Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.


:Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS and finds credible evidence lacking. EAE represents more a model of acute central nervous system inflammation than the counterpart of MS. We propose to reconsider the utilization of EAE, especially when this model is used to define therapy. This will also force us to examine MS without the restraints imposed by EAE, as to what it is, rather than what it looks like.


Ann Neurol


Annals of neurology


Sriram S,Steiner I





Has Abstract


2005-12-01 00:00:00












  • The role of positron emission tomography in the evaluation of seizure disorders.

    abstract::We studied patients with partial and primary generalized seizures using fluorine-18-labeled 2-fluorodeoxyglucose and positron emission tomography. Interictal studies of patients with partial seizures showed regions of focal or lateralized hypometabolism in 15 of 17 patients with unilateral electroencephalographic foci...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Theodore WH,Brooks R,Sato S,Patronas N,Margolin R,Di Chiro G,Porter RJ

    更新日期:1984-01-01 00:00:00

  • RNA-mediated neurodegeneration in repeat expansion disorders.

    abstract::Most neurodegenerative disorders are thought to result primarily from the accumulation of misfolded proteins, which interfere with protein homeostasis in neurons. For a subset of diseases, however, noncoding regions of RNAs assume a primary toxic gain-of-function, leading to degeneration in many tissues, including the...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Todd PK,Paulson HL

    更新日期:2010-03-01 00:00:00

  • Passive joint position sense after total hip replacement surgery.

    abstract::Passive joint position sense was tested in 10 subjects after unilateral total hip replacement surgery (which included capsulectomy). Varied initial limb position, amplitude, and velocity of movement were used. The unoperated side was used as a control. Statistically barely significant errors (p less than 0.025) on the...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Karanjia PN,Ferguson JH

    更新日期:1983-06-01 00:00:00

  • Levodopa induces dyskinesias in normal squirrel monkeys.

    abstract::This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Togasaki DM,Tan L,Protell P,Di Monte DA,Quik M,Langston JW

    更新日期:2001-08-01 00:00:00

  • Mitochondrial dysfunction in Parkinson's disease.

    abstract::This review discusses the etiology and pathogenesis of Parkinson's disease (PD). Mitochondrial respiratory failure and oxidative stress appear to be two major contributors to nigral neuronal death in PD. Complex I deficiency has been reported by several groups and appears to be one of the basic abnormalities responsib...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Mizuno Y,Yoshino H,Ikebe S,Hattori N,Kobayashi T,Shimoda-Matsubayashi S,Matsumine H,Kondo T

    更新日期:1998-09-01 00:00:00

  • Temporal lobectomy for uncontrolled seizures: the role of positron emission tomography.

    abstract::We evaluated the role of positron emission tomography (PET) with [18F]deoxyglucose (FDG) (FDG-PET) for planning surgery in 53 patients who had temporal lobectomy for uncontrolled seizures at National Institutes of Health from 1981 to 1990. Investigators blinded to PET data used results of telemetered video-electroence...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Theodore WH,Sato S,Kufta C,Balish MB,Bromfield EB,Leiderman DB

    更新日期:1992-12-01 00:00:00

  • Cognitive impairment in lacunar strokes: the SPS3 trial.

    abstract:OBJECTIVE:Lacunar strokes are a leading cause of cognitive impairment and vascular dementia. However, adequate characterization of cognitive impairment is lacking. The aim of this study was to estimate the prevalence and characterize the neuropsychological impairment in lacunar stroke patients. METHODS:All English-spe...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Jacova C,Pearce LA,Costello R,McClure LA,Holliday SL,Hart RG,Benavente OR

    更新日期:2012-09-01 00:00:00

  • The complex world of oligodendroglial differentiation inhibitors.

    abstract::Myelination is a central nervous system (CNS) process wherein oligodendrocyte-axon interactions lead to the establishment of myelin sheaths that stabilize, protect, and electrically insulate axons. In inflammatory demyelinating diseases such as multiple sclerosis (MS), the degeneration and eventual loss of functional ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Kremer D,Aktas O,Hartung HP,Küry P

    更新日期:2011-04-01 00:00:00

  • T118M PMP22 mutation causes partial loss of function and HNPP-like neuropathy.

    abstract:OBJECTIVE:To determine the clinical consequences of the PMP22 point mutation, T118M, which has been previously considered to either cause an autosomal recessive form of Charcot-Marie-Tooth (CMT) disease or be a benign polymorphism. METHODS:We analyzed patients from five separate kindreds and characterized their periph...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Shy ME,Scavina MT,Clark A,Krajewski KM,Li J,Kamholz J,Kolodny E,Szigeti K,Fischer RA,Saifi GM,Scherer SS,Lupski JR

    更新日期:2006-02-01 00:00:00

  • Phenotypic heterogeneity in families with the myoclonic epilepsy and ragged-red fiber disease point mutation in mitochondrial DNA.

