Abstract:
BACKGROUND:Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated. OBJECTIVE:To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors. MATERIALS AND METHODS:Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. We coded effusions as fluid-only or with associated pleural nodule or adjacent lung or bone involvement and correlated this with disease stage, tumor response, large mediastinal adenopathy, and mass effect on the superior vena cava (SVC) and left innominate vein. We recorded change in size and character of effusions post-chemotherapy. RESULTS:Pleural effusions were present in 217, with 204 having fluid-only and 13 having associated solid components. Patients with effusions were more likely to have large mediastinal adenopathy (P<0.0001), be slow early responders (P<0.0001) and have higher relapse rate (P<0.0001). Vascular compression was not significantly correlated with pleural effusion. Of 121 patients with adequate [F-18]2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/CT imaging, no FDG PET avidity was seen in any pleural effusion but was present in solid components. The side of the pleural effusion in those with moderate or large effusions was highly associated with the side of large mediastinal adenopathy (P<0.0001). Statistical analysis indicates that pleural effusion is an independent risk factor for poorer response and relapse. CONCLUSION:Pleural effusion in Hodgkin lymphoma is an important independent poor prognostic indicator for response and relapse.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
McCarten KM,Metzger ML,Drachtman RA,Pei Q,Friedman DL,Schwartz CL,Kelly KMdoi
10.1007/s00247-018-4197-6subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1736-1744issue
12eissn
0301-0449issn
1432-1998pii
10.1007/s00247-018-4197-6journal_volume
48pub_type
杂志文章,随机对照试验abstract::The Computed Tomography (CT) appearance of a pelvic haemangioma involving the rectum in two children, one with the Vater association and one with Klippel-Trenaunay syndrome, is described. Both cases complained of painless rectal bleeding and the diagnosis was suggested by the presence of pelvic phleboliths on the plai...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02387639
更新日期:1989-01-01 00:00:00
abstract::We describe an Egyptian boy with osteogenesis imperfecta who was born with thumb contractures and bilateral antecubital pterygia. He was seen at 16 months of age with femur and tibial fractures, thoracic vertebral compression fractures, scoliosis and Wormian bones. The findings are consistent with a diagnosis of Bruck...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050309
更新日期:1998-02-01 00:00:00
abstract::We present the case of a 4-year-old female with a complex fracture of the left hemipelvis who, on follow-up CT imaging, developed new ossific densities within the peripelvic soft tissues of the contralateral side. Three-dimensional surface reformations of the pelvis demonstrated myositis ossificans along the course of...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02012410
更新日期:1993-01-01 00:00:00
abstract::Retirement can be defined as a new stage of an active lifestyle. It is a unique chapter in life that can be fun and rewarding, if steps are taken to plan the process. Key factors to take into consideration during this process are family, friends, finances, and professional interests. With proper planning, rather than ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-009-1523-z
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The expected MRI-based dimensions of the intracranial optic nerve and optic tract in neonates are unknown. OBJECTIVE:To evaluate the sizes of the intracranial optic nerve and optic tract in neonates at term-equivalent age using MRI. MATERIALS AND METHODS:We retrospectively analyzed brain MRI examinations i...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-015-3495-5
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Primary placement of percutaneous radiologic button gastrostomy has been successfully performed in adults but research is lacking as to its success in children during cancer treatment. OBJECTIVE:To assess the safety and effectiveness of such treatment at a single center. MATERIALS AND METHODS:We conducted ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-015-3426-5
更新日期:2015-12-01 00:00:00
abstract::We report a rare case of atypical teratoid/rhabdoid tumor that presented with imaging findings similar to those of optic pathway glioma. The diagnosis of atypical teratoid/rhabdoid tumor was determined following surgical resection of the tumor by collective histologic and immunohistochemical staining, and cytogenetic ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-0923-9
更新日期:2008-10-01 00:00:00
abstract::We report a case of perforation, fistula formation, and small bowel obstruction in a 2-year-old child who had ingested 32 small magnets. Multiple magnets will attract one another through the bowel wall and lead to pressure necrosis with complications. We recommend early surgical intervention before the onset of gastro...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-005-0056-3
更新日期:2006-03-01 00:00:00
abstract::Extensive vascular calcification in an 8-year-old girl with perinatally acquired AIDS is reported. Complicating factors included cardiomyopathy, chronic lung disease, disseminated Mycobacterium avium complex (MAC), and wasting syndrome with total nutrition dependence. Plain abdominal films and CT of the abdomen immedi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01395718
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:A technique for reinsertion of an inadvertently removed tunneled central venous catheter is presented. A 6-year-old boy with short-gut syndrome caused by necrotizing enterocolitis accidentally removed his tunneled central venous catheter. MATERIALS AND METHODS:The existing subcutaneous catheter tract was re...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050724
更新日期:1999-12-01 00:00:00
abstract::The diagnosis of Wilms' tumor is usually made by excretory urography after the patient presents with an abdominal mass. A diagnosis prior to the appearance of an obvious mass might result in an improved cure rate and less morbid therapy. The three cases described illustrate the difficulty in making an earlier diagnosi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01000118
更新日期:1975-03-20 00:00:00
abstract::The Nuss procedure has succeeded in minimizing incisions, blood loss, sternal fracturing, operating room time, recovery time, and length of hospital stay. Knowledge of the pre- and postoperative radiologic considerations is essential in providing appropriate imaging support to the surgeons performing this innovative, ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470100455
更新日期:2001-06-01 00:00:00
