Chronic opioid therapy as alternative treatment for post-herpetic neuralgia.

Abstract:

:Neurosurgical procedures such as the dorsal root entry zone operation, ganglionectomy, and spinal-cord stimulation have been offered to patients with intractable post-herpetic neuralgia (PHN). Poor efficacy or high morbidity have limited the overall usefulness of these procedures. We recently conducted a preliminary open-label study with long-acting oral opioids. The mean pretreatment pain score, on a scale of 0 to 10 (0 = no pain) was 9.0 +/- 0.3 (mean +/- SEM, N = 20). At two months of treatment the average pain score was 4.0 +/- 0.4 (p < 0.001, paired t test), and at six months the average pain score was 3.8 +/- 0.2 (p < 0.001, N = 16). These observations warrant a controlled opioid trial for patients affected by PHN.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Pappagallo M,Campbell JN

doi

10.1002/ana.410350716

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

S54-6

eissn

0364-5134

issn

1531-8249

journal_volume

35 Suppl

pub_type

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