A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: a simulation study.

abstract：:Literature data are often reported as multiple (longitudinal) mean outcomes observed in several groups of patients within a study. Observations within a study are correlated because the patients come from a common population, and the mean observations over time within a treatment arm are correlated because they are ba...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahn JE,French JL

更新日期：2010-04-01 00:00:00

abstract：AIM:Chemotherapy with indisulam causes myelosuppression. This study aimed to evaluate the influence of patient-related covariates on pharmacokinetics and pharmacodynamics, to identify patients at risk for severe myelosuppression and to develop a dosing algorithm for treatment optimization. METHODS:Pharmacokinetic and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zandvliet AS,Schellens JH,Copalu W,Beijnen JH,Huitema AD

更新日期：2009-02-01 00:00:00

abstract：:Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to int...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krippendorff BF,Oyarzún DA,Huisinga W

更新日期：2012-04-01 00:00:00

abstract：:The majority of measures proposed to date for direct curve comparison in bioequivalence studies were investigated. These measures have often been called metrics, but in most cases this was incorrect in the mathematical sense. It was demonstrated, with a set of counter-examples, that the axioms of a metric are fulfille...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Jawień W

更新日期：2009-06-01 00:00:00

abstract：:A number of experimental observations in the late 1960s, early 1970s could not be explained by the pharmacokinetic theory available at that time. For example rats receiving phenobarbital as an enzyme inducing agent exhibited increased elimination of phenylbutazone in vitro in liver microsomes and in vivo in whole anim...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Benet LZ

更新日期：2010-12-01 00:00:00

abstract：:Target-mediated drug disposition (TMDD) is frequently reported for therapeutic monoclonal antibodies and is linked to the high affinity and high specificity of antibody molecules for their target. Understanding TMDD of a monoclonal antibody should go beyond the empirical description of its non-linear PK since valuable...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Grimm HP

更新日期：2009-10-01 00:00:00

abstract：:There are situations in drug development where one may wish to reduce the dimensionality and complexity of whole body physiologically based pharmacokinetic models. A technique for formal reduction of such models, based on global sensitivity analysis, is suggested. Using this approach mean and variance of tissue(s) and...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gueorguieva I,Nestorov IA,Rowland M

更新日期：2006-02-01 00:00:00

abstract：:Although selective 5-HT reuptake inhibitors (SSRIs) block monoamine uptake within hours of administration to patients, their full clinical effect does not appear until 2-4 weeks after treatment onset. Pindolol, a betablocker with weak partial 5-HT1A receptor agonist activity has been shown to produce a more rapid onse...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gruwez B,Dauphin A,Tod M

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to develop a population in vitro-in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model integrated meta-models of gastrointestinal pH and gastrointestinal transit ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Abuhelwa AY,Mudge S,Upton RN,Foster DJR

更新日期：2018-04-01 00:00:00

abstract：:The objective was to develop a physiologically-based pharmacokinetic (PBPK) model to characterize the whole-body disposition of paclitaxel (formulated in Cremophor EL and ethanol-Taxol®) in mice and to evaluate the utility of this model for predicting pharmacokinetics in other species. Published studies that reported ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zang X,Kagan L

更新日期：2018-08-01 00:00:00

abstract：:Optimizing designs using robust (global) optimality criteria has been shown to be a more flexible approach compared to using local optimality criteria. Additionally, model based adaptive optimal design (MBAOD) may be less sensitive to misspecification in the prior information available at the design stage. In this wor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Strömberg EA,Hooker AC

更新日期：2017-08-01 00:00:00

abstract：:We propose an efficient algorithm for screening covariates in population model building using Wald's approximation to the likelihood ratio test (LRT) statistic in conjunction with Schwarz's Bayesian criterion. The algorithm can be applied to a full model fit of k covariate parameters to calculate the approximate LRT f...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kowalski KG,Hutmacher MM

更新日期：2001-06-01 00:00:00

abstract：:This study developed an integrated model of severity scores of migraine headache and the incidence of nausea, photophobia, and phonophobia to predict the natural time course of migraine symptoms, which are likely to occur by a common disease progression mechanism. Data were acquired from two phase 3 clinical trials co...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Chae D,Park K

更新日期：2018-10-01 00:00:00

abstract：:During the course of therapeutic drug monitoring (TDM), doses are adjusted to attain a target concentration range and a correlation between clearance (CL) and dose is introduced. In population pharmacokinetic analyses of such TDM data, CL has frequently been modeled as a function of dose. This paper demonstrates by si...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahn JE,Birnbaum AK,Brundage RC

更新日期：2005-12-01 00:00:00

abstract：:To solve the problem of estimating an unknown input function to a linear time invariant system we propose an adaptive non-parametric method based on reversible jump Markov chain Monte Carlo (RJMCMC). We use piecewise polynomial functions (splines) to represent the input function. The RJMCMC algorithm allows the explor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kang D,Verotta D

