Abstract:
BACKGROUND:There is a considerable amount of literature on the potential relationship between human leukocyte antigen-G 14-bp Ins/Del polymorphism and virus infection; however, results from these studies were inconclusive. OBJECTIVES:A meta-analysis was carried out to determine whether the 14-bp Ins/Del polymorphism is a susceptible factor for virus infection. METHODS:Data were extracted from PubMed and Web of Science databases, and included 10 case-control studies (1835 patients and 2357 controls). RESULTS:A total of 177 records from 10 studies were retrieved. Overall, no significant correlation was found between HLA-G 14-bp Ins/Del polymorphism and total viruses under all genetic models (dominant model: OR = 0.93, 95% CI = 0.68-1.29; recessive model: OR = 1.12, 95% CI = 0.84-1.48; deletion/deletion (DD) vs insertion/insertion (II): OR = 1.03, 95% CI = 0.71-1.49; deletion (D) vs insertion (I): OR = 1.01, 95% CI = 0.81-1.25). However, further subgroup analyses by virus type and ethnicity revealed that HLA-G 14-bp Ins/Del polymorphism was significantly associated with HTLV-1 infection in mixed population under the dominant model. CONCLUSIONS:Our study demonstrated that HLA-G 14-bp Ins/Del polymorphism may not have any effect on susceptibility to viruses.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Lv H,Lv H,Lin Z,Chen L,Zhu M,Hong Ddoi
10.1097/MD.0000000000012262subject
Has Abstractpub_date
2018-09-01 00:00:00pages
e12262issue
38eissn
0025-7974issn
1536-5964pii
00005792-201809210-00018journal_volume
97pub_type
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