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The effect of cytidine diphosphate choline on in vivo lung mechanics in premature newborn rabbits.

Abstract：

:The influence of CDP-choline on neonatal lung adaptation was studied in premature rabbit neonates, delivered on day 28 of gestation. We found that the administration of CDP-choline (200 mg/kg body wt) at birth has a moderately beneficial effect on the respiratory frequency, dynamic lung compliance, and expiratory lung resistance. Since this effect was obtained within 60 min, and since the phospholipid content of the alveolar wash was similar on experimental and control animals, we concluded that the observed improvement in lung mechanics was probably not mediated by increased synthesis or release of surfactant phospholipids.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Lachmann B,Grossmann G,Malmqvist E,Nilsson R,Robertson B

doi

10.1016/0300-9572(80)90005-2

subject

Has Abstract

pub_date

1980-03-01 00:00:00

pages

43-52

issue

1

eissn

0300-9572

issn

1873-1570

pii

0300-9572(80)90005-2

journal_volume

8

pub_type

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