:00:00

  • Effects of a chronic exposure to different water temperatures and/or to an environmental cadmium concentration on the reproduction of the threespine stickleback (Gasterosteus aculeatus).

    abstract::Knowledge about combined effects of chemicals and temperature on reproductive capacity of fish are rare in literature, especially when it comes to the effects of chronic low-dose chemical exposure combined to the thermal stress. The aim of the study was to evaluate the single and combined effects of temperature (16, 1...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.02.032

    authors: Hani YMI,Turies C,Palluel O,Delahaut L,Bado-Nilles A,Geffard A,Dedourge-Geffard O,Porcher JM

    更新日期:2019-06-15 00:00:00

  • Acute and subacute toxicity study of inhaled methyl isocyanate in Charles Foster rats.

    abstract::Charles Foster male and female rats were exposed only once to 3.52 and 35.32 ppm doses of methyl isocyanate in separate experiments for 10 min each in an acute toxicity study, while in subacute toxicity experiments, they were exposed to 0.212, 0.265, and 0.349 ppm doses for 30 min daily, for 6 days, by inhalation. Cli...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(89)90092-4

    authors: Sethi N,Dayal R,Singh RK

    更新日期:1989-08-01 00:00:00

  • Residue and distribution of triforine in different cultivars and fruit periods of watermelon under field conditions.

    abstract::The dissipation of triforine in the immature and mature fruit periods was investigated under field conditions. Residue levels of triforine in watermelon were determined by gas chromatography with an electron capture detector (GC-ECD). The decline curves of triforine residues in the watermelon corresponded with first-o...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.03.026

    authors: Li YM,Li ZH,Huang RL,Wang SY,Zhang ZX

    更新日期:2018-07-30 00:00:00

  • Absorption, accumulation and distribution of metals and nutrient elements in poplars planted in land amended with composted sewage sludge: A field trial.

    abstract::Interest in the application of sewage sludge as amendments to grow trees has continued to increase, especially for fast-growing trees such as poplars. In this study, two-year field trial was conducted to determine the effects of compost sewage sludge (CSS) soil application on the distributions of metal and nutrient el...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.06.043

    authors: Guoqing X,Xiuqin C,Liping B,Hongtao Q,Haibo L

    更新日期:2019-10-30 00:00:00

  • Influence of pathogenic fungi on the life history and predation rate of mites attacking a psyllid pest.

    abstract::The two biological control agents, predatory mite Amblydromalus limonicus Garman & McGregor (Acari: Phytoseiidae) and entomopathogenic fungi (EPF) Beauveria bassiana (Balsamo) Vuillemin (Hypocreales: Cordycipitaceae), have the potential to independently suppress the invasive tomato potato psyllid (TPP), Bactericera co...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.109585

    authors: Liu JF,Zhang ZQ,Beggs JR,Wei XY

    更新日期:2019-11-15 00:00:00

  • A low-cost solvent-free method to synthesize α-Fe2O3 nanoparticles with applications to degrade methyl orange in photo-fenton system.

    abstract::Hematite nanoparticles (α-Fe2O3 NPs) were successfully synthesized by a low-cost solvent-free reaction using Ferrous sulfate waste (FeSO4·7H2O) and pyrite (FeS2) as raw materials and employed for the decolorization of Methyl Orange by the photo-Fenton system. The properties of α-Fe2O3 NPs before and after photo-Fenton...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.110744

    authors: Xiang H,Ren G,Yang X,Xu D,Zhang Z,Wang X

    更新日期:2020-09-01 00:00:00

  • Biochemical changes of polysaccharides and proteins within EPS under Pb(II) stress in Rhodotorula mucilaginosa.