    abstract::Two families with a point mutation in mtDNA associated with myoclonic epilepsy and ragged-red fiber disease showed pronounced clinical heterogeneity. The mothers of the two families had adult-onset myopathy with ragged-red fibers, partial deficiency of cytochrome c oxidase, and sensory neuropathy. Members of the first...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Graf WD,Sumi SM,Copass MK,Ojemann LM,Longstreth WT Jr,Shanske S,Lombes A,DiMauro S

    更新日期:1993-06-01 00:00:00

  • Long-term treatment response and fluorodopa positron emission tomographic scanning of parkinsonism in a family with dopa-responsive dystonia.

    abstract::Dopa-responsive dystonia (DRD) is one form of childhood-onset idiopathic torsion dystonia. Adult-onset parkinsonism has appeared in several previously unaffected members in families with DRD suggesting that this may be an additional phenotypical expression of the disease. We report a family with DRD in which 2 women a...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Nygaard TG,Takahashi H,Heiman GA,Snow BJ,Fahn S,Calne DB

    更新日期:1992-11-01 00:00:00

  • Neuronal migration abnormality in peroxisomal bifunctional enzyme defect.

    abstract::Patterns of brain dysgenesis that resemble those in the Zellweger syndrome were demonstrated in a boy with an isolated defect of the peroxisomal bifunctional enzyme. There was bilateral centrosylvian pachygyria and polymicrogyria, diffuse hemispheric hypomyelination with heterotopic neurons, Purkinje cell heterotopias...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kaufmann WE,Theda C,Naidu S,Watkins PA,Moser AB,Moser HW

    更新日期:1996-02-01 00:00:00

  • Syndromic parkinsonism and dementia associated with OPA1 missense mutations.

    abstract:OBJECTIVE:Mounting evidence links neurodegenerative disorders such as Parkinson disease and Alzheimer disease with mitochondrial dysfunction, and recent emphasis has focused on mitochondrial dynamics and quality control. Mitochondrial dynamics and mtDNA maintenance is another link recently emerged, implicating mutation...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Carelli V,Musumeci O,Caporali L,Zanna C,La Morgia C,Del Dotto V,Porcelli AM,Rugolo M,Valentino ML,Iommarini L,Maresca A,Barboni P,Carbonelli M,Trombetta C,Valente EM,Patergnani S,Giorgi C,Pinton P,Rizzo G,Tonon C,

    更新日期:2015-07-01 00:00:00

  • Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis.

    abstract:OBJECTIVE:This meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease. METHODS:Potentially eligible publications were those providing effect estimates of relative risk...

    journal_title:Annals of neurology

    pub_type: 杂志文章,meta分析


    authors: Psaltopoulou T,Sergentanis TN,Panagiotakos DB,Sergentanis IN,Kosti R,Scarmeas N

    更新日期:2013-10-01 00:00:00

  • Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions.

    abstract::In this postmortem study, we investigated the relationship between multiple sclerosis (MS) lesions in the hypothalamus and the state of activity of corticotropin-releasing hormone (CRH)-producing neurons that control the hypothalamus-pituitary-adrenal (HPA) axis. A high incidence (15/16) of MS lesions was found in the...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Huitinga I,Erkut ZA,van Beurden D,Swaab DF

    更新日期:2004-01-01 00:00:00

  • Chronic idiopathic anhidrosis.

    abstract::We describe the cases of eight patients with chronic idiopathic anhidrosis. These patients were heat intolerant and became hot, flushed, dizzy, dyspneic, and weak but did not sweat when the ambient temperature was high or when they exercised. Four patients had preganglionic sudomotor lesions and in the remaining 4 the...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Low PA,Fealey RD,Sheps SG,Su WP,Trautmann JC,Kuntz NL

    更新日期:1985-09-01 00:00:00

  • Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease.

    abstract:OBJECTIVE:The Veterans Administration Cooperative Studies Program #468, a multicenter study that randomized Parkinson's disease (PD) patients to either subthalamic nucleus (STN) or globus pallidus internus (GPi) deep brain stimulation (DBS), found that stimulation at either target provided similar overall motoric benef...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Katz M,Luciano MS,Carlson K,Luo P,Marks WJ Jr,Larson PS,Starr PA,Follett KA,Weaver FM,Stern MB,Reda DJ,Ostrem JL,CSP 468 study group.

