Abstract:
PURPOSE:To investigate whether the patterns of striatal dopamine depletion could provide prognostic information on the clinical profiles of early-stage Parkinson disease (PD). METHODS:Approximately 634 patients with drug-naive PD who underwent F-FP-CIT PET scans were followed up for at least 2 years. After quantifying dopamine transporter (DAT) availability in each striatal subregion, the patterns of striatal dopamine depletion of each patient were assessed based on (1) the degree of dopamine loss in the other striatal subregions compared to the posterior putamen (inter-subregional ratio [ISR]) and (2) the interhemispheric asymmetry of dopamine loss in the posterior putamen (asymmetry index [AI]). According to their patterns, we assessed the longitudinal changes in L-dopa-equivalent doses and L-dopa-induced dyskinesia (LID)-free times using the linear mixed model and Cox regression model, respectively. RESULTS:There was no significant correlation between the ISR and AI values (Pearson correlation coefficient, 0.150). The linear mixed model showed that higher AI values were associated with slower longitudinal increases in L-dopa-equivalent dose across time (P = 0.003), whereas ISR values were not (P = 0.154). The Cox regression model demonstrated that higher ISR values were associated with early development of LID (hazard ratio, 1.693; P = 0.010), whereas AI values were not (P = 0.269). CONCLUSIONS:The present study demonstrated that the pattern of anterior-to-posterior gradient and right-to-left asymmetry of striatal DAT availability predicted the development of LID and increasing doses of dopaminergic medications.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Chung SJ,Yoo HS,Lee HS,Oh JS,Kim JS,Sohn YH,Lee PHdoi
10.1097/RLU.0000000000002251subject
Has Abstractpub_date
2018-11-01 00:00:00pages
787-792issue
11eissn
0363-9762issn
1536-0229journal_volume
43pub_type
杂志文章abstract::The feasibility of using low doses of I-131 (30 mCi) for ablation of thyroid remnants following surgery for papillary and follicular thyroid carcinoma was examined in 21 patients. Six weeks following near-total thyroidectomy and three days following intramuscular thyroid-stimulating hormone (10 IU), patients were give...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198104000-00005
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journal_title:Clinical nuclear medicine
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更新日期:2007-12-01 00:00:00
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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pub_type: 临床试验,杂志文章
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