Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children's Oncology Group protocol AHOD0031.

Abstract:

BACKGROUND:Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated. OBJECTIVE:To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors. MATERIALS AND METHODS:Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. We coded effusions as fluid-only or with associated pleural nodule or adjacent lung or bone involvement and correlated this with disease stage, tumor response, large mediastinal adenopathy, and mass effect on the superior vena cava (SVC) and left innominate vein. We recorded change in size and character of effusions post-chemotherapy. RESULTS:Pleural effusions were present in 217, with 204 having fluid-only and 13 having associated solid components. Patients with effusions were more likely to have large mediastinal adenopathy (P<0.0001), be slow early responders (P<0.0001) and have higher relapse rate (P<0.0001). Vascular compression was not significantly correlated with pleural effusion. Of 121 patients with adequate [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT imaging, no FDG PET avidity was seen in any pleural effusion but was present in solid components. The side of the pleural effusion in those with moderate or large effusions was highly associated with the side of large mediastinal adenopathy (P<0.0001). Statistical analysis indicates that pleural effusion is an independent risk factor for poorer response and relapse. CONCLUSION:Pleural effusion in Hodgkin lymphoma is an important independent poor prognostic indicator for response and relapse.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

McCarten KM,Metzger ML,Drachtman RA,Pei Q,Friedman DL,Schwartz CL,Kelly KM

doi

10.1007/s00247-018-4197-6

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1736-1744

issue

12

eissn

0301-0449

issn

1432-1998

pii

10.1007/s00247-018-4197-6

journal_volume

48

pub_type

杂志文章,随机对照试验
  • Computerized tomography appearances of pelvic haemangioma involving the large bowel in childhood.

    abstract::The Computed Tomography (CT) appearance of a pelvic haemangioma involving the rectum in two children, one with the Vater association and one with Klippel-Trenaunay syndrome, is described. Both cases complained of painless rectal bleeding and the diagnosis was suggested by the presence of pelvic phleboliths on the plai...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02387639

    authors: Yeoman LJ,Shaw D

    更新日期:1989-01-01 00:00:00

  • Osteogenesis imperfecta with joint contractures: bruck syndrome.

    abstract::We describe an Egyptian boy with osteogenesis imperfecta who was born with thumb contractures and bilateral antecubital pterygia. He was seen at 16 months of age with femur and tibial fractures, thoracic vertebral compression fractures, scoliosis and Wormian bones. The findings are consistent with a diagnosis of Bruck...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050309

    authors: Blacksin MF,Pletcher BA,David M

    更新日期:1998-02-01 00:00:00

  • Three-dimensional CT diagnosis of myositis ossificans of the sacrospinous ligament.

    abstract::We present the case of a 4-year-old female with a complex fracture of the left hemipelvis who, on follow-up CT imaging, developed new ossific densities within the peripelvic soft tissues of the contralateral side. Three-dimensional surface reformations of the pelvis demonstrated myositis ossificans along the course of...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02012410

    authors: Agrons GA,Markowitz RI,Bronson WE

    更新日期:1993-01-01 00:00:00

  • The pediatric radiologist approaching retirement.

    abstract::Retirement can be defined as a new stage of an active lifestyle. It is a unique chapter in life that can be fun and rewarding, if steps are taken to plan the process. Key factors to take into consideration during this process are family, friends, finances, and professional interests. With proper planning, rather than ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-009-1523-z

    authors: Slovis TL

    更新日期:2010-04-01 00:00:00

  • Size of the intracranial optic nerve and optic tract in neonates at term-equivalent age at magnetic resonance imaging.

    abstract:BACKGROUND:The expected MRI-based dimensions of the intracranial optic nerve and optic tract in neonates are unknown. OBJECTIVE:To evaluate the sizes of the intracranial optic nerve and optic tract in neonates at term-equivalent age using MRI. MATERIALS AND METHODS:We retrospectively analyzed brain MRI examinations i...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-015-3495-5

    authors: Oyama J,Mori K,Imamura M,Mizushima Y,Tateishi U

    更新日期:2016-04-01 00:00:00

  • De novo radiologic placement of button gastrostomy: a feasibility study in children with cancer.

