Insulin-like growth factor binding protein-3 enhances etoposide-induced cell growth inhibition by suppressing the NF-κB activity in gastric cancer cells.

abstract：:Methotrexate (MTX), a folic acid antagonist, is widely used as a cytotoxic chemotherapeutic agent. MTX-associated neurotoxicity is an important clinical problem. The aim of this study was to investigate the role of caffeic acid phenethyl ester (CAPE) on cerebellar oxidative stress induced by MTX in rats. A total of 19...

journal_title：Molecular and cellular biochemistry

authors： Uzar E,Koyuncuoglu HR,Uz E,Yilmaz HR,Kutluhan S,Kilbas S,Gultekin F

更新日期：2006-10-01 00:00:00

abstract：:Endothelial dysfunction is one of the most important pathological events during the development of several diabetic complications including stroke. The aim of this work was to investigate the role of actin depolymerizing factor (ADF) in advanced glycation endproducts (AGEs)-induced impairment in mouse brain microvascu...

journal_title：Molecular and cellular biochemistry

authors： Liu X,Zhang R,Di H,Zhao D,Wang J

更新日期：2017-09-01 00:00:00

abstract：:A crude preparation of heavy sarcoplasmic reticulum (HSR) was isolated using 1 gram of muscle obtained from swine susceptible to malignant hyperthermia (MH) and from control swine. The caffeine and ATP concentration-dependency of Ca-release was determined using suction filtration with radioisotopic 45Ca as a tracer. R...

journal_title：Molecular and cellular biochemistry

authors： O'Brien PJ

更新日期：1990-03-05 00:00:00

abstract：:A rapid growth of the coronary vasculature occurs during prenatal and early postnatal periods as precursor cells from the epi- and sub-epicardium differentiate, migrate and form vascular structures (vasculogenesis) which then fuse, branch and in some cases recruit cells to form three tunics (angiogenesis). These proce...

journal_title：Molecular and cellular biochemistry

authors： Tomanek RJ,Zheng W,Yue X

更新日期：2004-09-01 00:00:00

abstract：:Enzymes have proven to be sensitive and versatile labels for immunochemical assays. The sensitivity of an enzyme label stems from its extraordinary catalytic power which in turn provides a great amplification of signals. Its versatility, however, stems from the fact that enzyme activity can be modulated by a number of...

journal_title：Molecular and cellular biochemistry

authors： Ngo TT,Lenhoff HM

更新日期：1982-04-16 00:00:00

abstract：:Loss of cardiomyocytes due to myocardial infarction results in ventricular remodeling which includes non-contractile scar formation, which can lead to heart failure. Stem cell therapy aims to replace the scar tissue with the functional myocardium. Mesenchymal stem cells (MSCs) are undifferentiated cells capable of sel...

journal_title：Molecular and cellular biochemistry

authors： Qazi RE,Naeem N,Khan I,Qadeer Q,Shaheen F,Salim A

更新日期：2020-12-01 00:00:00

abstract：:Ghrelin and obestatin are two peptide hormones with opposing roles in the control of appetite: orexigenic and anorexigenic, respectively. Loss of appetite is a common, serious complication of many forms of malignancy. The goals of this study were to investigate: (i) whether there are differences in ghrelin and obestat...

journal_title：Molecular and cellular biochemistry

authors： Karaoglu A,Aydin S,Dagli AF,Cummings DE,Ozercan IH,Canatan H,Ozkan Y

更新日期：2009-03-01 00:00:00

abstract：:Amida was first isolated from a rat hippocampal cDNA library as an Arc-associated protein. Although previous studies have shown that Amida mRNA is predominantly expressed and developmentally regulated in rat testis and overexpression induces apoptosis, the function of Amida remains unclear. In this study, we found tha...

journal_title：Molecular and cellular biochemistry

authors： Gan Y,Taira E,Irie Y,Fujimoto T,Miki N

更新日期：2003-04-01 00:00:00

abstract：:The aim of the study was to find out whether administration of selenium (Se) will protect the immature heart against ischemia/reperfusion.The control pregnant rats were fed laboratory diet (0.237 mg Se/kg diet); experimental rats received 2 ppm Na(2)SeO(3) in the drinking water from the first day of pregnancy until da...

journal_title：Molecular and cellular biochemistry

authors： Ostadalova I,Vobecky M,Chvojkova Z,Mikova D,Hampl V,Wilhelm J,Ostadal B

更新日期：2007-06-01 00:00:00

abstract：:The constitutive androstane receptor (CAR) has been reported to decrease insulin resistance along with obesity. 6,7-dimethylesculetin (DE) is an active component of Yin Zhi Huang which is a traditional Asian medicine used to treat neonatal jaundice via CAR. In this study, we examined whether DE could affect the expres...

