c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.

abstract：:Although increasing evidence indicated that deregulation of microRNAs (miRNAs) contributed to tumor initiation and progression, but little is known about the biological role of miR-340 in ovarian cancer (OC). In this study, we found that miR-340 expression was downregulated in OC tissues compared with its expression i...

journal_title：Cell death & disease

authors： Huang Z,Li Q,Luo K,Zhang Q,Geng J,Zhou X,Xu Y,Qian M,Zhang JA,Ji L,Wu J

更新日期：2019-05-08 00:00:00

abstract：:Paired-box 6 (PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it is also expressed in several types of tumors and has an oncogenic role. However, little is known about its role in non-small cell lung cancer (NSCLC). ...

journal_title：Cell death & disease

authors： Wu DM,Zhang T,Liu YB,Deng SH,Han R,Liu T,Li J,Xu Y

更新日期：2019-04-25 00:00:00

abstract：:Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical tr...

journal_title：Cell death & disease

authors： Bittner S,Knoll G,Ehrenschwender M

更新日期：2017-08-03 00:00:00

abstract：:Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...

journal_title：Cell death & disease

authors： Li TT,Jia LX,Zhang WM,Li XY,Zhang J,Li YL,Li HH,Qi YF,Du J

更新日期：2016-06-09 00:00:00

abstract：:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy a...

journal_title：Cell death & disease

authors： Liu B,Wen X,Cheng Y

更新日期：2013-10-31 00:00:00

abstract：:The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) ...

journal_title：Cell death & disease

authors： Li M,Hou T,Gao T,Lu X,Yang Q,Zhu Q,Li Z,Liu C,Mu G,Liu G,Bao Y,Wen H,Wang L,Wang H,Zhao Y,Gu W,Yang Y,Zhu WG

更新日期：2018-09-20 00:00:00

abstract：:Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA is related to GC. In this study, 11 miRNAs in the exosomes and six lncRNAs in the tissues was examined by qRT-PCR. Correlation analysis was used to analyze the relationship between miRNAs in exosome and lncRNAs in the tissues. Four miRNAs ...

journal_title：Cell death & disease

authors： Zhang J,Qiu WQ,Zhu H,Liu H,Sun JH,Chen Y,Shen H,Qian CL,Shen ZY

更新日期：2020-09-19 00:00:00

abstract：:Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...

journal_title：Cell death & disease

authors： Kelk P,Abd H,Claesson R,Sandström G,Sjöstedt A,Johansson A

更新日期：2011-03-10 00:00:00

abstract：:NRLP3 inflammasome is a protein complex involved in the maturation of IL1β. In the onset of type 1 diabetes as well as in islet transplantation, IL-1β is one of the cytokines involved in the recruitment of immune cells in islets and eventually in islet destruction. Whether IL-1β is produced by islet cells is still und...

journal_title：Cell death & disease

authors： Lebreton F,Berishvili E,Parnaud G,Rouget C,Bosco D,Berney T,Lavallard V

更新日期：2018-06-25 00:00:00

abstract：:Menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor that leads to multiple endocrine tumors upon loss of its function. Menin functions as a transcriptional activator by tethering MLL complex to mediate histone H3 K4 methylation. It also functions as a repressor. However, the mo...

journal_title：Cell death & disease

authors： Yang YJ,Song TY,Park J,Lee J,Lim J,Jang H,Kim YN,Yang JH,Song Y,Choi A,Lee HY,Jo CH,Han JW,Kim ST,Youn HD,Cho EJ

更新日期：2013-04-11 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

journal_title：Cell death & disease

authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

更新日期：2020-10-22 00:00:00

abstract：:Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improv...

journal_title：Cell death & disease

authors： Yadav SK,Kambis TN,Kar S,Park SY,Mishra PK

更新日期：2020-03-13 00:00:00

abstract：:Mediators produced by the airway epithelium control the activation, recruitment, and survival of pulmonary dendritic cells (DC) that present antigen to CD4(+) T cells during the genesis and exacerbation of allergic asthma. The epithelial-derived acute phase protein, serum amyloid A (SAA), induces DC maturation and TH1...

journal_title：Cell death & disease

authors： Ather JL,Fortner KA,Budd RC,Anathy V,Poynter ME

更新日期：2013-09-05 00:00:00

abstract：:Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character in pancreatic cancer remains unclear. The expression of HJURP was assessed in PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient...

journal_title：Cell death & disease

authors： Wang CJ,Li X,Shi P,Ding HY,Liu YP,Li T,Lin PP,Wang YS,Zhang GQ,Cao Y

更新日期：2020-05-21 00:00:00

abstract：:Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...

