Changes in H3K27ac following lipopolysaccharide stimulation of nasopharyngeal epithelial cells.

abstract：BACKGROUND:During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes. The evolutionary resolution to such dosage imbalance, as hypothesized by Susumu Ohno fifty years ago, should be doubling the expression of X-linked gene...

journal_title：BMC genomics

authors： Yang JR,Chen X

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:CRISPR is a microbial immune system likely to be involved in host-parasite coevolution. It functions using target sequences encoded by the bacterial genome, which interfere with invading nucleic acids using a homology-dependent system. The system also requires protospacer associated motifs (PAMs), short moti...

journal_title：BMC genomics

authors： Kupczok A,Bollback JP

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:Obesity, the excessive accumulation of body fat, is a highly heritable and genetically heterogeneous disorder. The complex, polygenic basis for the disease consisting of a network of different gene variants is still not completely known. RESULTS:In the current study we generated a BAC library of the obese-p...

journal_title：BMC genomics

authors： Vogel H,Jähnert M,Stadion M,Matzke D,Scherneck S,Schürmann A

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated by 1 to 5 bp (DR1-DR5). Although many known such response elements ...

journal_title：BMC genomics

authors： Laperriere D,Wang TT,White JH,Mader S

更新日期：2007-01-19 00:00:00

abstract：BACKGROUND:Improving fiber quality is a major challenge in cotton breeding, since the molecular basis of fiber quality traits is poorly understood. Fine mapping and candidate gene prediction of quantitative trait loci (QTL) controlling cotton fiber quality traits can help to elucidate the molecular basis of fiber quali...

journal_title：BMC genomics

authors： Liu D,Zhang J,Liu X,Wang W,Liu D,Teng Z,Fang X,Tan Z,Tang S,Yang J,Zhong J,Zhang Z

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Annotating mammalian genomes for noncoding RNAs (ncRNAs) is nontrivial since far from all ncRNAs are known and the computational models are resource demanding. Currently, the human genome holds the best mammalian ncRNA annotation, a result of numerous efforts by several groups. However, a more direct strateg...

journal_title：BMC genomics

authors： Anthon C,Tafer H,Havgaard JH,Thomsen B,Hedegaard J,Seemann SE,Pundhir S,Kehr S,Bartschat S,Nielsen M,Nielsen RO,Fredholm M,Stadler PF,Gorodkin J

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:An important subfamily of membrane proteins are the transmembrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices. Given the obvious biological and medical significance of these proteins, it is of tremendous practical importance to identify the location of transmem...

journal_title：BMC genomics

authors： Yang JY,Yang MQ,Dunker AK,Deng Y,Huang X

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Cold tolerance is a key determinant of the geographical distribution range of a plant species and crop production. Cold acclimation can enhance freezing-tolerance of plant species through a period of exposure to low nonfreezing temperatures. As a subtropical evergreen broadleaf plant, oil-tea camellia demons...

journal_title：BMC genomics

authors： Chen J,Yang X,Huang X,Duan S,Long C,Chen J,Rong J

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member, tritetraproline (TTP), binds to AU rich elements in 3' UTRs of unstable mRNAs, mediating their degradation. In kinetoplastids, CCCH type zinc finger proteins have...

journal_title：BMC genomics

authors： Kramer S,Kimblin NC,Carrington M

更新日期：2010-05-05 00:00:00

abstract：BACKGROUND:Periodic spacing of A-tracts (short runs of A or T) with the DNA helical period of ~10-11 bp is characteristic of intrinsically bent DNA. In eukaryotes, the DNA bending is related to chromatin structure and nucleosome positioning. However, the physiological role of strong sequence periodicity detected in man...

journal_title：BMC genomics

authors： Abel J,Mrázek J

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:The regenerative response of Schwann cells after peripheral nerve injury is a critical process directly related to the pathophysiology of a number of neurodegenerative diseases. This SC injury response is dependent on an intricate gene regulatory program coordinated by a number of transcription factors and m...

