Abstract：
:The majority of measures proposed to date for direct curve comparison in bioequivalence studies were investigated. These measures have often been called metrics, but in most cases this was incorrect in the mathematical sense. It was demonstrated, with a set of counter-examples, that the axioms of a metric are fulfilled only for the integral p-metric and some of its transforms. The Rescigno index and two other measures devised by Polli and McLean are the semi-metrics, lacking the triangle inequality, while others also lack symmetry. The use of the p-metric is therefore recommended, and statistical analysis is suggested as a point at which the scaling of differences might be carried out.
journal_name
J Pharmacokinet Pharmacodynjournal_title
Journal of pharmacokinetics and pharmacodynamicsauthors
Jawień Wdoi
10.1007/s10928-009-9121-0subject
Has Abstractpub_date
2009-06-01 00:00:00pages
261-79issue
3eissn
1567-567Xissn
1573-8744journal_volume
36pub_type
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