Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis.

abstract：:Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytosis may result in drug elimination. A general PK model for characteriz...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mager DE,Jusko WJ

更新日期：2001-12-01 00:00:00

abstract：:The population approach to estimating mixed effects model parameters of interest in pharmacokinetic (PK) studies has been demonstrated to be an effective method in quantifying relevant population drug properties. The information available for each individual is usually sparse. As such, care should be taken to ensure t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dodds MG,Hooker AC,Vicini P

更新日期：2005-02-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:The study aimed to characterize the population pharmacokinetics of amodiaquine (AQ) and its major metabolite N-desethylamodiaquine (N-DEAQ), and to assess the correlation between exposure to N-DEAQ and treatment outcome. Blood samples from children in two studies in Zanzibar and one in Papua New Guinea were included i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hietala SF,Bhattarai A,Msellem M,Röshammar D,Ali AS,Strömberg J,Hombhanje FW,Kaneko A,Björkman A,Ashton M

更新日期：2007-10-01 00:00:00

abstract：:We develop a mechanistic model for post-operative pain and apply it to describe the pharmacodynamic effects of the kappa-opioids nalbuphine and naloxone administered either alone or in combination in patients after surgical removal of one or more madibular third molar teeth. Data were obtained from 6 clinical studies ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kshirsagar S,Gear R,Levine J,Verotta D

更新日期：2008-02-01 00:00:00

abstract：:The conventional convection-dispersion model is widely used to interrelate hepatic availability (F) and clearance (Cl) with the morphology and physiology of the liver and to predict effects such as changes in liver bloodflow on F and Cl. The extension of this model to include nonlinear kinetics and zonal heterogeneity...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Anissimov YG,Roberts MS

更新日期：2002-04-01 00:00:00

abstract：:Although selective 5-HT reuptake inhibitors (SSRIs) block monoamine uptake within hours of administration to patients, their full clinical effect does not appear until 2-4 weeks after treatment onset. Pindolol, a betablocker with weak partial 5-HT1A receptor agonist activity has been shown to produce a more rapid onse...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gruwez B,Dauphin A,Tod M

更新日期：2005-12-01 00:00:00

abstract：:Optimizing designs using robust (global) optimality criteria has been shown to be a more flexible approach compared to using local optimality criteria. Additionally, model based adaptive optimal design (MBAOD) may be less sensitive to misspecification in the prior information available at the design stage. In this wor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Strömberg EA,Hooker AC

更新日期：2017-08-01 00:00:00

abstract：:In this work a model for analyzing categorical data is presented; the differential odds model. Unlike the commonly used proportional odds model, this model does not assume that a covariate affects all categories equally on the log odds scale. The differential odds model was compared to the proportional odds model, by ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kjellsson MC,Zingmark PH,Jonsson EN,Karlsson MO

更新日期：2008-10-01 00:00:00

abstract：:Bootstrap methods are used in many disciplines to estimate the uncertainty of parameters, including multi-level or linear mixed-effects models. Residual-based bootstrap methods which resample both random effects and residuals are an alternative approach to case bootstrap, which resamples the individuals. Most PKPD app...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Thai HT,Mentré F,Holford NH,Veyrat-Follet C,Comets E

更新日期：2014-02-01 00:00:00

abstract：:To solve the problem of estimating an unknown input function to a linear time invariant system we propose an adaptive non-parametric method based on reversible jump Markov chain Monte Carlo (RJMCMC). We use piecewise polynomial functions (splines) to represent the input function. The RJMCMC algorithm allows the explor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kang D,Verotta D

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to develop a population in vitro-in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model integrated meta-models of gastrointestinal pH and gastrointestinal transit ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Abuhelwa AY,Mudge S,Upton RN,Foster DJR

更新日期：2018-04-01 00:00:00

abstract：:This study aimed to characterize pharmacodynamic interaction between propofol and aminophylline. Nine beagle dogs were randomly allocated at the propofol rates of 0.75 (group A), 1.00 (group B), and 1.25 (group C) mg/kg/min. During period 1, propofol only was infused, while during period 2, aminophylline only, at the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lee SH,Kang HJ,Jin SJ,Park DY,Choi YJ,Choi BM,Lee EK,Noh GJ

更新日期：2014-12-01 00:00:00

abstract：:The citalopram for Alzheimer's disease trial evaluated citalopram for the management for agitation in Alzheimer's disease patients. Sparse data was available from this elderly patient population. A nonlinear mixed effects population pharmacokinetic modeling approach was used to describe the pharmacokinetics of R- and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Akil A,Bies RR,Pollock BG,Avramopoulos D,Devanand DP,Mintzer JE,Porsteinsson AP,Schneider LS,Weintraub D,Yesavage J,Shade DM,Lyketsos CG

更新日期：2016-02-01 00:00:00

abstract：:We propose an efficient algorithm for screening covariates in population model building using Wald's approximation to the likelihood ratio test (LRT) statistic in conjunction with Schwarz's Bayesian criterion. The algorithm can be applied to a full model fit of k covariate parameters to calculate the approximate LRT f...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kowalski KG,Hutmacher MM

更新日期：2001-06-01 00:00:00

abstract：:Structural identifiability is an often overlooked, but essential, prerequisite to the experiment design stage. The application of structural identifiability analysis to models of myelosuppression is used to demonstrate the importance of its considerations. It is shown that, under certain assumptions, these models are ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Evans ND,Cheung SYA,Yates JWT

