Corticosterone is correlated to mediators of neural plasticity and epigenetic potential in the hippocampus of Senegalese house sparrows (Passer domesticus).


:Our previous research on range-expanding house sparrows in Kenya revealed that (i) range-edge birds released more corticosterone (CORT) in response to a stressor than range-core birds, ii) that range-edge birds were more exploratory than range-core birds, and that (iii) all birds exhibited extensive variation in genome-wide DNA methylation among individuals, regardless of their position along the range expansion. Within the hippocampus, mediators of neural plasticity such as brain-derived neurotrophic factor (BDNF), can influence and be influenced by CORT, hippocampus-associated behaviors and regulatory epigenetic modification enzymes. Here, we investigated whether individuals and populations colonizing a new geographic range, Senegal, vary in the expression of BDNF and DNA methyltransferases (DNMTs) within the hippocampus and the release of CORT in response to a stressor. DNMT expression is an important mediator of epigenetic potential, the propensity of a genome to capacitate phenotypic variation via mechanisms such as DNA methylation. We surveyed three populations across Senegal, predicting that hippocampal BDNF and DNMT expression would be highest at the range-edge, and that BDNF and DNMT would be inversely related to one another, but would each positively covary with CORT within individuals. We found a nonlinear relationship between CORT and BDNF expression within individuals. Moreover, we found that CORT positively covaried with DNMT1 expression in a more recently established population, while the reverse was true in the oldest population (i.e. at the range-core). Our study is among the first to explore whether and how variation in CORT regulation contributes to variation in mediators of neural plasticity and epigenetic potential within the hippocampus of a range-expanding vertebrate.


Gen Comp Endocrinol


Kilvitis HJ,Ardia DR,Thiam M,Martin LB




Has Abstract


2018-12-01 00:00:00












  • Effects of fasting and feeding on the brain mRNA expressions of orexin, tyrosine hydroxylase (TH), PYY and CCK in the Mexican blind cavefish (Astyanax fasciatus mexicanus).

    abstract::The effects of fasting and feeding on the brain expression of orexin (OX), tyrosine hydroxylase (TH), peptide Y (PY) and cholecystokinin (CCK) were examined in the blind cavefish Astyanax fasciatus mexicanus. A 10-days fasting period induced increases in both OX and TH brain mRNA expression but had no effect on PYY an...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Wall A,Volkoff H

    更新日期:2013-03-01 00:00:00

  • Indirect evidence for a physiological role exerted by a "testicular gonadotropin-releasing hormone" in the frog, Rana esculenta.

    abstract::The possible physiological role of a putative testicular gonadotropin-releasing hormone (GnRH)-like material was studied in the frog, Rana esculenta. We have investigated (a) changes of mitotic index (MI) of primary spermatogonia (SPG) in GnRH agonist (GnRH-Ag)-treated testes in vitro; (b) changes of androgen concentr...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Di Matteo L,Minucci S,Fasano S,D'Antonio M,Pierantoni R,Chieffi G

    更新日期:1990-07-01 00:00:00

  • Gonadal modulation of in vitro steroidogenic properties of dispersed adrenocortical cells from Sceloporus lizards.

    abstract::Effects of adrenal corticosteroids on reproductive and endocrine functions of the gonads are well known, but reciprocal effects of gonadal hormones on the hypothalamo-pituitary-adrenal (HPA) axis and on adrenocortical steroidogenesis in particular have received much less attention. We investigated effects of gonadecto...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Carsia RV,McIlroy PJ,Cox RM,Barrett M,John-Alder HB

    更新日期:2008-09-01 00:00:00

  • Glucagon- and NPY-related peptide-immunoreactive cells in the gut of sea bass (Dicentrarchus labrax L.): a light and electron microscopic study.

    abstract::Glucagon and peptide of the neuropeptide Y (NPY) family immunoreactivities were studied in the gut of sea bass (Dicentrarchus labrax) using antisera against bovine/porcine glucagon, porcine glucagon, glicentin (10-30), bovine pancreatic polypeptide (PP), peptide tyrosine tyrosine (PYY), salmon PYY (sPYY), and NPY. Glu...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Gómez-visus I,García-Hernández MP,Lozano MT,Agulleiro B

    更新日期:1998-10-01 00:00:00

  • Effects of hypophysectomy on coho salmon interrenal: maintenance of steroidogenic pathway and restoration of in vitro responsiveness to adrenocorticotropin after handling.

    abstract::The role of the pituitary in regulating interrenal activity in coho salmon (Oncorhynchus kisutch) was examined using short- (1 week) or long- (10 week) term hypophysectomized (Hx) animals. In experiments in which Hx animals were injected with ovine growth hormone (oGH), triiodothyronine, or vehicle, plasma cortisol wa...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Young G

