当前位置： SCI文献检索 > Cell Death & Disease期刊下所有文献 > Reprogramming the fate of human glioma cells to impede brain tumor development.

Reprogramming the fate of human glioma cells to impede brain tumor development.

Abstract：

:Malignant gliomas, the most common solid tumors in the central nervous system, are essentially incurable due to their rapid growth and very invasive nature. One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic arrest. Here, we show that neurogenin 2 (NGN2, also known as NEUROG2) synergizes with sex-determining region Y-box 11 (SOX11) to very efficiently convert human glioma cells to terminally differentiated neuron-like cells in both cell culture and adult mouse brains. These cells exhibit neuronal morphology, marker expression, and electrophysiological properties. The conversion process is accompanied by cell cycle exit, which dramatically inhibits glioma cell proliferation and tumor development after orthotopic transplantation. Most importantly, intracranial injection of NGN2- and SOX11-expressing virus into the tumor mass also curtails glioma growth and significantly improves survival of tumor-bearing mice. Taken together, this study shows a simple and highly efficient strategy for reprogramming malignant glioma cells into postmitotic cells, which might be a promising therapeutic approach for brain tumors.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Su Z,Zang T,Liu ML,Wang LL,Niu W,Zhang CL

doi

10.1038/cddis.2014.425

subject

Has Abstract

pub_date

2014-10-16 00:00:00

pages

e1463

issn

2041-4889

pii

cddis2014425

journal_volume

5

pub_type

杂志文章

相关文献

Cell Death & Disease文献大全
  • Contribution of TMEM16F to pyroptotic cell death.

    abstract：:Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0373-8

    authors： Ousingsawat J,Wanitchakool P,Schreiber R,Kunzelmann K

    更新日期：2018-02-20 00:00:00

  • cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

    abstract：:The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas Bcl-xL inhibits por...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.34

    authors： Bleicken S,Hofhaus G,Ugarte-Uribe B,Schröder R,García-Sáez AJ

    更新日期：2016-02-25 00:00:00

  • miR-322/-503 rescues myoblast defects in myotonic dystrophy type 1 cell model by targeting CUG repeats.

    abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03112-6

    authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

    更新日期：2020-10-22 00:00:00

  • Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.

    abstract：:Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities, however, little is known regarding the effects of RSV on mtROS homeostasis in en...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2014.530

    authors： Zhou X,Chen M,Zeng X,Yang J,Deng H,Yi L,Mi MT

    更新日期：2014-12-18 00:00:00

  • Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152.

    abstract：:Glioblastomas (GBMs) are the most aggressive primary brain tumors in adult and remain a therapeutic challenge. Targeting key apoptosis regulators with the ultimate aim to restore apoptosis in tumor cells could be an interesting therapeutic strategy. The inhibitors of apoptosis proteins (IAPs) are regulators of cell de...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.214

    authors： Tchoghandjian A,Soubéran A,Tabouret E,Colin C,Denicolaï E,Jiguet-Jiglaire C,El-Battari A,Villard C,Baeza-Kallee N,Figarella-Branger D

    更新日期：2016-08-04 00:00:00

  • Release and activity of histone in diseases.

    abstract：:Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous histones to animals leads to ...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2014.337

    authors： Chen R,Kang R,Fan XG,Tang D

    更新日期：2014-08-14 00:00:00

  • Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.

    abstract：:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133(pos) and...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2012.93

    authors： Akunuru S,James Zhai Q,Zheng Y

    更新日期：2012-07-19 00:00:00

  • Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents.

    abstract：:Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies. Small-molecule inhibitors of the bromodomain and extra terminal domain (BET) family such as JQ1, I-BET762 and OTX-015 are active in a wide range of different cancer types...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.271

    authors： Klingbeil O,Lesche R,Gelato KA,Haendler B,Lejeune P

    更新日期：2016-09-08 00:00:00

  • The role of autophagy in asparaginase-induced immune suppression of macrophages.

