Modeling T cell responses to antigenic challenge.

abstract：:Quantitative systems pharmacology (QSP) is a recent addition to the modeling and simulation toolbox for drug discovery and development and is based upon mathematical modeling of biophysical realistic biological processes in the disease area of interest. The combination of preclinical neurophysiology information with c...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Geerts H,Spiros A,Roberts P,Carr R

更新日期：2013-06-01 00:00:00

abstract：:Ordinary differential equation models often contain a large number of parameters that must be determined from measurements by estimation procedure. For an estimation to be successful there must be a unique set of parameters that can have produced the measured data. This is not the case if a model is not structurally i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Iliadis A

更新日期：2019-04-01 00:00:00

abstract：:The aim of this study was to develop a population in vitro-in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model integrated meta-models of gastrointestinal pH and gastrointestinal transit ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Abuhelwa AY,Mudge S,Upton RN,Foster DJR

更新日期：2018-04-01 00:00:00

abstract：:The utilisation of physiologically-based pharmacokinetic models for the analysis of population data is an approach with progressively increasing impact. However, as we move from empirical to complex mechanistic model structures, incorporation of stochastic variability in model parameters can be challenging due to the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tsamandouras N,Wendling T,Rostami-Hodjegan A,Galetin A,Aarons L

更新日期：2015-08-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:Optimizing designs using robust (global) optimality criteria has been shown to be a more flexible approach compared to using local optimality criteria. Additionally, model based adaptive optimal design (MBAOD) may be less sensitive to misspecification in the prior information available at the design stage. In this wor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Strömberg EA,Hooker AC

更新日期：2017-08-01 00:00:00

abstract：:The distributed delay model has been introduced that replaces the transit compartments in the classic model of chemotherapy-induced myelosuppression with a convolution integral. The maturation of granulocyte precursors in the bone marrow is described by the gamma probability density function with the shape parameter (...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Hu S,Dunlavey M

更新日期：2018-04-01 00:00:00

abstract：:Stepwise covariate modeling (SCM) is a widely used tool in pharmacometric analyses to identify covariates that explain between-subject variability (BSV) in exposure and exposure-response relationships. However, this approach has several potential weaknesses, including over-estimated covariate effect and incorrect sele...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahamadi M,Largajolli A,Diderichsen PM,de Greef R,Kerbusch T,Witjes H,Chawla A,Davis CB,Gheyas F

更新日期：2019-06-01 00:00:00

abstract：:Cancer therapies that harness the actions of the immune response, such as targeted monoclonal antibody treatments and therapeutic vaccines, are relatively new and promising in the landscape of cancer treatment options. Mathematical modeling and simulation of immune-modifying therapies can help to offset the costs of d...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： dePillis LG,Eladdadi A,Radunskaya AE

更新日期：2014-10-01 00:00:00

abstract：:Bootstrap methods are used in many disciplines to estimate the uncertainty of parameters, including multi-level or linear mixed-effects models. Residual-based bootstrap methods which resample both random effects and residuals are an alternative approach to case bootstrap, which resamples the individuals. Most PKPD app...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Thai HT,Mentré F,Holford NH,Veyrat-Follet C,Comets E

更新日期：2014-02-01 00:00:00

abstract：:The objective was to develop a physiologically-based pharmacokinetic (PBPK) model to characterize the whole-body disposition of paclitaxel (formulated in Cremophor EL and ethanol-Taxol®) in mice and to evaluate the utility of this model for predicting pharmacokinetics in other species. Published studies that reported ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zang X,Kagan L

更新日期：2018-08-01 00:00:00

abstract：:In the present pharmacokinetic/pharmacodynamic (PK/PD) evaluation, cortisol, total lymphocytes, and lymphocyte subpopulations were monitored following single oral doses of two oral formulations of 3 mg budesonide (BUD) (Dosage Forms A and B) in order to assess the differential effects that BUD may have on cortisol sup...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Stark JG,Werner S,Homrighausen S,Tang Y,Krieg M,Derendorf H,Moellmann H,Hochhaus G

更新日期：2006-08-01 00:00:00

abstract：:Mixture modeling within the context of pharmacokinetic (PK)/pharmacodynamic (PD) mixed effects modeling is a useful tool to explore a population for the presence of two or more subpopulations, not explained by evaluated covariates. At present, statistical tests for the existence of mixed populations have not been deve...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Frame B,Miller R,Lalonde RL

更新日期：2003-06-01 00:00:00

abstract：:This study was designed to investigate the pharmacokinetics/pharmacodynamics (PK/PD) risk factors preceding the onset of type 2 diabetes using a population-based Bayesian nonlinear hierarchical model to describe the glucose-insulin kinetics. One hundred fifty-two healthy subjects with a family history of type 2 diabet...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lin CW,Veng-Pedersen P

