Abstract:
:Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wei TT,Hu ZD,Qin BD,Ma N,Tang QQ,Wang LL,Zhou L,Zhong RQdoi
10.1097/MD.0000000000003079subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e3079issue
11eissn
0025-7974issn
1536-5964pii
00005792-201603150-00047journal_volume
95pub_type
杂志文章,meta分析,评审相关文献
MEDICINE文献大全abstract::Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep disorder which is associated with a series of cardiovascular disorders, including right ventricular (RV) dysfunction. However, it is difficult to assess the RV function systematically using a conventional echocardiography because RV has a complex...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004788
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Collecting duct carcinoma (CDC) is a rare type of nonclear renal cell carcinoma, often presenting at an advanced stage of the disease, and standard treatment guidelines have not been established. PATIENT CONCERNS:A 73-year-old man was admitted to our hospital with complaints of fever and lower right back pai...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013173
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate the safety and efficacy of the cystotome-assisted prechop phacoemulsification surgery (CAPPS) and conventional phacoemulsification surgery (CPS) in patients with IV degree nucleus cataract. METHODS:The prospective, randomized, consecutive, comparative cohort study consecutive...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000013124
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is characterized as chronic or recurrent mononucleosis-like symptoms and elevated EBV deoxyribonucleic acid (EBV-DNA) copies. Cardiovascular complications have high morbidity and mortality. The treatment regimen for CAEBV has not been established ye...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000004384
更新日期:2016-08-01 00:00:00
abstract::The elevated platelet-to-lymphocyte ratio (PLR), determined using an easy blood test based on platelet and lymphocyte counts, is reported to be a predictor of poor survival in patients with several cancers. The prognostic role of preoperative PLR in patients with intrahepatic cholangiocarcinoma (ICC) has, until now, b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000574
更新日期:2015-04-01 00:00:00
abstract::Cancer patients can be well-connected to resources during treatment but become lost to follow-up and subsequently may receive treatment in free clinics for chronic morbidities. Few studies have examined outcomes for uninsured patients with cancer histories in free clinics, but research examining socioeconomic determin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013121
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:This meta-analysis aimed to systematically evaluate the effects of probiotics on blood lipid and blood pressure among patients with type 2 diabetes mellitus (T2DM) based on the randomized controlled studies. METHODS:PubMed, Cochrane, Embase, Wanfang, China National Knowledge Infrastructure, and VIP database...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000009166
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Sirenomelia is a rare congenital malformation that threatens fetal survivals. The cases in which twin with sirenomelia and chromosomal abnormality have been seldomly reported. We reported a dichorionic twin case in which one twin had sirenomelia, the other twin had a normal phenotype, and they had different c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000024229
更新日期:2021-01-08 00:00:00
abstract:PURPOSE:This meta-analysis assessed the clinical efficacy and safety of cefoperazone-sulbactam for empiric therapy febrile neutropenia. METHODS:The PubMed, Web of Science, EBSCO, Cochrane Library, Ovid Medline, EMBASE, and ClinicalTrial.gov database were searched through May 10, 2019. Only clinical trials comparing ce...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019321
更新日期:2020-02-01 00:00:00
abstract::Sleep disturbance is a common comorbidity among patients with acromegaly [patients with growth hormone (GH)-secreting tumor] due to somatotropic axis change and sleep apnea. However, no previous studies exist concerning sleep disturbance and delirium in the early postoperative period in patients with acromegaly underg...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023157
更新日期:2020-11-06 00:00:00
abstract:RATIONALE:Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS:Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES:Sorafenib refr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009598
更新日期:2018-01-01 00:00:00
abstract::Statin intake has been reported to reduce the risk of several malignancies beyond its cholesterol-lowering effects. However, little is known regarding the survival benefit of statins for patients with colorectal cancer (CRC).We conducted a systematic literature search of multiple databases for studies published before...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000908
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Prediabetes is an abnormal metabolic state that develops prior to the onset of diabetes with proven to common comorbid states of coronary artery disease. However, whether prediabetes worsens prognosis after percutaneous coronary intervention remains controversial. The aim of this study is to summarize previo...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021623
更新日期:2020-08-14 00:00:00
abstract::The aim of the study was to investigate the risk of retinal vein occlusion (RVO) following end-stage renal disease (ESRD). The study was designed as a retrospective, nationwide, matched cohort study. The subjects were ESRD patients identified by the International Classification of Diseases, Ninth Revision, Clinical Mo...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000003474
更新日期:2016-04-01 00:00:00
abstract:RATIONALE:Acute pancreatitis (AP) is one of the most common diseases of gastroenterological emergency with a highly variable clinical course and the incidence being on the rise in recent years. Posttraumatic diaphragmatic hernia is an uncommon disease and may manifest immediately or several years after the incident. De...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022482