    abstract:BACKGROUND:Primary placement of percutaneous radiologic button gastrostomy has been successfully performed in adults but research is lacking as to its success in children during cancer treatment. OBJECTIVE:To assess the safety and effectiveness of such treatment at a single center. MATERIALS AND METHODS:We conducted ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-015-3426-5

    authors: Richioud B,Louazon T,Beji H,Bertrand A,Roux P,Kalenderian AC,Cuinet M,Pilleul F,Marec-Bérard P

    更新日期:2015-12-01 00:00:00

  • Atypical teratoid/rhabdoid tumor of the optic nerve.

    abstract::We report a rare case of atypical teratoid/rhabdoid tumor that presented with imaging findings similar to those of optic pathway glioma. The diagnosis of atypical teratoid/rhabdoid tumor was determined following surgical resection of the tumor by collective histologic and immunohistochemical staining, and cytogenetic ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-008-0923-9

    authors: Verma A,Morriss C

    更新日期:2008-10-01 00:00:00

  • Ingestion of multiple magnets: hazardous foreign bodies for children.

    abstract::We report a case of perforation, fistula formation, and small bowel obstruction in a 2-year-old child who had ingested 32 small magnets. Multiple magnets will attract one another through the bowel wall and lead to pressure necrosis with complications. We recommend early surgical intervention before the onset of gastro...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-005-0056-3

    authors: Uchida K,Otake K,Iwata T,Watanabe H,Inoue M,Hatada T,Kusunoki M

    更新日期:2006-03-01 00:00:00

  • Extensive vascular calcification in a patient with perinatally acquired AIDS.

    abstract::Extensive vascular calcification in an 8-year-old girl with perinatally acquired AIDS is reported. Complicating factors included cardiomyopathy, chronic lung disease, disseminated Mycobacterium avium complex (MAC), and wasting syndrome with total nutrition dependence. Plain abdominal films and CT of the abdomen immedi...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF01395718

    authors: Marquis JR,D'Cruz C

    更新日期:1996-01-01 00:00:00

  • Reinsertion of accidentally removed tunneled central venous catheter via the existing subcutaneous tract.

    abstract:BACKGROUND:A technique for reinsertion of an inadvertently removed tunneled central venous catheter is presented. A 6-year-old boy with short-gut syndrome caused by necrotizing enterocolitis accidentally removed his tunneled central venous catheter. MATERIALS AND METHODS:The existing subcutaneous catheter tract was re...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050724

    authors: Funaki B,Lorenz J,Zaleski GX

    更新日期:1999-12-01 00:00:00

  • The incipient Wilms' tumor.

    abstract::The diagnosis of Wilms' tumor is usually made by excretory urography after the patient presents with an abdominal mass. A diagnosis prior to the appearance of an obvious mass might result in an improved cure rate and less morbid therapy. The three cases described illustrate the difficulty in making an earlier diagnosi...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF01000118

    authors: Woodard JR,Gay BB Jr,Rutherford CR Jr

    更新日期:1975-03-20 00:00:00

  • Radiologic considerations in patients undergoing the Nuss procedure for correction of pectus excavatum.

    abstract::The Nuss procedure has succeeded in minimizing incisions, blood loss, sternal fracturing, operating room time, recovery time, and length of hospital stay. Knowledge of the pre- and postoperative radiologic considerations is essential in providing appropriate imaging support to the surgeons performing this innovative, ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470100455

    authors: Sidden CR,Katz ME,Swoveland BC,Nuss D

    更新日期:2001-06-01 00:00:00

  • Barium enema findings in a case of Langerhans cell histiocytosis involving the colon.

    abstract::Gastrointestinal (GI) tract involvement in Langerhans cell histiocytosis is probably not uncommon [1,2], but reports of radiologic findings have been limited to the small intestine and mesenteric lymph nodes [3-5]. We report a 16-month-old child with known Langerhans cell histiocytosis, who was found to have mucosal i...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02014971

    authors: Gilmore BS,Cohen M

    更新日期:1993-01-01 00:00:00

  • Staging and following common pediatric malignancies: MRI versus CT versus functional imaging.

