Structural identifiability for mathematical pharmacology: models of myelosuppression.

abstract：:Several reviews on specific topics related to positron emission tomography (PET) ranging in complexity from introductory to highly technical have already been published. This introduction to the analysis of PET data was written as a simple guide of the different phases of analysis of a given PET dataset, from acquisit...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tomasi G,Aboagye EO

更新日期：2013-08-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:A number of experimental observations in the late 1960s, early 1970s could not be explained by the pharmacokinetic theory available at that time. For example rats receiving phenobarbital as an enzyme inducing agent exhibited increased elimination of phenylbutazone in vitro in liver microsomes and in vivo in whole anim...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Benet LZ

更新日期：2010-12-01 00:00:00

abstract：:This study developed an integrated model of severity scores of migraine headache and the incidence of nausea, photophobia, and phonophobia to predict the natural time course of migraine symptoms, which are likely to occur by a common disease progression mechanism. Data were acquired from two phase 3 clinical trials co...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Chae D,Park K

更新日期：2018-10-01 00:00:00

abstract：:Pharmacokinetic analysis in humans using compartmental models is restricted with respect to the estimation of parameter values. This is because the experimenter usually is only able to apply inputs and observations in a very small number of compartments in the system. This has implications for the structural identifia...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cheung SY,Yates JW,Aarons L

更新日期：2013-02-01 00:00:00

abstract：:Cancer therapies that harness the actions of the immune response, such as targeted monoclonal antibody treatments and therapeutic vaccines, are relatively new and promising in the landscape of cancer treatment options. Mathematical modeling and simulation of immune-modifying therapies can help to offset the costs of d...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： dePillis LG,Eladdadi A,Radunskaya AE

更新日期：2014-10-01 00:00:00

abstract：:The study aimed to characterize the population pharmacokinetics of amodiaquine (AQ) and its major metabolite N-desethylamodiaquine (N-DEAQ), and to assess the correlation between exposure to N-DEAQ and treatment outcome. Blood samples from children in two studies in Zanzibar and one in Papua New Guinea were included i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hietala SF,Bhattarai A,Msellem M,Röshammar D,Ali AS,Strömberg J,Hombhanje FW,Kaneko A,Björkman A,Ashton M

更新日期：2007-10-01 00:00:00

abstract：:A retrospective analysis was performed to modify our fourth-generation pharmacodynamic model for glucocorticoid receptor (GR) dynamics with incorporation of more physiological features. This modified model was developed by integrating previously reported free cytosolic GR and GR mRNA data following single (10, 50 mg/k...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hazra A,DuBois DC,Almon RR,Jusko WJ

更新日期：2007-06-01 00:00:00

abstract：:Drugs can affect the cardiovascular (CV) system either as an intended treatment or as an unwanted side effect. In both cases, drug-induced cardiotoxicities such as arrhythmia and unfavourable hemodynamic effects can occur, and be described using mathematical models; such a model informed approach can provide valuable ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cheung SYA,Parkinson J,Wählby-Hamrén U,Dota CD,Kragh ÅM,Bergenholm L,Vik T,Collins T,Arfvidsson C,Pollard CE,Tomkinson HK,Hamrén B

更新日期：2018-06-01 00:00:00

abstract：AIM:Chemotherapy with indisulam causes myelosuppression. This study aimed to evaluate the influence of patient-related covariates on pharmacokinetics and pharmacodynamics, to identify patients at risk for severe myelosuppression and to develop a dosing algorithm for treatment optimization. METHODS:Pharmacokinetic and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zandvliet AS,Schellens JH,Copalu W,Beijnen JH,Huitema AD

更新日期：2009-02-01 00:00:00

abstract：:A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of the measured pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mukherjee D,Hutmacher MM

更新日期：2004-02-01 00:00:00

abstract：:A population pharmacokinetic analysis was conducted to characterize the pharmacokinetics of fexofenadine in Japanese pediatric patients (6 months through 16 years) with perennial allergic rhinitis or atopic dermatitis. The dataset was composed of 515 patients (including 109 adults), for a total of 1,080 concentration-...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Martinez JM,Khier S,Morita S,Rauch C,Fabre D

更新日期：2014-04-01 00:00:00

abstract：:In this work a model for analyzing categorical data is presented; the differential odds model. Unlike the commonly used proportional odds model, this model does not assume that a covariate affects all categories equally on the log odds scale. The differential odds model was compared to the proportional odds model, by ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kjellsson MC,Zingmark PH,Jonsson EN,Karlsson MO

更新日期：2008-10-01 00:00:00

abstract：:We explore the use of fractional order differential equations for the analysis of datasets of various drug processes that present anomalous kinetics, i.e. kinetics that are non-exponential and are typically described by power-laws. A fractional differential equation corresponds to a differential equation with a deriva...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Macheras P

