Abstract:
:Protein aggregation into amyloid deposits and oxidative stress are key features of many neurodegenerative disorders including Parkinson's and Alzheimer's disease. We report here the creation of four highly sensitive bifunctional fluorescent probes, capable of H2O2 and/or amyloid aggregate detection. These bifunctional sensors use a benzothiazole core for amyloid localization and boronic ester oxidation to specifically detect H2O2. We characterized the optical properties of these probes using both bulk fluorescence measurements and single-aggregate fluorescence imaging, and quantify changes in their fluorescence properties upon addition of amyloid aggregates of α-synuclein and pathophysiological H2O2 concentrations. Our results indicate these new probes will be useful to detect and monitor neurodegenerative disease.
journal_name
R Soc Open Scijournal_title
Royal Society open scienceauthors
Needham LM,Weber J,Fyfe JWB,Kabia OM,Do DT,Klimont E,Zhang Y,Rodrigues M,Dobson CM,Ghandi S,Bohndiek SE,Snaddon TN,Lee SFdoi
10.1098/rsos.171399subject
Has Abstractpub_date
2018-02-07 00:00:00pages
171399issue
2issn
2054-5703pii
rsos171399journal_volume
5pub_type
杂志文章abstract::A global response function (GRF) of an elastic network is introduced as a generalization of the response function (RF) of a rigid network, relating the average flow along the network with the pressure difference at its extremes. The GRF can be used to explore the frequency behaviour of a fluid confined in a tree-like ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.190661
更新日期:2019-09-25 00:00:00
abstract::Recognition plays an important role in the formation and organization of animal groups. Many animals are capable of class-level recognition, discriminating, for example, on the basis of species, kinship or familiarity. Individual recognition requires that animals recognize distinct cues, and learn to associate these w...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.191703
更新日期:2020-07-08 00:00:00
abstract::Selten's game is a kidnapping model where the probability of capturing the kidnapper is independent of whether the hostage has been released or executed. Most often, in view of the elevated sensitivities involved, authorities put greater effort and resources into capturing the kidnapper if the hostage has been execute...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.171484
更新日期:2017-12-06 00:00:00
abstract::Ceratopsids are among the most ubiquitous dinosaur taxa from the Late Cretaceous terrestrial formations of the Western Interior of North America, comprising two subfamilies, Chasmosaurinae and Centrosaurinae. The Two Medicine Formation of northwestern Montana has produced numerous remains of centrosaurine dinosaurs, w...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200284
更新日期:2020-04-29 00:00:00
abstract::Marine mammals and diving birds face several physiological challenges under water, affecting their thermoregulation and locomotion as well as their sensory systems. Therefore, marine mammals have modified ears for improved underwater hearing. Underwater hearing in birds has been studied in a few species, but for the r...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.191988
更新日期:2020-02-26 00:00:00
abstract::The copper-containing nitrite reductases (CuNIRs) are a class of enzymes that mediate the reduction of nitrite to nitric oxide in biological systems. Metal-ligand complexes that reproduce the salient features of the active site of CuNIRs are therefore of fundamental interest, both for elucidating the possible mode of ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170593
更新日期:2017-08-16 00:00:00
abstract::Some species of criocerine beetles have a hyper-elongated part of the intromittent organ called a flagellum. In resting position, the flagellum is stored in a specialized internal sac in the intromittent organ. This specialized state of the flagellum and internal sac is indispensable during copulation for flagellar in...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.161029
更新日期:2017-08-09 00:00:00
abstract::Frugal products possess a proper mix of features including minimal consumption of resources, good functionality under nominal conditions and low cost. Therefore, increasing use of frugal products, that are designed and also fabricated systematically, is crucial to all-round sustainable development. However, their low ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.192057
更新日期:2020-07-08 00:00:00
abstract::Mounting evidence suggests that we are experiencing rapidly accelerating global climate change. Understanding how climate change may affect life is critical to identifying species and populations that are vulnerable. Most current research focuses on investigating how organisms may respond to gradual warming, but anoth...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.171604
更新日期:2018-05-09 00:00:00
abstract::The aim of this study was to compare young and adult sprinters on several biomechanical parameters that were previously highlighted as performance-related and to determine the behaviour of several muscle-tendon units (MTU) in the first stance phase following a block start in sprint running. The ground reaction force (...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.180332
更新日期:2018-06-13 00:00:00
abstract::Animals are predicted to selectively observe and learn from the conspecifics with whom they share social connections. Yet, hardly anything is known about the role of different connections in observation and learning. To address the relationships between social connections, observation and learning, we investigated tra...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160256
更新日期:2016-07-13 00:00:00
abstract::A key challenge in the fabrication of ferromagnetically filled carbon nano-onions (CNOs) is the control of their thickness, dimensions and electric properties. Up to now literature works have mainly focused on the encapsulation of different types of ferromagnetic materials including α-Fe, Fe3C, Co, FeCo, FePd3 and oth...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170981
更新日期:2018-01-17 00:00:00
abstract::A unique organosiloxane-polyether amine (OPA) was produced and used as mesoporogen to efficiently synthesize hierarchical ZSM-5 zeolites with great mesoporosity. We have employed silica sol and tetraethylorthosilicate, respectively, to investigate the influence of different silicon sources on hierarchical zeolites in ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.181691
更新日期:2018-12-12 00:00:00
abstract::The past 5 years have witnessed claims that infants as young as six months of age understand the meaning of several words. To reach this conclusion, researchers presented infants with pairs of pictures from distinct semantic domains and observed longer looks at an object upon hearing its name as compared with the name...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.180711
更新日期:2019-09-25 00:00:00
abstract::Stochastic fluctuations in reaction-diffusion processes often have substantial effect on spatial and temporal dynamics of signal transductions in complex biological systems. One popular approach for simulating these processes is to divide the system into small spatial compartments assuming that molecules react only wi...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160485
更新日期:2016-09-14 00:00:00
abstract::In the name of meritocracy, modern economies devote increasing amounts of resources to quantifying and ranking the performance of individuals and organizations. Rankings send out powerful signals, which lead to identifying the actions of top performers as the 'best practices' that others should also adopt. However, se...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.191255
更新日期:2019-11-06 00:00:00
abstract::[This corrects the article DOI: 10.1098/rsos.181295.]. ...
