Influence of exercise on cardiac and skeletal muscle myofibrillar proteins.

abstract：:Human monoblastoid cells (U937) grown in the presence of therapeutically relevant dideoxycytidine concentrations (0.1 microM) become resistant to the drug thanks to an altered deoxycytidine kinase. In this paper we show that deoxycytidine kinase mRNA is significantly reduced in drug-resistant U937 cells (U937-R) altho...

journal_title：Molecular and cellular biochemistry

authors： Innoceta A,Galluzzi L,Ruzzo A,Andreoni F,Chiarantini L,Magnani M

更新日期：2002-02-01 00:00:00

abstract：:Myocardial infarction is the most common cause of congestive cardiac failure. Free radicals, cytokines, nitric oxide (NO) and antioxidants play a major role both in atherosclerosis and myocardial damage and preservation. In the early stages of atherosclerosis, neutrophils and monocytes infiltrate the intima and genera...

journal_title：Molecular and cellular biochemistry

authors： Das UN

更新日期：2000-12-01 00:00:00

abstract：:The effect of Aclacinomycin B (ACM-B), an anthracycline antitumor antibiotic, on the DNA-dependent RNA synthesis using single- and double-stranded DNAs of known base content and sequence is studied. The data show that ACM-B effectively inhibits the double-stranded DNA-directed RNA synthesis with a preference of poly[d...

journal_title：Molecular and cellular biochemistry

authors： Li LH,Yu FL

更新日期：1989-10-05 00:00:00

abstract：:Tyrosine levels are abnormally elevated in tissues and physiological fluids of patients with inborn errors of tyrosine catabolism, especially in tyrosinemia type II, which is caused by deficiency of tyrosine aminotransferase and provokes eyes, skin, and central nervous system disturbances. Considering that the mechani...

journal_title：Molecular and cellular biochemistry

authors： de Andrade RB,Gemelli T,Rojas DB,Funchal C,Dutra-Filho CS,Wannmacher CM

更新日期：2012-05-01 00:00:00

abstract：:The molecular mechanism of fatty acid uptake and utilization is of high medical relevance for the treatment of obesity, diabetes, and cardiovascular disease. Neuronal processes, hormones, and transcription factors are master regulators of these essential processes while their fine-tuning is achieved by modulating the ...

journal_title：Molecular and cellular biochemistry

authors： Digel M,Ehehalt R,Stremmel W,Füllekrug J

更新日期：2009-06-01 00:00:00

abstract：:We investigated whether chronic in vivo treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates cardiac contractile function by impairing mitochondrial respiration. Wy-14,643 (25 mg kg(-1) day(-1)) was administered to Wistar rats by oral gavage for 14 consecutive days, after wh...

journal_title：Molecular and cellular biochemistry

authors： Zungu M,Young ME,Stanley WC,Essop MF

更新日期：2009-10-01 00:00:00

abstract：:Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well establishe...

journal_title：Molecular and cellular biochemistry

authors： Khwaja B,Thankam FG,Agrawal DK

更新日期：2021-01-25 00:00:00

abstract：:Pathophysiology of polyunsaturated fatty acids (PUFAs) is associated with aberrant lipid and oxygen metabolism. In particular, under oxidative stress, PUFAs are prone to autocatalytic degradation via peroxidation, leading to formation of reactive aldehydes with numerous potentially harmful effects. However, the pathol...

journal_title：Molecular and cellular biochemistry

authors： Andrisic L,Collinson EJ,Tehlivets O,Perak E,Zarkovic T,Dawes IW,Zarkovic N,Cipak Gasparovic A

更新日期：2015-01-01 00:00:00

abstract：:To identify PBMC-expressed genes significant for RA, and to ascertain their upstream regulatory factors, as well as downstream functional effects relevant to RA pathogenesis. We performed peripheral blood mononuclear cells (PBMCs) transcriptome-wide mRNA expression profiling in a case-control discovery sample. Differe...

journal_title：Molecular and cellular biochemistry

authors： He P,Wu LF,Bing PF,Xia W,Wang L,Xie FF,Lu X,Lei SF,Deng FY

更新日期：2019-06-01 00:00:00

abstract：:The effect of increased serum levels of thyroid hormone (triiodothyronine, T3) on young rat testis spermatogenesis was studied by analysing molecular and morphological parameters. Hyperthyroidism was induced by either T3-treatment or 2- and 10-day cold exposure. The poly(ADP-ribosyl)ation of proteins catalysed by poly...

