Nucleobindin 2 expression is an independent prognostic factor for bladder cancer.

Abstract:

:Nucleobindin 2 (NUCB2) has been reported to play an important role in both tumorigenesis and cancer progression. This study aimed to examine the clinical significance of NUCB2 expression urothelial carcinoma of the bladder (UCB).The expression level of NUCB2 and its correlation with clinicopathological parameters was analyzed in 225 UCB tissues by immunohistochemistry. Kaplan-Meier analysis and Cox proportional hazards regression models were used to investigate the correlation between NUCB2 expression and the prognosis of UCB patients. High NUCB2 expression of UCB patients significantly correlated with aggressive clinicopathological features. Patients with high NUCB2 had shorter overall survival and recurrence-free survival in Kaplan-Meier survival curve (P = .018 and P = .001, respectively).Our results show that high expression of NUCB2 associated with aggressive clinicopathological feature and predicted unfavorable prognosis in patients with UCB might serve as feasible biomarker for clinical outcome of UCB patients after surgery and potential therapeutic target in the future.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Cho JM,Moon KT,Lee HJ,Shin SC,Choi JD,Kang JY,Yoo TK

doi

10.1097/MD.0000000000019597

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

e19597

issue

13

eissn

0025-7974

issn

1536-5964

pii

00005792-202003270-00021

journal_volume

99

pub_type

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