Abstract:
:Pigmentary mosaicism of the (hypomelanosis of) Ito type is an umbrella term, which includes phenotypes characterized by mosaic hypopigmentation in the form of streaks, whorls, patchy, or more bizarre skin configurations (running along the lines of Blaschko): these cutaneous patterns can manifest as an isolated skin disorder (pigmentary mosaicism of the Ito type) or as a complex malformation syndrome in association with extracutaneous anomalies (most often of the musculoskeletal and/or nervous systems) (hypomelanosis of Ito). Affected individuals are anecdotally reported to have also partial or total body hemi-overgrowth (HOG), which often causes moderate to severe complications.We studied the occurrence and features of HOG in the 114 children and adults with mosaic pigmentary disorders of the Ito type diagnosed and followed up (from 2 to 22 years; average follow-up 16 years) at our Institutions.Eight patients (5 M, 3 F; aged 4 to 25 years; median age 16 years) out of the 114 analyzed (7%) fulfilled the criteria for unilateral HOG, with differences in diameter ranging from 0.4 to 4.0 cm (upper limbs) and 1.0 to 9.0 cm (lower limbs). Moreover, among these 8 patients, 5/8 filled in the 75th to 90th percentile for height; 6/8 had associated kyphoscoliosis; and 5/8 showed cognitive delays. No tumour complications were recorded. Overall, 6/8 HOG patients presented with additional (extracutaneous) syndromic manifestations, apart from the HOG (ie, with a clinical phenotype of hypomelanosis of Ito).The present study, which includes children and adults with the longest follow-up so far recorded, confirms the association between pigmentary mosaicism of the Ito type and HOG lowering previous estimates (7% vs 16%) for HOG in the context of mosaic hypopigmentation. A careful examination, looking at subtle to moderate asymmetries and associated complications within the spectrum of these mosaic pigmentary disorders, is recommended.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Pavone V,Signorelli SS,Praticò AD,Corsello G,Savasta S,Falsaperla R,Pavone P,Sessa G,Ruggieri Mdoi
10.1097/MD.0000000000002705subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e2705issue
10eissn
0025-7974issn
1536-5964pii
00005792-201603080-00007journal_volume
95pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Familial Mediterranean Fever is a rare disease which usually begins in childhood and occurs primarily among persons of Mediterranean ancestry. It is characterized by short, self-limited, febrile episodes that may occur alone or with inflammation of serosal surfaces. Some individuals may exhibit an erysipilas-like eryt...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Residual postoperative neuromuscular blockade is an important clinical issue. Neuromuscular monitoring is usually used to evaluate neuromuscular recovery in patients undergoing general anesthesia. However, this procedure is inconvenient and not widely adopted. We aimed to examine the correlation between grip...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000013940
更新日期:2019-01-01 00:00:00
abstract::Adjacent segmental degeneration (ASD) is a major issue after pedicular fixation. This study examined the degeneration of the adjacent levels due to the insertion of the Wallis interspinous stabilization system compared with discectomy, using magnetic resonance imaging (MRI).Thirty-eight patients diagnosed with lumbar ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007056
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Spinal cord injury (SCI) is one of the common complications of spinal surgery. There is no definite treatment and time of decompression for spinal cord induced by epidural hematoma during vertebroplasty. PATIENT CONCERNS:A total of 6 patients with SCI during vertebroplasty were included in our research. All ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010732
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Pancreatic pseudocyst can present single or multiple, inside or outside the pancreas. Pancreatic panniculitis is a rare skin lesion in pancreatic disease patients. The purpose of this study is to report a case of chronic pancreatitis coexisting with multiple pseudocysts and pancreatic panniculitis. PATIENT C...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010911
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:This meta-analysis assessed the effectiveness of probiotics and synbiotics for acute diarrhea (AD) in children and investigated probiotic formulations, types of interventions, and country factors. METHODS:Randomized, double-blind, placebo-controlled trials evaluating the effects of probiotics or synbiotics o...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016618
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Uterus-like masses (ULMs) are rare benign lesions that resemble the uterus. PATIENT CONCERNS:Here, we describe the case of a woman with a ULM in the right broad ligament. A 51-year-old woman with a 2-month history of irregular vaginal bleeding was found to have a mass in the right broad ligament. Imaging stu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017246
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Total hip arthroplasty (THA) concomitant with subtrochanteric femoral shortening osteotomy for Crowe type IV dysplastic hip has been reported. However, the combination of subtrochanteric femoral osteotomy and revision THA has only been mentioned in one case report. PATIENT CONCERNS:A 67-year-old female had a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012934
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insu...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000008406
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021331
更新日期:2020-07-24 00:00:00
abstract:RATIONALE:CRPS after a lumbar surgery has symptoms that are similar to PSSS. However, standard criteria for distinguishing CRPS from PSSS do not exist. We present a case report of a 31-year-old female with CRPS symptoms after lumbar spinal surgery treated by performing SELD. PATIENT CONCERNS:This patient was referred ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010694
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Ventricular double rupture (VDR) is a rare but lethal mechanical complication of acute myocardial infarction (AMI). The early identification and timely treatment of VDR remain challenging problems. We present a case of AMI with VDR and briefly review the characteristics and prognosis of this life-threatening ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005757
更新日期:2016-12-01 00:00:00
abstract::The aim of the study was to assess the independent contribution of hyperuricemia to coronary artery disease (CAD) confirmed by coronary angiography (CAG), and to explore associations between serum uric acid (SUA) level and CAD.We performed a retrospective cohort study of 5069 patients who underwent CAG. Patients were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012926
