Abstract:
:This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal movements. These dyskinesias did not merely reflect a generalized motor activation as locomotion was actually suppressed. The present data demonstrate that preexisting nigrostriatal damage is not necessary for the development of levodopa-induced dyskinesias.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Togasaki DM,Tan L,Protell P,Di Monte DA,Quik M,Langston JWdoi
10.1002/ana.1099keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
254-7issue
2eissn
0364-5134issn
1531-8249journal_volume
50pub_type
杂志文章abstract::We measured the intrinsic mechanical properties and protein content of single skinned muscle fibers obtained from patients who had Duchenne muscular dystrophy. To check for possible nonspecific changes caused by muscle disease per se, we also studied the properties of muscle fibers obtained from patients exhibiting se...
journal_title:Annals of neurology
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journal_title:Annals of neurology
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abstract::The clinical and neuropathological findings in 28 cases of paramedian thalamic and midbrain infarcts are reported. The 4 instances of unilateral paramedian thalamic infarct were characterized by mood and behavioral changes, limitation of the infarct to the center of the anatomical paramedian territory, and symmetrical...
journal_title:Annals of neurology
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更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:Metrics of diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) can detect diffuse axonal injury in traumatic brain injury (TBI). The relationship between the changes in these imaging measures and the underlying pathologies is still relatively unknown. This study investigated the radiologic...
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journal_title:Annals of neurology
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doi:10.1002/ana.22461
更新日期:2011-10-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/1531-8249(199905)45:5<583::aid-ana6>3.0.co
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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doi:
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pub_type: 临床试验,杂志文章,多中心研究
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doi:10.1002/ana.22087
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.23567
更新日期:2012-07-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.22222
更新日期:2011-05-01 00:00:00
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doi:10.1002/ana.25170
更新日期:2018-03-01 00:00:00