更新日期：2009-04-01 00:00:00

abstract：:Pegylated liposomal formulations contain lipid conjugated to polyethylene glycol. The disposition of encapsulated drug is dictated by the composition of the liposome, thus altering the pharmacokinetic (PK) profile of the drug. Allometric scaling is based on a power-log relationship between body weight (W) and drug cle...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Caron WP,Clewell H,Dedrick R,Ramanathan RK,Davis WL,Yu N,Tonda M,Schellens JH,Beijnen JH,Zamboni WC

更新日期：2011-10-01 00:00:00

abstract：:During the course of therapeutic drug monitoring (TDM), doses are adjusted to attain a target concentration range and a correlation between clearance (CL) and dose is introduced. In population pharmacokinetic analyses of such TDM data, CL has frequently been modeled as a function of dose. This paper demonstrates by si...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahn JE,Birnbaum AK,Brundage RC

更新日期：2005-12-01 00:00:00

abstract：:The population approach to estimating mixed effects model parameters of interest in pharmacokinetic (PK) studies has been demonstrated to be an effective method in quantifying relevant population drug properties. The information available for each individual is usually sparse. As such, care should be taken to ensure t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dodds MG,Hooker AC,Vicini P

更新日期：2005-02-01 00:00:00

abstract：:Previously, we developed a feedback model to describe the tolerance and oscillatory rebound of non-esterified fatty acid (NEFA) plasma concentrations in male Sprague Dawley rats after intravenous infusions of nicotinic acid (NiAc). This study challenges that model, using the following regimens of intravenous and oral ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahlström C,Peletier LA,Gabrielsson J

更新日期：2013-08-01 00:00:00

abstract：:Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytosis may result in drug elimination. A general PK model for characteriz...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mager DE,Jusko WJ

更新日期：2001-12-01 00:00:00

abstract：:Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Wiczling P,Gebre A

更新日期：2017-08-01 00:00:00

abstract：:Neutropenia is a common side-effect of oncology drugs. We aimed to study the impact of exposure and dosing schedule on neutropenia to guide selection of dosing schedules that minimize neutropenia potential while maintaining the desired minimum concentration (Cmin) required for target engagement. Dose, frequency and PK...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Guo Y,Haddish-Berhane N,Xie H,Ouellet D

更新日期：2020-02-01 00:00:00

abstract：:Effective long-term treatment of Type 2 Diabetes Mellitus (T2DM) implies modification of the disease processes that cause this progressive disorder. This paper proposes a mechanism-based approach to disease progression modeling of T2DM that aims to provide the ability to describe and quantify the effects of treatment ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： de Winter W,DeJongh J,Post T,Ploeger B,Urquhart R,Moules I,Eckland D,Danhof M

更新日期：2006-06-01 00:00:00

abstract：:The volume of distribution at steady state (Vss) of therapeutic proteins is usually assessed by non-compartmental or compartmental pharmacokinetic (PK) analysis wherein errors may arise due to the elimination of therapeutic proteins from peripheral tissues that are not in rapid equilibrium with the sampling compartmen...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Richter WF,Grimm HP,Theil FP

更新日期：2011-10-01 00:00:00

abstract：:The aim of this study was to develop a population in vitro-in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model integrated meta-models of gastrointestinal pH and gastrointestinal transit ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Abuhelwa AY,Mudge S,Upton RN,Foster DJR

更新日期：2018-04-01 00:00:00

abstract：:The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of dr...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Durisová M,Dedík L

更新日期：2002-12-01 00:00:00

abstract：:Tocilizumab is a recombinant humanized antihuman interleukin-6 receptor monoclonal antibody, which inhibits binding of IL-6 to its soluble (sIL-6R) and membrane-expressed (mIL-6R) receptors. The work investigated whether the observed decline in peripheral neutrophil and platelet counts after tocilizumab administration...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gibiansky L,Frey N

更新日期：2012-02-01 00:00:00

abstract：:The purpose of this study was to evaluate whether mixed effects modeling (MEM) performs better than either noncompartmental or compartmental naïve pooled data (NPD) analysis for the interpretation of single sample per subject pharmacokinetic (PK) data. Using PK parameters determined during a toxicokinetic study in rat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hing JP,Woolfrey SG,Greenslade D,Wright PM

更新日期：2001-04-01 00:00:00

abstract：:Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pillai N,Schwartz SL,Ho T,Dokoumetzidis A,Bies R,Freedman I

更新日期：2019-04-01 00:00:00

abstract：:This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2 (acyl-glucuronate), among Japanese, Chinese, and Korean populations, following oral administration. We used a population PK modeling approach using data from a clinic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaneko M,Aoyama T,Ishida Y,Miyamoto A,Saito Y,Tohkin M,Kawai S,Matsumoto Y

更新日期：2018-04-01 00:00:00

abstract：:Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population pharmacokinetic profile of intravenous acetaminophen and its metabolites in adult surgical patients and to identify patient characteristics associated with acetaminophen metabolism in the p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Owens KH,Murphy PG,Medlicott NJ,Kennedy J,Zacharias M,Curran N,Sreebhavan S,Thompson-Fawcett M,Reith DM

更新日期：2014-06-01 00:00:00