Designing a randomized controlled trial to evaluate a community-based narrative intervention for improving colorectal cancer screening for African Americans.

abstract：:Foundational elements of lifelong health are formed during the preschool years. Child care attendance has nearly doubled in the past 5 years making child care centers an ideal setting to establish healthy habits that prevent pediatric obesity. Despite the promising evidence of efficacy of child care-based obesity prev...

journal_title：Contemporary clinical trials

authors： Armstrong B,Trude ACB,Johnson C,Castelo RJ,Zemanick A,Haber-Sage S,Arbaiza R,Black MM

更新日期：2019-11-01 00:00:00

abstract：:Modified Zelen's approach is a randomization technique useful in multi-center trials where balance in treatment assignments within a center is desired. It has great balancing properties in a study with equal allocation to several treatment arms. This technique can also be used in studies with unequal allocation, where...

journal_title：Contemporary clinical trials

authors： Kuznetsova OM,Tymofyeyev Y

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:In the past 20-30 years, the prevalence of atopic diseases, particularly among children in the Western world, has increased. It has been suggested that Western lifestyle may have reduced the overall exposure to microbial stimulation early in life. The role of the gut flora in this connection has been studied...

journal_title：Contemporary clinical trials

authors： Øien T,Storrø O,Johnsen R

更新日期：2006-08-01 00:00:00

abstract：INTRODUCTION:Focal therapy offers the possibility of cancer control, without the side effect profile of radical therapies. Early single centre prospective development studies using high intensity focused ultrasound (HIFU) have demonstrated encouraging genitourinary functional preservation and short-term cancer control....

journal_title：Contemporary clinical trials

authors： Dickinson L,Ahmed HU,Kirkham AP,Allen C,Freeman A,Barber J,Hindley RG,Leslie T,Ogden C,Persad R,Winkler MH,Emberton M,INDEX Study Group.

更新日期：2013-09-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is a highly prevalent condition in aging men, which can be progressive and lead to acute urinary retention (AUR) and the need for surgery. It is commonly treated with alpha-blockers and 5alpha-reductase inhibitors (5ARIs), both of which improve the symptoms of BPH. Long-term treatmen...

journal_title：Contemporary clinical trials

authors： Siami P,Roehrborn CG,Barkin J,Damiao R,Wyczolkowski M,Duggan A,Major-Walker K,Morrill BB,CombAT study group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:The aims of the study protocol are to investigate different adapted physical training programs in patients with advanced lung cancer undergoing palliative chemo- or radiotherapy and to evaluate their effects on physical performance, quality of life, symptom burden, and efficacy of oncologic treatment. METHODS:...

journal_title：Contemporary clinical trials

authors： Jensen W,Oechsle K,Baumann HJ,Mehnert A,Klose H,Bloch W,Bokemeyer C,Baumann FT

更新日期：2014-01-01 00:00:00

abstract：:It is of vital importance to the success of a randomized clinical trial to maintain the balance of baseline characteristics (covariates) that could potentially confound the outcomes of the trial. Various randomization methods have been proposed to increase the likelihood of having balanced covariates at the end of a t...

journal_title：Contemporary clinical trials

authors： Su Z

更新日期：2011-07-01 00:00:00

abstract：:Among children with asthma, black children are two to four times as likely to have an emergency department (ED) visit and die from asthma, respectively, compared to white children in the United States. Despite the availability of evidence-based asthma management guidelines, minority children are less likely than white...

journal_title：Contemporary clinical trials

authors： Krishnan JA,Martin MA,Lohff C,Mosnaim GS,Margellos-Anast H,DeLisa JA,McMahon K,Erwin K,Zun LS,Berbaum ML,McDermott M,Bracken NE,Kumar R,Margaret Paik S,Nyenhuis SM,Ignoffo S,Press VG,Pittsenbarger ZE,Thompson TM,CHI

更新日期：2017-06-01 00:00:00

abstract：:Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective...

journal_title：Contemporary clinical trials

authors： McEvoy CT,Milner KF,Scherman AJ,Schilling DG,Tiller CJ,Vuylsteke B,Shorey-Kendrick LE,Spindel ER,Schuff R,Mitchell J,Peters D,Metz J,Haas D,Jackson K,Tepper RS,Morris CD