journal_title：BMC genomics

authors： Chang LW,Viader A,Varghese N,Payton JE,Milbrandt J,Nagarajan R

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Ancestry informative markers (AIMs) are a type of genetic marker that is informative for tracing the ancestral ethnicity of individuals. Application of AIMs has gained substantial attention in population genetics, forensic sciences, and medical genetics. Single nucleotide polymorphisms (SNPs), the materials ...

journal_title：BMC genomics

authors： Yang HC,Wang PL,Lin CW,Chen CH,Chen CH

更新日期：2012-07-28 00:00:00

abstract：BACKGROUND:Dictyostelium discoideum is frequently subjected to environmental changes in its natural habitat, the forest soil. In order to survive, the organism had to develop effective mechanisms to sense and respond to such changes. When cells are faced with a hypertonic environment a complex response is triggered. It...

journal_title：BMC genomics

authors： Na J,Tunggal B,Eichinger L

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it rapidly and proficiently kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B. pahangi are morphologically and biologically similar, the Armigeres-Brugia system serves as a valuable model for...

journal_title：BMC genomics

authors： Aliota MT,Fuchs JF,Mayhew GF,Chen CC,Christensen BM

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:Regions of the genome that are under evolutionary constraint across multiple species have previously been used to identify functional sequences in the human genome. Furthermore, it is known that there is an inverse relationship between evolutionary constraint and the allele frequency of a mutation segregatin...

journal_title：BMC genomics

authors： Hodgkinson A,Casals F,Idaghdour Y,Grenier JC,Hernandez RD,Awadalla P

更新日期：2013-07-23 00:00:00

abstract：BACKGROUND:Foxtail millet [Setaria italica (L.) P. Beauv.], a crop of historical importance in China, has been adopted as a model crop for studying C-4 photosynthesis, stress biology and biofuel traits. Construction of a high density genetic map and identification of stable quantitative trait loci (QTL) lay the foundat...

journal_title：BMC genomics

authors： Fang X,Dong K,Wang X,Liu T,He J,Ren R,Zhang L,Liu R,Liu X,Li M,Huang M,Zhang Z,Yang T

更新日期：2016-05-04 00:00:00

abstract：BACKGROUND:Laboratory evolution is an important tool for developing robust yeast strains for bioethanol production since the biological basis behind combined tolerance requires complex alterations whose proper regulation is difficult to achieve by rational metabolic engineering. Previously, we reported on the evolved i...

journal_title：BMC genomics

authors： Wallace-Salinas V,Brink DP,Ahrén D,Gorwa-Grauslund MF

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:Belonging to lineage I of Brassicaceae, Camelina sativa is formed by two hybridizations of three species (three sub-genomes). The three sub-genomes were diverged from a common ancestor, likely derived from lineage I (Ancestral Crucifer karyotype, ACK). The karyotype evolutionary trajectories of the C. sativa...

journal_title：BMC genomics

authors： Zhang Z,Meng F,Sun P,Yuan J,Gong K,Liu C,Wang W,Wang X

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Colon cancer occurrence is increasing worldwide, making it the third most frequent cancer. Although many therapeutic options are available and quite efficient at the early stages, survival is strongly decreased when the disease has spread to other organs. The identification of molecular markers of colon canc...

journal_title：BMC genomics

authors： Durand S,Trillet K,Uguen A,Saint-Pierre A,Le Jossic-Corcos C,Corcos L

更新日期：2017-09-30 00:00:00

abstract：BACKGROUND:Adaptive divergence driven by environmental heterogeneity has long been a fascinating topic in ecology and evolutionary biology. The study of the genetic basis of adaptive divergence has, however, been greatly hampered by a lack of genomic information. The recent development of transcriptome sequencing provi...

journal_title：BMC genomics

authors： Chu JH,Lin RC,Yeh CF,Hsu YC,Li SH

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Urechis unicinctus, an echiuran worm inhabiting the U-shaped burrows in the coastal mud flats, is an important commercial and ecological invertebrate in Northeast Asian countries, which has potential applications in the study of animal evolution, coastal sediment improvement and marine drug development. Furt...

