Apocrine lesions of the breast: part 1 of a two-part review: benign, atypical and in situ apocrine proliferations of the breast.

Abstract:

:Apocrine morphology is a common phenomenon encountered in everyday breast pathology practice, and is defined as cuboidal or columnar cells exhibiting abundant eosinophilic granular cytoplasm, prominent apical granules, a low nuclear-cytoplasmic ratio, and round nuclei with pale chromatin and prominent nucleoli. Apocrine morphology is recognised in benign, atypical and malignant lesions of the breast. The morphology of apocrine atypia and non-high-grade apocrine ductal carcinoma in situ (DCIS) is less well defined due to the relative rarity of these lesions. In part 1 of this two-part review, we focus on the morphological characteristics of benign, atypical and in situ apocrine lesions of the breast, summarise the available data to date regarding distinction of atypical apocrine proliferations from non-high-grade apocrine DCIS and the biological significance of apocrine atypia, and provide practical guidance on handling these difficult lesions. Part 2 of this review will focus on the concept of pure apocrine carcinoma with emphasis on its definition and molecular data, including the current understanding of the molecular apocrine signature in breast carcinoma. We complete the review with a synopsis on the utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast.

journal_name

J Clin Pathol

authors

D'Arcy C,Quinn C

doi

10.1136/jclinpath-2018-205484

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1-6

issue

1

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2018-205484

journal_volume

72

pub_type

杂志文章,评审
  • Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukaemia.

    abstract::As part of a wider survey of infections and defence mechanisms, concentrations of serum immunoglobulins IgG, IgA, and IgM were measured regularly by single radial immunodiffusion in a group of children receiving treatment for acute lymphoblastic leukaemia while in their first remission. IgM concentrations were often m...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.5.479

    authors: Reid MM,Craft AW,Cox JR

    更新日期:1981-05-01 00:00:00

  • Cerebral infection with Escherichia coli O157:H7 in humans and gnotobiotic piglets.

    abstract::Escherichia coli O157:H7 was isolated from a fatal case of haemorrhagic colitis with haemolytic uraemic syndrome and neurological symptoms. This strain induced diarrhoea and neurological symptoms including incoordination, ataxia, and convulsions in piglets after oral inoculation. Similar neurological signs were seen i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.10.1099

    authors: Tzipori S,Chow CW,Powell HR

    更新日期:1988-10-01 00:00:00

  • Incidence of sperm antibodies before and after vasectomy.

    abstract::Sperm-agglutinating antibodies were present in three (2-6%) of 117 fertile men and in 19 (33-9%) of 56 men who had been vasectomized. Twenty-four of the 56 vasectomized men had been studied before vasectomy; sperm-agglutinating antibodies were present in one (4-3%) compared with eight (33-3%) after vasectomy. No sperm...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.29.12.1127

    authors: Hunter J,Logan H,Greer G

    更新日期:1976-12-01 00:00:00

  • Epstein-Barr virus and regulatory T cells in Egyptian paediatric patients with acute B lymphoblastic leukaemia.

    abstract:OBJECTIVE:Acute B lymphoblastic leukaemia (B-ALL) is the most common type of childhood malignancy worldwide but little is known of its origin. Recently, many studies showed both a high incidence of Epstein-Barr virus (EBV) infection and high levels of CD4+CD25+Foxp3+(Treg cells) in children with B-ALL. In our study, we...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2016-203803

    authors: Ateyah ME,Hashem ME,Abdelsalam M

    更新日期:2017-02-01 00:00:00

  • A modified rapid slide test for anti-streptolysin O.

    abstract::This paper describes the modification of a commercially available rapid slide screening test(1) for anti-streptolysin O to give quantitative results. The modified technique is compared with the long-established haemolytic technique of Rantz and Randall (1945). The quantitative results for both techniques are shown to ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.6.543

    authors: Ingram GB,Hughes JE

    更新日期:1972-06-01 00:00:00

  • Effect of radiotherapy on oral mucosa assessed by quantitative exfoliative cytology.