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:The incidence of nocturia is high and will seriously affect patients' physical and mental health. Nocturnal polyuria is the most critical cause of nocturia, There are few drugs currently used to treat nocturia due to Nocturnal Polyuria (NP). The guide highly recommends only Desmopressin. There is an urgent n...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023742
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the outcomes of patients with pathologic T0 esophageal carcinoma after neoadjuvant therapy and surgery. METHODS:We searched PubMed, Embase, Cochrane Library, and Medline databases from inception up to November 12, 2016. The meta-analysis was performed to compare odds ra...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007342
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:A pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is a strong indicator of the benefit of therapy and presents an early surrogate for a favorable long-term outcome. It remains unclear whether Ki-67, a marker for tumor proliferation, can function as a predictor of the response to NCT...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000009384
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Glioblastoma multiforme (GBM) is a rare and deadly disease, with a reported average incidence rate of 3.19 cases per 100,000 inhabitants. Fotemustine, a third-generation nitrosourea with an alanine phosphor carrier that facilitates cellular penetration, has been extensively investigated in the setting of rec...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011254
更新日期:2018-07-01 00:00:00
abstract::Patients with suspected non-ST-segment elevation acute coronary syndromes (NSTEACS) constitute a heterogeneous population with variable outcomes. Risk stratification in this population of patients is difficult due to the complexity in patient risk profile. We conducted this study to characterize the value of clinical ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-200211000-00004
更新日期:2002-11-01 00:00:00
abstract::The study aim is to compare anal intraepithelial neoplasia (AIN) progression and regression rates in a cytology inception cohort to estimates based on the subcohort referred for ≥1 high-resolution anoscopies (HRAs).A cytology-based retrospective cohort was assembled including the anal cytology histories and invasive a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001476
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:In order to increase treatment choices for patients with Parkinson disease (PD), we performed a retrospective assessment of adverse events associated with a novel once-daily extended-release (ER) formulation versus the standard immediate-release (IR) of the nonergolinic dopamine agonist, pramipexole. METHOD...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000011316
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:Systemic Bartonella spp. infections are being increasingly reported in association with complex medical presentations. Individuals with frequent arthropod exposures or animal contact appear to be at risk for acquiring long standing infections with Bartonella spp. CASE REPORT:This case report describes inf...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010465
更新日期:2018-04-01 00:00:00
abstract::To investigate the safety and effectiveness of computed tomography (CT)-guided I seed implantation for locally advanced nonsmall cell lung cancer (NSCLC) after progression of concurrent radiochemotherapy (CCRT).We reviewed 78 locally advanced NSCLC patients who had each one cycle of first-line CCRT but had progressive...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002249
更新日期:2015-12-01 00:00:00
abstract::This study evaluated the clinical outcome of endoscopic submucosal dissection (ESD) in minute submucosa (SM) invasion or undifferentiated early gastric cancer (EGC) and analyzed factors related to local recurrence after ESD.We retrospectively reviewed the chart of EGC patients, who underwent ESD at our tertiary hospit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006710
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Femoroacetabular impingement (FAI) is a common cause of hip pain and restricted range of motion in young adults and athletes. This study aims to compare clinical results and complications between patients treated for FAI who underwent either arthroscopic or open treatment. METHODS:The 7 studies were acquire...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023364
更新日期:2020-11-20 00:00:00
abstract:RATIONALE:Sternoclavicular joint septic arthritis is an unusual disease in healthy adults, and Staphylococcus aureus is the most common causative pathogen. The current treatment of choice is surgery with sternoclavicular joint resection and pectoralis flap closure, especially when the disease is complicated by osteomye...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022938
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the manageme...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000004603
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Flavopiridol a semisynthetic flavone that inhibits cyclin-dependent kinases (CDKs) and has growth-inhibitory activity and induces a blockade of cell-cycle progression at G1-phase and apoptosis in numerous human tumor cell lines and is currently under investigation in phase II clinical trials. Cancer stem cel...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005150
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Hemolymphangioma is a rare developmental defect of combined vasal and lymphatic vasculature. It is very rare that hemolymphangioma affects the bones and bladder simultaneously, and this condition has never been reported in PubMed. PATIENT CONCERNS:A 12-year-old male has a history of hospitalization for recur...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015213
更新日期:2019-04-01 00:00:00