Potential role of contrast-enhanced ultrasound for the differentiation of malignant and benign gallbladder lesions in East Asia: A meta-analysis and systematic review.

Abstract:

BACKGROUND:The purpose of this study was to systematically review and evaluate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in differentiating malignant and benign gallbladder lesions. METHODS:We conducted a comprehensive search on PubMed, Embase, and Cochrane Library for all potential relevant articles published before December 2017. The pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the curve (AUC) of summary receiver operating characteristic (SROC) were calculated by Meta-Disc Version 1.4 and STATA 12.0. RESULTS:Twelve eligible studies were included in our study. A total of 1044 patients were assessed. The pooled sensitivity and specificity were 0.81 (95% confidence interval [CI], 0.77-0.84; inconsistency index [I] = 84.5%) and 0.87 (95% CI, 0.85-0.89; I = 94.4%), respectively. The pooled DOR was 58.84 (95% CI, 32.39-106.88; I = 51.9%). The AUC was 0.9371. According to Deek funnel plot asymmetry test, there was no significant publication bias (P = .31). CONCLUSIONS:The results yielded from the available evidence suggest that CEUS is a promising and adjuvant imaging technique to conventional ultrasound for the differential diagnosis of benign and malignant gallbladder lesions.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Cheng Y,Wang M,Ma B,Ma X

doi

10.1097/MD.0000000000011808

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

e11808

issue

33

eissn

0025-7974

issn

1536-5964

pii

00005792-201808170-00021

journal_volume

97

pub_type

杂志文章,meta分析,评审

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