Abstract:
AIM:In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of the present study was to investigate the potential difference in microcirculatory alterations and vascular reactivity in comatose patients after out of hospital cardiac arrest treated with target temperature management of 33 °C (TTM33) in comparison to patients treated with 36 °C (TTM36). METHODS:Our study was designed as a predefined substudy of the open label randomized controlled TTM trial in 2 Dutch mixed ICU's. Sublingual microvascular flow index (MFI) was assessed by Side Stream Darkfield imaging and vascular reactivity at the thenar region of the hand by near infrared spectroscopy. Variables, including systemic hemodynamics were recorded at start study (T1), after 12h (T2) and after 24h (T3). RESULTS:22 patients were included, 13 in TTM33 and 9 in TTM36. At T1 MFI between groups did not differ significantly (1.08 [0.4-1.9] versus 1.67 [0.7-2.4] respectively, p = 0.59). The difference between groups remained insignificant over time. At T1 tissue oxygenation (StO2) was significantly lower in TTM36 in comparison to TTM33: (44.6 ± 15.8 versus 58.9 ± 13.5, p = 0.03). Over time this difference between groups disappeared. However, vascular reactivity, expressed as the descending and ascending slope of StO2 after a standardized ischemic occlusion test was similar between groups. CONCLUSIONS:In this relatively small sample size study microcirculatory blood flow and vascular reactivity did not differ nor change between TTM33 and TTM36.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Koopmans M,Kuiper MA,Endeman H,Veenstra G,Vellinga NA,de Vos R,Boerma ECdoi
10.1016/j.resuscitation.2014.09.025subject
Has Abstractpub_date
2015-01-01 00:00:00pages
14-8eissn
0300-9572issn
1873-1570pii
S0300-9572(14)00767-9journal_volume
86pub_type
杂志文章,随机对照试验相关文献
RESUSCITATION文献大全abstract:AIM:To date, no clinical test is able to predict cognitive and functional outcome of cardiac arrest survivors. Improvement of auditory discrimination in acute coma indicates survival with high specificity. Whether the degree of this improvement is indicative of recovery remains unknown. Here we investigated if progress...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2016.06.032
更新日期:2016-09-01 00:00:00
abstract::The successful outcome of a resuscitation attempt relies frequently on the performance of many advanced life support interventions. A checklist of 27 procedures, following an alphabetical sequence, is presented as an educational memory aid for healthcare providers. ...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/s0300-9572(00)00368-3
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:In mechanically ventilated (MV) cardiac arrest (CA) survivors admitted to the intensive care unit (ICU) avoidance of hypoxia is considered crucial. However, avoidance of hyperoxia may also be important. A conservative approach to oxygen therapy may reduce exposure to both. METHODS:We evaluated the introduct...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.11.026
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Recommendations for extracorporeal cardiopulmonary resuscitation (ECPR) state that appropriate patient selection is important for the sake of efficacy and cost-effectiveness of ECPR. It is not known whether first documented rhythm plays a prominent role in economic outcomes of patients with cardiac arrest wh...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.05.013
更新日期:2019-07-01 00:00:00
abstract::We compared plasma epinephrine levels after three different tracheal epinephrine application techniques and intravenous injection in male and female anesthetized and paralyzed domestic pigs. Epinephrine was administered intravenously (10 microg/kg) (group i.v.) or tracheally (100 microg/kg) either by direct injection ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(98)00007-0
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Global cerebral ischaemia after cardiac arrest (CA) leads to programmed cell death (PCD) with characteristic signs of apoptosis in selectively vulnerable areas of the brain. The activation of caspase-3, an executioner caspase, plays a key role in the apoptotic cascade. We, therefore, studied the effects of t...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2008.02.010
更新日期:2008-07-01 00:00:00
abstract::A possible diagnostic role of procalcitonin (PCT) as a marker for ventilator associated pneumonia (VAP) in patients with an already triggered acute phase response after successful cardiopulmonary resuscitation (CPR) was investigated. In 28 patients with return of spontaneous circulation (ROSC) after out of hospital CP...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(02)00008-4
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of strategies to reduce the spread of simulated aerosol during chest compressions on manikin and cadaver experimental models. METHODS:To evaluate aerosol-spread we nebulized ultraviolet sensitive detergents into the artificial airway of a resuscitation dummy and performed CPR. The spre...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.05.012
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:For health professionals, the absence of pulse checked by manual palpation is a primary indicator for initiating chest compressions in patients considered to have cardiopulmonary arrest (CA). However, using a pulse check to evaluate perfusion during CA may be associated with some risks of its own. Our objecti...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.09.018
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS:A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated w...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.03.019
更新日期:2005-09-01 00:00:00
abstract:AIM:Various methods, including self-instruction, have been used to try to improve the acquisition of basic life support skills. This is a preliminary report of the effectiveness of a web-based self-training program for BLS and the use of an AED. METHODS:Sixteen volunteers completed on-line training in their own time o...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2007.05.014
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Animal studies and pathophysiological considerations suggest that therapeutic hypothermia after cardiopulmonary resuscitation is the more effective the earlier it is induced. Therefore this study is sought to examine whether pharmacological facilitated hypothermia by administration of 5'-adenosine monophosph...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2014.05.030
更新日期:2014-09-01 00:00:00
abstract::The haemodynamic effects of variations in the compression-decompression frequency, 60, 90 and 120 min(-1) during ACD-CPR, were tested in a randomized cross-over design during ventricular fibrillation (VF) in 12 anaesthetized pigs (17-22 kg) using an automatic hydraulic chest compression-decompression device. There wer...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(98)00139-7
