Abstract:
:The aim of the present study was to assess the effect of Endostar and temozolomide or dacarbazine plus 5-fluorouracil (5-FU) in patients with advanced pancreatic neuroendocrine tumors (pNETs).Phase II study of 14 patients with locally advanced or metastatic well-differentiated pNETs treated between April 2013 and September 2016. Patients received temozolomide or dacarbazine plus 5-FU, and Endostar. The primary outcome was the radiographic response rate.All 14 patients had nonfunctional pNETs. Six patients received temozolomide and 8 received dacarbazine + 5-FU, combined with Endostar. Thirteen patients were assessable for treatment response: 1(7%) with complete response, 5 (39%) with partial response, 5 (39%) with stable disease, and 2 (15%) with progression. The median progression-free survival was 12 months. The most common grade 1/2 toxicities were neutropenia (43%) and leucopenia (21%).Endostar combined with temozolomide or dacarbazine + 5-FU was effective in the treatment of advanced pNETs. The combinations were well tolerated.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Cheng YJ,Meng CT,Ying HY,Zhou JF,Yan XY,Gao X,Zhou N,Bai CMdoi
10.1097/MD.0000000000012750subject
Has Abstractpub_date
2018-11-01 00:00:00pages
e12750issue
45eissn
0025-7974issn
1536-5964pii
00005792-201811090-00003journal_volume
97pub_type
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