journal_title：Molecular and cellular biochemistry

authors： Masuyama H,Mitsui T,Maki J,Tani K,Nakamura K,Hiramatsu Y

更新日期：2016-08-01 00:00:00

abstract：:The possibility of amino acids biosynthesis from sucrose, metabolites of Krebs cycle or glyoxylate and ammonium by intact bacteroids has been studied. The suspension of intact Rhizobium lupini bacteroids in phosphate buffer solution pH 7.8 was shown to catalyse the biosynthesis from sucrose and ammonium of some amino ...

journal_title：Molecular and cellular biochemistry

authors： Kretovich WL,Kariakina TI,Kazakova OV,Sidelnikova LI,Kaloshina GS,Shaposhnikov GL

更新日期：1983-01-01 00:00:00

abstract：:Abnormal QT prolongation with the associated arrhythmias is a significant predictor of mortality in diabetic patients. Gap junctional intercellular communication allows electrical coupling between heart muscle cells. The effects of streptozotocin (STZ)-induced diabetes mellitus on the expression and distribution of co...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Chandler NJ,Kharche S,Tellez JO,Greener ID,Yamanushi TT,Billeter R,Boyett MR,Zhang H,Dobrzynski H

更新日期：2008-12-01 00:00:00

abstract：:In the past decades, a greater understanding of acute pancreatitis has led to improvement in mortality rates. Nevertheless, this disease continues to be a health care system problem due to its economical costs. Future strategies such as antioxidant supplementation could be very promising, regarding to beginning and pr...

journal_title：Molecular and cellular biochemistry

authors： Carrasco C,Holguín-Arévalo MS,Martín-Partido G,Rodríguez AB,Pariente JA

更新日期：2014-02-01 00:00:00

abstract：:The present study was aimed to investigate the protective effects of 17β-estradiol (E2) and estrogen receptor α (ERα) on isoproterenol (ISO)-treated H9c2 cardiomyoblast cells. In the present study, we treated H9c2 cells with ISO, a β-adrenergic receptor agonist, to induce myocardiac hypertrophy. Pre-administration of ...

journal_title：Molecular and cellular biochemistry

authors： Pai P,Velmurugan BK,Kuo CH,Yen CY,Ho TJ,Lin YM,Chen YF,Lai CH,Day CH,Huang CY

更新日期：2017-10-01 00:00:00

abstract：:The aim of the work was to study the influence of vaspin on oxidative stress-induced apoptosis of mouse mesenchymal stem cells (MSCs). MSCs originated from bone marrow of C57BL/6 mouse were treated with vaspin and/or H2O2 in a dose-dependent manner. Cellular viability detected by CCK-8 and cell apoptosis studied by fl...

journal_title：Molecular and cellular biochemistry

authors： Zhu X,Zhang L,Chen Y,Chen B,Huang H,Lv J,Hu S,Shen J

更新日期：2019-12-01 00:00:00

abstract：:Cytosolic phospholipases A2 (cPLA2) and cyclooxygenases-1 and -2 (COX-1 and -2) play a pivotal role in the metabolism of arachidonic acid (AA) and in eicosanoid production. The coordinate regulation and expression of these enzymes is not well defined. In this study, the effect of phorbol 12-myristate 13-acetate (PMA),...

journal_title：Molecular and cellular biochemistry

authors： Jiang YJ,Lu B,Choy PC,Hatch GM

更新日期：2003-04-01 00:00:00

abstract：:Several tyrosine phosphatases control cell motility; understanding their signaling helps to decipher cancer mechanisms. Previously, we found that the negative regulation of migration exerted by PTPN12 in ovarian cancer SKOV-3 cells involves direct FAK Y397 targeting, in HER2-dependent way. In this study, we describe t...

journal_title：Molecular and cellular biochemistry

authors： Villa-Moruzzi E

更新日期：2013-03-01 00:00:00

abstract：:Kawasaki disease is an immune-mediated acute, systemic vasculitis and is the leading cause of acquired heart disease in children in the developed world. Bifidobacterium (BIF) is one of the dominant bacteria in the intestines of humans and many mammals and is able to adjust the intestinal flora disorder. The Caco-2 cel...

journal_title：Molecular and cellular biochemistry

authors： Nie N,Bai C,Song S,Zhang Y,Wang B,Li Z

更新日期：2020-01-01 00:00:00

abstract：:CYP3A5 is an important genetic contributor to inter-individual differences in CYP3A-dependent clinically important drugs of metabolism and also of various endogenous compounds and environmental contaminants. The CYP3A5*3 allele results in a truncated protein with loss of CYP3A5 expression and CYP3A5*6 is associated wi...

