The effects of intraperitoneal chemotherapeutic agents on adhesion formation.

Abstract:

PURPOSE:Intra-abdominal adhesions are a major complication of healing. Furthermore these adhesions may cause morbidity and sometimes mortality for patients, and also are a financial burden to the health system. MATERIALS AND METHODS:Cecum abrasion was performed in all rats and solutions containing saline to group 1, 5-fluorouracil to group 2, cisplatin to group 3, paclitaxel to the group 4, and mitomycin-C were administered into the abdomen of the groups, respectively. The intra-abdominal adhesions were scored after the macroscopic evaluation. RESULTS:Among the chemotherapeutic drugs, paclitaxel significantly increases occurring of intra-abdominal adhesions in comparison with the control group and the other drugs according to the evaluation of scoring and statistical studies. CONCLUSION:It is suggested to use the drugs which have a proven anti-adhesion feature or barriers to the patients who are going to be applied intraperitoneal chemotherapy with paclitaxel.

journal_name

Eur J Gynaecol Oncol

authors

Akgol G,Yildiz C,Karakus S,Koc M,Dogan M,Turan K,Karadayi K

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

781-785

issue

6

eissn

0392-2936

issn

2709-0086

journal_volume

37

pub_type

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