journal_title：BMC genomics

authors： Liu X,Zhang L,Zhang Z,Ma X,Liu J

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Cucumber, Cucumis sativus L. (2n = 2 × = 14) and melon, C. melo L. (2n = 2 × = 24) are two important vegetable species in the genus Cucumis (family Cucurbitaceae). Both species have an Asian origin that diverged approximately nine million years ago. Cucumber is believed to have evolved from melon through chr...

journal_title：BMC genomics

authors： Li D,Cuevas HE,Yang L,Li Y,Garcia-Mas J,Zalapa J,Staub JE,Luan F,Reddy U,He X,Gong Z,Weng Y

更新日期：2011-08-05 00:00:00

abstract：UNLABELLED:Little is known, either experimentally or computationally, about the genomic sequence features that regulate malaria genes. A sequence conservation analysis of the malaria species P. falciparum, P. berghei, P. yoelii, and P. chabaudi could significantly advance knowledge of malaria gene regulation. RESULTS:...

journal_title：BMC genomics

authors： Imamura H,Persampieri JH,Chuang JH

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001. RESULTS:We did not find a significant difference between miRNA signature of both groups...

journal_title：BMC genomics

authors： Schmitt J,Backes C,Nourkami-Tutdibi N,Leidinger P,Deutscher S,Beier M,Gessler M,Graf N,Lenhof HP,Keller A,Meese E

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:The siRNA and piRNA pathways have been shown in insects to be essential for regulation of gene expression and defence against exogenous and endogenous genetic elements (viruses and transposable elements). The vast majority of endogenous small RNAs produced by the siRNA and piRNA pathways originate from repet...

journal_title：BMC genomics

authors： Biryukova I,Ye T

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Heat shock proteins (Hsps) are molecular chaperones that are involved in many normal cellular processes and stress responses, and heat shock factors (Hsfs) are the transcriptional activators of Hsps. Hsfs and Hsps are widely coordinated in various biological processes. Although the roles of Hsfs and Hsps in ...

journal_title：BMC genomics

authors： Zhang J,Liu B,Li J,Zhang L,Wang Y,Zheng H,Lu M,Chen J

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Interactions between fish and pathogens, that may be harmless under natural conditions, often result in serious diseases in aquaculture systems. This is especially important due to the fact that the strains used in aquaculture are derived from wild strains that may not have had enough time to adapt to new di...

journal_title：BMC genomics

authors： Rodríguez-Ramilo ST,Toro MA,Bouza C,Hermida M,Pardo BG,Cabaleiro S,Martínez P,Fernández J

更新日期：2011-11-02 00:00:00

abstract：BACKGROUND:Preterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization. Health ...

journal_title：BMC genomics

authors： Sheikh IA,Ahmad E,Jamal MS,Rehan M,Assidi M,Tayubi IA,AlBasri SF,Bajouh OS,Turki RF,Abuzenadah AM,Damanhouri GA,Beg MA,Al-Qahtani M

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:To understand gene expression networks leading to functional properties of the soybean seed, we have undertaken a detailed examination of soybean seed development during the stages of major accumulation of oils, proteins, and starches, as well as the desiccating and mature stages, using microarrays consistin...

journal_title：BMC genomics

authors： Jones SI,Gonzalez DO,Vodkin LO

更新日期：2010-02-24 00:00:00

abstract：BACKGROUND:The membrane protein CD46, a ubiquitous cell surface pathogen receptor, can bind Streptococcus to trigger cell autophagy, which is a critical step in the control of infection. RESULTS:In this study, we found a new splice variant designated CD46 transcript variant (CD46-TV). The splice variant is characteriz...

journal_title：BMC genomics

authors： Wang X,Zhong J,Gao Y,Ju Z,Huang J

更新日期：2014-07-28 00:00:00