    abstract::The effect of radiotherapy on normal buccal mucosa was investigated using the quantitative techniques of cytomorphology (measurement of nuclear and cytoplasmic area) and DNA cytophotometry. These techniques were applied to smears obtained before, during, and after irradiation. Nuclear area and cytoplasmic area increas...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.9.940

    authors: Ogden GR,Cowpe JG,Green MW

    更新日期:1989-09-01 00:00:00

  • Measurement of placental alkaline phosphatase activity in benign and malignant pleural effusions.

    abstract::The usefulness of placental alkaline phosphatase (PLAP) as a diagnostic marker of malignancy was assessed in pleural fluid from 60 patients with effusions. Pleural fluid PLAP activities were measured by an enzyme linked immunoassay (ELISA) using the two monoclonal antibodies H17E2 and H317. Similar values were found i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.45.12.1114

    authors: Fergusson RJ,Fisken J,McIntyre MA,Roulston JE,Leonard RC

    更新日期:1992-12-01 00:00:00

  • Autoimmune markers are undetectable in end stage idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:Autoreactive humoral and cellular immune responses may be involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC). Certain human leucocyte antigens (HLA) could also be linked to the development of IDC. AIM:To determine whether various markers of autoimmunity are present in the final phase of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.10.739

    authors: de Leeuw N,Melchers WJ,Ruiter DJ,Caforio AL,Balk AH,de Jonge N,Galama JM

    更新日期:1999-10-01 00:00:00

  • N. gonorrhoeae: pathogenicity of colonial type 5.

    abstract::This paper records the results of the intravenous inoculation of chick embryos with type 5 gonococci and establishes that these strains are pathogenic. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.31.5.437

    authors: Hafiz S,Jennings R,McEntegart MG,Jephcott AE

    更新日期:1978-05-01 00:00:00

  • Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens.

    abstract::In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against H...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.44.8.664

    authors: Athanasou NA,Puddle B,Quinn J,Woods CG

    更新日期:1991-08-01 00:00:00

  • On the histological diagnosis and prognosis of malignant melanoma.

    abstract::This review deals with difficulties of diagnosis in cutaneous malignant melanoma encountered by histopathologists of variable seniority and is based on referred material at The Royal Marsden Hospital over a 20-year period and on the experience of more than two-and-a-half thousand cases referred to The World Health Org...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.33.2.101

    authors: Levene A

    更新日期:1980-02-01 00:00:00

  • Predictive value of malignancy grading systems, DNA content, p53, and angiogenesis for stage I tongue carcinomas.

    abstract:AIM:To assess the clinical value of malignancy grading systems compared with nuclear DNA content, protein p53, and angiogenesis for predicting recurrence of stage I (UICC, 1987) tongue carcinomas. METHODS:Histopathological malignancy grading according to Jakobsson and tumour front grading according to Bryne et al were...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.1.35

    authors: Högmo A,Kuylenstierna R,Lindholm J,Munck-Wikland E

    更新日期:1999-01-01 00:00:00

  • Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines.

    abstract::Accurate histopathological assessment of biopsies is important for the diagnosis, subclassification, and management of chronic idiopathic inflammatory bowel disease (IBD). British Society of Gastroenterology (BSG) guidelines for the initial histopathological diagnosis of IBD were published in 1997. Changes since then ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,实务指引

    doi:10.1136/jclinpath-2013-201885

    authors: Feakins RM,British Society of Gastroenterology.

