Abstract:
:Alexander's law refers to the phenomenon in which the spontaneous nystagmus of a patient with a vestibular lesion is more intense when the patient looks in the quick-phase than in the slow-phase direction. Alexander's law was investigated in normal subjects as well as patients with vestibular lesions. During sinusoidal rotations of normal subjects, there was no trace of this phenomenon when subjects looked 25 degrees left and right in the dark. The phenomenon of Alexander's law is therefore created centrally and is not due to any mechanical properties of the orbit. During rotation at constant velocity in the dark, normal subjects did weakly demonstrate Alexander's law because of a mild gaze-evoked nystagmus present in normal subjects in the dark. Gaze-evoked nystagmus from a cerebellar lesion involved a pronounced demonstration of Alexander's law during rotatory nystagmus. In patients with a vestibular lesion and a mild spontaneous nystagmus in the dark that obeyed Alexander's law, the nystagmus reversed upon far gaze in the slow-phase direction. We propose that in patients with a vestibular lesion, the phenomenon of Alexander's law is created by the sum of vestibular nystagmus and an abnormally large gaze-evoked nystagmus that is consequent to the vestibular lesion. This conclusion has a number of neurological implications concerning the ways in which the nervous system attempts to compensate for vestibular lesions.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Robinson DA,Zee DS,Hain TC,Holmes A,Rosenberg LFdoi
10.1002/ana.410160614subject
Has Abstractpub_date
1984-12-01 00:00:00pages
714-22issue
6eissn
0364-5134issn
1531-8249journal_volume
16pub_type
杂志文章abstract::Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines ...
journal_title:Annals of neurology
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 临床试验,杂志文章
doi:10.1002/ana.410170405
更新日期:1985-04-01 00:00:00
abstract::The objective of this study was to assess which features of temporal lobe proton magnetic resonance spectroscopic imaging (1H-MRSI) are associated with satisfactory surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy. We studied 21 patients with intractable temporal l...
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journal_title:Annals of neurology
pub_type: 杂志文章
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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更新日期:2018-12-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:1985-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410020413
更新日期:1977-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410120408
更新日期:1982-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410210204
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:Whether intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. METHODS:We performed a systematic review and individual patient data meta-analysis of cohort studie...
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pub_type: 杂志文章,meta分析
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更新日期:2018-11-01 00:00:00
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更新日期:1983-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410350107
更新日期:1994-01-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410350522
更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410240608
更新日期:1988-12-01 00:00:00
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doi:10.1002/ana.1140
更新日期:2001-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410140610
更新日期:1983-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/1531-8249(200101)49:1<79::aid-ana11>3.0.co
更新日期:2001-01-01 00:00:00