Generation of a de novo transcriptome from equine lamellar tissue.

abstract：BACKGROUND:Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was introduced into European eels, Anguilla anguilla, 30 years ago. The parasite is more pathogenic i...

journal_title：BMC genomics

authors： Heitlinger E,Bridgett S,Montazam A,Taraschewski H,Blaxter M

更新日期：2013-02-08 00:00:00

abstract：BACKGROUND:Most microbial eukaryotes are uncultivated and thus poorly suited to standard genomic techniques. This is the case for Polykrikos lebouriae, a dinoflagellate with ultrastructurally aberrant plastids. It has been suggested that these plastids stem from a novel symbiosis with either a diatom or haptophyte, but...

journal_title：BMC genomics

authors： Gavelis GS,White RA,Suttle CA,Keeling PJ,Leander BS

更新日期：2015-07-17 00:00:00

abstract：BACKGROUND:Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide...

journal_title：BMC genomics

authors： Apolis L,Olivas J,Srinivasan P,Kushwaha AK,Desai SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Understanding the underlying genetic structure of human populations is of fundamental interest to both biological and social sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation. The most widely used methods for col...

journal_title：BMC genomics

authors： Maróti Z,Boldogkői Z,Tombácz D,Snyder M,Kalmár T

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Most studies on the paper mulberry are mainly focused on the medicated and pharmacology, fiber quality, leaves feed development, little is known about its mechanism of adaptability to abiotic stress. Physiological measurement, transcriptomics and proteomic analysis were employed to understand its response to...

journal_title：BMC genomics

authors： Peng X,Teng L,Yan X,Zhao M,Shen S

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind. MicroRNAs simultaneously target many transcripts and fine-tune the express...

journal_title：BMC genomics

authors： Nunez YO,Truitt JM,Gorini G,Ponomareva ON,Blednov YA,Harris RA,Mayfield RD

更新日期：2013-10-22 00:00:00

abstract：BACKGROUND:The importance of Indian germplasm as origin and primary center of diversity of cultivated melon is widely accepted. Genetic diversity of several collections from Indian has been studied previously, although an integrated analysis of these collections in a global diversity perspective has not been possible. ...

journal_title：BMC genomics

authors： Gonzalo MJ,Díaz A,Dhillon NPS,Reddy UK,Picó B,Monforte AJ

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:According to history, in the pre-Hispanic period, during the conquest and Inka expansion in Ecuador, many Andean families of the Cañar region would have been displaced to several places of Tawantinsuyu, including Kañaris, a Quechua-speaking community located at the highlands of the Province of Ferreñafe, Lam...

journal_title：BMC genomics

authors： Sandoval JR,Lacerda DR,Jota MMS,Robles-Ruiz P,Danos P,Paz-Y-Miño C,Wells S,Santos FR,Fujita R

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Oomycetes are a group of filamentous microorganisms that includes both animal and plant pathogens and causes major agricultural losses. Phytophthora species can infect most crops and plants from natural ecosystems. Despite their tremendous economic and ecologic importance, few effective methods exist for lim...

journal_title：BMC genomics

authors： Attard A,Evangelisti E,Kebdani-Minet N,Panabières F,Deleury E,Maggio C,Ponchet M,Gourgues M

更新日期：2014-06-29 00:00:00

abstract：BACKGROUND:Gene expression analysis by reverse transcription quantitative PCR (qPCR) is the most widely used method for analyzing the expression of a moderate number of genes and also for the validation of microarray results. Several issues are crucial for a successful qPCR study, particularly the selection of internal...

journal_title：BMC genomics

authors： Robledo D,Hernández-Urcera J,Cal RM,Pardo BG,Sánchez L,Martínez P,Viñas A

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid x receptor alpha (RXRalpha) are involved in hepatocellular carcinogenesis. The phenotype of hepatocyte RXRalpha deficient mice is different between genders. To...