    更新日期:2013-12-01 00:00:00

  • Electrophoretic behaviour of human urinary amylase.

    abstract::A saccharogenic method is described for estimating amylase activity in human urine. Results accord with those reported elsewhere except that in this study the peak in the beta zone is a new finding. Comparison between normal and pathological urines suggests that the amylase activity of the beta peak is not of pancreat...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.18.5.664

    authors: Franzini C

    更新日期:1965-09-01 00:00:00

  • Biopsy findings in malignant histiocytosis presenting as lethal midline granuloma.

    abstract::Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline ma...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.6.599

    authors: Aozasa K

    更新日期:1982-06-01 00:00:00

  • THE ABO BLOOD GROUPS OF CARCINOMA OF THE OESOPHAGUS AND OF BENIGN PROSTATIC HYPERPLASIA.

    abstract::The results of an investigation show that there is no statistically significant excess of blood group A in cases of carcinoma of the oesophagus or in cases of benign prostatic hyperplasia. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.17.1.42

    authors: BEASLEY WH

    更新日期:1964-01-01 00:00:00

  • Radial scar lesions of the breast diagnosed by needle core biopsy: analysis of cases containing occult malignancy.

    abstract:AIM:To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision. METHODS AND RESULTS:A total of 11 false negative NCB in RS/CSL lesions from 2...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2006.037069

    authors: Douglas-Jones AG,Denson JL,Cox AC,Harries IB,Stevens G

    更新日期:2007-03-01 00:00:00

  • Plasmacytoma of the thyroid.

    abstract::Three cases of plasmacytoma of the thyroid are described and their clinical and histological features recorded. Two were considered to be true extramedullary plasmacytomas, the third the initial manifestation of a disseminated myelomatous process. Plasmacytomas of the thyroid are shown to have many features in common ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.21.5.661

    authors: More JR,Dawson DW,Ralston AJ,Craig I

    更新日期:1968-09-01 00:00:00

  • A comparison of tests for thyroglobulin antibody.

    abstract::A comparison is made of tests for thyroglobulin antibody, using gel diffusion, electroprecipitin, bentonite flocculation, tanned red cell agglutination, and latex slide agglutination techniques on sera from cases of Hashimoto's disease and other thyroid disorders. Any increase in gamma globulin was also noted from the...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.15.2.153

    authors: RAWSTRON JR,FARTHING CP

    更新日期:1962-03-01 00:00:00

  • Continuous measurement of breast tumour hormone receptor expression: a comparison of two computational pathology platforms.

    abstract:AIMS:Computational pathology platforms incorporate digital microscopy with sophisticated image analysis to permit rapid, continuous measurement of protein expression. We compared two computational pathology platforms on their measurement of breast tumour oestrogen receptor (ER) and progesterone receptor (PR) expression...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2016-204107

    authors: Ahern TP,Beck AH,Rosner BA,Glass B,Frieling G,Collins LC,Tamimi RM

    更新日期:2017-05-01 00:00:00

  • My approach to the diagnosis of mesothelial lesions.

    abstract::Mesothelial lesions pose considerable diagnostic challenges not only because benign tumours, reactive proliferations and malignant mesothelioma can mimic one another, but also because the morphological patterns displayed by malignant mesothelioma can simulate a variety of epithelial and non-epithelial malignancies. Im...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2005.029652

    authors: Butnor KJ

    更新日期:2006-06-01 00:00:00

  • Multicentric evaluation of analytical performances digital morphology with respect to the reference methods by manual optical microscopy.

    abstract:AIMS:Optical microscopic (OM) evaluation of peripheral blood (PB) cells is still a crucial step of the laboratory haematological workflow. The morphological cell analysis is time-consuming and expensive and it requires skilled operator. To address these challenges, automated image-processing systems, as digital morphol...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2020-206857

    authors: Da Rin G,Benegiamo A,Di Fabio AM,Dima F,Francione S,Fanelli A,Germagnoli L,Lorubbio M,Marzoni A,Pajola R,Pipitone S,Rolla R,Seghezzi M,Baigorria Vaca MDC,Bartolini A,Buoro S

    更新日期:2020-09-14 00:00:00

  • Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy.

