Abstract：
:The fact that smooth muscle exists in almost every hollow organ and is involved in a large number of disease states has led to a vast increase in smooth muscle research, covering areas from testing response to antagonists and agonists to measuring the molecular force generated by a single actin filament. Yet, the exact mechanisms regulating contractile response of smooth muscle remain unsolved. Calcium has been a central player in mediating smooth muscle contraction through binding with calmodulin, although there is evidence showing that under special circumstances smooth muscle can contract without change in intracellular Ca2+. In addition to the major regulatory pathway of Ca(2+)-calmodulin-myosin light chain kinase, there are other thin filament linked regulatory mechanisms in which Ca(2+)-calmodulin dependent phosphorylation of calponin and caldesmon may be involved. Ca2+ sensitivity of smooth muscle contraction may vary under different situations and this has recently been recognized as an important regulatory mechanism. Examples are protein kinase C (PKC) dependent phosphorylation of myosin light chain kinase which results in partial inhibition of contraction, and activation of myosin light chain phosphatase. There is new evidence showing that not only does Ca2+ regulate contraction by regulating the interaction of contractile proteins in smooth muscle, but also that shortening of smooth muscle itself reduces intracellular Ca2+ concentration, via a negative feedback.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Jiang H,Stephens NLdoi
10.1007/BF00925956subject
Has Abstractpub_date
1994-06-15 00:00:00pages
1-9issue
1eissn
0300-8177issn
1573-4919journal_volume
135pub_type
杂志文章,评审abstract：:Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell signaling. One of the major systems participating in the transduction of signal from the cell membrane to nuclear and other intracellular targets is the highly conserved mitogen-activated protein kinase (MAPK) superfamily. The m...
journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：2019-05-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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更新日期：1993-06-09 00:00:00
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更新日期：2011-11-01 00:00:00
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更新日期：1984-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1983-01-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：10.1007/BF01751312
更新日期：1975-12-31 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
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更新日期：2005-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Molecular and cellular biochemistry
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更新日期：1985-05-01 00:00:00
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更新日期：1996-05-24 00:00:00
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更新日期：1992-11-18 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-10-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：1992-12-16 00:00:00
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更新日期：2003-10-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Logistic complexities of heart transplantation embossed the necessity of utilizing novel methods, which enable heart regeneration. Human cardiosphere-derived cells (hCDCs) are taken into consideration as a promising cell resource in cell therapy in recent years. In this study, we designed an electrochemical stimulatio...
journal_title：Molecular and cellular biochemistry
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更新日期：2020-07-01 00:00:00
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journal_title：Molecular and cellular biochemistry
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doi：
更新日期：1999-02-01 00:00:00
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更新日期：2017-07-01 00:00:00
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journal_title：Molecular and cellular biochemistry
pub_type： 杂志文章
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更新日期：1981-10-30 00:00:00