更新日期：2017-07-01 00:00:00

abstract：:Home-based telemedicine (HBT) is a validated method of evidence-based treatment delivery for posttraumatic stress disorder (PTSD), and justification for its use has centered on closing gaps related to provider availability and distance to treatment centers. However, another potential use of HBT may be to overcome barr...

journal_title：Contemporary clinical trials

authors： Gilmore AK,Davis MT,Grubaugh A,Resnick H,Birks A,Denier C,Muzzy W,Tuerk P,Acierno R

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Individuals with serious mental illness (SMI) smoke at disproportionately higher rates than those without SMI, have lifespans 25-32 years shorter, and thus bear an especially large burden of tobacco-related morbidity and mortality. Several recent studies demonstrate that smokers with SMI can successfully qui...

journal_title：Contemporary clinical trials

authors： Hecht J,Rigotti NA,Minami H,Kjome KL,Bloom EL,Kahler CW,Price LH,Levy DE,Carpenter KM,Brown RA

更新日期：2019-08-01 00:00:00

abstract：:Although the Diabetes Prevention Program (DPP) developed a lifestyle weight loss intervention that has been demonstrated to prevent type 2 diabetes in high-risk individuals, it has yet to be widely adopted at the community level. The Healthy Living Partnership to Prevent Diabetes study (HELP PD) was designed to transl...

journal_title：Contemporary clinical trials

authors： Katula JA,Vitolins MZ,Rosenberger EL,Blackwell C,Espeland MA,Lawlor MS,Rejeski WJ,Goff DC

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic stea...

journal_title：Contemporary clinical trials

authors： Kessoku T,Imajo K,Kobayashi T,Honda Y,Kato T,Ogawa Y,Tomeno W,Kato S,Higurashi T,Yoneda M,Kirikoshi H,Kubota K,Taguri M,Yamanaka T,Usuda H,Wada K,Saito S,Nakajima A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Comparative effectiveness research (CER) evidence on childhood obesity provides the basis for effective screening and management strategies in pediatric primary care. The uses of health information technology including decision support tools in the electronic health records (EHRs), as well as remote and mobi...

journal_title：Contemporary clinical trials

authors： Taveras EM,Marshall R,Horan CM,Gillman MW,Hacker K,Kleinman KP,Koziol R,Price S,Simon SR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Obesity, a disorder associated with a myriad of comorbidities, is increasing at an alarming rate around the world. Given that pharmacotherapy has limited available options and that bariatric surgery is reserved for those who are morbidly obese or who have significant comorbidities, the most common approach t...

journal_title：Contemporary clinical trials

authors： Burke LE,Choo J,Music E,Warziski M,Styn MA,Kim Y,Sevick MA

更新日期：2006-02-01 00:00:00

abstract：:Large, "practical" or streamlined trials (LSTs) are used to study the effectiveness and/or safety of medicines in real world settings with minimal study imposed interventions. While LSTs have benefits over traditional randomized clinical trials and observational studies, there are inherent challenges to their conduct....

journal_title：Contemporary clinical trials

authors： Kolitsopoulos FM,Strom BL,Faich G,Eng SM,Kane JM,Reynolds RF

更新日期：2013-03-01 00:00:00

abstract：:Establishing a holistic approach for the enrollment of subjects into clinical trials that includes strategies for the recruitment of non-traditional and minority populations has been an elusive task. The existence of such a design, that is understood and embraced by investigators and the target communities, would stre...

journal_title：Contemporary clinical trials

authors： Sweet S,Legro RS,Coney P

更新日期：2008-07-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：:Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better mee...

journal_title：Contemporary clinical trials

authors： Kluger BM,Katz M,Galifianakis N,Pantilat SZ,Kutner JS,Sillau S,Gritz M,Jones J,Fairclough D,Sumrall M,Hall K,Miyasaki J

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis is a chronic progressive neurological disease. Evidence attests to the benefits of exercise, guidelines for exercise in multiple sclerosis are available. Remote-delivery of exercise adherence programmes based on the exercise guidelines require urgent testing. AIMS:The design, and outcomes...