    abstract:BACKGROUND:Prognostic factors in predicting outcomes in patients with head and neck squamous-cell carcinoma (HNSCC) are limited to the clinical-pathological parameters, including lymph node metastasis, location, grade and stage of the disease. AIM:To determine whether the expression of these proteins has a value in pr...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2006.036624

    authors: Mhawech-Fauceglia P,Dulguerov P,Beck A,Bonet M,Allal AS

    更新日期:2007-02-01 00:00:00

  • Cerebral ventriculitis associated with Achromobacter xylosoxidans.

    abstract::Six patients in the neurosurgical ward of Fukushima Medical College Hospital suffering from ventriculitis due to Achromobacter xylosoxidans infection had undergone craniotomy or cranial trepanation before the infection. The strains of A. xylosoxidans isolated from the patients were resistant to streptomycin, ampicilli...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.31.2.156

    authors: Shigeta S,Yasunaga Y,Honzumi K,Okamura H,Kumata R,Endo S

    更新日期:1978-02-01 00:00:00

  • MUC1 and MUC2 in pancreatic neoplasia.

    abstract::MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other actions, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. In contrast, MUC2 is normally found only in goblet cells, where it contributes to the prote...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2003.013292

    authors: Levi E,Klimstra DS,Andea A,Basturk O,Adsay NV

    更新日期:2004-05-01 00:00:00

  • Recurrent MED12 exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults.

    abstract:AIMS:Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic MED12 exon 2 mutations and rare TERT promoter hotspot mutations. We sought to determine the frequency of MED12 exon 2 and TERT promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2018-205570

    authors: Pareja F,Da Cruz Paula A,Murray MP,Hoang T,Gularte-Mérida R,Brown D,da Silva EM,Sebastiao APM,Giri DD,Weigelt B,Reis-Filho JS,Brogi E

    更新日期:2019-03-01 00:00:00

  • An evaluation of 12 methods for the demonstration of penicillinase.

    abstract::Twelve methods for the demonstration of bacterial penicillinase production by strains of Haemophilus influenzae and Staphylococcus aureus are compared, and their suitability for routine clinical laboratory use is evaluated. The acidometric agar plate method is recommended. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.10.1061

    authors: Lucas TJ

    更新日期:1979-10-01 00:00:00

  • Herpesvirus in the oral cavity of children with leukaemia and its impact on the oral bacterial community profile.

    abstract:AIMS:This cross-sectional study investigated the association between eight herpesviruses and the bacterial community profiles from the oral cavity of children with and without leukaemia. METHODS:Sixty participants (aged 3-13), divided into the leukaemia group (LG) and healthy group (HG), were evaluated. Collection of ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2014-202668

    authors: Bezerra TM,Ferreira DC,Carmo FL,Pinheiro R,Leite DC,Cavalcante FS,Belinho RA,Peixoto RS,Rosado AS,dos Santos KR,Castro GF

    更新日期:2015-03-01 00:00:00

  • Examination of breast needle core biopsy specimens performed for screen-detected microcalcification.

    abstract:AIMS:To establish the number of histological levels necessary for the evaluation of breast needle core biopsy (NCB) specimens taken from areas of mammographic calcification in patients presenting via the UK National Health Service Breast Screening Programme. METHODS:Retrospective review of a series of breast NCB speci...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2006.038190

    authors: Kumaraswamy V,Carder PJ

    更新日期:2007-06-01 00:00:00

  • Detection of surface immunoglobulins of human lymphoid cells: a comparative study of live and fixed cells using a direct immunoperoxidase procedure.

    abstract::Surface immunoglobulins (Ig) of normal and malignant lymphoid cells were detected on prefixed, smeared (method A) and live (method B) cell suspensions; the results were compared with regard to staining patterns, specificity and sensitivity. In both methods surface Ig were detected by a direct immunoperoxidase procedur...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.2.139

    authors: Laurent G,Gourdin MF,Reyes F

    更新日期:1982-02-01 00:00:00