journal_title：Molecular and cellular biochemistry

authors： Faraone-Mennella MR,Ferone A,Marino L,Cardone A,Comitato R,Venditti P,Di Meo S,Farina B

更新日期：2009-03-01 00:00:00

abstract：:Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia...

journal_title：Molecular and cellular biochemistry

authors： Hegele RA,Pollex RL

更新日期：2009-06-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:GPR12, a member of the orphan G-protein-coupled receptor family, constitutively activates the Gs protein and increases intracellular cyclic AMP concentrations. GPR12 can be activated by its known ligand-sphingosylphosphorylcholine, which regulates cellular physiological activities, including proliferation, neurite ext...

journal_title：Molecular and cellular biochemistry

authors： Lu X,Zhang N,Meng B,Dong S,Hu Y

更新日期：2012-07-01 00:00:00

abstract：:The T-786C, Glu298Asp, and 27 bp variable number of tandem repeats (27 bp-VNTR-a/b) polymorphsims of the endothelial nitric oxide synthase (eNOS) gene are thought to alter nitric oxide production and contribute to the development of vascular and renal disease risk. The objective of this study is to investigate whether...

journal_title：Molecular and cellular biochemistry

authors： Nath SD,He X,Voruganti VS,Blangero J,MacCluer JW,Comuzzie AG,Arar NH,Abboud HE,Thameem F

更新日期：2009-11-01 00:00:00

abstract：:SRY-related box (Sox) transcription factors are conserved among vertebrate species. These proteins regulate multiple processes including sex determination and testis differentiation of the male embryo. Members of the Sox family have been identified in pre- and postnatal testis and are known to play an important role i...

journal_title：Molecular and cellular biochemistry

authors： Roumaud P,Haché J,Martin LJ

更新日期：2018-10-01 00:00:00

abstract：:In order to establish the distribution with time of proteins microinjected into mammalian cells, horseradish peroxidase (HRP) was microinjected into baby hamster kidney (BHK) cells using chicken erythrocyte ghosts. At time intervals following initiation of fusion between ghosts and target cells, samples were fixed wit...

journal_title：Molecular and cellular biochemistry

authors： McClung JK,Ulrich RG,Kletzien RF

更新日期：1987-01-01 00:00:00

abstract：:Exogenous growth factors could accelerate the process of wound healing. However, the underlying mechanisms have not been clearly clarified. The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the expression of type I collagen (cola1),...

journal_title：Molecular and cellular biochemistry

authors： Shen T,Gao K,Miao Y,Hu Z

更新日期：2018-05-01 00:00:00

abstract：:Nuclear factor-kappaB (NF-κB) is a transcription factor that is activated in various neoplasms, including gastric cancer. Insulin-like growth factor binding protein-3 (IGFBP-3) is a potent tumor suppressor and is significantly suppressed in a variety of cancers. Although IGFBP-3 has been reported to have antiprolifera...

journal_title：Molecular and cellular biochemistry

authors： Kim MS,Lee DY

更新日期：2015-05-01 00:00:00

abstract：:The function of the uterine smooth muscle in gestation and parturition is affected by a variety of hormones and biomolecules, some of which alter the intracellular levels of cAMP and Ca2+. Since the activity of smooth muscle MLCK has been shown to be modulated by phosphorylation, the effect of this modification of pre...

journal_title：Molecular and cellular biochemistry

authors： Pato MD,Kerc E,Lye SJ

更新日期：1995-08-01 00:00:00

abstract：:Cellular FLICE-like inhibitory protein (Flip) is a negative regulator of nuclear factor κB signaling which has been shown previously to complicate with cardiac hypertrophy. In the present study, we tested the hypothesis that the knockout of Flip would increase cardiac hypertrophy in vivo and in vitro. The effects of F...

journal_title：Molecular and cellular biochemistry

authors： Huang Y,Wu L,Wu J,Li Y,Hou L

更新日期：2014-12-01 00:00:00

abstract：:Studies have shown that long noncoding RNA Zinc finger E-box-binding homeobox 2 antisense RNA 1 (ZEB2-AS1) is involved in the progression of lung cancer, bladder cancer, and hepatocellular carcinoma. However, its role in the pathogenesis of gastric cancer remains unknown. The Wnt/β-catenin pathway contributes to the d...