    更新日期:2015-04-01 00:00:00

  • Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system.

    abstract::Acute Epstein-Barr virus (EBV) infection of the central nervous system (CNS) is associated with meningoencephalitis and other neurological syndromes and with CNS lymphomas (CNSLs). Diagnosis is based on serological studies and more recently on detection of EBV DNA in cerebrospinal fluid (CSF) by polymerase chain react...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Weinberg A,Li S,Palmer M,Tyler KL

    更新日期:2002-11-01 00:00:00

  • Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy.

    abstract:OBJECTIVE:Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEE...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Rosenthal ES,Biswal S,Zafar SF,O'Connor KL,Bechek S,Shenoy AV,Boyle EJ,Shafi MM,Gilmore EJ,Foreman BP,Gaspard N,Leslie-Mazwi TM,Rosand J,Hoch DB,Ayata C,Cash SS,Cole AJ,Patel AB,Westover MB

    更新日期:2018-05-01 00:00:00

  • Multiple sclerosis: activated cells in cerebrospinal fluid in acute exacerbations.

    abstract::Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell-surface antigens and the cell-cycle phase, we determined that the CSF lymphocytes in these patients were activated. T...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Noronha A,Richman DP,Arnason BG

    更新日期:1985-12-01 00:00:00

  • α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.

    abstract::Urinary urgency and frequency are common in α-synucleinopathies such as Parkinson disease, Lewy body dementia, and multiple system atrophy. These symptoms cannot be managed with dopamine therapy, and their underlying pathophysiology is unclear. We show that in individuals with Parkinson disease, Lewy body dementia, or...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: VanderHorst VG,Samardzic T,Saper CB,Anderson MP,Nag S,Schneider JA,Bennett DA,Buchman AS

    更新日期:2015-07-01 00:00:00

  • Epilepsy in adults.

    abstract::The past decade has seen advances in the management of patients with epilepsy. The development of practical long-term electroencephalographic techniques, with or without simultaneous video recording, has increased the accuracy of diagnosis of seizure types. The technique also provides clinicians and investigators with...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: So EL,Penry JK

    更新日期:1981-01-01 00:00:00

  • Mitochondrial abnormalities in Alzheimer brain: mechanistic implications.

    abstract::Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also occur in Alzheimer's disease (AD). The degree of clinical disability in AD correlates closely to the magnitude of the reduction in brain metabolism. Therefore, we tested whether impairments in tricarboxylic acid (TCA) cycle enz...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bubber P,Haroutunian V,Fisch G,Blass JP,Gibson GE

    更新日期:2005-05-01 00:00:00

  • Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.

    abstract::Immunohistochemical examination of 20 Down's syndrome brains, using antibodies to alpha-, beta-, and gamma-synuclein, demonstrated many alpha-synuclein-positive Lewy bodies and dystrophic neurites in 50% of amygdala samples from Down's syndrome brains with Alzheimer's disease. Similar lesions were less common in other...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Lippa CF,Schmidt ML,Lee VM,Trojanowski JQ

    更新日期:1999-03-01 00:00:00

  • Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis.

    abstract::Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic neuritis as a model of multiple sclerosis relapse to quantify axonal loss of the retinal nerve fiber layer (RNFL) and second...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Trip SA,Schlottmann PG,Jones SJ,Altmann DR,Garway-Heath DF,Thompson AJ,Plant GT,Miller DH

    更新日期:2005-09-01 00:00:00

  • In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3.

    abstract::Neurotrophic factors have been demonstrated to prevent the development of peripheral neuropathy in animal models, but the therapeutic use of these factors in human disease has been limited by the short serum half-life and dose-limiting side effects of these potent peptides. We used peripheral subcutaneous inoculation ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Chattopadhyay M,Wolfe D,Huang S,Goss J,Glorioso JC,Mata M,Fink DJ

    更新日期:2002-01-01 00:00:00

  • Effects of hypothermia on the human brainstem auditory response.

    abstract::Latency measurements between three potentials (waves I, III, and IV/V) of the human brainstem auditory response can allow early detection of certain posterior fossa lesions. The diagnostic use of these interwave latencies requires knowledge of what factors may prolong them in the absence of disease. Hypothermia appear...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Stockard JJ,Sharbrough FW,Tinker JA

    更新日期:1978-04-01 00:00:00

  • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease.

    abstract::Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases. We examined whether Alzheimer's disease (AD) is associated with increased oxidative damage to nDNA and mtDNA in postmortem brain tissue. We measured the oxidized nucleoside, 8-hydroxy-2'-deoxyguanosine (OH8dG), in DNA isola...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Mecocci P,MacGarvey U,Beal MF

    更新日期:1994-11-01 00:00:00

  • Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions.

    abstract::An inception cohort of 40 children and adolescents with traumatic brain injury and suspected diffuse axonal injury were studied using a new high-resolution magnetic resonance imaging susceptibility-weighted technique that is very sensitive for hemorrhage. A blinded comparison was performed between the extent of parenc...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Tong KA,Ashwal S,Holshouser BA,Nickerson JP,Wall CJ,Shutter LA,Osterdock RJ,Haacke EM,Kido D

    更新日期:2004-07-01 00:00:00

  • Comparative cranial CT enhancement in a primate model of cerebral infarction.

    abstract::The value of various enhancement techniques as opposed to nonenhanced CT scanning was compared in 15 baboons with cerebral infarction secondary to embolization of the left middle cerebral artery. The most prominent CT findings in infarction included an area of low absorption in the opercula--basal ganglia--centrum sem...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Drayer BP,Dujovny M,Wolfson SK Jr,Boehnke M,Cook EE,Rosenbaum AE

    更新日期:1979-01-01 00:00:00