更新日期：2018-02-01 00:00:00

abstract：:A modeling and simulation approach was used for quantitative comparison of a new generation HER2 antibody drug conjugate (ADC, PF-06804103) with trastuzumab-DM1 (T-DM1). To compare preclinical efficacy, the pharmacokinetic (PK)/pharmacodynamic (PD) relationship of PF-06804103 and T-DM1 was determined across a range of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Betts A,Clark T,Jasper P,Tolsma J,van der Graaf PH,Graziani EI,Rosfjord E,Sung M,Ma D,Barletta F

更新日期：2020-10-01 00:00:00

abstract：:Significant arterio-venous differences in nicotine concentrations have been observed during and after cigarette smoking, nicotine nasal spray, and intravenous nicotine administration. In this paper we describe a novel mathematical method for estimating arterial blood levels from venous blood level data. The model allo...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pitsiu M,Gries JM,Benowitz N,Gourlay SG,Verotta D

更新日期：2002-08-01 00:00:00

abstract：:A number of experimental observations in the late 1960s, early 1970s could not be explained by the pharmacokinetic theory available at that time. For example rats receiving phenobarbital as an enzyme inducing agent exhibited increased elimination of phenylbutazone in vitro in liver microsomes and in vivo in whole anim...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Benet LZ

更新日期：2010-12-01 00:00:00

abstract：:Pharmacokinetic analysis in humans using compartmental models is restricted with respect to the estimation of parameter values. This is because the experimenter usually is only able to apply inputs and observations in a very small number of compartments in the system. This has implications for the structural identifia...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cheung SY,Yates JW,Aarons L

更新日期：2013-02-01 00:00:00

abstract：:T cell responses are a crucial part of the adaptive immune system in the fight against infections. This article discusses the use of mathematical models for understanding the dynamics of cytotoxic T lymphocyte (CTL) responses against viral infections. Complementing experimental research, mathematical models have been ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Wodarz D

更新日期：2014-10-01 00:00:00

abstract：:3-hydroxybenzo(a)pyrene (3-OHBaP) in urine has been proposed as a biomarker of occupational exposure to polycyclic aromatic hydrocarbons. However, to reconstruct exposure doses in workers from biomarker measurements, a thorough knowledge of the kinetics of the benzo(a)pyrene (BaP) and 3-OHBaP given different routes of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Heredia-Ortiz R,Bouchard M

更新日期：2013-12-01 00:00:00

abstract：:The distributed delay model has been introduced that replaces the transit compartments in the classic model of chemotherapy-induced myelosuppression with a convolution integral. The maturation of granulocyte precursors in the bone marrow is described by the gamma probability density function with the shape parameter (...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Hu S,Dunlavey M

更新日期：2018-04-01 00:00:00

abstract：:We investigated the propagation of population pharmacokinetic information across clinical studies by applying Bayesian techniques. The aim was to summarize the population pharmacokinetic estimates of a study in appropriate statistical distributions in order to use them as Bayesian priors in consequent population pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Aarons L

更新日期：2005-08-01 00:00:00

abstract：:Previously, we developed a feedback model to describe the tolerance and oscillatory rebound of non-esterified fatty acid (NEFA) plasma concentrations in male Sprague Dawley rats after intravenous infusions of nicotinic acid (NiAc). This study challenges that model, using the following regimens of intravenous and oral ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahlström C,Peletier LA,Gabrielsson J

更新日期：2013-08-01 00:00:00

abstract：:We explored the type I error rate (false positive rate) associated with exposure-response (ER) analyses for two compounds in a fixed-dose combination product through simulations. In the simulations, at least one compound was assumed to be inactive, whereas the active compound followed E(max) model at different concent...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zhu H,Wang Y

更新日期：2011-12-01 00:00:00

abstract：AIM:Chemotherapy with indisulam causes myelosuppression. This study aimed to evaluate the influence of patient-related covariates on pharmacokinetics and pharmacodynamics, to identify patients at risk for severe myelosuppression and to develop a dosing algorithm for treatment optimization. METHODS:Pharmacokinetic and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zandvliet AS,Schellens JH,Copalu W,Beijnen JH,Huitema AD

更新日期：2009-02-01 00:00:00

abstract：:The majority of measures proposed to date for direct curve comparison in bioequivalence studies were investigated. These measures have often been called metrics, but in most cases this was incorrect in the mathematical sense. It was demonstrated, with a set of counter-examples, that the axioms of a metric are fulfille...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Jawień W

更新日期：2009-06-01 00:00:00

abstract：:The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model. The WB-PBPK model w...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Sadiq MW,Nielsen EI,Khachman D,Conil JM,Georges B,Houin G,Laffont CM,Karlsson MO,Friberg LE

更新日期：2017-04-01 00:00:00

abstract：:There has been little evaluation of maximum likelihood approximation methods for non-linear mixed effects modelling of count data. The aim of this study was to explore the estimation accuracy of population parameters from six count models, using two different methods and programs. Simulations of 100 data sets were per...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Plan EL,Maloney A,Trocóniz IF,Karlsson MO

更新日期：2009-08-01 00:00:00