    更新日期:1993-12-01 00:00:00

  • Ultrastructural comparison of the perisympathetic organs in three Coleoptera: Chrysocarabus auronitens F., Oryctes rhinoceros L. and Tenebrio molitor L.

    abstract::Ultrastructural comparison of different types of perisympathetic organs (POs) in three species of Coleoptera (Chrysocarabus auronitens, Oryctes rhinoceros, and Tenebrio molitor) showed that the structure of these organs was not related to their morphological types but to their topography. Two kinds of PO structure may...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Provansal-Baudez A,Baudry-Partiaoglou N

    更新日期:1983-03-01 00:00:00

  • Plasma steroids in mature common dentex (Dentex dentex) stimulated with a gonadotropin-releasing hormone agonist.

    abstract::The aim of this study was to identify the major C21 steroids produced in vivo during artificially induced final oocyte maturation and spawning in female common dentex (Dentex dentex). During the spawning season, mature females were treated with a gonadotropin-releasing hormone agonist (GnRHa)-loaded delivery system, w...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Greenwood LN,Scott AP,Vermeirssen EL,Mylonas CC,Pavlidis M

    更新日期:2001-07-01 00:00:00

  • Effects of steroids and human chorionic gonadotrophin on in vitro oocyte final maturation in two marine flatfish: the dab, Limanda limanda, and the plaice, Pleuronectes platessa.

    abstract::This study investigated the role of gonadotrophin and steroids in the induction of in vitro oocyte maturation in dab (Limanda limanda) and plaice (Pleuronectes platessa), two marine flatfish (Pleuronectiformes) in which the oocytes mature and ovulate in groups (or batches). Clusters of folliculated oocytes were incuba...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Canario AV,Scott AP

    更新日期:1990-02-01 00:00:00

  • Seasonal differences in hypothalamic EGR-1 and GnIH expression following capture-handling stress in house sparrows (Passer domesticus).

    abstract::Stress is a known inhibitor of reproductive function. The mechanisms by which stress acts to influence the reproductive axis have been intensely studied and appear to be extremely varied. Gonadotropin-releasing hormone (GnRH) is a critical component of the vertebrate reproductive axis and directly causes pituitary gon...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Calisi RM,Rizzo NO,Bentley GE

    更新日期:2008-07-01 00:00:00

  • Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: receptor and enzyme genes associated with endocrine system in the neural complex.

    abstract::Identification of orthologs of vertebrate neuropeptides and hypothalamic hormones in the neural complex of ascidians suggests integral roles of the ascidian neural complex in the endocrine system. In the present study, we investigated endocrine-related genes expressed in the neural complex of Ciona intestinalis. Compr...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Sekiguchi T,Kawashima T,Satou Y,Satoh N

    更新日期:2007-01-15 00:00:00

  • Thyroid and annual gonad development, body weight, plumage pigmentation, and bill color cycles of lal munia, Estrilda amandava.

    abstract::Long-term administration of L-thyroxine (T4) in the wax bill (lal munia) inhibited the current gonad development cycle, and the increase in gonadal volume in the second cycle was suppressed only by higher concentrations. Gonadal inhibition by high but not by low doses of L-T4 was associated with a failure in the devel...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Thapliyal JP,Gupta BB

    更新日期:1984-07-01 00:00:00

  • Hormones regulating hepatic glycogenolysis in two chelonians use cyclic AMP, and not Ca2+, as intracellular messenger.

    abstract::In teleosts, lungfish, amphibians, and a reptile, Amphibolurus nuchalis, hormonal stimulation of hepatic glycogenolysis is mediated by a rise in intracellular cyclic AMP concentration. In mammals, by contrast, the inositol trisphosphate/Ca2+/diacylglycerol signal transduction pathways are also involved. The present st...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Janssens PA,Grigg JA

    更新日期:1992-10-01 00:00:00

  • Serotonin and N-acetylserotonin effects on pigment cells of the toad Bufo ictericus: pharmacological characterization of melatonin receptors.

    abstract::Melatonin is a skin lightening agonist of the toad Bufo ictericus. The hormone also exhibits an autodesensitizing action as well as an inhibitory activity on the darkening response to alpha-MSH. In an attempt to pharmacologically characterize the melatonin receptor of the toad pigment cells, serotonin and N-acetylsero...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Filadelfi AM,Castrucci AM

    更新日期:1996-08-01 00:00:00

  • Tissue-specific promoter methylation coincides with Cyp19 gene expression in buffalo (Bubalus bubalis) placenta of different stages of gestation.

