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Effect of GTP-binding protein (YPT1 protein) on the enhanced yeast vacuolar activity.

Abstract：

:Yeast GTP-binding protein (YPT1 protein) has been reported to function in the early stages of the secretory pathway. Particularly, YPT1 protein is observed to regulate both the endoplasmic reticulum-to-Golgi transport and the autophagy. Therefore, the YPT1 protein overexpressed in yeast vacuoles is expected to enhance antimicrobial and anticancer activity. The enhancement of yeast vacuolar activity under the overexpression of YPT1 was evaluated by the analysis of lysozyme activity, antimicrobial activity against Escherichia coli and Staphylococcus aureus, and MTT assay against HeLa cell lines. Additionally, the rise in concentration of some important proteinases inside the vacuole, such as proteinase A, proteinase B, and vacuolar carboxypeptidase Y (CPY) were also recorded using a 2DE technique. All results imply YPT1 involvement in the recruitment of some specific proteinases into vacuoles, which leads to the enhancement of vacuolar activity. Since these there proteinases belong to the CPY pathway, YPT1 is even believed to up-regulate this trafficking pathway in yeast cells. Future studies, however, should be carried out to discover the mechanisms that allow YPT1 to recruit these proteins into yeast vacuoles.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Tran le M,Bang SH,Yoon J,Kim YH,Min J

doi

10.1007/s11010-016-2670-9

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

179-86

issue

1-2

eissn

0300-8177

issn

1573-4919

pii

10.1007/s11010-016-2670-9

journal_volume

414

pub_type

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