journal_title：Molecular and cellular biochemistry

authors： Bajpai P,Tripathi AK,Agrawal D

更新日期：2010-03-01 00:00:00

abstract：:In previous publications from our laboratory, we reported that a soluble, cytochrome P-450-dependent fatty acid monooxygenase from Bacillus megaterium ATCC 14581 can be induced by phenobarbital and a variety of other barbiturates. The tested barbiturates showed an excellent correlation between increasing lipophilicity...

journal_title：Molecular and cellular biochemistry

authors： Wen LP,Fulco AJ

更新日期：1985-05-01 00:00:00

abstract：:The action of micrococcal nuclease, DNase I and DNase II on mouse TLT hepatoma chromatin revealing the periodicity of its structure as visualized by denaturing and non-denaturing gel electrophoresis, was consistent with the action of these enzymes on other chromatins. Micrococcal nuclease showed a complex subnucleosom...

journal_title：Molecular and cellular biochemistry

authors： Duerksen JD,Connor KW

更新日期：1978-04-11 00:00:00

abstract：:The pathophysiologic importance of insulin resistance in diseases such as obesity and diabetes mellitus has led to great interest in defining the mechanism of insulin action as well as the means to overcome the biochemical defects responsible for the resistance. Vanadium compounds have been discovered to mimic many of...

journal_title：Molecular and cellular biochemistry

authors： Fantus IG,Tsiani E

更新日期：1998-05-01 00:00:00

abstract：:This review describes a comprehensive analysis of a surface plasmon resonance (SPR)-based biosensor study of molecular interactions in the insulin-like growth factor (IGF) molecular axis. In this study, we focus on the interaction between the polypeptide growth factors IGF-I and IGF-II with six soluble IGF binding pro...

journal_title：Molecular and cellular biochemistry

authors： Beattie J,Phillips K,Shand JH,Szymanowska M,Flint DJ,Allan GJ

更新日期：2008-01-01 00:00:00

abstract：:Serratia marcescens utilizes two types of quorum-sensing signal molecules: N-acyl homoserine lactones and furanosyl borate diester (AI-2). S-adenosylmethionine synthetase (METK), S-adenosylhomocysteine nucleosidase (PFS), and S-ribosylhomocysteinase (LUXS) are three key enzymes in the biosynthetic pathway leading to A...

journal_title：Molecular and cellular biochemistry

authors： Zhu H,Shen YL,Wei DZ,Zhu JW

更新日期：2008-08-01 00:00:00

abstract：:The fibrinolytic system is known to play an important role in the protection of lung architecture and function. This study investigated the effects on lungs of inhibiting the fibrinolytic system using tranexamic acid (TXA). Thirty cats were used, 15 experimental and 15 control. TXA was administered intravenously to th...

journal_title：Molecular and cellular biochemistry

authors： Hoşgör I,Yarat A,Tüzüner N,Alkan F,Emekli N,Ahmad S

更新日期：2002-12-01 00:00:00

abstract：:In this paper we review some of the large quantities of information currently available concerning the identification, structure and function of Ca(2+)-binding proteins of endoplasmic and sarcoplasmic reticulum membranes. The review places particular emphasis on identification and discussion of Ca2+ 'storage' proteins...

journal_title：Molecular and cellular biochemistry

authors： Milner RE,Famulski KS,Michalak M

更新日期：1992-05-13 00:00:00

abstract：:Increased matrix metalloproteinase (MMP) levels are involved in vascular remodeling of hypertension. In this study, we hypothesized that doxycycline (a MMP inhibitor) could exert antioxidant effects, reverse establish vascular remodeling, and lower blood pressure in spontaneously hypertensive rats (SHR). SHR and Wista...

journal_title：Molecular and cellular biochemistry

authors： Antonio RC,Ceron CS,Rizzi E,Coelho EB,Tanus-Santos JE,Gerlach RF

更新日期：2014-01-01 00:00:00

abstract：:A multi-component solution, containing α-ketoglutaric acid (α-KG), 5-hydroxymethylfurfural (5-HMF), N-acetyl-seleno-L-methionine (NASeLM), and N-acetyl-L-methionine (NALM) as active ingredients, has been tested considering its supposed antioxidative effect with respect to heart transplantations. Oxidative stress was i...

journal_title：Molecular and cellular biochemistry

authors： Russ M,Jauk S,Wintersteiger R,Andrä M,Brcic I,Ortner A

更新日期：2019-11-01 00:00:00

abstract：:The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging. This study was designed to examine whether (E)-anethole possesses a protective effect on H2O2-induced alterations in collagen metabolism as well as whether it c...

journal_title：Molecular and cellular biochemistry

authors： Galicka A,Krętowski R,Nazaruk J,Cechowska-Pasko M

更新日期：2014-09-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00