The landscape of mitochondrial small non-coding RNAs in the PGCs of male mice, spermatogonia, gametes and in zygotes.

abstract：BACKGROUND:Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant detections are prone...

journal_title：BMC genomics

authors： Bhagwate AV,Liu Y,Winham SJ,McDonough SJ,Stallings-Mann ML,Heinzen EP,Davila JI,Vierkant RA,Hoskin TL,Frost M,Carter JM,Radisky DC,Cunningham JM,Degnim AC,Wang C

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Engineered nanomaterials may release nanosized residues, by degradation, throughout their life cycle. These residues may be a threat for living organisms. They may be ingested by humans through food and water. Although the toxicity of pristine CeO2 nanoparticles (NPs) has been documented, there is a lack of ...

journal_title：BMC genomics

authors： Fisichella M,Berenguer F,Steinmetz G,Auffan M,Rose J,Prat O

更新日期：2014-08-21 00:00:00

abstract：BACKGROUND:The pituitary is a critical neuroendocrine gland that is comprised of five hormone-secreting cell types, which develops in tandem during the embryonic stage. Some essential genes have been identified in the early stage of adenohypophysial development, such as PITX1, FGF8, BMP4 and SF-1. However, it is likely...

journal_title：BMC genomics

authors： Ma Y,Qi X,Du J,Song S,Feng D,Qi J,Zhu Z,Zhang X,Xiao H,Han Z,Hao X

更新日期：2009-03-15 00:00:00

abstract：BACKGROUND:Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell wall, and its biosynthesis is not yet well characterized. Studies in Bacillus subtilis have disc...

journal_title：BMC genomics

authors： Qian Z,Yin Y,Zhang Y,Lu L,Li Y,Jiang Y

更新日期：2006-04-05 00:00:00

abstract：BACKGROUND:Microsatellites are widely used for many genetic studies. In contrast to single nucleotide polymorphism (SNP) and genotyping-by-sequencing methods, they are readily typed in samples of low DNA quality/concentration (e.g. museum/non-invasive samples), and enable the quick, cheap identification of species, hyb...

journal_title：BMC genomics

authors： Dawson DA,Ball AD,Spurgin LG,Martín-Gálvez D,Stewart IR,Horsburgh GJ,Potter J,Molina-Morales M,Bicknell AW,Preston SA,Ekblom R,Slate J,Burke T

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Chinese bayberry (Myrica rubra Sieb. and Zucc.) is a subtropical evergreen tree originating in China. It has been cultivated in southern China for several thousand years, and annual production has reached 1.1 million tons. The taste and high level of health promoting characters identified in the fruit in rec...

journal_title：BMC genomics

authors： Jiao Y,Jia HM,Li XW,Chai ML,Jia HJ,Chen Z,Wang GY,Chai CY,van de Weg E,Gao ZS

更新日期：2012-05-23 00:00:00

abstract：BACKGROUND:Laminitis, the structural failure of interdigitated tissue that suspends the distal skeleton within the hoof capsule, is a devastating disease that is the second leading cause of both lameness and euthanasia in the horse. Current transcriptomic research focuses on the expression of known genes. However, as t...

journal_title：BMC genomics

authors： Holl HM,Gao S,Fei Z,Andrews C,Brooks SA

更新日期：2015-10-03 00:00:00

abstract：BACKGROUND:Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth. Nevertheless, MZ twins are sometimes discordant for common complex diseases. The goal of this study is to identify genomic and epig...

journal_title：BMC genomics

authors： Lyu G,Zhang C,Ling T,Liu R,Zong L,Guan Y,Huang X,Sun L,Zhang L,Li C,Nie Y,Tao W

更新日期：2018-06-04 00:00:00

abstract：BACKGROUND:Understanding the evolution of the vertebrate pancreas is key to understanding its functions. The chondrichthyes (cartilaginous fish such as sharks and rays) have often been suggested to possess the most ancient example of a distinct pancreas with both hormonal (endocrine) and digestive (exocrine) roles. The...