journal_title：BMC genomics

authors： Guo M,Gong L,He L,Lehman-McKeeman L,Wan YJ

更新日期：2008-08-28 00:00:00

abstract：BACKGROUND:Quercetin is a polyphenol of great interest given its antioxidant activity and involvement in the immune response. Although quercetin has been well studied at the molecular level as a gene regulator and an activator of specific cellular pathways, not much attention has been given to its mechanism of action a...

journal_title：BMC genomics

authors： Atrahimovich D,Samson AO,Barsheshet Y,Vaya J,Khatib S,Reuveni E

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:New and improved antimicrobial countermeasures are urgently needed to counteract increased resistance to existing antimicrobial treatments and to combat currently untreatable or new emerging infectious diseases. We demonstrate that computational comparative genomics, together with experimental screening, can...

journal_title：BMC genomics

authors： Stubben CJ,Duffield ML,Cooper IA,Ford DC,Gans JD,Karlyshev AV,Lingard B,Oyston PC,de Rochefort A,Song J,Wren BW,Titball RW,Wolinsky M

更新日期：2009-10-29 00:00:00

abstract：BACKGROUND:Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001. RESULTS:We did not find a significant difference between miRNA signature of both groups...

journal_title：BMC genomics

authors： Schmitt J,Backes C,Nourkami-Tutdibi N,Leidinger P,Deutscher S,Beier M,Gessler M,Graf N,Lenhof HP,Keller A,Meese E

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Phenylalanine ammonia lyase (PAL) is a key enzyme of the phenylpropanoid pathway that catalyzes the deamination of phenylalanine to trans-cinnamic acid, a precursor for the lignin and flavonoid biosynthetic pathways. To date, PAL genes have been less extensively studied in gymnosperms than in angiosperms. Ou...

journal_title：BMC genomics

authors： Bagal UR,Leebens-Mack JH,Lorenz WW,Dean JF

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:In recent years, the number of human infections caused by opportunistic pathogens has increased dramatically. Plant rhizospheres are one of the most typical natural reservoirs for these pathogens but they also represent a great source for beneficial microbes with potential for biotechnological applications. ...

journal_title：BMC genomics

authors： Alavi P,Starcher MR,Thallinger GG,Zachow C,Müller H,Berg G

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND:Homology-based comparisons of the genes involved in innate immunity across many insect taxa with fully sequenced genomes has revealed a striking pattern of gene gain and loss, particularly among genes that encode proteins involved in clearing pathogens (effectors). However, limited functional annotation in n...

journal_title：BMC genomics

authors： Sackton TB,Clark AG

更新日期：2009-06-07 00:00:00

abstract：BACKGROUND:Ultrasound imaging technology has wide applications in cattle reproduction and has been used to monitor individual follicles and determine the patterns of follicular development. However, the speckles in ultrasound images affect the post-processing, such as follicle segmentation and finally affect the measur...

journal_title：BMC genomics

authors： Tang J,Guo S,Sun Q,Deng Y,Zhou D

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:In natural environments, bacteria must frequently cope with extremely scarce nutrients. Most studies focus on bacterial growth in nutrient replete conditions, while less is known about the stationary phase. Here, we are interested in global gene expression throughout all growth phases, including the adjustme...

journal_title：BMC genomics

authors： Bathke J,Konzer A,Remes B,McIntosh M,Klug G

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in human populations as a result of ...

journal_title：BMC genomics

authors： Ni X,Zhou M,Wang H,He KY,Broeckel U,Hanis C,Kardia S,Redline S,Cooper RS,Tang H,Zhu X

更新日期：2020-07-11 00:00:00

abstract：BACKGROUND:Mitochondria are organelles that fulfill a fundamental role in cell bioenergetics, as well as in other processes like cell signaling and death. Small non-coding RNAs (sncRNA) are now being considered as pivotal post-transcriptional regulators, widening the landscape of their diversity and functions. In mamma...

journal_title：BMC genomics

authors： Larriba E,Rial E,Del Mazo J

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:Poxviruses constitute one of the largest and most complex animal virus families known. The notorious smallpox disease has been eradicated and the virus contained, but its simian sister, monkeypox is an emerging, untreatable infectious disease, killing 1 to 10 % of its human victims. In the case of poxviruses...

