Abstract:
AIM:To describe the cerebral blood flow velocity pattern and investigate cerebral autoregulation using transcranial Doppler ultrasonography (TCD) following a global hypoxic-ischaemic (HI) event in children. METHODS:This was a prospective, observational study in a quaternary-level paediatric intensive care unit. Intubated children, newborn to 17 years admitted to the PICU following HI injury (asphyxia, drowning, cardiac arrest) were eligible for inclusion. TCD was performed daily until post-injury day 8, discharge, or death, whichever occurred earliest. RESULTS:Twenty-six patients were enrolled. Median age was 3 years (0.33, 11.75), initial pH 6.95, and initial lactate 5.4. Median post-resuscitation Glasgow Coma Score was 3T. Across the entire cohort, cerebral blood flow velocity (CBFV) was near normal on day 1. Flow velocity increased to a maximum median value of 1.4 standard deviations above normal on day 3 and slowly downtrended back to baseline by the end of the study period. Median Paediatric Extended Version of the Glasgow Outcome Score was 4 at three months. No patient in the favourable outcome group had extreme CBFV on day one, and only one patient in the favourable group had extreme CBFV on PID 2. In contrast, 38% of patients in the unfavourable group had extreme CBFV on PID 1 (p=.039 compared to frequency in favourable group), and 55% had extreme CBFV on PID 2 (p = .023 compared to frequency in favourable group). No patient had consistently intact cerebral autoregulation throughout the study period. CONCLUSIONS:Following a HI event, patients with favourable neurologic outcomes had flow velocity near normal whereas unfavourable outcomes had more extreme flow velocity. Intermittently intact cerebral autoregulation was more frequently seen in those with favourable neurologic outcomes though return to the autoregulatory baseline appears delayed.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Lovett ME,Maa T,Chung MG,O'Brien NFdoi
10.1016/j.resuscitation.2018.02.005subject
Has Abstractpub_date
2018-05-01 00:00:00pages
191-196eissn
0300-9572issn
1873-1570pii
S0300-9572(18)30071-6journal_volume
126pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract::In order to investigate the acute effects on lung morphology, lung function, hemodynamic and blood coagulation system, elastase (330 units (U) kg-1 h-1) was continuously infused into 16 anesthetized and mechanically ventilated minipigs. Elastase infusion induced a disturbance of blood coagulation leading to hypocoagul...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(86)90007-9
更新日期:1986-09-01 00:00:00
abstract:INTRODUCTION:Implementing prehospital advanced life support (ALS) services requires more medical and societal resources in training and equipment. The actual demand for ALS services in our communities was not clear. To ensure good use of expensive resources, it is important to evaluate the demand and appropriateness of...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2006.03.016
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The quality of life support delivered during cardiopulmonary resuscitation affects outcomes. However, little data exist regarding the quality of resuscitation delivered to children and factors associated with adherence to American Heart Association (AHA) resuscitation guidelines. PARTICIPANTS:Pediatric resi...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2009.03.020
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Postresuscitation myocardial dysfunction (PRMD) can develop after successful resuscitation from cardiac arrest. However, echocardiographic patterns of PRMD remain unknown. This study aimed to investigate PRMD manifestations with serial echocardiography during the post-cardiac arrest period. METHODS:We enrol...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.01.019
更新日期:2018-03-01 00:00:00
abstract:AIM:Emergency cardiopulmonary bypass (E-CPB) is an advanced and rarely used procedure for patients in cardiac arrest that do not regain restoration of spontaneous circulation with standard resuscitation methods. The feasibility, safety and outcome of the intervention with E-CPB in cardiac arrest situations at our depar...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.05.029
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Electroencephalogram (EEG) background reactivity is a potentially interesting outcome predictor in comatose patients, especially after cardiac arrest, but recent studies report only fair interrater reliability. Furthermore, there are no definite guidelines for its testing. We therefore investigated the EEG...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.09.380
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The merit of rapid response systems (RRSs) remains controversial. A tailored approach to specific groups may increase the efficacy of these teams. The purpose of this study was to compare differences in triggers for RRS activation, interventions, and outcomes in patients on medical and surgical services. ME...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2010.12.005
更新日期:2011-04-01 00:00:00
abstract::The endotracheal route for drug administration provides a rapid means of accessing the systemic circulation when intravenous routes cannot be established in emergent situations. This route is relatively free of significant complications and has been documented as being successful numerous times in various clinical set...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(84)90001-7
更新日期:1984-11-01 00:00:00
abstract:STUDY AIM:Videoconferencing technology may be useful for providing Pediatric Advanced Life Support (PALS) re-training to geographically isolated providers. Yet, it is unclear whether learning outcomes will be similar to those obtained with traditional, face-to-face instruction. This study assess whether PALS re-trainin...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2008.05.008
更新日期:2008-10-01 00:00:00
abstract:AIMS:Out of Hospital Cardiac Arrest (OHCA) is frequently attributed to coronary artery disease, thus guidelines recommend coronary angiography (CAG) for survivors of OHCA. However, the real-world application of these guidelines is unknown, and we sought to evaluate CAG practices in the contemporary OHCA population. ME...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.10.007
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Survival following out-of-hospital cardiac arrest (OHCA) continues to be disappointingly low world-wide, despite advances in technology and international guidelines for resuscitation. Few cities or emergency medical service (EMS) agencies report patient outcomes after OHCA. Among those who do, survival from w...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2009.07.019
更新日期:2009-11-01 00:00:00
abstract:AIM:To mimic chest compression during cardiopulmonary resuscitation (CPR), this study aimed to produce time-resolved 3D (volumetric) reformats of thoracic and upper abdominal tissue movement during incremental closed chest compression/decompression from 0 to 8 to 0 cm. METHODS:Sequential angiography enhanced computed ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.05.037
更新日期:2020-08-01 00:00:00