更新日期:1998-12-01 00:00:00
abstract:AIM:Cardiopulmonary resuscitation (CPR) guidelines recommend specific chest compression (CC) target depths for children. We quantitatively describe relative anterior-posterior diameter (APD) depth, actual depth, and force of CCs during real CPR events in children. METHODS:CC depth and force were recorded during real C...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.10.014
更新日期:2012-03-01 00:00:00
abstract:AIM OF THE STUDY:Regionalization of care for out-of-hospital cardiac arrests (OHCA) may improve patient outcomes. We evaluated inter-hospital variations in post-arrest care provision and the relation between hospital case volume and survival in Pennsylvania. METHODS:This retrospective study (2013-2017) used data from ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.02.004
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:A head-to-head trial was conducted to compare laypersons' long-term retention of life-saving psychomotor and cognitive skills learned in the traditional multi-hour training format for basic cardiopulmonary resuscitation and automated external defibrillator use to those learned in an abbreviated (30 min) cours...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2006.12.017
更新日期:2007-08-01 00:00:00
abstract::Twenty-six of 31 seriously injured patients (84%) showed a marked elevation of serum pancreatic secretory trypsin inhibitor (PSTI) to more than twice the initial level within the first 2 weeks after admission. Serum PSTI rose from the second or third post-traumatic day and reached the maximum at day 5.8 on average. In...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(88)90043-3
更新日期:1988-07-01 00:00:00
abstract::Open-chest cardiac massage appears beneficial in improving hemodynamics during resuscitation efforts and in improving resuscitation success. The time between cardiac arrest and the initiation of open-chest cardiac massage is crucial. It would appear that if initiation of open chest cardiac massage is delayed for more ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(87)90097-9
更新日期:1987-03-01 00:00:00
abstract:AIM:To describe the relationship of gag and cough reflexes to Glasgow coma score (GCS) in Chinese adults requiring critical care. METHOD:Prospective observational study of adult patients requiring treatment in the trauma or resuscitation rooms of the Emergency Department, Prince of Wales Hospital, Hong Kong. A long co...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.07.017
更新日期:2012-01-01 00:00:00
abstract::The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(89)90115-9
更新日期:1989-10-01 00:00:00
abstract:AIM:There are limited data on long-term outcome in out-of-hospital cardiac arrest patients following the treatment shift of target temperature management (TTM) from 33 °C to 36 °C outside the controlled settings of randomised trials. The aim of this study was to evaluate the adherence to TTM guidelines after the public...
journal_title:Resuscitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.resuscitation.2019.08.029
更新日期:2019-10-01 00:00:00
abstract:AIM:Evaluate the roles of water temperature and submersion duration in the outcome of drowning victims. METHODS:Subjects were those who drowned in open water (lakes, rivers, and ocean) in three counties in Washington State between 1975 and 1996. We performed a case control study to assess the association between age, ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2014.02.024
更新日期:2014-06-01 00:00:00
abstract::This study evaluated the effects of sodium-hydrogen exchanger (NHE1) inhibition on enhancing fluid resuscitation outcomes in traumatic hemorrhagic shock, and examined the mechanisms related to NHE1 inhibitor-induced protection and recovery from hemorrhagic shock. Traumatic hemorrhage was modeled in anesthetized pigs b...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.11.025
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Pulseless electrical activity is an important cause of cardiac arrest. Our purpose was to determine if induction of hypothermia with a cold perfluorocarbon-based total liquid ventilation (TLV) system would improve resuscitation success in a swine model of asphyxial cardiac arrest/PEA. METHODS:Twenty swine w...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2009.11.018
更新日期:2010-03-01 00:00:00
abstract:AIM:Circadian variation in human ventricular fibrillation (VF) dominant frequency is unknown. If present this would provide evidence of physiological influence on VF. The objective was to quantify the circadian variation in human VF dominant frequency. METHODS:Eight-lead Holter ECG recordings were obtained from a pati...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2010.03.026
更新日期:2010-08-01 00:00:00
abstract:AIM:We examined the relationship between time from collapse to arrival of emergency medical services (EMS) and survival to hospital discharge for out-of-hospital ventricular fibrillation cardiac arrests in order to determine meaningful interpretations of this association. METHODS:We calculated survival rates in 1-min ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2010.02.004
更新日期:2010-05-01 00:00:00
abstract::A previously asymptomatic 15-year-old boy was treated at our institution after an episode of chest pain, palpitation, and syncope while playing in a high school soccer game. The patient's resting electrocardiogram was normal. A transthoracic echocardiogram showed an anomalous left main coronary artery originating from...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2006.11.012
更新日期:2007-07-01 00:00:00
abstract:AIMS:The cerebellum is among the brain regions most vulnerable to damage caused by cardiac arrest, and cerebellar Purkinje cell loss may contribute to neurologic dysfunction, including post-hypoxic myoclonus. However, it remains unknown whether cerebellar Purkinje cells are protected by post-cardiac arrest therapeutic ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.05.022
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:The CAREvent Public Access Resuscitator (PAR, O-Two Medical Technologies, Ontario, Canada) is a new oxygen-driven device alternating two ventilations with 15 prompts for chest compressions. The PAR is designed for use with a standard resuscitation face mask and is equipped with mask leakage and obstruction...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.04.012
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:For prolonged VF, perfusion of the myocardium by pre-shock chest compressions can improve myocardial readiness for successful defibrillation. Characteristics of the VF waveform correlate with the duration of VF when there is no structural heart disease. A "smart" automated external defibrillator (AED) could ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.10.017
更新日期:2006-06-01 00:00:00