    abstract::Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumor...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-018-4162-4

    authors: Voss SD

    更新日期:2018-08-01 00:00:00

  • Implementation of a competency check-off in diagnostic fluoroscopy for radiology trainees: impact on reducing radiation for three common fluoroscopic exams in children.

    abstract:BACKGROUND:Fluoroscopy is an important tool for diagnosis in the pediatric population, but it carries the risk of radiation exposure. Because radiology resident education and experience in the use of fluoroscopy equipment in children vary, we implemented an intervention to standardize fluoroscopy training. OBJECTIVE:T...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-014-3108-8

    authors: Shah S,Desouches SL,Lowe LH,Kasraie N,Reading B

    更新日期:2015-02-01 00:00:00

  • Pediatric digital radiography education for radiologic technologists: current state.

    abstract:BACKGROUND:Digital radiography (DR) is one of several new products that have changed our work processes from hard copy to digital formats. The transition from analog screen-film radiography to DR requires thorough user education because of differences in image production, processing, storage and evaluation between the ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-010-1904-3

    authors: Morrison G,John SD,Goske MJ,Charkot E,Herrmann T,Smith SN,Culbertson J,Carbonneau K

    更新日期:2011-05-01 00:00:00

  • Rib head protrusion into the central canal in type 1 neurofibromatosis.

    abstract:BACKGROUND:Intraspinal rib head dislocation is an important but under-recognized consequence of dystrophic scoliosis in patients with neurofibromatosis 1 (NF1). OBJECTIVE:To present clinical and imaging findings of intraspinal rib head dislocation in NF1. MATERIALS AND METHODS:We retrospectively reviewed clinical pre...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-010-1789-1

    authors: Ton J,Stein-Wexler R,Yen P,Gupta M

    更新日期:2010-12-01 00:00:00

  • Multifocal metachronous giant cell tumor in a 15-year-old boy.

    abstract::We report a case of multifocal metachronous giant cell tumor (GCT) that involved the fibula, tibia, and sacrum of a 15-year-old boy. Multifocal GCT of bone presenting in children is an exceedingly rare phenomenon; however, there is evidence that multifocal GCT presents, on average, at a younger age than solitary GCT. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-004-1346-x

    authors: Stratil PG,Stacy GS

    更新日期:2005-04-01 00:00:00

  • Limitations of using logarithmic transformation and linear fitting to estimate relaxation rates in iron-loaded liver.

    abstract:BACKGROUND:MRI is being increasingly used to evaluate tissue relaxation in the setting of iron overload. Diagnostic accuracy is strongly dependent upon the acquisition and analysis methods employed. Typically, a multi-echo train of relaxation data is acquired, the resulting curve is fit using a non-linear (exponential)...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-011-2082-7

    authors: Otto R,Ferguson MR,Marro K,Grinstead JW,Friedman SD

    更新日期:2011-10-01 00:00:00

  • Anatomic distribution of renal artery stenosis in children: implications for imaging.

    abstract:BACKGROUND:Renal artery stenosis (RAS) causes significant hypertension in children. Frequently, pediatric RAS occurs with systemic disorders. In these cases, stenoses are often complex and/or include long segments. We believed that hypertensive children without comorbid conditions had a different lesion distribution an...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-006-0253-8

    authors: Vo NJ,Hammelman BD,Racadio JM,Strife CF,Johnson ND,Racadio JM

    更新日期:2006-10-01 00:00:00

  • Paediatric post-traumatic cortical defects of the distal radius.

    abstract::Paediatric post-traumatic cortical defects, although rare, are predominately seen affecting the distal radius following a greenstick or torus fracture. We review the literature and present a further two cases supported by CT and MRI. Images from an acute greenstick fracture are also presented to help understand the pa...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-001-0608-0

    authors: Roach RT,Cassar-Pullicino V,Summers BN

    更新日期:2002-05-01 00:00:00

  • Congenital hemihypertrophy and epithelioid haemangioendothelioma in a 10-year-old boy: a case report.