journal_title:Royal Society open science
pub_type: 已发布勘误
doi:10.1098/rsos.201358
更新日期:2020-09-16 00:00:00
abstract::We show that the spin-wave spectrum in an elliptical helix has a band character. The size of the first band gap calculated using the perturbation theory is shown to scale as square root of the eccentricity. Curved magnonic waveguides of the kind considered here could be used as structural elements of future three-dime...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.172285
更新日期:2018-01-31 00:00:00
abstract::The formation mechanism of pentazolate anion (PZA) is not yet clear. In order to present the possible formation pathways of PZA, the potential energy surfaces of phenylpentazole (PPZ), phenylpentazole radical (PPZ-R), phenylpentazole radical anion (PPZ-RA), PPZ and m-chloroperbenzoic acid (m-CPBA), p-pentazolylphenola...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.172269
更新日期:2018-05-23 00:00:00
abstract::Highwall mining (HWM) technology is an efficient method for exploiting residual coal resources in Chinese open-pit coal mines. However, on-site personnel and equipment can be damaged by the instability of the highwall mining residual coal pillars and subsidence of final end-walls. This paper considers the geological c...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.181817
更新日期:2019-04-03 00:00:00
abstract::By 2040, roughly two-thirds of humanity are expected to live in urban areas. As cities expand, humans irreversibly transform natural ecosystems, creating both opportunities and challenges for wildlife. Here, we investigate how the Northern Goshawk (Accipiter gentilis) is adjusting to urban environments. We measured a ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.201356
更新日期:2020-12-23 00:00:00
abstract::Like most ectothermic vertebrates, keelback snakes (Tropidonophis mairii) do not exhibit parental care. Thus, offspring must possess an immune system capable of dealing with challenges such as pathogens, without assistance from an attendant parent. We know very little about immune system characteristics of neonatal re...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160041
更新日期:2016-03-16 00:00:00
abstract::The transition to agriculture is one of the most significant events in human prehistory; yet, explaining why people initially domesticated plants and animals remains a contentious research problem in archaeology. Two competing hypotheses dominate current debates. The first draws on niche construction theory to emphasi...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160319
更新日期:2016-08-03 00:00:00
abstract::Skeletal muscle bulges when it contracts. These three-dimensional (3D) dynamic shape changes play an important role in muscle performance by altering the range of fascicle velocities over which a muscle operates. However traditional muscle models are one-dimensional (1D) and cannot fully explain in vivo shape changes....
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.172371
更新日期:2018-05-16 00:00:00
abstract::A shift-periodic map is a one-dimensional map from the real line to itself which is periodic up to a linear translation and allowed to have singularities. It is shown that iterative sequences xn+1 = F(x n ) generated by such maps display rich dynamical behaviour. The intege...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.191423
更新日期:2019-11-27 00:00:00
abstract::We report all-atom molecular dynamics simulations of asymmetric bilayers containing phosphoinositides in the presence of monovalent and divalent cations. We have characterized the molecular mechanism by which these divalent cations interact with phosphoinositides. Ca2+ desolvates more readily, consistent with single-m...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.192208
更新日期:2020-05-20 00:00:00
abstract::Biodiversity and ecosystem functioning (BEF) research has progressed from the detection of relationships to elucidating their drivers and underlying mechanisms. In this context, replacing taxonomic predictors by trait-based measures of functional composition (FC)-bridging functions of species and of ecosystems-is a wi...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.140541
更新日期:2015-03-25 00:00:00
abstract::Giraffidae are represented by many extinct species. The only two extant taxa possess diametrically contrasting cervical morphology, as the okapi is short-necked and the giraffe is exceptionally long-necked. Samotherium major, known from the Late Miocene of Samos in Greece and other Eurasian localities, is a key extinc...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.150521
更新日期:2015-11-25 00:00:00
abstract::Numerous studies have reported impairments in perception and recognition, and, particularly, in part-integration of faces following picture-plane inversion. Whether these findings support the notion that inversion changes face processing qualitatively remains a topic of debate. To examine whether associations and diss...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.181350
更新日期:2019-01-09 00:00:00
abstract::Analyses of life history and population dynamics are essential for effective population control of wild mammals. We developed a model for the simultaneous estimation of seasonal changes in three parameters-population density, habitat preference and trap catchability of target animals-based on camera-trapping data and ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200579
更新日期:2020-08-19 00:00:00