    abstract：:Erwinia asparaginase, a bacteria-derived enzyme drug, has been used in the treatment of various cancers, especially acute lymphoblastic leukemia (ALL). One of the most significant side effects associated with asparaginase administration is immune suppression, which limits its application in clinic. Macrophages are pha...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.144

    authors： Song P,Wang Z,Zhang X,Fan J,Li Y,Chen Q,Wang S,Liu P,Luan J,Ye L,Ju D

    更新日期：2017-03-30 00:00:00

  • Resistance to caspase-8 and -9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance.

    abstract：:Apoptotic cysteine-aspartate proteases (caspases) are essential for the progression and execution of apoptosis, and detection of caspase fragmentation or activity is often used as markers of apoptosis. Cisplatin (cis-diamminedichloroplatinum (II)) is a chemotherapeutic drug that is clinically used for the treatment of...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2010.54

    authors： Janson V,Johansson A,Grankvist K

    更新日期：2010-09-23 00:00:00

  • Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification.

    abstract：:The most common complication after cataract surgery is postoperative capsular opacification, which includes anterior capsular opacification (ACO) and posterior capsular opacification (PCO). Increased adhesion of lens epithelial cells (LECs) to the intraocular lens material surface promotes ACO formation, whereas proli...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.315

    authors： Qin Y,Zhu Y,Luo F,Chen C,Chen X,Wu M

    更新日期：2017-07-13 00:00:00

  • Dissecting cell diversity and connectivity in skeletal muscle for myogenesis.

    abstract：:Characterized by their slow adhering property, skeletal muscle myogenic progenitor cells (MPCs) have been widely utilized in skeletal muscle tissue engineering for muscle regeneration, but with limited efficacy. Skeletal muscle regeneration is regulated by various cell types, including a large number of rapidly adheri...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1647-5

    authors： Liu YX,Wu BB,Gong L,An CR,Lin JX,Li QK,Jiang DM,Jin KX,Mechakra A,Bunpetch V,Li Y,Zou YW,Ouyang HW,Zou XH

    更新日期：2019-06-03 00:00:00

  • The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells.

    abstract：:Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population within the tumor-driving therapy resistance and recurrence. While temozolomide (TMZ), an alkylating agent, constitutes the first-line chemother...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1477-5

    authors： Mazor G,Levin L,Picard D,Ahmadov U,Carén H,Borkhardt A,Reifenberger G,Leprivier G,Remke M,Rotblat B

    更新日期：2019-03-13 00:00:00

  • m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.

    abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1417-4

    authors： Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

    更新日期：2019-02-20 00:00:00

  • The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia.

    abstract：:Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA1). Additionally, a...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02743-z

    authors： Ninoyu Y,Sakaguchi H,Lin C,Suzuki T,Hirano S,Hisa Y,Saito N,Ueyama T

    更新日期：2020-07-16 00:00:00

  • The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis.

    abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0040-5

    authors： Gao Y,Ge W

    更新日期：2018-01-18 00:00:00

  • lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling.

    abstract：:Hepatocellular carcinoma is the sixth most common cancer and gives rise to numerous deaths around the world every year. However, the molecular mechanism that controls hepatocarcinogenesis remains largely unknown. Here we found out an uncharacterized long noncoding RNA named lncAKHE. We found that lncAKHE was highly ex...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0554-5

    authors： Huang G,Jiang H,Lin Y,Wu Y,Cai W,Shi B,Luo Y,Jian Z,Zhou X

    更新日期：2018-05-01 00:00:00

  • Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7.

    abstract：:Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs and PTK7 in cancers. In this study, we showed that PTK7 was significantly correlated with the Wnt/β-Catenin pathway and aggressive cli...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1116-6

    authors： Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

    更新日期：2018-10-22 00:00:00

  • Heme oxygenase-1 protects against Alzheimer's amyloid-β(1-42)-induced toxicity via carbon monoxide production.