更新日期：2007-06-01 00:00:00

abstract：:This study aimed to characterize pharmacodynamic interaction between propofol and aminophylline. Nine beagle dogs were randomly allocated at the propofol rates of 0.75 (group A), 1.00 (group B), and 1.25 (group C) mg/kg/min. During period 1, propofol only was infused, while during period 2, aminophylline only, at the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lee SH,Kang HJ,Jin SJ,Park DY,Choi YJ,Choi BM,Lee EK,Noh GJ

更新日期：2014-12-01 00:00:00

abstract：:We explore the use of fractional order differential equations for the analysis of datasets of various drug processes that present anomalous kinetics, i.e. kinetics that are non-exponential and are typically described by power-laws. A fractional differential equation corresponds to a differential equation with a deriva...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Macheras P

更新日期：2009-04-01 00:00:00

abstract：:Current physiologically based pharmacokinetic (PBPK) models are inductive. We present an additional, different approach that is based on the synthetic rather than the inductive approach to modeling and simulation. It relies on object-oriented programming. A model of the referent system in its experimental context is s...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hunt CA,Ropella GE,Yan L,Hung DY,Roberts MS

更新日期：2006-12-01 00:00:00

abstract：:Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population pharmacokinetic profile of intravenous acetaminophen and its metabolites in adult surgical patients and to identify patient characteristics associated with acetaminophen metabolism in the p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Owens KH,Murphy PG,Medlicott NJ,Kennedy J,Zacharias M,Curran N,Sreebhavan S,Thompson-Fawcett M,Reith DM

更新日期：2014-06-01 00:00:00

abstract：:We investigated the propagation of population pharmacokinetic information across clinical studies by applying Bayesian techniques. The aim was to summarize the population pharmacokinetic estimates of a study in appropriate statistical distributions in order to use them as Bayesian priors in consequent population pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Aarons L

更新日期：2005-08-01 00:00:00

abstract：:The number of counts (events) per unit of time is a discrete response variable that is generally analyzed with the Poisson distribution (PS) model. The PS model makes two assumptions: the mean number of counts (lambda) is assumed equal to the variance, and counts occurring in non-overlapping intervals are assumed inde...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Trocóniz IF,Plan EL,Miller R,Karlsson MO

更新日期：2009-10-01 00:00:00

abstract：:In the present pharmacokinetic/pharmacodynamic (PK/PD) evaluation, cortisol, total lymphocytes, and lymphocyte subpopulations were monitored following single oral doses of two oral formulations of 3 mg budesonide (BUD) (Dosage Forms A and B) in order to assess the differential effects that BUD may have on cortisol sup...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Stark JG,Werner S,Homrighausen S,Tang Y,Krieg M,Derendorf H,Moellmann H,Hochhaus G

更新日期：2006-08-01 00:00:00

abstract：:Structural identifiability is an often overlooked, but essential, prerequisite to the experiment design stage. The application of structural identifiability analysis to models of myelosuppression is used to demonstrate the importance of its considerations. It is shown that, under certain assumptions, these models are ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Evans ND,Cheung SYA,Yates JWT

更新日期：2018-02-01 00:00:00

abstract：:HER2-positive breast cancer (BC) is a rapidly growing and aggressive BC subtype that predominantly affects younger women. Despite improvements in patient outcomes with anti-HER2 therapy, primary and/or acquired resistance remain a major clinical challenge. Here, we sought to use a quantitative systems pharmacological ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Franco YL,Ramakrishnan V,Vaidya TR,Mody H,Perez L,Ait-Oudhia S

更新日期：2021-01-03 00:00:00

abstract：:In this work a model for analyzing categorical data is presented; the differential odds model. Unlike the commonly used proportional odds model, this model does not assume that a covariate affects all categories equally on the log odds scale. The differential odds model was compared to the proportional odds model, by ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kjellsson MC,Zingmark PH,Jonsson EN,Karlsson MO

更新日期：2008-10-01 00:00:00

abstract：:A population pharmacokinetic analysis was conducted to characterize the pharmacokinetics of fexofenadine in Japanese pediatric patients (6 months through 16 years) with perennial allergic rhinitis or atopic dermatitis. The dataset was composed of 515 patients (including 109 adults), for a total of 1,080 concentration-...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Martinez JM,Khier S,Morita S,Rauch C,Fabre D

更新日期：2014-04-01 00:00:00

abstract：:The pharmacokinetics of cyclosporin (CsA) are unusual because of several heterogeneous features which include the presence of more than one conformer, considerable accumulation in erythrocytes and lipoproteins, extensive plasma protein binding, distribution into deep tissues, biliary secretion and hepatic clearance in...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Claret L,Iliadis A,Macheras P

更新日期：2001-10-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists Physical Statu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Choi BM,Lee HG,Byon HJ,Lee SH,Lee EK,Kim HS,Noh GJ

更新日期：2015-04-01 00:00:00

abstract：:This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2 (acyl-glucuronate), among Japanese, Chinese, and Korean populations, following oral administration. We used a population PK modeling approach using data from a clinic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaneko M,Aoyama T,Ishida Y,Miyamoto A,Saito Y,Tohkin M,Kawai S,Matsumoto Y

更新日期：2018-04-01 00:00:00