Abstract:
BACKGROUND:DM is a common chronic metabolic disease. COVID-19 is an infectious disease infected by enveloped single-stranded RNA coronavirus. Meanwhile, DM is a common comorbidity of SARS-CoV-2 infection. The virus can directly or indirectly damage the pancreatic islets and cause stress hyperglycemia by causing cytokine storms, acute inflammatory reactions, binding to the ACE2 receptor, etc. At the same time, hyperglycemia is a risk factor for severe infection and an independent risk factor for mild to severe disease. However, there is no evidence-based medicine to confirm the relationship between hyperglycemia and the infection of COVID-19 in diabetic patients. Therefore, we will conduct a systematic review and meta-analysis to synthesize the existing clinical evidence. METHODS AND ANALYSIS:We will retrieve each database from December 2019 to July 2020. Chinese literature comes from CNKI, Wanfang, VIP, CBM databases. English literature mainly searches Cochrane Library, PubMed, Web of Science, EMBASE. At the same time, we will look for clinical trial registration and gray literature. This study only included clinical randomized controlled trials. The reviewers independently conduct literature selection, data analysis, bias risk assessment, subgroup and sensitivity analysis. The primary outcomes include fasting blood glucose, 2-hour postprandial blood glucose, glycated hemoglobin, fasting insulin, adverse effects, etc. Finally, we will conduct a meta-analysis through Review Manager software version 5.3. RESULTS:The results will be published in peer-reviewed journals. CONCLUSION:This study will explore the relationship between hyperglycemia and COVID-19 infection in diabetic patients. It will provide evidence-based support for clinical regulation of blood glucose and combating the COVID-19 epidemic. REGISTRATION NUMBER:INPLASY202060114.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu Y,Yang Y,Chen Y,Zhou L,Xiong Q,Xie Cdoi
10.1097/MD.0000000000021806subject
Has Abstractpub_date
2020-09-04 00:00:00pages
e21806issue
36eissn
0025-7974issn
1536-5964pii
00005792-202009040-00022journal_volume
99pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract:RATIONALE:Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly comple...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008599
更新日期:2017-12-01 00:00:00
abstract::The association between sleep duration and prostate cancer (PCa) risk is still unclear. We performed a systematic review and meta-analysis to explore if sleep duration is associated with PCa in men.A comprehensive literature search was conducted in November 2019 based on the Pubmed, Embase, and Cochrane databases. Aft...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021180
更新日期:2020-07-10 00:00:00
abstract::Under the assumption of gene-environment independence, unknown/unmeasured environmental factors, irrespective of what they may be, cannot confound the genetic effects. This may lead many people to believe that genetic heterogeneity across different levels of the studied environmental exposure should only mean gene-env...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002743
更新日期:2016-03-01 00:00:00
abstract::The purpose of this study was to report the outcomes of patients with symptomatic locally advanced/recurrent gastric cancer treated with radiotherapy (RT) using modern 3-dimensional conformal techniques.We retrospectively reviewed patients who had palliative RT for index symptoms of gastric bleeding, pain, and obstruc...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000118
更新日期:2014-11-01 00:00:00
abstract::Few attention has been directed to the potential effects of intermittent hypoxia experienced in obstructive sleep apnea on the integrity and permeability of intestinal barrier, particularly in adults. Therefore, we evaluated alteration in serum d-lactate concentration in middle-aged males with obstructive sleep apnea ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009144
更新日期:2017-12-01 00:00:00
abstract::This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to gastric carcinoma (GC) and investigate the association between genetic polymorphisms in the telomere length related genes and GC risk.RTL was measured using the real-time quantitative polymerase chain reaction from 1...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020551
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:To evaluate the effect of no drainage in patients who underwent thyroidectomy and neck lymph node dissection. METHODS:We followed the methodological standard expected by Cochrane. We searched the following databases by March 23, 2017: PubMed, The Cochrane Library, EMBASE via Ovid SP, and Medline via Ovid SP...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000009052
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Carotid-ophthalmic aneurysms are relatively rare, and represent 1% of all intracranial aneurysms. Generally, endovascular coiling and surgical clipping are the 2 most commonly used methods to treat ruptured carotid-ophthalmic aneurysms, it provides the most favorable outcome for a patient. This study aims to...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023235
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Chronic atrophic gastritis (CAG) is a common digestive disease. Without active treatment, it may induce gastric cancer. Western medicine has a certain effect on chronic atrophic gastritis, but there are many adverse reactions after long-term medication, and the disease is prone to relapse after treatment, wh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022110
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:This randomized controlled trial (RCT) aimed to compare the clinical outcomes of thoracolumbar burst fractures (TLBFs) treated with open reduction and internal fixation via the posterior paraspinal muscle approach (PPMA) and the post-middle approach (PA). METHODS:Patients with a traumatic single-level TLBFs...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000011193
更新日期:2018-06-01 00:00:00
abstract::Along with article-based checklists, structured template recording systems have been reported as useful to create more accurate clinical recording, but their contributions to the improvement of the quality of patient care have been controversial. An emergency department (ED) must manage many patients in a short time. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005105
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Mirizzi syndrome (MS) is an uncommon condition characterized by common hepatic duct (CHD) compression by an impacted gallbladder or cystic duct stones or adjacent inflammation. To date, a standardized therapeutic strategy for MS has not been established yet, owing to its complex clinical presentation. Thus, r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022649
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:To determine the diagnostic accuracy of techniques with chronic thromboembolic pulmonary hypertension (CTEPH) patients via a protocol for systemic review and network meta-analysis. METHODS:We will search PubMed, EMBASE, Web of Science, and Google Scholar from inception to October 1, 2018. The reference list...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016787
更新日期:2019-08-01 00:00:00
abstract::To assess the role of circulating immune complexes (CIC) in chronic hepatitis C virus (HCV) infection, the relative frequency of CIC was determined in 60 patients with chronic hepatitis C alone, 19 patients co-infected with hepatitis B and C, 15 asymptomatic HCV carriers, and 54 healthy controls. Levels of CIC were de...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199505000-00003
更新日期:1995-05-01 00:00:00
abstract::To study the prevalence of burnout and job satisfaction in Chinese pediatrics residents.Prospective participants were invited via a WeChat group to participate from October 1, 2018 to January 31, 2019. The Maslach Burnout Inventory-Human Services Survey was used to measure physician burnout, and the Minnesota Satisfac...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019249
更新日期:2020-02-01 00:00:00
abstract::Although the new oral P2Y12 inhibitors, prasugrel/ticagrelor have shown greater efficacy than clopidogrel in patients with the acute coronary syndrome, but they have not shown better efficacy in Korean patients. So we evaluated the efficacy of the prasugrel/ticagrelor in patients with myocardial infarction (MI) and di...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000014833
更新日期:2019-03-01 00:00:00
abstract::Preoperative autologous blood donation is a well-established procedure to reduce the need for allogeneic blood transfusion. We hypothesized that coagulation activity is maintained in cold-stored whole blood, because the fundamental polymerization properties of fibrin are preserved.Fifty adult patients who underwent el...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017357
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Multiple system atrophy is a late-onset rare neurodegenerative movement disorder which results in debilitating disease. Fever frequently ensues in the context of infections which can be associated with significant morbidity and mortality, but among alternative diagnostic possibilities neoplasms and autoimmune...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018005
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to summarize current evidence evaluating the association between antenatal infection and intraventricular hemorrhage (IVH) in preterm infants. MATERIALS AND METHODS:We searched for published articles on antenatal infection and IVH in 3 English (PubMed, the Cochrane Library, and EBS...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016665
更新日期:2019-08-01 00:00:00
abstract::Purpose of this study was to evaluate the outcomes of patients underwent hemiarthroplasty for proximal femoral fracture converted to total hip arthroplasty (THA).A total of 138 patients from October 2009 till October 2014 had conversion of their failed hemiarthroplasties following a proximal femoral fracture to total ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008235
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Dislocation of the distal radioulnar joint and injury to distal forearm are commonly encountered. However, delayed diagnosis or misdiagnosis has been relatively rare due to improved diagnosis and treatment. Treatment of old dislocation of radioulnar joint is challenging due to development of secondary chronic...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010752
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Postoperative atrial arrhythmias (PAAs) are common complications after esophagectomy, however research findings are contradicted on the prognosis. Therefore this meta-analysis was conducted to determine whether PAAs after esophagectomy had an impact on prognosis. METHODS:Studies comparing prognosis between ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000010948
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:The impact of dexamethasone on pain management for knee arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexamethasone for knee arthroscopy. METHODS:We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through Octobe...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019417
更新日期:2020-04-01 00:00:00
abstract::Children with fibrous dysplasia (FD) chronically suffer from pain, pathological fractures, and limb deformities. The most effective methods for managing the associated pathological fractures remain controversial. The purpose of this study was to evaluate the clinical results of the treatment of diaphyseal pathological...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014318
更新日期:2019-02-01 00:00:00
abstract::Diabetes mellitus (DM) is prevalent in patients with pancreatic cancer and tends to improve after tumor resection. However, the glycemic response of non-pancreatic cancer patients after surgery has not been examined in detail. We aimed to investigate the changes in glucose metabolism in patients with pancreatic cancer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010590
更新日期:2018-05-01 00:00:00
abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199401000-00003
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Well-developed coronary collateral circulation usually results in fewer infarct size, improved cardiac function, and fewer mortality. Traditional coronary risk factors (diabetes, hypertension, and smoking) have some effects on coronary collateral circulation. However, the association between these risk facto...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010417
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Tall cell variant papillary thyroid carcinoma (TCPTC) is reportedly associated with aggressive clinicopathological parameters and poor outcomes; however, the molecular mechanisms underlying TCPTC remain poorly understood. METHODS:The gene mutation types and mRNA expression profiles of patients with TCPTC we...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000013802
更新日期:2018-12-01 00:00:00
abstract:RATIONALE:Neurenteric cysts, are rare benign tumors of the central nervous system that are mostly located in the spinal cord and predominantly seen in male children although adult form of the disorder also occurs. The etiology and treatment of this disorder is still a matter of debate. Our case further throws more ligh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010489
更新日期:2018-04-01 00:00:00
abstract::Identification of meaningful cluster modules of differential genes or representative biomarkers related to the stages of ovarian cancer (OC) is pivotal, which may help to detect mechanisms of OC progression and evaluate OC patients' prognosis.We downloaded gene expression data and the corresponding clinical informatio...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011895
更新日期:2018-08-01 00:00:00