Procaspase-3-activating compound 1 stabilizes hypoxia-inducible factor 1α and induces DNA damage by sequestering ferrous iron.

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...

journal_title：Cell death & disease

authors： Lin S,Zhang R,Xu L,Ma R,Xu L,Zhu L,Hu J,An X

更新日期：2020-08-26 00:00:00

abstract：:Correction to: NPG Asia Materials (2018) https://doi.org/10.1038/s41427-018-0014-9 published online on 16 April 2018. ...

journal_title：Cell death & disease

authors： Press E,Alaga KC,Barr K,Shao Q,Bosen F,Willecke K,Laird DW

更新日期：2018-05-24 00:00:00

abstract：:The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here, we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that mitochondrial morphology was altered in the early stage of ischemic injury while mitochondrial dysfunction occurred in the late stage of i...

journal_title：Cell death & disease

authors： Duan C,Kuang L,Xiang X,Zhang J,Zhu Y,Wu Y,Yan Q,Liu L,Li T

更新日期：2020-04-20 00:00:00

abstract：:Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that inhibits de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Phosphorylation of eIF2α alleviates endoplasmic reticu...

journal_title：Cell death & disease

authors： Li J,Li X,Liu D,Hamamura K,Wan Q,Na S,Yokota H,Zhang P

更新日期：2019-12-04 00:00:00

abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

journal_title：Cell death & disease

authors： Gao Y,Ge W

更新日期：2018-01-18 00:00:00

abstract：:The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) ...

journal_title：Cell death & disease

authors： Li M,Hou T,Gao T,Lu X,Yang Q,Zhu Q,Li Z,Liu C,Mu G,Liu G,Bao Y,Wen H,Wang L,Wang H,Zhao Y,Gu W,Yang Y,Zhu WG

更新日期：2018-09-20 00:00:00

abstract：:P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), has been found to regulate numerous cell signaling pathways controlling cell fate by acetylating both histone and non-histone proteins. We previously reported that PCAF upregulates cell apoptosis by inactivating Serine/Threonine Protein Kinase 1 (AK...

journal_title：Cell death & disease

authors： Gai X,Tu K,Li C,Lu Z,Roberts LR,Zheng X

更新日期：2015-04-09 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...

journal_title：Cell death & disease

authors： Kong Y,Zhao X,Qiu M,Lin Y,Feng P,Li S,Liang B,Zhu Q,Huang H,Li C,Wang W

更新日期：2021-01-21 00:00:00

abstract：:Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impa...

journal_title：Cell death & disease

authors： Domínguez-García S,Geribaldi-Doldán N,Gómez-Oliva R,Ruiz FA,Carrascal L,Bolívar J,Verástegui C,Garcia-Alloza M,Macías-Sánchez AJ,Hernández-Galán R,Nunez-Abades P,Castro C

更新日期：2020-04-22 00:00:00

abstract：:CEMIP (for "Cell migration-inducing protein" also called KIAA1199 and Hybid for "Hyaluronan-binding protein") expression is increased in cancers and described as a regulator of cell survival, growth and invasion. In rheumatoid arthritis, CEMIP is referred to as an angiogenic marker and participates in hyaluronic acid ...

journal_title：Cell death & disease

authors： Deroyer C,Charlier E,Neuville S,Malaise O,Gillet P,Kurth W,Chariot A,Malaise M,de Seny D

更新日期：2019-02-04 00:00:00

abstract：:The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed SOX12 expression patterns in two independent CRC cohorts (cohort I, n = 3...

journal_title：Cell death & disease

authors： Du F,Chen J,Liu H,Cai Y,Cao T,Han W,Yi X,Qian M,Tian D,Nie Y,Wu K,Fan D,Xia L

更新日期：2019-03-11 00:00:00

abstract：:In this study, the roles of p53 in impaired spermatogenic male germ cells of p53-deficient medaka were investigated by analyzing histological changes, and gene expressions of 42Sp50, Oct 4 and vitellogenin (VTG2) by RT-PCR or in situ hybridization in the testes. We found that a small number of oocyte-like cells (testi...

journal_title：Cell death & disease

authors： Yasuda T,Oda S,Li Z,Kimori Y,Kamei Y,Ishikawa T,Todo T,Mitani H

更新日期：2012-10-04 00:00:00

abstract：:Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) protei...

journal_title：Cell death & disease

authors： Yang C,Hu Y,Zhou B,Bao Y,Li Z,Gong C,Yang H,Wang S,Xiao Y

更新日期：2020-11-08 00:00:00

abstract：:While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell li...