journal_title：BMC genomics

authors： Mulley JF,Hargreaves AD,Hegarty MJ,Heller RS,Swain MT

更新日期：2014-12-06 00:00:00

abstract：BACKGROUND:An important subfamily of membrane proteins are the transmembrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices. Given the obvious biological and medical significance of these proteins, it is of tremendous practical importance to identify the location of transmem...

journal_title：BMC genomics

authors： Yang JY,Yang MQ,Dunker AK,Deng Y,Huang X

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:In silico, secretome proteins can be predicted from completely sequenced genomes using various available algorithms that identify membrane-targeting sequences. For metasecretome (collection of surface, secreted and transmembrane proteins from environmental microbial communities) this approach is impractical,...

journal_title：BMC genomics

authors： Ciric M,Moon CD,Leahy SC,Creevey CJ,Altermann E,Attwood GT,Rakonjac J,Gagic D

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Use of genomic tools to characterize wildlife populations has increased in recent years. In the past, genetic characterization has been accomplished with more traditional genetic tools (e.g., microsatellites). The explosion of genomic methods and the subsequent creation of large SNP datasets has led to the p...

journal_title：BMC genomics

authors： Zimmerman SJ,Aldridge CL,Oyler-McCance SJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool for studying transcription and chromatin modifica...

journal_title：BMC genomics

authors： Zhu Z,Shi M,Hu W,Estrella H,Engebretsen J,Nichols T,Briere D,Hosea N,Los G,Rejto PA,Fanjul A

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:The domestic cat (Felis catus) is an important companion animal and is used as a large animal model for human disease. However, the comprehensive study of adaptive immunity in this species is hampered by the lack of data on lymphocyte antigen receptor genes and usage. The objectives of this study were to ann...

journal_title：BMC genomics

authors： Radtanakatikanon A,Keller SM,Darzentas N,Moore PF,Folch G,Nguefack Ngoune V,Lefranc MP,Vernau W

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Aedes aegypti is the principle vector of many arboviruses, including dengue virus and Zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. During blood digestion, ~ 10 mM heme-iron is ingested into the midgut lumen. While heme acts as both...

journal_title：BMC genomics

authors： Eggleston H,Adelman ZN

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:The human gastric pathogen Helicobacter pylori is a paradigm for chronic bacterial infections. Its persistence in the stomach mucosa is facilitated by several mechanisms of immune evasion and immune modulation, but also by an unusual genetic variability which might account for the capability to adapt to chan...

journal_title：BMC genomics

authors： Fischer W,Breithaupt U,Kern B,Smith SI,Spicher C,Haas R

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:Foxtail millet [Setaria italica (L.) P. Beauv.], a crop of historical importance in China, has been adopted as a model crop for studying C-4 photosynthesis, stress biology and biofuel traits. Construction of a high density genetic map and identification of stable quantitative trait loci (QTL) lay the foundat...

journal_title：BMC genomics

authors： Fang X,Dong K,Wang X,Liu T,He J,Ren R,Zhang L,Liu R,Liu X,Li M,Huang M,Zhang Z,Yang T

更新日期：2016-05-04 00:00:00

abstract：BACKGROUND:The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AM...

journal_title：BMC genomics

authors： Gandemer V,Rio AG,de Tayrac M,Sibut V,Mottier S,Ly Sunnaram B,Henry C,Monnier A,Berthou C,Le Gall E,Le Treut A,Schmitt C,Le Gall JY,Mosser J,Galibert MD

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:Genome-wide association studies show that most human traits and diseases are caused by a combination of environmental and genetic causes, with each one of these having a relatively small effect. In contrast, most therapies based on macromolecules like antibodies, antisense oligonucleotides or peptides focus ...

journal_title：BMC genomics

authors： Varela MA

更新日期：2015-07-18 00:00:00

abstract：BACKGROUND:Chlamydia pecorum is an important pathogen of domesticated livestock including sheep, cattle and pigs. This pathogen is also a key factor in the decline of the koala in Australia. We sequenced the genomes of three koala C. pecorum strains, isolated from the urogenital tracts and conjunctiva of diseased koala...

