Abstract:
OBJECTIVE:Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? METHODS:To identify possible biomarkers linking meningeal inflammation, GM damage, and disease severity, gene and protein expression were analyzed in meninges and cerebrospinal fluid (CSF) from 27 postmortem secondary progressive MS and 14 control cases. Combined cytokine/chemokine CSF profiling and 3T magnetic resonance imaging (MRI) were performed at diagnosis in 2 independent cohorts of MS patients (35 and 38 subjects) and in 26 non-MS patients. RESULTS:Increased expression of proinflammatory cytokines (IFNγ, TNF, IL2, and IL22) and molecules related to sustained B-cell activity and lymphoid-neogenesis (CXCL13, CXCL10, LTα, IL6, and IL10) was detected in the meninges and CSF of postmortem MS cases with high levels of meningeal inflammation and GM demyelination. Similar proinflammatory patterns, including increased levels of CXCL13, TNF, IFNγ, CXCL12, IL6, IL8, and IL10, together with high levels of BAFF, APRIL, LIGHT, TWEAK, sTNFR1, sCD163, MMP2, and pentraxin III, were detected in the CSF of MS patients with higher levels of GM damage at diagnosis. INTERPRETATION:A common pattern of intrathecal (meninges and CSF) inflammatory profile strongly correlates with increased cortical pathology, both at the time of diagnosis and at death. These results suggest a role for detailed CSF analysis combined with MRI as a prognostic marker for more aggressive MS. Ann Neurol 2018 Ann Neurol 2018;83:739-755.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Magliozzi R,Howell OW,Nicholas R,Cruciani C,Castellaro M,Romualdi C,Rossi S,Pitteri M,Benedetti MD,Gajofatto A,Pizzini FB,Montemezzi S,Rasia S,Capra R,Bertoldo A,Facchiano F,Monaco S,Reynolds R,Calabrese Mdoi
10.1002/ana.25197subject
Has Abstractpub_date
2018-04-01 00:00:00pages
739-755issue
4eissn
0364-5134issn
1531-8249journal_volume
83pub_type
杂志文章abstract::Mutations in AbetaPP cause deposition of Abeta amyloid fibrils in brain parenchyma and cerebral vessels, resulting in Alzheimer's disease (AD) and/or cerebral amyloid angiopathy (CAA). We report a novel mutation (L705V) within the Abeta sequence of AbetaPP in a family with autosomal dominant, recurrent intracerebral h...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20571
更新日期:2005-10-01 00:00:00
abstract::Four patients, aged 7-20 years, suffered from recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy. Using homozygosity mapping, a pathogenic missense mutation in the SLC25A19 gene that encodes the mitochondrial thiamine pyrophosph...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.21752
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journal_title:Annals of neurology
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doi:10.1002/ana.410310212
更新日期:1992-02-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410290409
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doi:10.1002/ana.23596
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abstract::We previously reported that the monoclonal antibody Alz-50 recognizes a protein (A68) with an apparent molecular weight of 68,000 daltons in the brains of patients who died with Alzheimer's disease, but not in brain tissue from individuals free of neurological disease. We now report that substantial quantities of this...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410220412
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journal_title:Annals of neurology
pub_type: 杂志文章,meta分析
doi:10.1002/ana.25342
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410120308
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abstract:OBJECTIVE:To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE). METHODS:Retrospective analysis of 44 patients with polymerase chain reaction-proven HSE for the presence of a large panel of onconeuronal and synaptic receptor antibodies. ...
journal_title:Annals of neurology
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doi:10.1002/ana.23689
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journal_title:Annals of neurology
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doi:10.1002/ana.410350306
更新日期:1994-03-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,meta分析
doi:10.1002/ana.20017
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410400515
更新日期:1996-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410320709
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.10404
更新日期:2002-12-01 00:00:00
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doi:10.1002/ana.25044
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410140506
更新日期:1983-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410160614
更新日期:1984-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20060
更新日期:2004-04-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2005-07-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.24104
更新日期:2014-03-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.10133
更新日期:2002-04-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410400320
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doi:10.1002/ana.410350716
更新日期:1994-01-01 00:00:00
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