journal_title：Cell death & disease

authors： Zhang JS,Herreros-Villanueva M,Koenig A,Deng Z,de Narvajas AA,Gomez TS,Meng X,Bujanda L,Ellenrieder V,Li XK,Kaufmann SH,Billadeau DD

更新日期：2014-03-27 00:00:00

abstract：:Detailed understanding of the mechanistic steps underlying tumor initiation and malignant progression is critical for insights of potentially novel therapeutic modalities. Cellular reprogramming is an approach of particular interest because it can provide a means to reset the differentiation state of the cancer cells ...

journal_title：Cell death & disease

authors： Yao J,Zhang L,Hu L,Guo B,Hu X,Borjigin U,Wei Z,Chen Y,Lv M,Lau JT,Wang X,Li G,Hu YP

更新日期：2016-07-28 00:00:00

abstract：:As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

journal_title：Cell death & disease

authors： He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

更新日期：2020-06-05 00:00:00

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Aberrant re-activation of transcription factors occurs frequently in cancer. Recently, we found the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in a model of highly aggressive thyroid cancer, raising the hypothesis that these factors might be part of the program driving progre...

journal_title：Cell death & disease

authors： Gallo C,Fragliasso V,Donati B,Torricelli F,Tameni A,Piana S,Ciarrocchi A

更新日期：2018-08-29 00:00:00

abstract：:Spermidine, a natural polyamine presented widely in mammalian cells, has been implicated to extend the lifespan of several model organisms by inducing autophagy. However, the effect of spermidine against neuronal damage has not yet been fully determined. In this study, neuronal cell injury was induced by treating PC12...

journal_title：Cell death & disease

authors： Yang Y,Chen S,Zhang Y,Lin X,Song Y,Xue Z,Qian H,Wang S,Wan G,Zheng X,Zhang L

更新日期：2017-04-06 00:00:00

abstract：:Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...

journal_title：Cell death & disease

authors： Hou S,Tian T,Qi D,Sun K,Yuan Q,Wang Z,Qin Z,Wu Z,Chen Z,Zhang J

更新日期：2018-02-15 00:00:00

abstract：:Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...

journal_title：Cell death & disease

authors： Cheteh EH,Augsten M,Rundqvist H,Bianchi J,Sarne V,Egevad L,Bykov VJ,Östman A,Wiman KG

更新日期：2017-06-01 00:00:00

abstract：:Evidence is mounting that proinflammatory and proapoptotic thioredoxin-interacting protein (TXNIP) has a causative role in the development of diabetes. However, there are no studies investigating the role of TXNIP in diabetic retinopathy (DR). Here, we show that, in diabetic rats, TXNIP expression and hexosamine biosy...

journal_title：Cell death & disease

authors： Perrone L,Devi TS,Hosoya KI,Terasaki T,Singh LP

更新日期：2010-08-19 00:00:00

abstract：:Previously, we confirmed that sphingosine kinase 1 (SphK1) inhibition improves sepsis-associated liver injury. High-mobility group box 1 (HMGB1) translocation participates in the development of acute liver failure. However, little information is available on the association between SphK1 and HMGB1 translocation during...

journal_title：Cell death & disease

authors： Tian T,Yao D,Zheng L,Zhou Z,Duan Y,Liu B,Wang P,Li Y

更新日期：2020-12-06 00:00:00

abstract：:Tumor-associated thrombosis is the second leading risk factor for cancer patient death, and platelets activity is abnormal in cancer patients. Discovering the mechanism of platelet activation and providing effective targets for therapy are urgently needed. Cancer cell- derived IgG has been reported to regulate develop...

journal_title：Cell death & disease

authors： Miao S,Shu D,Zhu Y,Lu M,Zhang Q,Pei Y,He AD,Ma R,Zhang B,Ming ZY

更新日期：2019-01-28 00:00:00

abstract：:Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

journal_title：Cell death & disease

authors： He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

更新日期：2014-01-16 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration in tumors. Mas...

journal_title：Cell death & disease

authors： Lv YP,Peng LS,Wang QH,Chen N,Teng YS,Wang TT,Mao FY,Zhang JY,Cheng P,Liu YG,Kong H,Wu XL,Hao CJ,Chen W,Zhu J,Han B,Ma Q,Li K,Zou Q,Zhuang Y

更新日期：2018-10-10 00:00:00