    abstract::Aromatase is the key enzyme for estrogen biosynthesis and is encoded by Cyp19 gene. Placental cotyledons are the main site of Cyp19 gene expression during pregnancy. The present study was aimed to investigate if DNA methylation and thus epigenetic mechanisms play a potential role in stage-specific regulation of Cyp19 ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Ghai S,Monga R,Mohanty TK,Chauhan MS,Singh D

    更新日期:2010-11-01 00:00:00

  • Abnormal growth hormone receptor gene expression in the sex-linked dwarf chicken.

    abstract::Sex-linked dwarfism is a recessive mutation that causes a reduction in body weight gain and long bone growth of chickens. We examined the effect of the dwarfing gene on body weight, hepatic GH-binding activity, and the structure and expression of the growth hormone receptor (GHR) gene in two different lines of sex-lin...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Burnside J,Liou SS,Zhong C,Cogburn LA

    更新日期:1992-10-01 00:00:00

  • Changes in steroid profiles of the blue mussel Mytilus trossulus as a function of season, stage of gametogenesis, sex, tissue and mussel bed depth.

    abstract::This paper describes changes in the content of free steroid hormones e.g. testosterone (T), estradiol-17β (E2), estrone (E1) and estriol (E3) of Mytilus trossulus from the southern Baltic Sea as a function of season, stage of gametogenesis, sex, tissue (gonadal and somatic) and depth. The highest levels of T, E2, E1 a...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Smolarz K,Zabrzańska S,Konieczna L,Hallmann A

    更新日期:2018-04-01 00:00:00

  • The presence of a pregnenolone-binding factor in the copulatory organ of the migratory locust, Locusta migratoria migratorioides R. & F.

    abstract::The presence of binding sites for nonecdysteroid steroids was investigated in the cytosol of several tissues of the migratory locust, Locusta migratoria migratorioides. Binding of androgens was not observed. Most tissues, however, showed nonsaturable binding of estrogens and in some tissues saturable progestin binding...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Paesen G,Novak F,Swevers L,De Clerck D,De Loof A

    更新日期:1988-12-01 00:00:00

  • Characterization of an estrogen receptor in the turtle testis.

    abstract::Using DNA-cellulose affinity chromatography, an estrogen-binding component having the properties of a classical estrogen receptor was characterized from testicular cytosol of the freshwater turtle, Chrysemys picta. This putative cytoplasmic receptor exhibited high affinity (Kd = 7.0 X 10(-10) M), low capacity (1-4 fmo...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Mak P,Ho SM,Callard IP

    更新日期:1983-11-01 00:00:00

  • Extrapituitary growth hormone in the chicken reproductive system.

    abstract::Increasing evidence shows that growth hormone (GH) expression is not limited to the pituitary, as it can be produced in many other tissues. It is known that growth hormone (GH) plays a role in the control of reproductive tract development. Acting as an endocrine, paracrine and/or autocrine regulator, GH influences pro...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Luna M,Martínez-Moreno CG,Ahumada-Solórzano MS,Harvey S,Carranza M,Arámburo C

    更新日期:2014-07-01 00:00:00

  • The role of JH III and ecdysterone in the regulation of the left colleterial gland activities in Periplaneta americana during the reproductive cycle.

    abstract::We studied the in vitro effects of JH III and ecdysterone on RNA synthesis and secretory activities of the left colleterial gland (LCG) in mature females of Periplaneta americana during the reproductive cycle. We found that RNA synthesis is a cyclic and highly dynamic process. The major increases in poly(A)- RNA synth...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Iris FJ,Sin FY

    更新日期:1988-07-01 00:00:00

  • Mutual regulation by GnRH and kisspeptin of their receptor expression and its impact on the gene expression of gonadotropin subunits.

    abstract::Hypothalamic kisspeptin plays a pivotal role in the regulation of the hypothalamic-pituitary-gonadal axis by stimulating gonadotropin-releasing hormone (GnRH) release into the portal circulation, with the subsequent release of gonadotropins. Kisspeptin and its receptor, the kisspeptin 1 receptor (Kiss1R), are also exp...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Mijiddorj T,Kanasaki H,Sukhbaatar U,Oride A,Hara T,Kyo S

    更新日期:2017-05-15 00:00:00

  • Production of symmetrical flatfish by controlling the timing of thyroid hormone treatment in spotted halibut Verasper variegatus.

    abstract::The thyroid hormone plays an essential role in the metamorphosis in flatfish, during which external asymmetry (for example, eye relocation and pigmentation) is established. However, no information is available on the expression mechanisms of metamorphic asymmetry. Since the presence of malformed juveniles (having eith...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Tagawa M,Aritaki M

    更新日期:2005-04-01 00:00:00

  • Neurosteroids; potential underpinning roles in maintaining homeostasis.

    abstract::The neuroactive steroids which are synthesized in the brain and nervous system are known as "Neurosteroids". These steroids have crucial functions such as contributing to the myelination and organization of the brain connectivity. Under the stressful circumstances, the concentrations of neurosteroid products such as a...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Rahmani B,Ghasemi R,Dargahi L,Ahmadiani A,Haeri A

    更新日期:2016-01-01 00:00:00

  • Preovulatory follicle dynamics and ovulatory efficiency in sows with thrifty genotype and leptin resistance due to leptin receptor gene polymorphisms (Iberian pig).

    abstract::This study compares follicular function and ovulatory efficiency in 20 sows with obesity/leptin resistance genotype (Iberian pig) and 20 females of lean commercial crosses (Large White × Landrace; LW×L). Estrous cycle was synchronized with progestagens; ovulation was induced with eCG and hCG, in half of the females of...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Gonzalez-Añover P,Encinas T,Sanz E,Letelier CA,Torres-Rovira L,de Mercado E,Pallares P,Sanchez-Sanchez R,Gonzalez-Bulnes A

    更新日期:2011-01-01 00:00:00

  • The transcripts of CRF and CRF receptors under fasting stress in Dabry's sturgeon (Acipenser dabryanus Dumeril).

    abstract::Dabry's sturgeon (Acipenser dabryanus Dumeril, 1868) belongs to Sturgeon and is distributed throughout the mainstream of the upper Yangtze River. While there is little research onphysiological mechanism of Dabry's sturgeon, such as feeding regulation by the CRF system. At present, CRF is thought to regulate feeding vi...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Qi J,Tang N,Wu Y,Chen H,Wang S,Wang B,Xu S,Wang M,Zhang X,Chen D,Zhou B,Li Z

    更新日期:2019-09-01 00:00:00

  • Effects of storage treatment on fecal steroid hormone concentrations of a rodent, the Cape ground squirrel (Xerus inauris).

    abstract::Fecal steroid analysis is an increasingly common non-invasive technique used in both captive and field studies to measure an animal's approximate hormonal levels and corresponding physiological state. Fecal collection in the field necessitates storage and transportation methods that will prevent the degradation of hor...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Pettitt BA,Wheaton CJ,Waterman JM

    更新日期:2007-01-01 00:00:00

  • Control of vascular smooth muscle cell growth in fowl.

    abstract::In adult domestic fowl, angiotensin (ANG) receptors are present in the vascular smooth muscles (VSM) and in the endothelium, mediating vasorelaxation via endothelium-derived relaxing factor/cGMP. ANG II-induced relaxation is minor in chicks and becomes more marked as they mature but diminishes in adult birds, whereas ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Shimada T,Fabian M,Yan HQ,Nishimura H

    更新日期:1998-10-01 00:00:00

  • Circannual changes in plasma aldosterone levels in Bufo japonicus formosus.

    abstract::Plasma aldosterone levels of Bufo japonicus formosus captured in their natural environment were determined each month throughout 1 year by radioimmunoassay. Low values were recorded in winter and spring, and the maximum occurred in July or August. High summer levels of aldosterone and increases in live weight were cor...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Jolivet-Jaudet G,Inoue M,Takada K,Ishii S

    更新日期:1984-01-01 00:00:00

  • Molecular characterization, expression analysis, and functional properties of multiple 5-hydroxytryptamine receptors in Pacific abalone (Haliotis discus hannai).

    abstract::Neurotransmitters such as serotonin (5-hydroxytryptamine; 5-HT) in the central nervous system regulate diverse physiological functions, including reproduction, feeding, learning, and memory, in diverse animal phyla. 5-HT and the 5-HT1 subtype receptor play important roles in sexual maturation and in the initiation of ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Kim KS,Kim MA,Sohn YC

    更新日期:2019-05-15 00:00:00

  • Variations of calcitonin-like immunoreactivity in the crustacean Orchestia cavimana during a molt cycle.

    abstract::The investigation of calcitonin-like immunoreactivity performed in whole extracts of the terrestrial crustacean Orchestia cavimana using radioimmunoassay revealed large amounts of these peptides varying in concentration according to the stages of the molt cycle. Their level is maximum at the time of the exuviation. Th...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Graf F,Fouchereau-Peron M,Van-Wormhoudt A,Meyran JC

    更新日期:1989-01-01 00:00:00