    abstract：:Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer's disease, catabolises heme to biliverdin, Fe2+ and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K+ efflux as an early step in the apoptotic cascade. Sin...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2014.529

    authors： Hettiarachchi N,Dallas M,Al-Owais M,Griffiths H,Hooper N,Scragg J,Boyle J,Peers C

    更新日期：2014-12-11 00:00:00

  • NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells.

    abstract：:Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of glioma...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1149-x

    authors： Fan Z,Zheng J,Xue Y,Liu X,Wang D,Yang C,Ma J,Liu L,Ruan X,Wang Z,Liu Y

    更新日期：2018-12-05 00:00:00

  • MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway.

    abstract：:Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite cells (SSCs) drive skeletal muscle regeneration. Increased autophagy can reduce the proliferative capacity of SS...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02756-8

    authors： Song KY,Guo XM,Wang HQ,Zhang L,Huang SY,Huo YC,Zhang G,Feng JZ,Zhang RR,Ma Y,Hu QZ,Qin XY

    更新日期：2020-07-18 00:00:00

  • Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development.

    abstract：:Transient receptor potential vanilloid type 4 (TRPV4) is a Ca2+-permeable cation channel that is known to be an osmosensor and thermosensor. Currently, limited evidence shows that TRPV4 plays opposite roles in either promoting or inhibiting cancer development in different cancer types. Furthermore, the precise biologi...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1700-4

    authors： Liu X,Zhang P,Xie C,Sham KWY,Ng SSM,Chen Y,Cheng CHK

    更新日期：2019-06-12 00:00:00

  • PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor.

    abstract：:Nilotinib is a second-generation tyrosine kinase inhibitor, designed to specifically inhibit break-point cluster region (BCR)-Abelson (ABL) and developed to treat chronic myeloid leukemia (CML) in patients showing a resistance to imatinib. We previously demonstrated that nilotinib-induced apoptosis was reduced by stem...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2013.309

    authors： Airiau K,Mahon FX,Josselin M,Jeanneteau M,Belloc F

    更新日期：2013-10-03 00:00:00

  • Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity.

    abstract：:The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0677-8

    authors： Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

    更新日期：2018-05-23 00:00:00

  • Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity.

    abstract：:Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular target of GCs are monocytes/macrophages. The role of GCs in monocyte survival is also debated. Although both granulocyte macrophage-colony stimulating factor (GM-CSF) and macrophage-CSF (M-...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0332-4

    authors： Achuthan A,Aslam ASM,Nguyen Q,Lam PY,Fleetwood AJ,Frye AT,Louis C,Lee MC,Smith JE,Cook AD,Olshansky M,Turner SJ,Hamilton JA

    更新日期：2018-02-15 00:00:00

  • Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.

    abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03074-9

    authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

    更新日期：2020-10-14 00:00:00

  • Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells.

    abstract：:Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell deat...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-2081-4

    authors： Kleih M,Böpple K,Dong M,Gaißler A,Heine S,Olayioye MA,Aulitzky WE,Essmann F

    更新日期：2019-11-07 00:00:00

  • SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.

    abstract：:The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed SOX12 expression patterns in two independent CRC cohorts (cohort I, n = 3...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1481-9

    authors： Du F,Chen J,Liu H,Cai Y,Cao T,Han W,Yi X,Qian M,Tian D,Nie Y,Wu K,Fan D,Xia L

    更新日期：2019-03-11 00:00:00

  • Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.

    abstract：:Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of Leydig cells expose...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1728-5

    authors： Li MY,Zhu XL,Zhao BX,Shi L,Wang W,Hu W,Qin SL,Chen BH,Zhou PH,Qiu B,Gao Y,Liu BL

    更新日期：2019-06-20 00:00:00

  • Alterations of specific chromatin conformation affect ATRA-induced leukemia cell differentiation.

    abstract：:Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chrom...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0173-6

    authors： Li Y,He Y,Liang Z,Wang Y,Chen F,Djekidel MN,Li G,Zhang X,Xiang S,Wang Z,Gao J,Zhang MQ,Chen Y

    更新日期：2018-02-08 00:00:00