abstract:REVIEW:The interval between collapse and emergency call influences the prognosis of out-of-hospital cardiac arrest (OHCA). To reduce the interval, it is essential to identify the causes of delay. METHODS:Basal data were collected prospectively by fire departments from 3746 OHCAs witnessed or recognised by citizens and...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2010.05.022
更新日期:2010-11-01 00:00:00
abstract:AIM:To assess the experience, knowledge and attitudes of local primary health-care doctors towards resuscitation in out-of-hospital cardiac arrest. METHODS:We conducted a survey of general practitioners (GPs) working in both private and public sectors. The survey consisted of 29 questions and was self-administered. R...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2004.11.021
更新日期:2005-05-01 00:00:00
abstract:AIM:Survival after out-of-hospital cardiac arrest (OHCA) has tripled during the past decade in Denmark as a likely result of improvements in cardiac arrest management. This study analyzed whether these improvements were applicable for patients with chronic obstructive pulmonary disease (COPD). METHODS:Patients ≥18 yea...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2016.04.017
更新日期:2016-07-01 00:00:00
abstract:AIM:The LUCAS™ device has been shown to improve organ perfusion during cardiac arrest in experimental studies. In this pilot study the aim was to compare short-term survival between cardiopulmonary resuscitation (CPR) performed with mechanical chest compressions using the LUCAS™ device and CPR performed with manual che...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2011.01.032
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Physiologic monitoring of resuscitative efforts during cardiac arrest is gaining in importance, as it provides a real-time window into the cellular physiology of patients. The aim of this review is to assess the quality of evidence surrounding the use of physiologic monitoring to guide cardiopulmon...
journal_title:Resuscitation
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.resuscitation.2016.01.025
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective, single-center, observational study was to investigate the accuracy of modeling and reproduction of human anatomical dimensions in manikins by comparing radiographic upper airway measurements of 13 different models with humans. METHODS:13 commonly used airway manikins (male or fem...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.05.001
更新日期:2015-07-01 00:00:00
abstract:AIM:Cardiopulmonary resuscitation (CPR) guidelines recommend specific chest compression (CC) target depths for children. We quantitatively describe relative anterior-posterior diameter (APD) depth, actual depth, and force of CCs during real CPR events in children. METHODS:CC depth and force were recorded during real C...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.10.014
更新日期:2012-03-01 00:00:00
abstract::This study was undertaken to determine if checking for a pulse between initial defibrillations causes a clinically significant delay in the administration of the defibrillations. Ten emergency department nurses and 10 emergency medicine resident physicians were timed delivering three successive defibrillations (200, 3...
journal_title:Resuscitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0300-9572(96)01043-x
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Mathematical optimisation models have recently been applied to identify ideal Automatic External Defibrillator (AED) locations that maximise coverage of Out of Hospital Cardiac Arrest (OHCA). However, these fixed location models cannot relocate existing AEDs in a flexible way, and have nearly exclusively bee...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.01.055
更新日期:2018-04-01 00:00:00
abstract::Myocardial perfusion pressure, defined as the aortic diastolic pressure minus the right atrial diastolic pressure, correlates with coronary blood flow during cardiopulmonary resuscitation (CPR) and predicts initial resuscitation success. Whether this hemodynamic parameter can predict 24-h survival is not known. We exa...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(88)90111-6
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Pre-shock pause duration of <20s is associated with improved survival after cardiac arrest. Manual mode defibrillation has been associated with the shortest duration of pre-shock pause but is largely practiced by advanced life support paramedics (ALS) whereas defibrillator only paramedics (basic life support...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.02.022
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To validate an existing theoretical model for the mechanics of chest compression (CC) during constant peak force cardiopulmonary resuscitation (CPR) using experimental human and manikin CC data from the literature. Also, to gain insights into the clinical application of force guided CPR. METHODS:The experim...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.11.027
更新日期:2013-06-01 00:00:00
abstract:AIMS OF THE STUDY:Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) an...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.04.012
更新日期:2019-06-01 00:00:00
abstract::Cardiopulmonary homeostasis for the high risk surgical patient is dependent on invasive monitoring techniques which are designed to allow for the early detection of physiological dysfunction during the development stages. One must maintain both minimum and maximum predetermined cardiorespiratory values by the early ut...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(84)90014-5
更新日期:1984-03-01 00:00:00
abstract::"Bystanders" or lay persons are typically the first caregivers to attend to a victim of out-of-hospital cardiopulmonary arrest. Astronaut crew medical officers (CMO) play a similar role to bystanders aboard the International Space Station (ISS). Studies have demonstrated the importance of bystander cardiopulmonary res...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2006.07.027
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Efficient trials of interventions for patients with out-of-hospital cardiac arrest (OHCA) should have adequate but not excess power to detect a difference in outcomes. The minimum clinically important difference (MCID) is the threshold value in outcomes observed in a trial at which providers should choose to...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2016.08.004
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Health-related quality of life (HRQoL) has been reported for out-hospital (OHCA) and in-hospital cardiac arrest (IHCA) separately, but potential differences between the two groups are unknown. The aim of this study is therefore to describe and compare HRQoL in patients surviving OHCA and IHCA. METHODS:Patie...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.04.002
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The relationship between duration of cardiopulmonary resuscitation (CPR) and post-arrest outcomes based on severity stratification in out-of-hospital cardiac arrest (OHCA) patients without prehospital return of spontaneous circulation (ROSC) remains unclear. METHODS:We analysed 420,959 adult patients withou...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.01.008
更新日期:2018-03-01 00:00:00