journal_title：BMC genomics

authors： Zhao K,Wohlhueter RM,Li Y

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. Agastric fish are found throughout the teleost phylogeny, in quite diverse and unrelated lineages, indicating stomach ...

journal_title：BMC genomics

authors： Lie KK,Tørresen OK,Solbakken MH,Rønnestad I,Tooming-Klunderud A,Nederbragt AJ,Jentoft S,Sæle Ø

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Human induced pluripotent stem cells (iPSCs) have a wide range of applications throughout the fields of basic research, disease modeling and drug screening. Epigenetic instable iPSCs with aberrant DNA methylation may divide and differentiate into cancer cells. Unfortunately, little effort has been taken to c...

journal_title：BMC genomics

authors： Shao X,Zhang C,Sun MA,Lu X,Xie H

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:Although an adverse early-life environment has been linked to an increased risk of developing the metabolic syndrome, the molecular mechanisms underlying altered disease susceptibility as well as their relevance to humans are largely unknown. Importantly, emerging evidence suggests that these effects operate...

journal_title：BMC genomics

authors： Emerald BS,Chng K,Masuda S,Sloboda DM,Vickers MH,Kambadur R,Gluckman PD

更新日期：2011-10-16 00:00:00

abstract：BACKGROUND:Many plant genes have been identified through whole genome and deep transcriptome sequencing and other methods; yet our knowledge on the function of many of these genes remains limited. The integration and analysis of large gene-expression datasets gives researchers the ability to formalize hypotheses concer...

journal_title：BMC genomics

authors： Wilson TJ,Lai L,Ban Y,Ge SX

更新日期：2012-06-13 00:00:00

abstract：BACKGROUND:The orange pigmentation of the agar cultures of many Fusarium species is due to the production of carotenoids, terpenoid pigments whose synthesis is stimulated by light. The genes of the carotenoid pathway and their regulation have been investigated in detail in Fusarium fujikuroi. In this and other Fusarium...

journal_title：BMC genomics

authors： Ruger-Herreros M,Parra-Rivero O,Pardo-Medina J,Romero-Campero FJ,Limón MC,Avalos J

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:Epidermal Growth Factor (EGF) is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation and survival. Here we use a combined approach to study the EGF dependent transcriptome of HeLa cells by using multiple long oligonucleotide based ...

journal_title：BMC genomics

authors： Llorens F,Hummel M,Pastor X,Ferrer A,Pluvinet R,Vivancos A,Castillo E,Iraola S,Mosquera AM,González E,Lozano J,Ingham M,Dohm JC,Noguera M,Kofler R,del Río JA,Bayés M,Himmelbauer H,Sumoy L

更新日期：2011-06-23 00:00:00

abstract：BACKGROUND:The only known albino gorilla, named Snowflake, was a male wild born individual from Equatorial Guinea who lived at the Barcelona Zoo for almost 40 years. He was diagnosed with non-syndromic oculocutaneous albinism, i.e. white hair, light eyes, pink skin, photophobia and reduced visual acuity. Despite previo...

journal_title：BMC genomics

authors： Prado-Martinez J,Hernando-Herraez I,Lorente-Galdos B,Dabad M,Ramirez O,Baeza-Delgado C,Morcillo-Suarez C,Alkan C,Hormozdiari F,Raineri E,Estellé J,Fernandez-Callejo M,Valles M,Ritscher L,Schöneberg T,de la Calle-Mustienes E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:The increased multi-omics information on carefully phenotyped patients in studies of complex diseases requires novel methods for data integration. Unlike continuous intensity measurements from most omics data sets, phenome data contain clinical variables that are binary, ordinal and categorical. RESULTS:In ...

journal_title：BMC genomics

authors： Kim S,Herazo-Maya JD,Kang DD,Juan-Guardela BM,Tedrow J,Martinez FJ,Sciurba FC,Tseng GC,Kaminski N

更新日期：2015-11-11 00:00:00