journal_title：Cell death & disease

authors： Li T,Zhao H,Han X,Yao J,Zhang L,Guo Y,Shao Z,Jin Y,Lai D

更新日期：2017-10-26 00:00:00

abstract：:Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...

journal_title：Cell death & disease

authors： Kong Y,Zhao X,Qiu M,Lin Y,Feng P,Li S,Liang B,Zhu Q,Huang H,Li C,Wang W

更新日期：2021-01-21 00:00:00

abstract：:Mucin is an important physical barrier against enteric pathogens. VvpE is an elastase encoded by Gram-negative bacterium Vibrio vulnificus; however, the functional role of VvpE in intestinal mucin (Muc) production is yet to be elucidated. The recombinant protein (r) VvpE significantly reduced the level of Muc2 in huma...

journal_title：Cell death & disease

authors： Lee SJ,Jung YH,Oh SY,Jang KK,Lee HS,Choi SH,Han HJ

更新日期：2015-06-18 00:00:00

abstract：:Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has ...

journal_title：Cell death & disease

authors： Vasileva EA,Shuvalov OU,Garabadgiu AV,Melino G,Barlev NA

更新日期：2015-07-23 00:00:00

abstract：:Malignant gliomas, the most common solid tumors in the central nervous system, are essentially incurable due to their rapid growth and very invasive nature. One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic ar...

journal_title：Cell death & disease

authors： Su Z,Zang T,Liu ML,Wang LL,Niu W,Zhang CL

更新日期：2014-10-16 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role of 15-LO-1 in osteoarthritis (OA). The levels of 15-LO-1 expression were measured by western blotting and quantitative real-time PCR in articular cartilage from the OA rat models and OA...

journal_title：Cell death & disease

authors： Chen K,Yan Y,Li C,Yuan J,Wang F,Huang P,Qian N,Qi J,Zhou H,Zhou Q,Deng L,He C,Guo L

更新日期：2017-10-12 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, whi...

journal_title：Cell death & disease

authors： Yang L,Chao J,Kook YH,Gao Y,Yao H,Buch SJ

更新日期：2013-12-12 00:00:00

abstract：:Met, the tyrosine kinase receptor for hepatocyte growth factor (HGF), mainly activates prosurvival pathways, including protection from apoptosis. In this work, we investigated the cardioprotective mechanisms of Met activation by agonist monoclonal antibodies (mAbs). Cobalt chloride (CoCl2), a chemical mimetic of hypox...

journal_title：Cell death & disease

authors： Gallo S,Gatti S,Sala V,Albano R,Costelli P,Casanova E,Comoglio PM,Crepaldi T

更新日期：2014-04-17 00:00:00

abstract：:Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast canc...

journal_title：Cell death & disease

authors： Wang Q,Mo J,Zhao C,Huang K,Feng M,He W,Wang J,Chen S,Xie Z,Ma J,Fan S

更新日期：2018-03-07 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with very poor prognosis. Therefore, it is important to fully understand the molecular mechanism underlying its occurrence and development. Pumilio RNA-binding family member 1 (PUM1) has been reported to function as an oncogene in ovarian cancer and nonsmall...

journal_title：Cell death & disease

authors： Dai H,Shen K,Yang Y,Su X,Luo Y,Jiang Y,Shuai L,Zheng P,Chen Z,Bie P

更新日期：2019-08-08 00:00:00

abstract：:Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...

journal_title：Cell death & disease

authors： Wassermann-Dozorets R,Rubinstein M

更新日期：2017-04-06 00:00:00

abstract：:Hypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause of heart failure and mortality. Our previous studies found that heat shock factor 1 (HSF1) protected cardiomyo...

journal_title：Cell death & disease

authors： Huang CY,Pai PY,Kuo CH,Ho TJ,Lin JY,Lin DY,Tsai FJ,Padma VV,Kuo WW,Huang CY

更新日期：2017-08-10 00:00:00

abstract：:Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism and hepatic steatosis. We aimed to analyze the consequences of hepatocyte-specific Cav1 knockout under healthy conditions and upon non-alcoholic fatty liver di...

journal_title：Cell death & disease

authors： Han M,Piorońska W,Wang S,Nwosu ZC,Sticht C,Wang S,Gao Y,Ebert MP,Dooley S,Meyer C

更新日期：2020-02-06 00:00:00

abstract：:Apoptotic cysteine-aspartate proteases (caspases) are essential for the progression and execution of apoptosis, and detection of caspase fragmentation or activity is often used as markers of apoptosis. Cisplatin (cis-diamminedichloroplatinum (II)) is a chemotherapeutic drug that is clinically used for the treatment of...

journal_title：Cell death & disease

authors： Janson V,Johansson A,Grankvist K

更新日期：2010-09-23 00:00:00