A model of fracture risk used to examine the link between bone mineral density and the impact of different therapeutic mechanisms on fracture outcomes in patients with osteoporosis.

abstract：:We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van de Pas NC,Rullmann JA,Woutersen RA,van Ommen B,Rietjens IM,de Graaf AA

更新日期：2014-08-01 00:00:00

abstract：:Structural identifiability is an often overlooked, but essential, prerequisite to the experiment design stage. The application of structural identifiability analysis to models of myelosuppression is used to demonstrate the importance of its considerations. It is shown that, under certain assumptions, these models are ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Evans ND,Cheung SYA,Yates JWT

更新日期：2018-02-01 00:00:00

abstract：:Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to int...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krippendorff BF,Oyarzún DA,Huisinga W

更新日期：2012-04-01 00:00:00

abstract：:In the present pharmacokinetic/pharmacodynamic (PK/PD) evaluation, cortisol, total lymphocytes, and lymphocyte subpopulations were monitored following single oral doses of two oral formulations of 3 mg budesonide (BUD) (Dosage Forms A and B) in order to assess the differential effects that BUD may have on cortisol sup...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Stark JG,Werner S,Homrighausen S,Tang Y,Krieg M,Derendorf H,Moellmann H,Hochhaus G

更新日期：2006-08-01 00:00:00

abstract：:We investigated the propagation of population pharmacokinetic information across clinical studies by applying Bayesian techniques. The aim was to summarize the population pharmacokinetic estimates of a study in appropriate statistical distributions in order to use them as Bayesian priors in consequent population pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Aarons L

更新日期：2005-08-01 00:00:00

abstract：:Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pillai N,Schwartz SL,Ho T,Dokoumetzidis A,Bies R,Freedman I

更新日期：2019-04-01 00:00:00

abstract：:Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of antibody molecules for their target. Understanding TMDD of a monoclonal antibody should go beyond the empirical description of its non-linear PK since valuable...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Grimm HP

更新日期：2009-10-01 00:00:00

abstract：:There are situations in drug development where one may wish to reduce the dimensionality and complexity of whole body physiologically based pharmacokinetic models. A technique for formal reduction of such models, based on global sensitivity analysis, is suggested. Using this approach mean and variance of tissue(s) and...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gueorguieva I,Nestorov IA,Rowland M

更新日期：2006-02-01 00:00:00

abstract：:The utilisation of physiologically-based pharmacokinetic models for the analysis of population data is an approach with progressively increasing impact. However, as we move from empirical to complex mechanistic model structures, incorporation of stochastic variability in model parameters can be challenging due to the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tsamandouras N,Wendling T,Rostami-Hodjegan A,Galetin A,Aarons L

更新日期：2015-08-01 00:00:00

abstract：:There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists Physical Statu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Choi BM,Lee HG,Byon HJ,Lee SH,Lee EK,Kim HS,Noh GJ

更新日期：2015-04-01 00:00:00

abstract：:Neutropenia is a common side-effect of oncology drugs. We aimed to study the impact of exposure and dosing schedule on neutropenia to guide selection of dosing schedules that minimize neutropenia potential while maintaining the desired minimum concentration (Cmin) required for target engagement. Dose, frequency and PK...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Guo Y,Haddish-Berhane N,Xie H,Ouellet D

更新日期：2020-02-01 00:00:00

abstract：:Quantitative systems pharmacology (QSP) is a recent addition to the modeling and simulation toolbox for drug discovery and development and is based upon mathematical modeling of biophysical realistic biological processes in the disease area of interest. The combination of preclinical neurophysiology information with c...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Geerts H,Spiros A,Roberts P,Carr R

更新日期：2013-06-01 00:00:00

abstract：:The pharmacokinetics of cyclosporin (CsA) are unusual because of several heterogeneous features which include the presence of more than one conformer, considerable accumulation in erythrocytes and lipoproteins, extensive plasma protein binding, distribution into deep tissues, biliary secretion and hepatic clearance in...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Claret L,Iliadis A,Macheras P

更新日期：2001-10-01 00:00:00

abstract：:The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model. The WB-PBPK model w...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Sadiq MW,Nielsen EI,Khachman D,Conil JM,Georges B,Houin G,Laffont CM,Karlsson MO,Friberg LE

更新日期：2017-04-01 00:00:00

abstract：:The citalopram for Alzheimer's disease trial evaluated citalopram for the management for agitation in Alzheimer's disease patients. Sparse data was available from this elderly patient population. A nonlinear mixed effects population pharmacokinetic modeling approach was used to describe the pharmacokinetics of R- and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Akil A,Bies RR,Pollock BG,Avramopoulos D,Devanand DP,Mintzer JE,Porsteinsson AP,Schneider LS,Weintraub D,Yesavage J,Shade DM,Lyketsos CG

更新日期：2016-02-01 00:00:00

abstract：:The purpose of this study was to evaluate whether mixed effects modeling (MEM) performs better than either noncompartmental or compartmental naïve pooled data (NPD) analysis for the interpretation of single sample per subject pharmacokinetic (PK) data. Using PK parameters determined during a toxicokinetic study in rat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hing JP,Woolfrey SG,Greenslade D,Wright PM

