Abstract：
:In order to investigate the acute effects on lung morphology, lung function, hemodynamic and blood coagulation system, elastase (330 units (U) kg-1 h-1) was continuously infused into 16 anesthetized and mechanically ventilated minipigs. Elastase infusion induced a disturbance of blood coagulation leading to hypocoagulability, a pulmonary leukostasis, interstitial edema, a progressive respiratory failure with prompt increase in pulmonary vascular resistance, decrease in systemic vascular resistance, increased venous admixture, and increased dead space ventilation. Agranulocytosis prevented interstitial edema but not disturbances in pulmonary or hemodynamic function or hypocoagulability. The results clearly indicate that elastase may be involved in the pathophysiology of acute lung failure and defects in the blood coagulation system.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Stokke T,Burchardi H,Hensel I,Köstering H,Käthner T,Rahlf Gdoi
10.1016/0300-9572(86)90007-9subject
Has Abstractpub_date
1986-09-01 00:00:00pages
61-79issue
1-2eissn
0300-9572issn
1873-1570pii
0300-9572(86)90007-9journal_volume
14pub_type
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