abstract::Gastrointestinal (GI) tract involvement in Langerhans cell histiocytosis is probably not uncommon [1,2], but reports of radiologic findings have been limited to the small intestine and mesenteric lymph nodes [3-5]. We report a 16-month-old child with known Langerhans cell histiocytosis, who was found to have mucosal i...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02014971
更新日期:1993-01-01 00:00:00
abstract::Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumor...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-018-4162-4
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Fluoroscopy is an important tool for diagnosis in the pediatric population, but it carries the risk of radiation exposure. Because radiology resident education and experience in the use of fluoroscopy equipment in children vary, we implemented an intervention to standardize fluoroscopy training. OBJECTIVE:T...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-014-3108-8
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Digital radiography (DR) is one of several new products that have changed our work processes from hard copy to digital formats. The transition from analog screen-film radiography to DR requires thorough user education because of differences in image production, processing, storage and evaluation between the ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1904-3
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Intraspinal rib head dislocation is an important but under-recognized consequence of dystrophic scoliosis in patients with neurofibromatosis 1 (NF1). OBJECTIVE:To present clinical and imaging findings of intraspinal rib head dislocation in NF1. MATERIALS AND METHODS:We retrospectively reviewed clinical pre...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-010-1789-1
更新日期:2010-12-01 00:00:00
abstract::We report a case of multifocal metachronous giant cell tumor (GCT) that involved the fibula, tibia, and sacrum of a 15-year-old boy. Multifocal GCT of bone presenting in children is an exceedingly rare phenomenon; however, there is evidence that multifocal GCT presents, on average, at a younger age than solitary GCT. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1346-x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:MRI is being increasingly used to evaluate tissue relaxation in the setting of iron overload. Diagnostic accuracy is strongly dependent upon the acquisition and analysis methods employed. Typically, a multi-echo train of relaxation data is acquired, the resulting curve is fit using a non-linear (exponential)...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2082-7
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Renal artery stenosis (RAS) causes significant hypertension in children. Frequently, pediatric RAS occurs with systemic disorders. In these cases, stenoses are often complex and/or include long segments. We believed that hypertensive children without comorbid conditions had a different lesion distribution an...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-006-0253-8
更新日期:2006-10-01 00:00:00
abstract::Paediatric post-traumatic cortical defects, although rare, are predominately seen affecting the distal radius following a greenstick or torus fracture. We review the literature and present a further two cases supported by CT and MRI. Images from an acute greenstick fracture are also presented to help understand the pa...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-001-0608-0
更新日期:2002-05-01 00:00:00
abstract::Epithelioid haemangioendothelioma has not been previously described in a patient with congenital hemihypertrophy and diabetes mellitus. Hepatic nodules were incidentally discovered on a routine US examination searching for known associated abnormalities. Pulmonary nodules were present on chest X-ray and CT of the lung...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050661
更新日期:1999-08-01 00:00:00
abstract::Classic metaphyseal lesions associated with childbirth are rare. We report a distal tibial metaphyseal fracture following a difficult breech delivery. Classic metaphyseal fractures are considered highly specific injuries associated with non-accidental trauma. This case depicts a classic metaphyseal lesion sustained du...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04490-6
更新日期:2019-12-01 00:00:00
abstract::Eighty children suffering from pulmonary and/or hepatic echinococcosis are reported. The epidemiological and parasitological aspects are reviewed, and the importance of the radiological signs and differential diagnosis are emphasized. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00975441
更新日期:1978-09-26 00:00:00
abstract::We report an atypical leiomyoma arising in an hepatic vein and extending into the inferior vena cava and right atrium in a fourteen year old boy. US, CT and MRI facilitated diagnosis and removal of this tumor. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02012978
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A new children's hospital provided the impetus to investigate radiation dose and image quality in a fluoroscope that was specially engineered for pediatric fluoroscopy. Radiation protection management recommends radiation exposures that are as low as reasonably achievable, while still maintaining diagnostic ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050728
更新日期:2000-04-01 00:00:00
abstract::The prevalence of Inferior Right Hepatic Veins (IRHVs) in 82 children who had magnetic resonance imaging (MRI) of the abdomen was assessed. IRHVs larger than or equal in size to the Superior Right Hepatic Vein were found in 23% (19/82). In two patients with radiological evidence of Superior Hepatic Venous occlusion an...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02129069
更新日期:1990-01-01 00:00:00
abstract::This paper is a comprehensive review of the Doppler waveform appearance of ureteric jets. Six jet waveform patterns have been identified: monophasic, biphasic, triphasic, polyphasic, square and continuous. Details of the physical properties of jet patterns and their changes under various physiological conditions are i...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-007-0433-1
更新日期:2007-05-01 00:00:00
abstract::In a previous paper, the normal sonographic anatomy of the larynx has been described. The pathological findings of this method, its advantages and its drawbacks are now discussed and compared to endoscopy and plain films. It appears to be a very interesting method for functional disorders and space-occupying lesions. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011037
更新日期:1991-01-01 00:00:00
abstract::Hydrostatic reduction of an ileocolic intussusception has not been reported when barium dissects around the intussusceptum as opposed to pushing it retrograde. Consequently, this development is considered an indication to discontinue hydrostatic reduction. We have studied a baby in whom draining the colon caused a see...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02387971
更新日期:1986-01-01 00:00:00