journal_title：BMC genomics

authors： Bachmann NL,Fraser TA,Bertelli C,Jelocnik M,Gillett A,Funnell O,Flanagan C,Myers GS,Timms P,Polkinghorne A

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:The central role of the somatotrophic axis in animal post-natal growth, development and fertility is well established. Therefore, the identification of genetic variants affecting quantitative traits within this axis is an attractive goal. However, large sample numbers are a pre-requisite for the identificati...

journal_title：BMC genomics

authors： Mullen MP,Creevey CJ,Berry DP,McCabe MS,Magee DA,Howard DJ,Killeen AP,Park SD,McGettigan PA,Lucy MC,Machugh DE,Waters SM

更新日期：2012-01-11 00:00:00

abstract：BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...

journal_title：BMC genomics

authors： Borghini L,Hibberd M,Davila S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity make the promoter attractive for in silico analysis and reporter gene studies in zebrafish (Danio re...

journal_title：BMC genomics

authors： Torgersen J,Nourizadeh-Lillabadi R,Husebye H,Aleström P

更新日期：2002-08-21 00:00:00

abstract：BACKGROUND:The small airway epithelium (SAE), the cell population that covers the human airway surface from the 6th generation of airway branching to the alveoli, is the major site of lung disease caused by smoking. The focus of this study is to provide quantitative assessment of the SAE transcriptome in the resting st...

journal_title：BMC genomics

authors： Hackett NR,Butler MW,Shaykhiev R,Salit J,Omberg L,Rodriguez-Flores JL,Mezey JG,Strulovici-Barel Y,Wang G,Didon L,Crystal RG

更新日期：2012-02-29 00:00:00

abstract：BACKGROUND:Embryonic and fetal exposure to maternal obesity causes several maladaptive morphological and epigenetic changes in exposed offspring. The timing of these events is unclear, but changes can be observed even after a short exposure to maternal obesity around the time of conception. The hypothesis of this work ...

journal_title：BMC genomics

authors： McCoski SR,Vailes MT,Owens CE,Cockrum RR,Ealy AD

更新日期：2018-10-11 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is an important opportunistic pathogen responsible for many infections in hospitalized and immunocompromised patients. Previous reports estimated that approximately 10% of its 6.6 Mbp genome varies from strain to strain and is therefore referred to as "accessory genome". Elements withi...

journal_title：BMC genomics

authors： Ozer EA,Allen JP,Hauser AR

更新日期：2014-08-29 00:00:00

abstract：BACKGROUND:Understanding the genetic basis of adaptive evolution is one of the major goals in evolutionary biology. Recently, it has been revealed that gene copy number variations (GCNVs) constitute significant proportions of genomic diversities within natural populations. However, it has been unclear whether GCNVs are...

journal_title：BMC genomics

authors： Hirase S,Ozaki H,Iwasaki W

更新日期：2014-08-29 00:00:00

abstract：BACKGROUND:Chronic Allograft Nephropathy (CAN) is a clinical entity of progressive kidney transplant injury. The defining histology is tubular atrophy with interstitial fibrosis (IFTA). Using a meta-analysis of microarrays from 84 kidney transplant biopsies, we revealed growth factor and integrin adhesion molecule path...

journal_title：BMC genomics

authors： Dosanjh A,Robison E,Mondala T,Head SR,Salomon DR,Kurian SM

更新日期：2013-04-23 00:00:00

abstract：:Following the publication of the original article [1], the authors reported an error in Fig. 2 of the PDF version of their article. ...

journal_title：BMC genomics

authors： Maarsingh JD,Yang S,Park JG,Haydel SE

更新日期：2019-12-31 00:00:00

abstract：BACKGROUND:As economically relevant traits, feeding behavior and food preference domestication determine production cost and profitability. Although there are intensive research efforts on feeding behavior and food intake, little is known about food preference. Mandarin fish accept only live prey fish and refuse dead p...

journal_title：BMC genomics

authors： He S,Liang XF,Sun J,Li L,Yu Y,Huang W,Qu CM,Cao L,Bai XL,Tao YX

更新日期：2013-09-05 00:00:00