    abstract::Microorganisms have been widely applied to heavy metal adsorption due to their strong secretion of extracellular polymeric substances (EPS). This study explored the responses of Rhodotorula mucilaginosa (R1, a red yeast with substantial EPS supply) under Pb stress. The maximum sorption of Pb cations by R1 was ~650 mg/...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.03.004

    authors: Li J,Jiang Z,Chen S,Wang T,Jiang L,Wang M,Wang S,Li Z

    更新日期:2019-06-15 00:00:00

  • Effects of silver nanoparticles on survival, biomass change and avoidance behaviour of the endogeic earthworm Allolobophora chlorotica.

    abstract::Increasing commercial application of silver nanoparticles (Ag NP) and subsequent presence in wastewater and sewage sludge has raised concerns regarding their effects in the aquatic and terrestrial environment. Several studies have employed standardised acute and chronic earthworm-based tests to establish the toxicolog...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2017.03.015

    authors: Brami C,Glover AR,Butt KR,Lowe CN

    更新日期:2017-07-01 00:00:00

  • Experimental field exposure of brown trout to river water receiving effluent from an integrated newsprint mill.

    abstract::Effects of effluents from mechanical pulp production on brown trout were studied for 8 weeks at environmentally relevant concentrations. The exposure took place in laboratory-based pools upstream and downstream of the effluent discharge point of an integrated newsprint mill using ground wood/thermomechanical pulp. The...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1998.1683

    authors: Johnsen K,Tana J,Lehtinen KJ,Stuthridge T,Mattsson K,Hemming J,Carlberg GE

    更新日期:1998-07-01 00:00:00

  • Preventive effects of sodium molybdate in lead intoxication in rats.

    abstract::The role of sodium molybdate (1 mg/kg, intraperitoneally, once daily) supplementation during the course of lead exposure (0.1% lead acetate in drinking water for 4 weeks) in preventing the accumulation of lead in blood and soft tissues and in restoring altered lead-sensitive biochemical variables and the levels of hep...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1993.1045

    authors: Flora SJ,Jeevaratnam K,Kumar D

    更新日期:1993-10-01 00:00:00

  • Induction of atrazine tolerance in a natural soil assemblage of microalgae reared in the laboratory.

    abstract::We investigated the occurrence of tolerance to atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) in soil microalgae by means of the pollution-induced community tolerance methodology. To this end, a natural soil assemblage of microalgae, reared under laboratory conditions, was used as experimental model. Exp...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2005.09.003

    authors: García-Villada L,Reboud X

    更新日期:2007-01-01 00:00:00

  • Liver phosphatases in mice treated with lead during murine ancylostomiasis.

    abstract::Both infective larvae and pollutants disturb the homeostasis of female Swiss albino mice, causing ancylostomiasis and severe immunophysiological changes. In our experimental design, mice in group A were fed 0.01 mg of lead nitrate before infection with 500 larvae of Ancylostoma caninum, mice in group B were infected w...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2004.01.013

    authors: Satyalatha BD,Vardhani VV

    更新日期:2005-05-01 00:00:00

  • Biological and biochemical effects of chronic exposure to very low levels of dietary cypermethrin (Cymbush) on honeybee colonies (Hymenoptera: Apidae).

    abstract::Cymbush (100 g of pure cypermethrin/liter of petroleum ether) was added to sucrose syrup at 12.5 microg/L and given to honeybee colonies (Apis mellifera mellifera, L.) in their diet for 5 months (July to November). Many perturbations have been recorded in treated groups in contrast to controls placed in the same area....

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1999.1812

    authors: Bendahou N,Fleche C,Bounias M

    更新日期:1999-10-01 00:00:00

  • Imidacloprid in leaves from systemically treated trees may inhibit litter breakdown by non-target invertebrates.

    abstract::Imidacloprid is a systemic insecticide that is used in trees to control several invasive, wood-boring insect pests in North America. Applications to deciduous trees result in foliar concentrations of imidacloprid that could pose a risk of harm to non-target decomposer invertebrates when autumn-shed leaves fall to fore...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2008.09.017

    authors: Kreutzweiser DP,Thompson DG,Scarr TA

    更新日期:2009-05-01 00:00:00