更新日期：2001-04-01 00:00:00

abstract：:3-hydroxybenzo(a)pyrene (3-OHBaP) in urine has been proposed as a biomarker of occupational exposure to polycyclic aromatic hydrocarbons. However, to reconstruct exposure doses in workers from biomarker measurements, a thorough knowledge of the kinetics of the benzo(a)pyrene (BaP) and 3-OHBaP given different routes of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Heredia-Ortiz R,Bouchard M

更新日期：2013-12-01 00:00:00

abstract：:During the course of therapeutic drug monitoring (TDM), doses are adjusted to attain a target concentration range and a correlation between clearance (CL) and dose is introduced. In population pharmacokinetic analyses of such TDM data, CL has frequently been modeled as a function of dose. This paper demonstrates by si...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahn JE,Birnbaum AK,Brundage RC

更新日期：2005-12-01 00:00:00

abstract：:Ordinary differential equation models often contain a large number of parameters that must be determined from measurements by estimation procedure. For an estimation to be successful there must be a unique set of parameters that can have produced the measured data. This is not the case if a model is not structurally i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Iliadis A

更新日期：2019-04-01 00:00:00

abstract：:Pegylated liposomal formulations contain lipid conjugated to polyethylene glycol. The disposition of encapsulated drug is dictated by the composition of the liposome, thus altering the pharmacokinetic (PK) profile of the drug. Allometric scaling is based on a power-log relationship between body weight (W) and drug cle...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Caron WP,Clewell H,Dedrick R,Ramanathan RK,Davis WL,Yu N,Tonda M,Schellens JH,Beijnen JH,Zamboni WC

更新日期：2011-10-01 00:00:00

abstract：:The number of counts (events) per unit of time is a discrete response variable that is generally analyzed with the Poisson distribution (PS) model. The PS model makes two assumptions: the mean number of counts (lambda) is assumed equal to the variance, and counts occurring in non-overlapping intervals are assumed inde...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Trocóniz IF,Plan EL,Miller R,Karlsson MO

更新日期：2009-10-01 00:00:00

abstract：:Previously, we developed a feedback model to describe the tolerance and oscillatory rebound of non-esterified fatty acid (NEFA) plasma concentrations in male Sprague Dawley rats after intravenous infusions of nicotinic acid (NiAc). This study challenges that model, using the following regimens of intravenous and oral ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahlström C,Peletier LA,Gabrielsson J

更新日期：2013-08-01 00:00:00

abstract：:Altered expressions of the key enzymes in arachidonic acid (AA) metabolism, prostaglandin synthase 1 and 2 and cysteinyl leukotriene C(4) synthase, are of importance in understanding aspirin-induced asthma. We propose a mathematical model of AA metabolism and its interaction with non-steroidal anti-inflammatory drugs ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dobovišek A,Fajmut A,Brumen M

更新日期：2011-04-01 00:00:00

abstract：:Development of novel therapies for bone diseases can benefit from mathematical models that predict drug effect on bone remodeling biomarkers. Therefore, a bone cycle model (BCM) was developed that takes into consideration the concept of the basic multicellular unit and the dynamic equilibrium of bone remodeling. The m...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van Schaick E,Zheng J,Perez Ruixo JJ,Gieschke R,Jacqmin P

更新日期：2015-08-01 00:00:00

abstract：:Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population pharmacokinetic profile of intravenous acetaminophen and its metabolites in adult surgical patients and to identify patient characteristics associated with acetaminophen metabolism in the p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Owens KH,Murphy PG,Medlicott NJ,Kennedy J,Zacharias M,Curran N,Sreebhavan S,Thompson-Fawcett M,Reith DM

更新日期：2014-06-01 00:00:00

abstract：:The distributed delay model has been introduced that replaces the transit compartments in the classic model of chemotherapy-induced myelosuppression with a convolution integral. The maturation of granulocyte precursors in the bone marrow is described by the gamma probability density function with the shape parameter (...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Hu S,Dunlavey M

更新日期：2018-04-01 00:00:00

abstract：:The study aimed to characterize the population pharmacokinetics of amodiaquine (AQ) and its major metabolite N-desethylamodiaquine (N-DEAQ), and to assess the correlation between exposure to N-DEAQ and treatment outcome. Blood samples from children in two studies in Zanzibar and one in Papua New Guinea were included i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hietala SF,Bhattarai A,Msellem M,Röshammar D,Ali AS,Strömberg J,Hombhanje FW,Kaneko A,Björkman A,Ashton M

更新日期：2007-10-01 00:00:00

abstract：:Changes in the reticulocyte subtype distribution (high, medium and low reticulocytes count (HR, MR, LR)) measured by flow cytometry following phlebotomy-induced stress erythropoiesis (abruptly dropping hemoglobin to 3-4 g/dl over 4-5 hr) and the pharmacodynamic (PD) relationship to the stimulated erythropoietin (EPO) ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Al-Huniti NH,Widness JA,Schmidt RL,Veng-Pedersen P

更新日期：2005-08-01 00:00:00

abstract：AIM:Chemotherapy with indisulam causes myelosuppression. This study aimed to evaluate the influence of patient-related covariates on pharmacokinetics and pharmacodynamics, to identify patients at risk for severe myelosuppression and to develop a dosing algorithm for treatment optimization. METHODS:Pharmacokinetic and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zandvliet AS,Schellens JH,Copalu W,Beijnen JH,Huitema AD

更新日期：2009-02-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gómez-Mantilla JD,Trocóniz IF,Parra-Guillén Z,Garrido MJ

更新日期：2014-10-01 00:00:00