Abstract:
RATIONALE:Tigecycline is the first member of the glycylcycline family. There are rarely reports of tigecycline causing coagulopathy and hypofibrinogenemia until now. We report a case on tigecycline-associated coagulopathy and hypofibrinogenemia and discuss the characteristics of the adverse reaction. PATIENT CONCERNS:A 47-year-old male patient with severe acute cholangitis who developed sepsis was treated with a high dosage (100 mg twice daily) of tigecycline. He experienced coagulopathy and hypofibrinogenemia as substantiated by increased levels of prolonged prothrombin time (PT), the international normalized ratio (INR) and activated partial thromboplastin time (APTT), and in particular, the fibrinogen (FIB) levels obviously decreased. DIAGNOSES:Coagulopathy and hypofibrinogenemia. INTERVENTIONS:We discontinued tigecycline and gave the patient several blood products to prevent spontaneous bleeding. OUTCOMES:The adverse reaction disappeared after the withdrawal of tigecycline. After 30 days of hospitalization, the patient discharged with symptom free. LESSONS:We suggest that coagulation parameters should be closely monitored in patients treated with tigecycline, specifically in patients who may be renal insufficiency, female or use the high-dose.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wu X,Zhao P,Dong L,Zhang Xdoi
10.1097/MD.0000000000009124subject
Has Abstractpub_date
2017-12-01 00:00:00pages
e9124issue
49eissn
0025-7974issn
1536-5964pii
00005792-201712080-00139journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract:INTRODUCTION:Contracture of dacryocyst by an implanted lacrimal silicone tube is rare. This report describes a unique case of secondary dacryocystitis and the contracture of dacryocyst caused by a lacrimal silicone tube that was placed in the lacrimal system for 10 years. PATIENT CONCERNS:A 63-year-old female was diag...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023073
更新日期:2020-11-06 00:00:00
abstract:INTRODUCTION:Early diagnosis of acute kidney injury (AKI) remains a challenge. Recently, [TIMP-2]·[IGFBP7], which is a combination of urine tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor (IGF) binding protein 7 (IGFBP7), has been identified as a potential biomarker of AKI. We performed ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007484
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Pulmonary embolism can manifest by a myriad of clinical symptoms. High grade fever is a rare presentation of thromboembolic phenomenon. PATIENT CONCERNS:A middle aged woman presented with high grade fevers. DIAGNOSES:Patient remained febrile despite broad spectrum antibiotics. All cultures were negative. CT...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010002
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Insomnia has become a universal subhealth disease, affecting more and more modern people's health and quality of life. At present, western medicine is only symptomatic treatment for insomnia. Bailemian Capsule (BLMC) is a proprietary Chinese medicine for treating insomnia. It has been widely used in China, b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014275
更新日期:2019-01-01 00:00:00
abstract:RATIONALE:The duplex ureter is a common anomaly of urinary tract, but preoperative sonography, plain abdominal radiography, or nonenhanced computed tomography (CT) often overlooked it when involved with urinary tract obstruction. In this report, We present a rare case of left Y-shaped bifid ureter and both ureter of up...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011474
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Prophylactic anticoagulant therapy is recommended to reduce the risk of venous thromboembolism (VTE) after total hip or knee arthroplasty, and has become the standard of care. Rivaroxaban is a novel oral medication that directly inhibits factor Xa for the prevention and treatment of thromboembolic conditions...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000014539
更新日期:2019-03-01 00:00:00
abstract::Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk of additional autoimmune diseases (ADs).To investigate the prevalence of ADs in a population of adult coeliac patients.This was a retrospective case-control study. Data from coeliac patients and controls referred to a tert...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008562
更新日期:2017-11-01 00:00:00
abstract::Sulphonylureas (SUs) subclasses have different risks of all-cause mortality, acute myocardial infarction (AMI), and stroke. Therefore, we assessed these risks in patients with type 2 diabetes mellitus administered gliclazide, glimepiride, or metformin monotherapy with retrospective cohort study design. Total 195,235 s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021236
更新日期:2020-07-17 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is one of the most frequent malignancies of salivary glands. The objective of this study was to identify key genes and potential mechanisms during ACC samples.The gene expression profiles of GSE88804 data set were downloaded from Gene Expression Omnibus. The GSE88804 data set contained 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018676
更新日期:2020-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) is the most effective intravesical immunotherapy for superficial bladder cancer. Although generally well tolerated, BCG-related infectious complications may occur following instillation. Much of the current knowledge about this complication comes from single case reports, with heterogene...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000119
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Patients with simple obesity suffer from poor quality of life, as well as high risk of hypertension, diabetes, cardiovascular, and cerebrovascular accidents. Lots of Clinical trials suggested that acupuncture is beneficial for simple obesity, and it aims to gather solid evidence in order to provide reliable ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017353
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Celiac disease is an autoimmune enteropathy characterized by an aberrant immune response to ingested gluten in genetically predisposed individuals. Studies have pointed to a rising prevalence of celiac disease in recent decades. Changes in diet and use of medication that may impact the gut microbiome have be...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000021488
更新日期:2020-08-28 00:00:00
abstract::Patients with classical heat stroke are different in many ways from those with exertional injury; contrasts included difference in demographic factors, prior general health, in-hospital complications and laboratory abnormalities (lactate, liver enzymes, pH, electrolytes). Severe hyperkalemia, acute renal failure, rhab...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
abstract::The contributions of micro RNAs (miRNAs) to rheumatoid arthritis (RA) are beginning to be uncovered during the last decade. Many studies in efforts to use miRNAs as biomarkers in disease diagnosis, prognosis, and treatment are ongoing.We conducted a systematic literature review to reveal the role of miRNAs in the path...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000001326
更新日期:2015-08-01 00:00:00
abstract:RATIONALE:X-linked dominant hypophosphatemia rickets (XLH, OMIM 307800) is the most common hereditary hypophosphatemic rickets and characterized by growth retardation, skeletal malformations, dental dysplasia, spontaneous fractures and osteomalacia. PHEX gene was identified for XLH and novel mutations were consistent w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011453
更新日期:2018-08-01 00:00:00
abstract::A minimum of 12 harvested lymph nodes (hLNs) are recommended in colorectal cancer. However, a paucity of hLNs is frequently presented after preoperative chemoradiation (pCRT) in rectal cancer and the significance of this is still uncertain. The aim of this study is to analyze the impact of hLNs on long-term oncologic ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001133
更新日期:2015-07-01 00:00:00
abstract::Serum albumin (SA) is associated with inflammation and thrombosis, which are involved in acute aortic dissection (AAD). Our aim was to investigate the effect of SA level on survival in patients with AAD.We analyzed 777 patients with AAD. The patients were divided into hypoalbuminemia and non-hypoalbuminemia groups acc...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014486
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:Circulating cell-free DNA (cfDNA) has been reported to predict outcomes in patients with various types of cancer. However, its prognostic value in patients with breast cancer is not well established still now. In this meta-analysis, we evaluated the prognostic role of cfDNA in breast cancer patients. METHODS:W...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011417
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Hypertension is one of the most common chronic diseases and an increasingly public-health challenge worldwide. Previous meta-analyses evaluated the effects of azilsartan medoxomil compared to placebo or other antihypertensive drugs in patients with hypertension. However, it is still unclear which dose of azi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017050
更新日期:2019-09-01 00:00:00
abstract::Orthostatic hypotension (OH) is a common problem in the elderly age group, and some studies have reported an association between OH and increased mortality. We evaluated possible associations between OH and mortality in a retrospective study of frail elderly patients who came for a comprehensive geriatric assessment. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000977
更新日期:2015-06-01 00:00:00
abstract:RATIONALE:Stress urinary incontinence (SUI) refers to the involuntary leakage of urine when abdominal pressure increases. Midurethral slings (MUS) have become the main surgical method for treating SUI, but no quantitative standard for the degree of sling tightness during operation exists. We achieved this quantitative ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021100
更新日期:2020-07-10 00:00:00
abstract::Aberrant glycosylated IgA1 molecules, mainly galactose-deficient IgA1 (Gd-IgA1), are important causal factors in IgA nephropathy; however, the underlying mechanism for the production of aberrantly glycosylated IgA1 is unknown. A recent genome-wide association study identified a novel IgAN susceptibility gene, TNFSF13,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003099
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The use of hysteroscopy for the diagnosis and treatment of uterine and endometrial abnormalities is often associated with postoperative pain. This randomized controlled trial aimed to assess the efficacy of preoperative intravenous (IV) lidocaine in reducing pain after hysteroscopy. METHODS:In total, 138 pa...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000022751
更新日期:2020-10-16 00:00:00
abstract:BACKGROUND:To investigate the radiation dose and image quality for iterative reconstruction combined with the CARE kV technique in chest computed tomography (CT) scanning for physical examination. METHODS:A total of 130 patients who underwent chest CT scanning were randomly chosen and the quality reference value was s...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006175
更新日期:2017-03-01 00:00:00
abstract::The present study aimed to explore the influence of sirtuin 1 (SIRT1) polymorphisms (rs12778366 and rs3758391) on diabetic foot (DF) susceptibility and severity in patients with type 2 diabetes mellitus (T2DM).This case-control study recruited 142 patients with DF, 148 patients with T2DM, and 148 healthy controls. SIR...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011455
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:A rigid video-stylet intubation device provides safe and accurate access to the trachea by enabling visualization of the airway structures during tracheal intubation. The primary purpose of this study was to examine the effects of glycopyrrolate premedication on tracheal intubation with a rigid video-stylet....
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000011834
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the sensitivity and accuracy of magnetic resonance imaging-guided targeted biopsy (MRI-TB) in patients undergoing active surveillance (AS) procedure. METHODS:We searched databases to identify relevant studies which compared MRI-TB with systemic biopsy for diagnosing prost...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016122
更新日期:2019-06-01 00:00:00
abstract::Factors associated with the physician workload are scarcely reported. The study aims to investigate the associated factors of on-call physician workload based on a published conceptual framework.The study was conducted in a general internal medicine unit of National Taiwan University Hospital. On-call physician worklo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004719
更新日期:2016-08-01 00:00:00
abstract::Daily sleep duration is known to be associated with obesity and dyslipidemia.This study was performed to examine the interactions between daily sleep duration and the risks of obesity and dyslipidemia according to dietary macronutrient consumption in 14,680 Korean adults using the 5th Korean National Health and Nutrit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005360
更新日期:2016-11-01 00:00:00
abstract::We report 3 cases of systemic strongyloidiasis in HIV-infected individuals and review 11 additional cases reported in the English-language literature. Systemic strongloidiasis is a rare and potentially fatal complication of late-stage HIV disease. A combination of gastrointestinal and respiratory symptoms in an HIV-in...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199409000-00004
更新日期:1994-09-01 00:00:00