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Hemodynamic effects of naloxone in anaphylactic shock.

Abstract：

:Recent reports suggest that endorphins may contribute to hemodynamic depression in septic and hemorrhagic shock. There is also evidence that reversal of endorphin effects with high dose naloxone may improve hemodynamic function and improve survival in shock states. The purpose of this study was to examine the effects of naloxone on hemodynamic parameters in anaphylactic shock. Anaphylactic shock was induced in sensitized rabbits with horse serum. Three minutes after serum challenge, rabbits were treated with a 3 mg/kg bolus of naloxone followed by a 3 mg/kg per h infusion (group I, n = 8), or by injection with an equal volume of saline (group II, n = 8). Cardiac output, blood pressure, heart rate and body temperature were monitored continuously for 60 min and the experiment was terminated. There was a significant increase in cardiac index in group I animals at 10 min (P less than 0.01) and 15 min (P less than 0.01). Stroke volume index was also higher in naloxone treated animals at 10 min and 15 min (P less than 0.05). Although mean blood pressure was higher in group I animals at all time intervals after naloxone was begun, the difference was statistically significant only at 60 min (P less than 0.05). Peripheral vascular resistance index was not significantly different for the two groups.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Barsan WG,Hedges JR,Syverud SA

doi

10.1016/0300-9572(86)90076-6

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

223-31

issue

4

eissn

0300-9572

issn

1873-1570

pii

0300-9572(86)90076-6

journal_volume

13

pub_type

杂志文章

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