journal_title：Molecular and cellular biochemistry

authors： Wang F,Zhu W,Yang R,Xie W,Wang D

更新日期：2019-06-01 00:00:00

abstract：:When cells of the thymus or mouse leukemias P288 and L1210 are exposed in vitro to the potent synthetic glucocorticoid, 3H-Triamcinolone acetonide, the steroid enters the cells passively and binds to macromolecules in the cytoplasm. At 37 degrees C this hormone-receptor complex enters the nucleus and associates with t...

journal_title：Molecular and cellular biochemistry

authors： Turnell RW,Burton AF

更新日期：1975-12-31 00:00:00

abstract：:A homeostatic balance exists between the cellular generation of oxidant species and endogenous antioxidants under normal physiological conditions. Human Immunodeficiency Virus (HIV) infection is known to affect this balance causing oxidative stress. However, the interaction of HIV infection with a substance abuse on c...

journal_title：Molecular and cellular biochemistry

authors： Pérez-Casanova A,Husain K,Noel RJ Jr,Rivera-Amill V,Kumar A

更新日期：2008-01-01 00:00:00

abstract：:The purification and functional characterization of protein kinase A catalytic subunit (PKAcat) from bovine lens cytosol has been described. Purification to homogeneity has been achieved by using 100 kDa cut-off membrane filtration followed by Sephacryl S-300 chromatography and finally fractionating on High Q anion ex...

journal_title：Molecular and cellular biochemistry

authors： Samanta B,Nagdas SK,Das K,Sen PC

更新日期：2007-10-01 00:00:00

abstract：:The fact that smooth muscle exists in almost every hollow organ and is involved in a large number of disease states has led to a vast increase in smooth muscle research, covering areas from testing response to antagonists and agonists to measuring the molecular force generated by a single actin filament. Yet, the exac...

journal_title：Molecular and cellular biochemistry

authors： Jiang H,Stephens NL

更新日期：1994-06-15 00:00:00

abstract：:Cardiac myocytes proliferate most rapidly during the hyperplastic phase of heart development; however, the level of cell cycle activity is drastically down regulated after birth. Further growth of the heart is achieved by hypertrophic growth of cardiac myocytes. The mechanism that controls the switch from hyperplastic...

journal_title：Molecular and cellular biochemistry

authors： Evans HJ,Goodwin RL

更新日期：2007-09-01 00:00:00

abstract：:Two forms of the regulatory subunit of the type II cAMP-dependent protein kinase (RII55 and RII52) were identified from bovine heart by gel electrophoretic behaviour. After autophosphorylation the RII55 isoform migrated more slowly (RII55/57) while the migration of RII52 isoform did not shift. Both isoforms showed dif...

journal_title：Molecular and cellular biochemistry

authors： González-Nicolás J,Jiménez JS,Moreno FJ

更新日期：1990-07-17 00:00:00

abstract：:Apocytochrome c has a potent ability to insert spontaneously into membrane. To identify which sequences were critical for this insertion activity, a series of peptides N19, C8, C15 and C21, corresponding to sequences 1-19, 81-88, 74-88 and 68-88 of apocytochrome c, respectively, were synthesized and purified. Insertio...

journal_title：Molecular and cellular biochemistry

authors： Wang X,Han X,Yang F

更新日期：2004-07-01 00:00:00

abstract：:The action of micrococcal nuclease, DNase I and DNase II on mouse TLT hepatoma chromatin revealing the periodicity of its structure as visualized by denaturing and non-denaturing gel electrophoresis, was consistent with the action of these enzymes on other chromatins. Micrococcal nuclease showed a complex subnucleosom...

journal_title：Molecular and cellular biochemistry

authors： Duerksen JD,Connor KW

更新日期：1978-04-11 00:00:00

abstract：:The aim of this study was to investigate estrogen's effect on age-related changes in bladder function. Female Wistar rats were divided into three groups that included young rats (3-month-old) (YR), old rats (13-month-old) (OR), and old rats given subcutaneous treatments of estradiol for 6 weeks (OR + E). The groups we...

journal_title：Molecular and cellular biochemistry

authors： Watanabe T,Matsumoto M,Toji S,Miyagawa I

更新日期：2008-11-01 00:00:00