当前位置： SCI文献检索 > INDIAN JOURNAL OF OPHTHALMOLOGY期刊下所有文献 > Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation.

Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation.

Abstract：

Purpose:To study the demographic profile, clinical features, treatment outcome, and ocular morbidity of microbiologically proven Pythium keratitis in South India. Methods:A retrospective analysis of clinical records of microbiologically proven Pythium keratitis at a tertiary eye care referral center in South India from January 2016 to November 2017 was performed. Demographic details, predisposing risk factors, microbiological investigations, clinical course, and visual outcome were analyzed. Results:Seventy-one patients with microbiologically proven Pythium keratitis were identified. The mean age was 44(±18.2) years with an increase in male preponderance and 50% were farmers. Duration of delay at time of presentation to the hospital was a mean of 14(±7.2) days. The visual acuity at baseline ranged from 6/6 to no light perception (median 2.1 logMAR). A combination of 5% natamycin and 1% voriconazole was given to 42% patients, and natamycin alone was given to 39.4% patients. 1% itraconazole eye drops alone was initiated in 7 (10%) patients and 3 among this group responded. Therapeutic keratoplasty (TPK) was performed in 48 (67.6%) patients. None of the primary grafts remained clear after a period of 1 month. Twenty-six eyes (54.2%) had graft reinfection and all these eyes either developed anterior staphyloma (4) or were eviscerated (3) and 13 eyes became phthisical. The remaining 22 patients who had TPK resulted in failed graft. Among these, re-grafts were performed in 6 patients, of which 5 were doing well at the last follow-up. Conclusion:We report a large series of patients with Pythium keratitis. Promoting early and differential diagnosis, awareness of clinicians and specific treatment options are needed for this devastating corneal disease.

journal_name

Indian J Ophthalmol

journal_title

Indian journal of ophthalmology

authors

Hasika R,Lalitha P,Radhakrishnan N,Rameshkumar G,Prajna NV,Srinivasan M

doi

10.4103/ijo.IJO_445_18

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

42-47

issue

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2019_67_1_42_248146

journal_volume

pub_type

杂志文章

在线工具

Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation.