Corticosterone is correlated to mediators of neural plasticity and epigenetic potential in the hippocampus of Senegalese house sparrows (Passer domesticus).


:Our previous research on range-expanding house sparrows in Kenya revealed that (i) range-edge birds released more corticosterone (CORT) in response to a stressor than range-core birds, ii) that range-edge birds were more exploratory than range-core birds, and that (iii) all birds exhibited extensive variation in genome-wide DNA methylation among individuals, regardless of their position along the range expansion. Within the hippocampus, mediators of neural plasticity such as brain-derived neurotrophic factor (BDNF), can influence and be influenced by CORT, hippocampus-associated behaviors and regulatory epigenetic modification enzymes. Here, we investigated whether individuals and populations colonizing a new geographic range, Senegal, vary in the expression of BDNF and DNA methyltransferases (DNMTs) within the hippocampus and the release of CORT in response to a stressor. DNMT expression is an important mediator of epigenetic potential, the propensity of a genome to capacitate phenotypic variation via mechanisms such as DNA methylation. We surveyed three populations across Senegal, predicting that hippocampal BDNF and DNMT expression would be highest at the range-edge, and that BDNF and DNMT would be inversely related to one another, but would each positively covary with CORT within individuals. We found a nonlinear relationship between CORT and BDNF expression within individuals. Moreover, we found that CORT positively covaried with DNMT1 expression in a more recently established population, while the reverse was true in the oldest population (i.e. at the range-core). Our study is among the first to explore whether and how variation in CORT regulation contributes to variation in mediators of neural plasticity and epigenetic potential within the hippocampus of a range-expanding vertebrate.


Gen Comp Endocrinol


Kilvitis HJ,Ardia DR,Thiam M,Martin LB




Has Abstract


2018-12-01 00:00:00












  • Follistatin suppresses FSHbeta but increases LHbeta expression in the goldfish - evidence for an activin-mediated autocrine/paracrine system in fish pituitary.

    abstract::Our previous study demonstrated that recombinant goldfish activin B stimulated goldfish FSHbeta but inhibited LHbeta expression. Similar to activin B, activin A also exhibited the inverse effects on the expression of the two gonadotropins. The novel dual effects of activins on FSH and LH in the goldfish raise an inter...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Yuen CW,Ge W

    更新日期:2004-01-01 00:00:00

  • Intersex in teleost fish: are we distinguishing endocrine disruption from natural phenomena?

    abstract::Intersex is defined as the simultaneous presence of male and female gonadal tissue in a gonochoristic (fixed-sex) species. The intersex condition has been documented in both wild and laboratory animals, including fish, amphibians, and reptiles. In aquatic animals, intersex is often viewed as a signature effect of expo...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Bahamonde PA,Munkittrick KR,Martyniuk CJ

    更新日期:2013-10-01 00:00:00

  • Effects of developmental conditions on nestling American Kestrel (Falco sparverius) corticosterone concentrations.

    abstract::How nestling birds respond to stressful situations may constitute an important survival component that has lasting developmental effects on the hypothalamic pituitary adrenal (HPA) axis. As birds are exposed to increasing amounts of potential anthropogenic stressors through land use change, understanding how these fac...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Strasser EH,Heath JA

    更新日期:2011-08-01 00:00:00

  • No evidence for sex-specific effects of the maternal social environment on offspring development in Japanese quail (Coturnix japonica).

    abstract::The social environment of reproducing females can cause physiological changes, with consequences for reproductive investment and offspring development. These prenatal maternal effects are often found to be sex-specific and may have evolved as adaptations, maximizing fitness of male and female offspring for their futur...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Langen EMA,von Engelhardt N,Goerlich-Jansson VC

    更新日期:2018-07-01 00:00:00

  • Characterization of spermatogonial cells and niche in the scorpion mud turtle (Kinosternon scorpioides).

    abstract::Undifferentiated spermatogonia (Aund) or spermatogonial stem cells (SSCs) are committed to the establishment and maintenance of spermatogenesis and fertility throughout a male's life and are located in a highly specialized microenvironment called niche that regulates their fate. Although several studies have been deve...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Costa GMJ,Sousa AL,Figueiredo AFA,Lacerda SMSN,França LR

    更新日期:2019-03-01 00:00:00

  • Evolution of insulin-like growth factor (IGF) function: production and characterization of recombinant hagfish IGF.

    abstract::While there is considerable structural evidence that insulin-like growth factors (IGFs) share a long evolutionary history, little is known about the conservation of IGF function. In order to address this, we have made recombinant hagfish IGF, hence allowing characterization of an IGF from a representative of the primi...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Upton Z,Francis GL,Chan SJ,Steiner DF,Wallace JC,Ballard FJ

    更新日期:1997-01-01 00:00:00

  • The role of myostatin in chicken (Gallus domesticus) myogenic satellite cell proliferation and differentiation.

    abstract::Myostatin (GDF-8) inhibits the activation, proliferation, and differentiation of myogenic satellite cells. The relative importance of this growth factor is demonstrated in myostatin-null mice and cattle possessing defective myostatin genes. These defects result in greatly enhanced musculature. In the present study, th...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: McFarland DC,Velleman SG,Pesall JE,Liu C

    更新日期:2007-05-01 00:00:00

  • Role of cortisol in hypoosmoregulation in larvae of the tilapia (Oreochromis mossambicus).

    abstract::The total cortisol content in tilapia was 55 pg immediately following fertilization, then decreased abruptly and maintained a lower level of 10-20 pg until hatching; after hatching the cortisol content increased to 50 pg by the 7th day. Fertilized eggs were incubated in either 32% saltwater or fresh water and sampled ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Hwang PP,Wu SM

    更新日期:1993-11-01 00:00:00

  • Gene expression during ovarian differentiation in parasitic and non-parasitic lampreys: implications for fecundity and life history types.

    abstract::Lampreys diverged from the jawed vertebrate lineage approximately 500million years ago. Lampreys undergo sex differentiation much later than most other vertebrates, and ovarian differentiation occurs several years before testicular differentiation. The genetic basis of lamprey sex differentiation is of particular inte...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Spice EK,Whyard S,Docker MF

    更新日期:2014-11-01 00:00:00

  • Hormone studies in Myxine glutinosa: failure of calcitonin to influence urine flow or plasma and urine electrolyte balance.

    abstract::Hagfish, Myxine glutinosa, were used in a series of experiments to determine a possible role for calcitonin in plasma and urine electrolyte balance. Individual animals were anaesthetised and implanted with polythene cannulae for monitoring blood pressure and for infusion/injection. Urine was collected by manual palpat...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Wales NA

    更新日期:1988-07-01 00:00:00

  • Deiodination and deconjugation of thyroid hormone conjugates and type I deiodination in liver of rainbow trout, Oncorhynchus mykiss.

    abstract::We studied the hepatic in vitro deconjugation and deiodination of glucuronide (G) and sulfate (S) conjugates of the thyroid hormones (TH) thyroxine (T(4)), 3,5,3'-triiodothyronine (T(3)), and 3,3', 5'-triiodothyronine (rT(3)) in trout. These conversions have not been studied in nonmammals. Deconjugation of T(4)G, T(3)...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Finnson KW,McLeese JM,Eales JG

    更新日期:1999-09-01 00:00:00

  • Biology and identity of fish spermatogonial stem cell.

    abstract::Although present at relatively low number in the testis, spermatogonial stem cells (SSCs) are crucial for the establishment and maintenance of spermatogenesis in eukaryotes and, until recently, those cells were investigated in fish using morphological criteria. The isolation and characterization of these cells in fish...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Lacerda SM,Costa GM,de França LR

    更新日期:2014-10-01 00:00:00

  • Tissue-specific regulation of the growth hormone/insulin-like growth factor axis during fasting and re-feeding: Importance of muscle expression of IGF-I and IGF-II mRNA in the tilapia.

    abstract::The effects of prolonged nutrient restriction (fasting) and subsequent restoration (re-feeding) on the growth hormone (GH)/insulin-like growth factor (IGF) axis were investigated in the tilapia (Oreochromis mossambicus). Mean weight and specific growth rate declined within 1 week in fasted fish, and remained lower tha...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Fox BK,Breves JP,Davis LK,Pierce AL,Hirano T,Grau EG

    更新日期:2010-05-01 00:00:00

  • Thyroid hormone receptor: A new player in epinephrine-induced larval metamorphosis of the hard-shelled mussel.

    abstract::Many marine invertebrate larvae undergo a dramatic morphological and physiological transition from a planktonic larva to a benthic juvenile. The mechanisms of this metamorphosis in bivalves are mainly unknown. The recent identification in bivalves of a thyroid hormone receptor (TR) gene raises the possibility that as ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Li YF,Cheng YL,Chen K,Cheng ZY,Zhu X,C R Cardoso J,Liang X,Zhu YT,Power DM,Yang JL

    更新日期:2020-02-01 00:00:00

  • Characterization, tissue distribution, and regulation of agouti-related protein (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY) in Atlantic salmon (Salmo salar).

    abstract::Key peptide hormones involved in the control of appetite in vertebrates were identified, their genes characterized and their regulation studied in Atlantic salmon: two agouti-related proteins (AgRP), cocaine- and amphetamine-regulated transcript (CART) and neuropeptide Y (NPY). The AgRP-1 and AgRP-2 genes encode prepr...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Murashita K,Kurokawa T,Ebbesson LO,Stefansson SO,Rønnestad I

    更新日期:2009-06-01 00:00:00

  • Neural remodelling in spiny lobster larvae is characterized by broad neuropeptide suppression.

    abstract::Neuropeptides are ancient endocrine components which have evolved to regulate many aspects of biology across the animal kingdom including behaviour, development and metabolism. To supplement current knowledge, we have utilized a transcriptome series describing larval development in the ornate spiny lobster, Panulirus ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Hyde CJ,Nguyen T,Fitzgibbon QP,Elizur A,Smith GG,Ventura T

    更新日期:2020-08-01 00:00:00

  • Gonadotropin-releasing hormone (GnRH) in bony fish that are phylogenetically ancient: reedfish (Calamoichthys calabaricus), sturgeon (Acipenser transmontanus), and alligator gar (Lepisosteus spatula).

    abstract::Three species of fish that are phylogenetically older than other members of the bony fish lineage were selected to determine if gonadotropin-releasing hormone (GnRH) is present in their brains. Brain extracts were prepared from each species and found to contain immunoreactive (ir) GnRH. To further characterize the mol...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Sherwood NM,Doroshov S,Lance V

    更新日期:1991-10-01 00:00:00

  • New insights into the signaling system and function of insulin in fish.

    abstract::Fish have provided essential information about the structure, biosynthesis, evolution, and function of insulin (INS) as well as about the structure, evolution, and mechanism of action of insulin receptors (IR). INS, insulin-like growth factor (IGF)-1, and IGF-2 share a common ancestor; INS and a single IGF occur in Ag...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章,评审


    authors: Caruso MA,Sheridan MA

    更新日期:2011-09-01 00:00:00

  • Egg deposition of maternal testosterone is primarily controlled by the preovulatory peak of luteinizing hormone in Japanese quail.

    abstract::Differential transfer of maternal testosterone (T) into egg yolk provides a means of adjusting an offspring's phenotype to ambient environmental conditions. While the environmental and genetic driven variability in yolk T levels is widely described, the underlying mechanisms are poorly understood. Here, we investigate...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Okuliarova M,Meddle SL,Zeman M

    更新日期:2018-01-15 00:00:00

  • Secretagogues for pancreatic hormone release in the channel catfish (Ictalurus punctatus).

    abstract::We investigated the effect of several potential carbohydrate secretagogues, amino acids, a ketoacid, and potassium chloride on insulin, glucagon, and somatostatin release from the in vitro perfused Brockmann body of channel catfish (Ictalurus punctatus). Mannose (15 mM) stimulated the release of insulin and somatostat...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Ronner P,Scarpa A

    更新日期:1987-03-01 00:00:00

  • Formation of ecdysteroids by Y-organs of the crab, Menippe mercenaria. II. Incorporation of cholesterol into 7-dehydrocholesterol and secretion products in vitro.

    abstract::The conversion in vitro of cholesterol (Ch) to nonpolar metabolites and ecdysteroids was studied in Y-organs of the xanthid crab, Menippe mercenaria. In one set of experiments, Y-organs were prelabeled in vivo by injecting crabs with 100 microCi of [3H]Ch, and halved glands were then incubated for 24 and 48 hr in the ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Rudolph PH,Spaziani E

    更新日期:1992-11-01 00:00:00

  • Localization, expression and role of Orexin A and its receptor in testes of neonatal mice.

    abstract::Orexin A (OXA), a hypothalamic neuropeptide, and its receptor (OX1R) are primarily expressed in lateral hypothalamus and are involved in the control of various biological functions. Expressions of OXA and OX1R have also been reported in peripheral organs like gastrointestinal and genital tracts. In the present study, ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Joshi D,Singh SK

    更新日期:2016-12-01 00:00:00

  • The distribution of lysine vasopressin (lysipressin) in placental mammals: a reinvestigation of the Hippopotamidae (Hippopotamus amphibius) and Tayassuidae (Tayassu angulatus) families.

    abstract::The neurohypophyseal hormones of the hippopotamus (Hippopotamus amphibius) and collared peccary (Tayassu angulatus) were isolated by molecular sieving and preparative high-pressure liquid chromatography (HPLC). Oxytocin and arginine vasopressin have been identified by their amino acid compositions and their retention ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Rouille Y,Chauvet MT,Chauvet J,Acher R,Hadley ME

    更新日期:1988-09-01 00:00:00

  • Seasonal changes in body mass, insulin, and glucocorticoids of free-living golden-mantled ground squirrels.

    abstract::The aim of the present study was to determine the relationship between seasonal variation in levels of insulin, cortisol, and corticosterone and body mass in a natural population of golden-mantled ground squirrels (Spermophilus saturatus) over the active season, from April to August. The body mass of females is at an ...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Boswell T,Woods SC,Kenagy GJ

    更新日期:1994-12-01 00:00:00

  • Experimental increase in temperature affects eggshell thickness, and not egg mass, eggshell spottiness or egg composition in the great tit (Parus major).

    abstract::Phenotypic effects of global warming have been documented in many different taxa. However, the importance of transgenerational phenotypic plasticity in these adaptations are seldom studied. In birds, temperature could affect egg characteristics. Higher temperatures during egg-laying may reduce maintenance costs for fe...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Bleu J,Agostini S,Angelier F,Biard C

    更新日期:2019-05-01 00:00:00

  • The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes.

    abstract::The vertebrate oxytocin and vasopressin receptors form a family of G-protein-coupled receptors (GPCRs) that mediate a large variety of functions, including social behavior and the regulation of blood pressure, water balance and reproduction. In mammals four family members have been identified, three of which respond t...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Ocampo Daza D,Lewicka M,Larhammar D

    更新日期:2012-01-01 00:00:00

  • In vitro study of the direct ovarian effects of gonadotropin-releasing hormone (GnRH) in the frogs, Rana pipiens and Rana catesbeiana.

    abstract::Ovaries from the leopard frog, Rana pipiens, and bullfrog, R. catesbeiana, were used to study potential direct extrapituitary effects of gonadotropin-releasing hormone (GnRH). GnRH alone did not alter steroid secretion from ovaries in either species. Ovarian fragments containing mature follicles from R. pipiens were i...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Hubbard GM,Licht P

    更新日期:1985-11-01 00:00:00

  • Hormones regulating hepatic glycogenolysis in two chelonians use cyclic AMP, and not Ca2+, as intracellular messenger.

    abstract::In teleosts, lungfish, amphibians, and a reptile, Amphibolurus nuchalis, hormonal stimulation of hepatic glycogenolysis is mediated by a rise in intracellular cyclic AMP concentration. In mammals, by contrast, the inositol trisphosphate/Ca2+/diacylglycerol signal transduction pathways are also involved. The present st...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Janssens PA,Grigg JA

    更新日期:1992-10-01 00:00:00

  • Histochemical and immunocytochemical identification of the pituitary cell types in three sciaenid fishes: Atlantic croaker (Micropogonias undulatus), spotted seatrout (Cynoscion nebulosus), and red drum (Sciaenops ocellatus).

    abstract::The adenohypophysial cell types in three species of sciaenid teleosts were identified using a combination of classical histochemical techniques and immunocytochemistry with antisera raised against piscine and human pituitary hormones. In general greater specificity for the different cell types was observed with antise...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Yan HY,Thomas P

    更新日期:1991-12-01 00:00:00

  • Neuropeptide Evolution: Chelicerate Neurohormone and Neuropeptide Genes may reflect one or more whole genome duplications.

    abstract::Four genomes and two transcriptomes from six Chelicerate species were analyzed for the presence of neuropeptide and neurohormone precursors and their GPCRs. The genome from the spider Stegodyphus mimosarum yielded 87 neuropeptide precursors and 101 neuropeptide GPCRs. High neuropeptide transcripts were also found in t...

    journal_title:General and comparative endocrinology

    pub_type: 杂志文章


    authors: Veenstra JA

    更新日期:2016-11-09 00:00:00