journal_title：Contemporary clinical trials

authors： Learmonth YC,Kaur I,Baynton SL,Fairchild T,Paul L,van Rens F

更新日期：2021-01-12 00:00:00

abstract：:Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study treatments. Go/no-go ...

journal_title：Contemporary clinical trials

authors： Zhong B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Lifelong antiretroviral therapy (ART) (Option B+) is recommended for all HIV-infected pregnant/postpartum women, but high adherence is required to maximize HIV prevention potential and maintain maternal health. Mobile health (mHealth) interventions may provide treatment adherence support for women during, an...

journal_title：Contemporary clinical trials

authors： Drake AL,Unger JA,Ronen K,Matemo D,Perrier T,DeRenzi B,Richardson BA,Kinuthia J,John-Stewart G

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening by annual fecal immunochemical test (FIT) is an accessible and cost-effective strategy to lower CRC incidence and mortality. However, this mode of screening depends on follow-up colonoscopy after a positive FIT result. Unfortunately, nearly one-half of FIT-positive patients ...

journal_title：Contemporary clinical trials

authors： Coronado GD,Johnson ES,Leo MC,Schneider JL,Smith D,Mummadi R,Petrik AF,Thompson JH,Jimenez R

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Many studies on the health effects of the glycemic index (GI) are confounded by differences in the intakes of other macronutrients and fibre. Little data exist about the within- and between-subject variability of the GI. OBJECTIVE:Our objectives were therefore (i) to calculate the GI of eight commonly used ...

journal_title：Contemporary clinical trials

authors： Vrolix R,Mensink RP

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Hypertension disproportionately affects African Americans compared to whites, and it is the single most common explanation for the disparity in mortality between African Americans and whites. Adherence with antihypertensive medications can help reduce risk of negative hypertension-related outcomes. Motivatio...

journal_title：Contemporary clinical trials

authors： Ogedegbe G,Schoenthaler A,Richardson T,Lewis L,Belue R,Espinosa E,Spencer J,Allegrante JP,Charlson ME

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Medicaid recipients with serious mental illness die 25-30 years earlier than people in the general population due to health conditions that are modifiable through lifestyle changes. Cardiovascular diseases from excess weight, smoking, and sedentary lifestyle contribute substantially to this life expectancy d...

journal_title：Contemporary clinical trials

authors： Pratt SI,Brunette MF,Wolfe R,Scherer EA,Xie H,Bartels S,Ferron JC,Capuchino K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Management of asthma involves adherence to medication regimens. Assessing adherence is difficult for health care providers and researchers. Self-reported medication use is subjective, so objective methods of data collection for medication use are frequently used in asthma research. The aim of this project is...

journal_title：Contemporary clinical trials

authors： Mudd KE,Bollinger ME,Hsu VD,Manning A,Tsoukleris MG,Butz AM

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Characteristics that may influence participation in DNA banks are not well defined. The purpose of this study was to examine characteristics associated with participation in a DNA bank among veterans diagnosed with Amyotrophic Lateral Sclerosis (ALS). METHODS:Veterans who screened eligible for the National R...

journal_title：Contemporary clinical trials

authors： DiMartino L,Allen KD,Kasarskis E,Lindquist JH,Coffman CJ,Oddone EZ,National Registry of Veterans with ALS.

更新日期：2007-09-01 00:00:00

abstract：:Identifying effective strategies for treating obesity is a clinical challenge and a public health priority. The present study is an innovative test of the relative effectiveness of lottery-based financial incentives and environmental strategies on weight loss and maintenance. The Healthy Weigh study is evaluating the ...

journal_title：Contemporary clinical trials

authors： Glanz K,Shaw PA,Hoffer K,Chung A,Zhu J,Wu R,Huang QE,Choi JR,Volpp KG

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Cardiac rehabilitation (CR) programs reduce overall and cardiovascular mortality in patients with a history of acute coronary events or revascularization procedures, but only 30% of patients enroll in CR and attrition rates reach up to 60%. Tai chi, a mind-body practice based on light/moderate aerobic exer...

journal_title：Contemporary clinical trials

authors： Salmoirago-Blotcher E,Wayne P,Bock BC,Dunsiger S,Wu WC,Stabile L,Yeh G

更新日期：2015-07-01 00:00:00