    abstract::Epithelioid haemangioendothelioma has not been previously described in a patient with congenital hemihypertrophy and diabetes mellitus. Hepatic nodules were incidentally discovered on a routine US examination searching for known associated abnormalities. Pulmonary nodules were present on chest X-ray and CT of the lung...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050661

    authors: Miller JH,Gillet PM,Hendry GM,Wallace WH

    更新日期:1999-08-01 00:00:00

  • Classic metaphyseal lesion of distal tibia following footling breech delivery.

    abstract::Classic metaphyseal lesions associated with childbirth are rare. We report a distal tibial metaphyseal fracture following a difficult breech delivery. Classic metaphyseal fractures are considered highly specific injuries associated with non-accidental trauma. This case depicts a classic metaphyseal lesion sustained du...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-019-04490-6

    authors: Lee GS,Methratta ST,Frasier LD

    更新日期:2019-12-01 00:00:00

  • Pulmonary and hepatic echinococcosis in children.

    abstract::Eighty children suffering from pulmonary and/or hepatic echinococcosis are reported. The epidemiological and parasitological aspects are reviewed, and the importance of the radiological signs and differential diagnosis are emphasized. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF00975441

    authors: Thümler J,Muñoz A

    更新日期:1978-09-26 00:00:00

  • Atypical leiomyoma arising in an hepatic vein with extension into the inferior vena cava and right atrium. Report of a case in a child.

    abstract::We report an atypical leiomyoma arising in an hepatic vein and extending into the inferior vena cava and right atrium in a fourteen year old boy. US, CT and MRI facilitated diagnosis and removal of this tumor. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02012978

    authors: Dunlap HJ,Udjus K

    更新日期:1990-01-01 00:00:00

  • Optimization of a fluoroscope to reduce radiation exposure in pediatric imaging.

    abstract:BACKGROUND:A new children's hospital provided the impetus to investigate radiation dose and image quality in a fluoroscope that was specially engineered for pediatric fluoroscopy. Radiation protection management recommends radiation exposures that are as low as reasonably achievable, while still maintaining diagnostic ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050728

    authors: Brown PH,Thomas RD,Silberberg PJ,Johnson LM

    更新日期:2000-04-01 00:00:00

  • Inferior right hepatic veins: MR assessment of prevalence and potential clinical significance in children.

    abstract::The prevalence of Inferior Right Hepatic Veins (IRHVs) in 82 children who had magnetic resonance imaging (MRI) of the abdomen was assessed. IRHVs larger than or equal in size to the Superior Right Hepatic Vein were found in 23% (19/82). In two patients with radiological evidence of Superior Hepatic Venous occlusion an...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02129069

    authors: Ng YY,Finn JP,Hall-Craggs MA

    更新日期:1990-01-01 00:00:00

  • Doppler waveforms of the ureteric jet: an overview and implications for the presence of a functional sphincter at the vesicoureteric junction.

    abstract::This paper is a comprehensive review of the Doppler waveform appearance of ureteric jets. Six jet waveform patterns have been identified: monophasic, biphasic, triphasic, polyphasic, square and continuous. Details of the physical properties of jet patterns and their changes under various physiological conditions are i...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-007-0433-1

    authors: Leung VY,Chu WC,Yeung CK,Metreweli C

    更新日期:2007-05-01 00:00:00

  • Laryngeal ultrasonography in infants and children: pathological findings.

    abstract::In a previous paper, the normal sonographic anatomy of the larynx has been described. The pathological findings of this method, its advantages and its drawbacks are now discussed and compared to endoscopy and plain films. It appears to be a very interesting method for functional disorders and space-occupying lesions. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02011037

    authors: Garel C,Hassan M,Legrand I,Elmaleh M,Narcy P

    更新日期:1991-01-01 00:00:00

  • Ileocolic intussusception: hydrostatic reduction in the presence of the dissection sign.

    abstract::Hydrostatic reduction of an ileocolic intussusception has not been reported when barium dissects around the intussusceptum as opposed to pushing it retrograde. Consequently, this development is considered an indication to discontinue hydrostatic reduction. We have studied a baby in whom draining the colon caused a see...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02387971

    authors: Johnson JF,Shiels WE 2nd

    更新日期:1986-01-01 00:00:00