更新日期：2009-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a chronic obstructive disease of the airways. An exacerbation of COPD is defined as shortness of breath, cough, and sputum production. New therapies for COPD exacerbations are examined in clinical trials frequently based on the number of exacerbations that implies long-t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Largajolli A,Beerahee M,Yang S

更新日期：2019-08-01 00:00:00

abstract：:A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of the measured pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mukherjee D,Hutmacher MM

更新日期：2004-02-01 00:00:00

abstract：:The pharmacokinetic-pharmacodynamic (PK-PD) relationship of the granulopoietic effects of Filgrastim in healthy volunteers was characterized via a population approach. Healthy male volunteers were enrolled into a four-way crossover clinical trial. Subjects received four single doses of Filgrastim (375 and 750 microgra...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Wang B,Ludden TM,Cheung EN,Schwab GG,Roskos LK

更新日期：2001-08-01 00:00:00

abstract：:3-hydroxybenzo(a)pyrene (3-OHBaP) in urine has been proposed as a biomarker of occupational exposure to polycyclic aromatic hydrocarbons. However, to reconstruct exposure doses in workers from biomarker measurements, a thorough knowledge of the kinetics of the benzo(a)pyrene (BaP) and 3-OHBaP given different routes of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Heredia-Ortiz R,Bouchard M

更新日期：2013-12-01 00:00:00

abstract：:Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to int...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krippendorff BF,Oyarzún DA,Huisinga W

更新日期：2012-04-01 00:00:00

abstract：:Literature data are often reported as multiple (longitudinal) mean outcomes observed in several groups of patients within a study. Observations within a study are correlated because the patients come from a common population, and the mean observations over time within a treatment arm are correlated because they are ba...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahn JE,French JL

更新日期：2010-04-01 00:00:00

abstract：:Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Wiczling P,Gebre A

更新日期：2017-08-01 00:00:00

abstract：:The conventional convection-dispersion model is widely used to interrelate hepatic availability (F) and clearance (Cl) with the morphology and physiology of the liver and to predict effects such as changes in liver bloodflow on F and Cl. The extension of this model to include nonlinear kinetics and zonal heterogeneity...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Anissimov YG,Roberts MS

更新日期：2002-04-01 00:00:00

abstract：:This study developed an integrated model of severity scores of migraine headache and the incidence of nausea, photophobia, and phonophobia to predict the natural time course of migraine symptoms, which are likely to occur by a common disease progression mechanism. Data were acquired from two phase 3 clinical trials co...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Chae D,Park K

更新日期：2018-10-01 00:00:00

abstract：:Several reviews on specific topics related to positron emission tomography (PET) ranging in complexity from introductory to highly technical have already been published. This introduction to the analysis of PET data was written as a simple guide of the different phases of analysis of a given PET dataset, from acquisit...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tomasi G,Aboagye EO

更新日期：2013-08-01 00:00:00

abstract：:There has been little evaluation of maximum likelihood approximation methods for non-linear mixed effects modelling of count data. The aim of this study was to explore the estimation accuracy of population parameters from six count models, using two different methods and programs. Simulations of 100 data sets were per...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Plan EL,Maloney A,Trocóniz IF,Karlsson MO

更新日期：2009-08-01 00:00:00

abstract：:Multiple classes of antihypertensive drugs inhibit components of the renin-angiotensin-aldosterone system (RAAS). The primary physiological effector of the RAAS is angiotensin II (AngII) bound to the AT1 receptor (AT1-bound AngII). There is a strong non-linear feedback from AT1-bound AngII on renin secretion. Since AT...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gebremichael Y,Lahu G,Vakilynejad M,Hallow KM

更新日期：2019-02-01 00:00:00

abstract：:Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytosis may result in drug elimination. A general PK model for characteriz...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mager DE,Jusko WJ

更新日期：2001-12-01 00:00:00

abstract：:We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van de Pas NC,Rullmann JA,Woutersen RA,van Ommen B,Rietjens IM,de Graaf AA

更新日期：2014-08-01 00:00:00

abstract：:Significant arterio-venous differences in nicotine concentrations have been observed during and after cigarette smoking, nicotine nasal spray, and intravenous nicotine administration. In this paper we describe a novel mathematical method for estimating arterial blood levels from venous blood level data. The model allo...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pitsiu M,Gries JM,Benowitz N,Gourlay SG,Verotta D

更新日期：2002-08-01 00:00:00

abstract：:The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model. The WB-PBPK model w...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Sadiq MW,Nielsen EI,Khachman D,Conil JM,Georges B,Houin G,Laffont CM,Karlsson MO,Friberg LE

更新日期：2017-04-01 00:00:00