Abstract：
OBJECTIVE/BACKGROUND:Massive changes in brain morphology and function in the first years of life reveal a postero-anterior trajectory of cortical maturation accompanied by regional modifications of NREM sleep. One of the most sensible marker of this maturation process is represented by electroencephalographic (EEG) activity within the frequency range of sleep spindles. However, direct evidence that these changes actually reflect maturational modifications of fast and slow spindles still lacks. Our study aimed at answering the following questions: 1. Do cortical changes at 11.50 Hz frequency correspond to slow spindles? 2. Do fast and slow spindles show different age trajectories and different topographical distributions? 3. Do changes in peak frequency explain age changes of slow and fast spindles? PATIENTS/METHODS:We measured the antero-posterior changes of slow and fast spindles in the first 60 min of nightly sleep of 39 infants and children (0-48 mo.). RESULTS:We found that (A) changes of slow spindles from birth to childhood mostly affect frontal areas (B) variations of fast and slow spindles across age groups go in opposite direction, the latter progressively increasing across ages; (C) this process is not merely reducible to changes of spindle frequency. CONCLUSIONS:As a main finding, our cross-sectional study shows that the first form of mature spindle (i.e., corresponding to the adult phasic event of NREM sleep) is marked by the emergence of slow spindles on anterior regions around the age of 12 months.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
D'Atri A,Novelli L,Ferrara M,Bruni O,De Gennaro Ldoi
10.1016/j.sleep.2017.11.1138subject
Has Abstractpub_date
2018-02-01 00:00:00pages
73-82eissn
1389-9457issn
1878-5506pii
S1389-9457(17)31583-6journal_volume
42pub_type
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