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:DM is a common chronic metabolic disease. COVID-19 is an infectious disease infected by enveloped single-stranded RNA coronavirus. Meanwhile, DM is a common comorbidity of SARS-CoV-2 infection. The virus can directly or indirectly damage the pancreatic islets and cause stress hyperglycemia by causing cytokin...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021806
更新日期:2020-09-04 00:00:00
abstract:RATIONALE:Primary pulmonary diffuse large B-cell lymphoma (PPL-DLBCL) is rare and its clinical manifestations lack specificity. In this report, we present one case of PPL-DLBCL with complete clinical and imaging data, including uncontrast-enhanced CT, contrast-enhanced CT, and positron emission tomography (PET)/CT. Pre...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000008876
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Chemotherapy-induced peripheral neuropathy (CIPN) occurs in approximately 30% to 40% of patients who receive chemotherapy; however, standardized treatment for CIPN has not yet been developed. Acupuncture is widely used to treat CIPN in Korea, but its efficacy has not been investigated. The purpose of this ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015098
更新日期:2019-04-01 00:00:00
abstract:ABSTRACT:Acute respiratory distress syndrome (ARDS) is very common in patients with severe acute pancreatitis (SAP), the early interventions are essential to the prognosis of SAP patients. We aimed to evaluate the risk factors for ARDS in SAP patients, to provide insights into the management of SAP.SAP patients treated...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023982
更新日期:2021-01-15 00:00:00
abstract::Blood glucose control in patients with diabetes mellitus (DM) is reportedly influenced by the seasons, with hemoglobin A1c (HbA1c) levels decreasing in the summer or warm season and increasing in the winter or cold season. In addition, several studies have shown that sepsis is also associated with the seasons. Althoug...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000148
更新日期:2014-11-01 00:00:00
abstract::The objective of this study was to carry out a large population-based study to understand the factors associated with hypoglycemia-related hospitalizations among older Korean adults with diabetes mellitus.This study analyzed data from a subset of the 2013 Health Insurance and Review and Assessment service-Adult Patien...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000005016
更新日期:2016-10-01 00:00:00
abstract::Preoperational hemogram parameters have been reported to be associated with the prognosis of several types of cancers. This study aimed to investigate the prognostic value of hematological parameters in gastric cancer in a Chinese population. A total of 870 gastric cancer patients who underwent radical tumorectomy wer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013896
更新日期:2018-12-01 00:00:00
abstract::The long-term cardiovascular outcomes of a population-based cohort presenting to the emergency department (ED) with chest pain and classified with a clinical risk stratification algorithm are not well documented. The Olmsted County Chest Pain Study is a community-based study that included all consecutive patients pres...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3181b98782
更新日期:2009-09-01 00:00:00
abstract::Determination of Fuhrman grade (FG) on biopsies of renal masses is relatively inaccurate, being prone to underestimating the true grade as ascertained from surgical specimens. This study evaluated whether anatomical features of tumors could predict tumor upgrading between core biopsies and surgical specimens. We prosp...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000000581
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Crohn disease includes 3 phenotypes, inflammatory, stricturing, and penetrating. In cases where corticosteroids and immunosuppressive agents are not suitable treatment options, enteral nutrition (EN) can be used to reduce disease severity and enhance barrier defense with fewer potential adverse effects. PATI...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016750
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is a common disorder in systemic lupus erythematosus (SLE) patients. It is still inconclusive whether antimalarial drugs could affect the serum lipids in SLE patients, therefore we conducted a systematic review and meta-analysis of available data to address this issue. METHODS:We comprehensivel...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015030
更新日期:2019-04-01 00:00:00
abstract:RATIONALE:We studied the feasibility of total arathyroidectomy(tPTX)+multi-point transplantation in the forearm for treatment of secondary hyperparathyroidism. Considering the controversial nature of the appropriate timing for and location of this type of surgery, relevant research is relatively rare. Our experience ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017649
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA), also known as degenerative osteoarthritis, is a common and frequently occurring disease in orthopedics with cartilage degeneration as the pathogenic cause and articular bone hyperplasia as the sign. Many studies have confirmed that KOA can be effectively treated by traditional Chin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000024115
更新日期:2021-01-08 00:00:00
abstract::(Sca) is a ubiquitous filamentous fungus capable of causing invasive disease. We reviewed our electronic microbiology records and the English-language literature. Between 1976 and December 1999 we identified 23 solid organ transplant recipients with Sca infection, 7 of which occurred between December 1987 and December...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-200209000-00001
更新日期:2002-09-01 00:00:00
abstract::We retrospectively analyzed the long-term outcome of idiopathic pulmonary hemosiderosis (IPH) in 15 children. IPH started at a mean age of 5 years, and the mean duration of follow-up was 17.2 years (range, 10-36 yr). Four patients developed immune disorders, 3 cases of rheumatoid polyarthritis or rheumatoid polyarthri...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-200009000-00005
更新日期:2000-09-01 00:00:00
abstract::Strength training has, in recent years, been shown to be beneficial for people with Parkinson disease and multiple sclerosis. Consensus regarding its utility for these disorders nevertheless remains contentious among healthcare professionals. Greater clarity is required, especially in regards to the type and magnitude...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000411
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS. METHODS:Databases including PubMed, Embase, Web of Science, and C...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016948
更新日期:2019-08-01 00:00:00